{"id":"https://openalex.org/W3208971274","doi":"https://doi.org/10.1016/j.phrs.2021.105963","title":"Saffron, as an adjunct therapy, contributes to relieve depression symptoms: An umbrella meta-analysis","display_name":"Saffron, as an adjunct therapy, contributes to relieve depression symptoms: An umbrella meta-analysis","publication_year":2021,"publication_date":"2021-10-29","ids":{"openalex":"https://openalex.org/W3208971274","doi":"https://doi.org/10.1016/j.phrs.2021.105963","mag":"3208971274","pmid":"https://pubmed.ncbi.nlm.nih.gov/34757208"},"language":"en","primary_location":{"id":"doi:10.1016/j.phrs.2021.105963","doi":"https://doi.org/10.1016/j.phrs.2021.105963","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.phrs.2021.105963","pdf_url":null,"source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086204549","display_name":"Vali Musazadeh","orcid":"https://orcid.org/0000-0002-4978-9474","observed_orcids":["https://orcid.org/0000-0002-4978-9474"]},"institutions":[{"id":"https://openalex.org/I163205636","display_name":"Tabriz University of Medical Sciences","ror":"https://ror.org/04krpx645","country_code":"IR","type":"education","lineage":["https://openalex.org/I163205636"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Vali Musazadeh","raw_affiliation_strings":["Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Community Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: musazadehv@tbzmed.ac.ir","Department of Community Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran","Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Community Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: musazadehv@tbzmed.ac.ir","institution_ids":["https://openalex.org/I163205636"]},{"raw_affiliation_string":"Department of Community Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran","institution_ids":["https://openalex.org/I163205636"]},{"raw_affiliation_string":"Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran","institution_ids":["https://openalex.org/I163205636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011825950","display_name":"Meysam Zarezadeh","orcid":"https://orcid.org/0000-0002-4268-4178","observed_orcids":["https://orcid.org/0000-0002-4268-4178"]},"institutions":[{"id":"https://openalex.org/I163205636","display_name":"Tabriz University of Medical Sciences","ror":"https://ror.org/04krpx645","country_code":"IR","type":"education","lineage":["https://openalex.org/I163205636"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Meysam Zarezadeh","raw_affiliation_strings":["Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: meysam.za93@gmail.com","Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran","Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: meysam.za93@gmail.com","institution_ids":["https://openalex.org/I163205636"]},{"raw_affiliation_string":"Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran","institution_ids":["https://openalex.org/I163205636"]},{"raw_affiliation_string":"Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran","institution_ids":["https://openalex.org/I163205636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079262149","display_name":"Amir Hossein Faghfouri","orcid":"https://orcid.org/0000-0003-0356-7267","observed_orcids":["https://orcid.org/0000-0003-0356-7267"]},"institutions":[{"id":"https://openalex.org/I163205636","display_name":"Tabriz University of Medical Sciences","ror":"https://ror.org/04krpx645","country_code":"IR","type":"education","lineage":["https://openalex.org/I163205636"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Amir Hossein Faghfouri","raw_affiliation_strings":["Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Community Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran","Department of Community Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran","Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Community Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran","institution_ids":["https://openalex.org/I163205636"]},{"raw_affiliation_string":"Department of Community Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran","institution_ids":["https://openalex.org/I163205636"]},{"raw_affiliation_string":"Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran","institution_ids":["https://openalex.org/I163205636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072496802","display_name":"Majid Keramati","orcid":"https://orcid.org/0000-0002-2693-5475","observed_orcids":["https://orcid.org/0000-0002-2693-5475"]},"institutions":[{"id":"https://openalex.org/I163205636","display_name":"Tabriz University of Medical Sciences","ror":"https://ror.org/04krpx645","country_code":"IR","type":"education","lineage":["https://openalex.org/I163205636"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Majid Keramati","raw_affiliation_strings":["Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Community Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran","Department of Community Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran","Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Community Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran","institution_ids":["https://openalex.org/I163205636"]},{"raw_affiliation_string":"Department of Community Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran","institution_ids":["https://openalex.org/I163205636"]},{"raw_affiliation_string":"Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran","institution_ids":["https://openalex.org/I163205636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021675199","display_name":"Zohreh Ghoreishi","orcid":"https://orcid.org/0000-0001-7522-5755","observed_orcids":["https://orcid.org/0000-0001-7522-5755"]},"institutions":[{"id":"https://openalex.org/I163205636","display_name":"Tabriz University of Medical Sciences","ror":"https://ror.org/04krpx645","country_code":"IR","type":"education","lineage":["https://openalex.org/I163205636"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Zohreh Ghoreishi","raw_affiliation_strings":["Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran","institution_ids":["https://openalex.org/I163205636"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006505361","display_name":"Alireza Farnam","orcid":"https://orcid.org/0000-0002-6985-6961","observed_orcids":["https://orcid.org/0000-0002-6985-6961"]},"institutions":[{"id":"https://openalex.org/I163205636","display_name":"Tabriz University of Medical Sciences","ror":"https://ror.org/04krpx645","country_code":"IR","type":"education","lineage":["https://openalex.org/I163205636"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Alireza