{"id":"https://openalex.org/W3209102319","doi":"https://doi.org/10.7150/ijbs.63732","title":"Lrp6 Genotype affects Individual Susceptibility to Nonalcoholic Fatty Liver Disease and Silibinin Therapeutic Response via Wnt/\u03b2-catenin-Cyp2e1 Signaling","display_name":"Lrp6 Genotype affects Individual Susceptibility to Nonalcoholic Fatty Liver Disease and Silibinin Therapeutic Response via Wnt/\u03b2-catenin-Cyp2e1 Signaling","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3209102319","doi":"https://doi.org/10.7150/ijbs.63732","mag":"3209102319","pmid":"https://pubmed.ncbi.nlm.nih.gov/34671210","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8495406"},"language":"en","primary_location":{"id":"doi:10.7150/ijbs.63732","doi":"https://doi.org/10.7150/ijbs.63732","is_oa":true,"landing_page_url":"https://doi.org/10.7150/ijbs.63732","pdf_url":"https://www.ijbs.com/v17p3936.pdf","source":{"id":"https://openalex.org/S26312460","display_name":"International Journal of Biological Sciences","issn_l":"1449-2288","issn":["1449-2288"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.ijbs.com/v17p3936.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100611491","display_name":"Lijie Chen","orcid":"https://orcid.org/0000-0002-6870-9708","observed_orcids":["https://orcid.org/0000-0002-6870-9708"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Jie Chen","raw_affiliation_strings":["Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, P. R. China","Institute of Clinical Pharmacology, Central South University, Changsha 410078, Hunan, China","National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha 410008, Hunan, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, P. R. China","institution_ids":[]},{"raw_affiliation_string":"Institute of Clinical Pharmacology, Central South University, Changsha 410078, Hunan, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha 410008, Hunan, P.R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085515243","display_name":"Xiu\u2010Xian Lin","orcid":"https://orcid.org/0000-0003-2134-6396","observed_orcids":["https://orcid.org/0000-0003-2134-6396"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiu-Xian Lin","raw_affiliation_strings":["Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, P. R. China","Institute of Clinical Pharmacology, Central South University, Changsha 410078, Hunan, China","National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha 410008, Hunan, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, P. R. China","institution_ids":[]},{"raw_affiliation_string":"Institute of Clinical Pharmacology, Central South University, Changsha 410078, Hunan, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha 410008, Hunan, P.R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080252623","display_name":"J\u00ecng Guo","orcid":"https://orcid.org/0000-0002-2177-6970","observed_orcids":["https://orcid.org/0000-0002-2177-6970","https://orcid.org/0009-0001-7245-4189"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Guo","raw_affiliation_strings":["Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, P. R. China","Institute of Clinical Pharmacology, Central South University, Changsha 410078, Hunan, China","National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha 410008, Hunan, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, P. R. China","institution_ids":[]},{"raw_affiliation_string":"Institute of Clinical Pharmacology, Central South University, Changsha 410078, Hunan, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha 410008, Hunan, P.R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074976551","display_name":"Ying Xu","orcid":"https://orcid.org/0000-0002-9987-2057","observed_orcids":["https://orcid.org/0000-0002-9987-2057"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Xu","raw_affiliation_strings":["Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, P. R. China","Institute of Clinical Pharmacology, Central South University, Changsha 410078, Hunan, China","National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha 410008, Hunan, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, P. R. China","institution_ids":[]},{"raw_affiliation_string":"Institute of Clinical Pharmacology, Central South University, Changsha 410078, Hunan, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha 410008, Hunan, P.R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015480027","display_name":"Song-Xia Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Song-Xia Zhang","raw_affiliation_strings":["Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, P. R. China","Institute of Clinical Pharmacology, Central South University, Changsha 410078, Hunan, China","National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha 410008, Hunan, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, P. R. China","institution_ids":[]},{"raw_affiliation_string":"Institute of Clinical Pharmacology, Central South University, Changsha 410078, Hunan, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha 410008, Hunan, P.R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100444008","display_name":"Dan