{"id":"https://openalex.org/W3209080693","doi":"https://doi.org/10.1007/s11596-021-2454-7","title":"Relationship Between Myocardial Injury and Expression of PGC-1\u03b1 and Its Coactivators in Chronic Keshan Disease","display_name":"Relationship Between Myocardial Injury and Expression of PGC-1\u03b1 and Its Coactivators in Chronic Keshan Disease","publication_year":2021,"publication_date":"2021-10-27","ids":{"openalex":"https://openalex.org/W3209080693","doi":"https://doi.org/10.1007/s11596-021-2454-7","mag":"3209080693","pmid":"https://pubmed.ncbi.nlm.nih.gov/34705216"},"language":"en","primary_location":{"id":"doi:10.1007/s11596-021-2454-7","doi":"https://doi.org/10.1007/s11596-021-2454-7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11596-021-2454-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210178822","display_name":"Current Medical Science","issn_l":"2096-5230","issn":["2096-5230","2523-899X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","medline","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054482344","display_name":"Shuai Jiang","orcid":"https://orcid.org/0000-0003-1235-6269","observed_orcids":["https://orcid.org/0000-0003-1235-6269"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210136497","display_name":"Jilin Medical University","ror":"https://ror.org/03mzw7781","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210136497"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuai Jiang","raw_affiliation_strings":["Affiliated Hospital of Jilin Medical College, Jilin, 132013, China","Institute of Keshan Disease, Chinese Center for Endemic Disease Control, Harbin Medical University, Harbin, 150081, China","Affiliated Hospital of Jilin Medical College, Jilin, China","Institute of Keshan Disease, Chinese Center for Endemic Disease Control, Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Jilin Medical College, Jilin, 132013, China","institution_ids":["https://openalex.org/I4210136497"]},{"raw_affiliation_string":"Institute of Keshan Disease, Chinese Center for Endemic Disease Control, Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Affiliated Hospital of Jilin Medical College, Jilin, China","institution_ids":["https://openalex.org/I4210136497"]},{"raw_affiliation_string":"Institute of Keshan Disease, Chinese Center for Endemic Disease Control, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049313045","display_name":"Qianru Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210092071","display_name":"Hangzhou Center for Disease Control and Prevention","ror":"https://ror.org/00dr1cn74","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210092071"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian-ru Ye","raw_affiliation_strings":["Hangzhou Center for Disease Control and Prevention, Hangzhou, 310021, China","Institute of Keshan Disease, Chinese Center for Endemic Disease Control, Harbin Medical University, Harbin, 150081, China","Hangzhou Center for Disease Control and Prevention, Hangzhou, China","Institute of Keshan Disease, Chinese Center for Endemic Disease Control, Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hangzhou Center for Disease Control and Prevention, Hangzhou, 310021, China","institution_ids":["https://openalex.org/I4210092071"]},{"raw_affiliation_string":"Institute of Keshan Disease, Chinese Center for Endemic Disease Control, Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Hangzhou Center for Disease Control and Prevention, Hangzhou, China","institution_ids":["https://openalex.org/I4210092071"]},{"raw_affiliation_string":"Institute of Keshan Disease, Chinese Center for Endemic Disease Control, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004820779","display_name":"Rongxia Zhen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405278473","display_name":"Sanya Institute of Technology","ror":"https://ror.org/003n2wz13","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405278473"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong-xia Zhen","raw_affiliation_strings":["Sanya Institute of Technology, Sanya, 572022, China","Sanya Institute of Technology, Sanya, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanya Institute of Technology, Sanya, 572022, China","institution_ids":["https://openalex.org/I4405278473"]},{"raw_affiliation_string":"Sanya Institute of Technology, Sanya, China","institution_ids":["https://openalex.org/I4405278473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091417219","display_name":"Juan-niu Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan-niu Zhang","raw_affiliation_strings":["Inner Mongolia Autonomous Region Mental Health Center, Hohhot, 010010, China","Inner Mongolia Autonomous Region Mental Health Center, Hohhot, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inner Mongolia Autonomous Region Mental Health Center, Hohhot, 010010, China","institution_ids":[]},{"raw_affiliation_string":"Inner Mongolia Autonomous Region Mental Health Center, Hohhot, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yi-yi Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi-yi Zhang","raw_affiliation_strings":["Institute of Keshan Disease, Chinese Center for Endemic Disease Control, Harbin Medical University, Harbin, 150081, China","Institute of Keshan Disease, Chinese Center for Endemic Disease Control, Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Keshan Disease, Chinese Center for Endemic Disease Control, Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Institute of Keshan Disease, Chinese Center for Endemic Disease Control, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100331686","display_name":"Xu Liu","orcid":"https://orcid.org/0000-0002-1620-3932","observed_orcids":["https://orcid.org/0000-0002-1620-3932"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu Liu","raw_affiliation_strings":["Institute of Keshan Disease, Chinese Center for Endemic Disease Control, Harbin Medical University, Harbin, 150081, China","Institute of Keshan Disease, Chinese Center for Endemic Disease Control, Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Keshan Disease, Chinese Center for Endemic Disease Control, Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Institute of Keshan Disease, Chinese Center for Endemic Disease Control, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034017949","display_name":"Jie Hou","orcid":"https://orcid.org/0000-0002-0836-8251","observed_orcids":["https://orcid.org/0000-0002-0836-8251"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jie Hou","raw_affiliation_strings":["Institute of Keshan Disease, Chinese Center for Endemic Disease Control, Harbin Medical University, Harbin, 150081, China. houjie@ems.hrbmu.edu.cn","Institute of Keshan Disease, Chinese Center for Endemic Disease