Farnam","raw_affiliation_strings":["Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: farnama@tbzmed.ac.ir","Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran","Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: farnama@tbzmed.ac.ir","institution_ids":["https://openalex.org/I163205636"]},{"raw_affiliation_string":"Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran","institution_ids":["https://openalex.org/I163205636"]},{"raw_affiliation_string":"Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran","institution_ids":["https://openalex.org/I163205636"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006505361","https://openalex.org/A5011825950"],"corresponding_institution_ids":["https://openalex.org/I163205636"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.789,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.54220315,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"175","issue":null,"first_page":"105963","last_page":"105963"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12758","display_name":"Saffron Plant Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12758","display_name":"Saffron Plant Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saffron","display_name":"saffron","score":1.0},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9940000176429749},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.7870000004768372},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.9620000123977661},{"id":"https://openalex.org/keywords/antidepressant-effects","display_name":"antidepressant effects","score":0.7699999809265137},{"id":"https://openalex.org/keywords/beck-depression-inventory","display_name":"Beck Depression Inventory","score":0.8389999866485596},{"id":"https://openalex.org/keywords/hamilton-depression-rating-scale","display_name":"Hamilton Depression Rating Scale","score":0.9779999852180481},{"id":"https://openalex.org/keywords/depression-anxiety-stress-scale","display_name":"DASS","score":0.3880000114440918},{"id":"https://openalex.org/keywords/depression-severity","display_name":"depression severity","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C2779571273","wikidata":"https://www.wikidata.org/wiki/Q15041677","display_name":"Crocus sativus","level":2,"score":0.8766492009162903},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.7881024479866028},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7207835912704468},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.694958508014679},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.6440615653991699},{"id":"https://openalex.org/C3020774429","wikidata":"https://www.wikidata.org/wiki/Q1201886","display_name":"Web of science","level":3,"score":0.5320855975151062},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.49020200967788696},{"id":"https://openalex.org/C2777198177","wikidata":"https://www.wikidata.org/wiki/Q3765927","display_name":"Hamd","level":3,"score":0.4886241555213928},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.48424383997917175},{"id":"https://openalex.org/C2777056012","wikidata":"https://www.wikidata.org/wiki/Q1975444","display_name":"Adjunct","level":2,"score":0.47328823804855347},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.4455479085445404},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42993465065956116},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.4223115146160126},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.33856794238090515},{"id":"https://openalex.org/C3018023364","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Significant difference","level":2,"score":0.08543729782104492},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D027622","descriptor_name":"Crocus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D028321","descriptor_name":"Plant Preparations","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.phrs.2021.105963","doi":"https://doi.org/10.1016/j.phrs.2021.105963","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.phrs.2021.105963","pdf_url":null,"source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},{"id":"pmid:34757208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34757208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[{"id":"https://openalex.org/G4658005512","display_name":null,"funder_award_id":"67919","funder_id":"https://openalex.org/F4320322587","funder_display_name":"Tabriz University of Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320322587","display_name":"Tabriz University of Medical Sciences","ror":"https://ror.org/04krpx645"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W496281","https://openalex.org/W93044161","https://openalex.org/W1483936248","https://openalex.org/W1543613740","https://openalex.org/W1665775627","https://openalex.org/W1911245840","https://openalex.org/W1950423950","https://openalex.org/W1967240735","https://openalex.org/W1992456991","https://openalex.org/W1994714011","https://openalex.org/W1999317538","https://openalex.org/W2005424649","https://openalex.org/W2021293105","https://openalex.org/W2024985387","https://openalex.org/W2039744916","https://openalex.org/W2058051739","https://openalex.org/W2092075716","https://openalex.org/W2114190754","https://openalex.org/W2114818277","https://openalex.org/W2119790985","https://openalex.org/W2137296158","https://openalex.org/W2139752584","https://openalex.org/W2141974739","https://openalex.org/W2159061031","https://openalex.org/W2162732991","https://openalex.org/W2166822947","https://openalex.org/W2280569955","https://openalex.org/W2285977544","https://openalex.org/W2554331488","https://openalex.org/W2765850776","https://openalex.org/W2803731232","https://openalex.org/W2883745699","https://openalex.org/W2922071298","https://openalex.org/W2939068847","https://openalex.org/W2947531029","https://openalex.org/W2978795816","https://openalex.org/W2990455503","https://openalex.org/W2999438882","https://openalex.org/W3015840940","https://openalex.org/W3109023111","https://openalex.org/W3134388291","https://openalex.org/W3142286129","https://openalex.org/W3175394985"],"related_works":["https://openalex.org/W2999438882","https://openalex.org/W1994714011","https://openalex.org/W2939068847","https://openalex.org/W2883745699","https://openalex.org/W7000009278","https://openalex.org/W7133310271","https://openalex.org/W2947531029","https://openalex.org/W2803731232","https://openalex.org/W1950423950","https://openalex.org/W2990455503"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-11-08T00:00:00"}