Chen","orcid":"https://orcid.org/0000-0003-1289-1077","observed_orcids":["https://orcid.org/0000-0003-1289-1077"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dan Chen","raw_affiliation_strings":["Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, P. R. China","Institute of Clinical Pharmacology, Central South University, Changsha 410078, Hunan, China","National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha 410008, Hunan, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, P. R. China","institution_ids":[]},{"raw_affiliation_string":"Institute of Clinical Pharmacology, Central South University, Changsha 410078, Hunan, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha 410008, Hunan, P.R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100622474","display_name":"Qing Zhao","orcid":"https://orcid.org/0000-0001-9927-8907","observed_orcids":["https://orcid.org/0000-0001-9927-8907","https://orcid.org/0000-0002-8740-0271"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Zhao","raw_affiliation_strings":["Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, P. R. China","Institute of Clinical Pharmacology, Central South University, Changsha 410078, Hunan, China","National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha 410008, Hunan, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, P. R. China","institution_ids":[]},{"raw_affiliation_string":"Institute of Clinical Pharmacology, Central South University, Changsha 410078, Hunan, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha 410008, Hunan, P.R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104007560","display_name":"Jian Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Xiao","raw_affiliation_strings":["Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110719671","display_name":"Guanghui Lian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guang-Hui Lian","raw_affiliation_strings":["Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066346724","display_name":"Shifang Peng","orcid":"https://orcid.org/0000-0001-5923-4029","observed_orcids":["https://orcid.org/0000-0001-5923-4029"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shi-Fang Peng","raw_affiliation_strings":["Department of Hepatology and Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatology and Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017542783","display_name":"Dong Guo","orcid":"https://orcid.org/0000-0002-1055-482X","observed_orcids":["https://orcid.org/0000-0002-1055-482X"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong Guo","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201. USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201. USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hong Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Yang","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201. USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201. USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065113416","display_name":"Yan Shu","orcid":"https://orcid.org/0000-0001-8492-1437","observed_orcids":["https://orcid.org/0000-0001-8492-1437"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Shu","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201. USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201. USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101632032","display_name":"Honghao Zhou","orcid":"https://orcid.org/0000-0001-6104-7927","observed_orcids":["https://orcid.org/0000-0001-6104-7927"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-Hao Zhou","raw_affiliation_strings":["Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, P. R. China","Institute of Clinical Pharmacology, Central South University, Changsha 410078, Hunan, China","National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha 410008, Hunan, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, P. R. China","institution_ids":[]},{"raw_affiliation_string":"Institute of Clinical Pharmacology, Central South University, Changsha 410078, Hunan, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha 410008, Hunan, P.R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100441818","display_name":"Wei Zhang","orcid":"https://orcid.org/0009-0002-3507-4504","observed_orcids":["https://orcid.org/0009-0002-3507-4504","https://orcid.org/0000-0002-6190-3129"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, P. R. China","Institute of Clinical Pharmacology, Central South University, Changsha 410078, Hunan, China","National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha 410008, Hunan, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, P. R. China","institution_ids":[]},{"raw_affiliation_string":"Institute of Clinical Pharmacology, Central South University, Changsha 410078, Hunan, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha 410008, Hunan, P.R. China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100394237","display_name":"Yao Chen","orcid":"https://orcid.org/0000-0001-7231-9860","observed_orcids":["https://orcid.org/0000-0001-7231-9860","https://orcid.org/0009-0005-0736-2412"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yao Chen","raw_affiliation_strings":["Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, P. R. China","Institute