Control, Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Keshan Disease, Chinese Center for Endemic Disease Control, Harbin Medical University, Harbin, 150081, China. houjie@ems.hrbmu.edu.cn","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Institute of Keshan Disease, Chinese Center for Endemic Disease Control, Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5034017949"],"corresponding_institution_ids":["https://openalex.org/I156144747"],"apc_list":{"value":3280,"currency":"USD","value_usd":3280},"apc_paid":null,"fwci":0.0699,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.26379927,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"42","issue":"1","first_page":"85","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.6929000020027161,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.6929000020027161,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.037300001829862595,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.02889999933540821,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-keshan-disease","display_name":"chronic Keshan disease","score":0.9589999914169312},{"id":"https://openalex.org/keywords/myocardial-injury","display_name":"myocardial injury","score":0.9089999794960022},{"id":"https://openalex.org/keywords/pgc-1alpha","display_name":"PGC-1\u03b1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ppargamma-coactivator","display_name":"PPAR\u03b3 coactivator","score":0.8730000257492065},{"id":"https://openalex.org/keywords/mitochondrial-cardiomyopathy","display_name":"mitochondrial cardiomyopathy","score":0.8889999985694885},{"id":"https://openalex.org/keywords/pparalpha","display_name":"PPAR\u03b1","score":0.8889999985694885},{"id":"https://openalex.org/keywords/nrf1","display_name":"NRF1","score":0.8709999918937683},{"id":"https://openalex.org/keywords/estrogen-related-receptor-alpha","display_name":"estrogen-related receptor alpha","score":0.9110000133514404},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/creatine-kinase","display_name":"creatine kinase","score":0.7730000019073486},{"id":"https://openalex.org/keywords/atrial-natriuretic-peptide","display_name":"atrial natriuretic peptide","score":0.9589999914169312},{"id":"https://openalex.org/keywords/bradykinin","display_name":"bradykinin","score":0.9810000061988831},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.7300000190734863},{"id":"https://openalex.org/keywords/peripheral-blood-gene-expression","display_name":"peripheral blood gene expression","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C74438686","wikidata":"https://www.wikidata.org/wiki/Q18030218","display_name":"NRF1","level":4,"score":0.8975052833557129},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6309472322463989},{"id":"https://openalex.org/C77445288","wikidata":"https://www.wikidata.org/wiki/Q637488","display_name":"Coactivator","level":4,"score":0.6276907324790955},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.5857709646224976},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5776498317718506},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.544398844242096},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.524226725101471},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48091551661491394},{"id":"https://openalex.org/C2775915353","wikidata":"https://www.wikidata.org/wiki/Q1571529","display_name":"Natriuretic peptide","level":3,"score":0.4803634583950043},{"id":"https://openalex.org/C36880943","wikidata":"https://www.wikidata.org/wiki/Q409458","display_name":"Creatine kinase","level":2,"score":0.45919549465179443},{"id":"https://openalex.org/C127078168","wikidata":"https://www.wikidata.org/wiki/Q138639","display_name":"Peroxisome","level":3,"score":0.4532247483730316},{"id":"https://openalex.org/C2777229759","wikidata":"https://www.wikidata.org/wiki/Q6881848","display_name":"Mitochondrial biogenesis","level":3,"score":0.393776535987854},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30876845121383667},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.27525395154953003},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.23313182592391968},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18324270844459534},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17431950569152832},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.14776942133903503},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1198553740978241}],"mesh":[{"descriptor_ui":"D000071248","descriptor_name":"Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004769","descriptor_name":"Enterovirus Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009202","descriptor_name":"Cardiomyopathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11596-021-2454-7","doi":"https://doi.org/10.1007/s11596-021-2454-7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11596-021-2454-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210178822","display_name":"Current Medical Science","issn_l":"2096-5230","issn":["2096-5230","2523-899X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","medline","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Science","raw_type":"journal-article"},{"id":"pmid:34705216","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34705216","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current medical science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1968197570","https://openalex.org/W1982882767","https://openalex.org/W1990463092","https://openalex.org/W1996821192","https://openalex.org/W2012288312","https://openalex.org/W2012614233","https://openalex.org/W2018427433","https://openalex.org/W2020581392","https://openalex.org/W2020600607","https://openalex.org/W2038040985","https://openalex.org/W2046459336","https://openalex.org/W2051559909","https://openalex.org/W2069558144","https://openalex.org/W2079033189","https://openalex.org/W2082984525","https://openalex.org/W2118794684","https://openalex.org/W2120293566","https://openalex.org/W2147993424","https://openalex.org/W2149775430","https://openalex.org/W2162782596","https://openalex.org/W2163785511","https://openalex.org/W2165547205","https://openalex.org/W2197859747","https://openalex.org/W2337579874","https://openalex.org/W2409804567","https://openalex.org/W2791616904","https://openalex.org/W2993159883","https://openalex.org/W4251691729"],"related_works":["https://openalex.org/W2012288312","https://openalex.org/W2067137741","https://openalex.org/W4404021669","https://openalex.org/W1997272517","https://openalex.org/W2409804567","https://openalex.org/W4251691729","https://openalex.org/W990341289","https://openalex.org/W3032659700","https://openalex.org/W2386502726","https://openalex.org/W7126176165"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-11-08T00:00:00"}