of Clinical Pharmacology, Central South University, Changsha 410078, Hunan, China","National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha 410008, Hunan, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, P. R. China","institution_ids":[]},{"raw_affiliation_string":"Institute of Clinical Pharmacology, Central South University, Changsha 410078, Hunan, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha 410008, Hunan, P.R. China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100394237"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"],"apc_list":{"value":2000,"currency":"AUD","value_usd":1337},"apc_paid":{"value":2000,"currency":"AUD","value_usd":1337},"fwci":0.7074,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.68657562,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"17","issue":"14","first_page":"3936","last_page":"3953"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12689","display_name":"Silymarin and Mushroom Poisoning","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.984000027179718},{"id":"https://openalex.org/keywords/lrp6","display_name":"LRP6","score":0.9559999704360962},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7429999709129333},{"id":"https://openalex.org/keywords/silibinin","display_name":"silibinin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cyp2e1","display_name":"CYP2E1","score":0.8989999890327454},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.824999988079071},{"id":"https://openalex.org/keywords/methionine-and-choline-deficient-diet","display_name":"methionine-choline-deficient diet","score":0.9710000157356262},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.5550000071525574},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C2777130413","wikidata":"https://www.wikidata.org/wiki/Q425702","display_name":"Silibinin","level":2,"score":0.8641281127929688},{"id":"https://openalex.org/C170320316","wikidata":"https://www.wikidata.org/wiki/Q18028667","display_name":"LRP6","level":4,"score":0.7826896905899048},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.6469962000846863},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.5972775816917419},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.5716755390167236},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4693542420864105},{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.45301228761672974},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4434123635292053},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35706931352615356},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35589247941970825},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3393312096595764},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.21202436089515686},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17234888672828674},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.14611154794692993}],"mesh":[{"descriptor_ui":"D000077385","descriptor_name":"Silybin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000077385","descriptor_name":"Silybin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019392","descriptor_name":"Cytochrome P-450 CYP2E1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D060488","descriptor_name":"Low Density Lipoprotein Receptor-Related Protein-6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.7150/ijbs.63732","doi":"https://doi.org/10.7150/ijbs.63732","is_oa":true,"landing_page_url":"https://doi.org/10.7150/ijbs.63732","pdf_url":"https://www.ijbs.com/v17p3936.pdf","source":{"id":"https://openalex.org/S26312460","display_name":"International Journal of Biological Sciences","issn_l":"1449-2288","issn":["1449-2288"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8495406","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8495406","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Biol Sci","raw_type":"Text"},{"id":"pmid:34671210","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34671210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of biological sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7150/ijbs.63732","doi":"https://doi.org/10.7150/ijbs.63732","is_oa":true,"landing_page_url":"https://doi.org/10.7150/ijbs.63732","pdf_url":"https://www.ijbs.com/v17p3936.pdf","source":{"id":"https://openalex.org/S26312460","display_name":"International Journal of Biological Sciences","issn_l":"1449-2288","issn":["1449-2288"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2620897740","display_name":null,"funder_award_id":"2019ZX09201-002-006","funder_id":"https://openalex.org/F4320329860","funder_display_name":"National Science and Technology Major Project"}],"funders":[{"id":"https://openalex.org/F4320329860","display_name":"National Science and Technology Major Project","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3209102319.pdf","grobid_xml":"https://content.openalex.org/works/W3209102319.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W35682690","https://openalex.org/W82388168","https://openalex.org/W153333864","https://openalex.org/W1176741214","https://openalex.org/W1564148916","https://openalex.org/W1969867759","https://openalex.org/W1976094170","https://openalex.org/W1979443397","https://openalex.org/W1979973839","https://openalex.org/W1988994274","https://openalex.org/W2003272885","https://openalex.org/W2009973913","https://openalex.org/W2017511982","https://openalex.org/W2021112085","https://openalex.org/W2034298464","https://openalex.org/W2037599820","https://openalex.org/W2037617478","https://openalex.org/W2038927157","https://openalex.org/W2052015281","https://openalex.org/W2072737785","https://openalex.org/W2080361134","https://openalex.org/W2084967585","https://openalex.org/W2107648723","https://openalex.org/W2109299785","https://openalex.org/W2118230770","https://openalex.org/W2123969140","https://openalex.org/W2128286750","https://openalex.org/W2130781866","https://openalex.org/W2145430183","https://openalex.org/W2154921543","https://openalex.org/W2169624083","https://openalex.org/W2181483150","https://openalex.org/W2241329404","https://openalex.org/W2291173445","https://openalex.org/W2291276541","https://openalex.org/W2404306813","https://openalex.org/W2513903220","https://openalex.org/W2514402876","https://openalex.org/W2569170670","https://openalex.org/W2622908974","https://openalex.org/W2758047358","https://openalex.org/W2759997926","https://openalex.org/W2767612730","https://openalex.org/W2767801219","https://openalex.org/W2778645498","https://openalex.org/W2884546546","https://openalex.org/W2899595328","https://openalex.org/W2908472980","https://openalex.org/W2911312028","https://openalex.org/W2938973179","https://openalex.org/W2955630694","https://openalex.org/W2962151738","https://openalex.org/W2981432004","https://openalex.org/W2982178384","https://openalex.org/W3003865038","https://openalex.org/W3005185184","https://openalex.org/W3006567489","https://openalex.org/W3029861899","https://openalex.org/W4241398143","https://openalex.org/W6600648412","https://openalex.org/W6773941974"],"related_works":["https://openalex.org/W2059571707","https://openalex.org/W2099540722","https://openalex.org/W2938973179","https://openalex.org/W3208067807","https://openalex.org/W1991594587","https://openalex.org/W2924664273","https://openalex.org/W4240973617","https://openalex.org/W1966549856","https://openalex.org/W4281784090","https://openalex.org/W4293522720"],"abstract_inverted_index":{"Background:":[0],"Nonalcoholic":[1],"fatty":[2],"liver":[3,88,173],"disease":[4],"(NAFLD)":[5],"is":[6],"a":[7,15,19,105,125,143,170,179,197,266],"serious":[8],"threat":[9],"to":[10,29,37,79,140,182,189,218,233,257],"human":[11,86,149,254],"health":[12],"worldwide,":[13],"with":[14,31,43,85,142,163,203,260],"high":[16],"genetic":[17],"susceptibility.Rs2302685,":[18],"functional":[20,116],"germline":[21],"variant":[22],"of":[23,53,93,114,127,135,146,152,157,185,199,212,239,272],"LRP6,":[24],"has":[25,248],"been":[26],"recently":[27],"found":[28],"associate":[30,141],"NAFLD":[32,61,147,225,234,258,275],"risk.This":[33],"study":[34],"was":[35,77,122,138],"aimed":[36],"clarify":[38],"the":[39,81,164,183,190,210,236,242,269],"underlying":[40,251],"mechanism":[41,252],"associated":[42,84,259],"rs2302685":[44,137,153],"risk":[45,145],"and":[46,62,90,100,129,159,235],"its":[47],"impact":[48],"on":[49,118],"pharmacotherapy":[50],"in":[51,148,187,216,274],"treatment":[52,184,223],"NAFLD.Methods:":[54],"Venous":[55],"blood":[56],"samples":[57],"were":[58,95],"collected":[59],"from":[60],"non-NAFLD":[63],"patients":[64],"for":[65,253,268],"SNP":[66],"genotyping":[67],"by":[68,124,176,209],"using":[69],"mass":[70],"spectrometry.The":[71],"Lrp6-floxdel":[72],"mouse":[73],"(Lrp6":[74],"(+/-)":[75,99,167],")":[76],"generated":[78],"model":[80],"partial":[82],"function":[83,229],"rs2302685.The":[87],"injury":[89,174],"therapeutic":[91,237],"effects":[92],"silibinin":[94,186,222,240,273],"compared":[96,162],"between":[97],"Lrp6":[98,101,115,166,191,195,219,228,261],"(+/+)":[102,192],"mice":[103,168],"received":[104],"methionine-choline":[106],"deficient":[107],"(MCD)":[108],"diet":[109],"or":[110,221],"normal":[111],"diet.The":[112],"effect":[113,238],"alteration":[117],"Wnt/\u03b2-catenin-Cyp2e1":[119,243],"signaling":[120,201,244],"activities":[121],"evaluated":[123],"series":[126],"cellular":[128],"molecular":[130],"assays.Results:":[131],"The":[132,227],"T":[133],"allele":[134],"LRP6":[136],"confirmed":[139],"higher":[144],"subjects.The":[150],"carriers":[151],"had":[154],"reduced":[155,180],"level":[156],"AST":[158],"ALT":[160],"as":[161,196,263,265],"noncarriers.The":[165],"exhibited":[169],"less":[171],"severe":[172],"induced":[175],"MCD":[177],"but":[178],"response":[181,217],"comparison":[188],"mice,":[193],"suggesting":[194],"target":[198],"silibinin.Wnt/\u03b2-catenin-Cyp2e1":[200],"together":[202],"ROS":[204],"generation":[205],"could":[206],"be":[207],"exacerbated":[208],"overexpression":[211],"Lrp6,":[213],"while":[214],"decreased":[215],"siRNA":[220],"under":[224],"modeling.Conclusions:":[226],"affects":[230],"individual":[231,255],"susceptibility":[232,256],"through":[241],"pathway.The":[245],"present":[246],"work":[247],"provided":[249],"an":[250],"polymorphisms":[262],"well":[264],"rationale":[267],"effective":[270],"use":[271],"patients.":[276]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-11-08T00:00:00"}