{"id":"https://openalex.org/W3208961851","doi":"https://doi.org/10.52586/4978","title":"Reply to Comment on Shen H, et al. \u201cCo-signaling receptors regulate T-cell plasticity and immune tolerance\u201d. Frontiers in Bioscience-Landmark. 2019; 24: 96\u2013132","display_name":"Reply to Comment on Shen H, et al. \u201cCo-signaling receptors regulate T-cell plasticity and immune tolerance\u201d. Frontiers in Bioscience-Landmark. 2019; 24: 96\u2013132","publication_year":2021,"publication_date":"2021-10-29","ids":{"openalex":"https://openalex.org/W3208961851","doi":"https://doi.org/10.52586/4978","mag":"3208961851","pmid":"https://pubmed.ncbi.nlm.nih.gov/34719196"},"language":"en","primary_location":{"id":"doi:10.52586/4978","doi":"https://doi.org/10.52586/4978","is_oa":true,"landing_page_url":"https://doi.org/10.52586/4978","pdf_url":null,"source":{"id":"https://openalex.org/S4210236708","display_name":"Frontiers in Bioscience-Landmark","issn_l":"2768-6698","issn":["2768-6698","2768-6701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310322753","host_organization_name":"IMR Press","host_organization_lineage":["https://openalex.org/P4310322753"],"host_organization_lineage_names":["IMR Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioscience-Landmark","raw_type":"journal-article"},"volume":null,"type":"letter","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.52586/4978","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100640147","display_name":"Haitao Shen","orcid":"https://orcid.org/0000-0002-0533-0872","observed_orcids":["https://orcid.org/0000-0002-0533-0872"]},"institutions":[{"id":"https://openalex.org/I2800370534","display_name":"Sheng Jing Hospital","ror":"https://ror.org/0202bj006","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800370534"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Haitao Shen","raw_affiliation_strings":["Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","Department of Emergency Medicine, Shengjing Hospital of China Medical University, 110004 Shenyang, Liaoning, China","Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Department of Emergency Medicine, Shengjing Hospital of China Medical University, 110004 Shenyang, Liaoning, China","institution_ids":["https://openalex.org/I2800370534","https://openalex.org/I91656880"]},{"raw_affiliation_string":"Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027075447","display_name":"Na Wu","orcid":"https://orcid.org/0000-0003-1156-3231","observed_orcids":["https://orcid.org/0000-0003-1156-3231"]},"institutions":[{"id":"https://openalex.org/I2800370534","display_name":"Sheng Jing Hospital","ror":"https://ror.org/0202bj006","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800370534"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Na Wu","raw_affiliation_strings":["Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","Department of Endocrinology, Shengjing Hospital of China Medical University, 110004 Shenyang, Liaoning, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Department of Endocrinology, Shengjing Hospital of China Medical University, 110004 Shenyang, Liaoning, China","institution_ids":["https://openalex.org/I2800370534","https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113834922","display_name":"Gayani Nanayakkara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gayani Nanayakkara","raw_affiliation_strings":["Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065784618","display_name":"Hangfei Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hangfei Fu","raw_affiliation_strings":["Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068206190","display_name":"Qian Yang","orcid":"https://orcid.org/0000-0003-4401-1257","observed_orcids":["https://orcid.org/0000-0003-4401-1257"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qian Yang","raw_affiliation_strings":["Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027371867","display_name":"William Y. Yang","orcid":"https://orcid.org/0009-0004-1801-8978","observed_orcids":["https://orcid.org/0009-0004-1801-8978"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Y. Yang","raw_affiliation_strings":["Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102904499","display_name":"Angus H. Li","orcid":"https://orcid.org/0000-0002-7330-465X","observed_orcids":["https://orcid.org/0000-0002-7330-465X"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angus Li","raw_affiliation_strings":["Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA","Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100769959","display_name":"Yu Sun","orcid":"https://orcid.org/0000-0002-0877-7186","observed_orcids":["https://orcid.org/0000-0002-0877-7186"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Sun","raw_affiliation_strings":["Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004792622","display_name":"Charles Drummer","orcid":"https://orcid.org/0000-0001-9059-1454","observed_orcids":["https://orcid.org/0000-0001-9059-1454"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Drummer","raw_affiliation_strings":["Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027354226","display_name":"Candice Johnson","orcid":"https://orcid.org/0000-0003-1622-7544","observed_orcids":["https://orcid.org/0000-0003-1622-7544"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Candice Johnson","raw_affiliation_strings":["Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047172495","display_name":"Ying Shao","orcid":"https://orcid.org/0000-0001-5879-0154","observed_orcids":["https://orcid.org/0000-0001-5879-0154"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Shao","raw_affiliation_strings":["Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030913107","display_name":"Luqiao Wang","orcid":"https://orcid.org/0000-0003-0263-9492","observed_orcids":["https://orcid.org/0000-0003-0263-9492"]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]},{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Luqiao Wang","raw_affiliation_strings":["Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","Department of Cardiovascular Medicine, the First Affiliated Hospital of Kunming Medical University, 650031 Kunming, Yunnan, China","Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Department of Cardiovascular Medicine, the First Affiliated Hospital of Kunming Medical University, 650031 Kunming, Yunnan, China","institution_ids":["https://openalex.org/I26080491","https://openalex.org/I4210120169"]},{"raw_affiliation_string":"Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Keman Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keman Xu","raw_affiliation_strings":["Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100727140","display_name":"Wenhui Hu","orcid":"https://orcid.org/0000-0001-8152-6116","observed_orcids":["https://orcid.org/0000-0001-8152-6116"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenhui Hu","raw_affiliation_strings":["Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","Department of Pathology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Department of Pathology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037650801","display_name":"Marion Man-Ying Chan","orcid":"https://orcid.org/0000-0003-1706-2964","observed_orcids":["https://orcid.org/0000-0003-1706-2964"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marion Chan","raw_affiliation_strings":["Department of Microbiology and Immunology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089546452","display_name":"Vincent C. Tam","orcid":"https://orcid.org/0000-0003-0898-2531","observed_orcids":["https://orcid.org/0000-0003-0898-2531"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent Tam","raw_affiliation_strings":["Department of Microbiology and Immunology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112870482","display_name":"Eric T. Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric T. Choi","raw_affiliation_strings":["Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","Department of Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Department of Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Wang","raw_affiliation_strings":["Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100742379","display_name":"Xiaofeng Yang","orcid":"https://orcid.org/0000-0002-6854-6195","observed_orcids":["https://orcid.org/0000-0002-6854-6195","https://orcid.org/0000-0002-9892-525X"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaofeng Yang","raw_affiliation_strings":["Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"10","first_page":"678","last_page":"679"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-plasticity","display_name":"T cell plasticity","score":0.996999979019165},{"id":"https://openalex.org/keywords/immune-tolerance","display_name":"immune tolerance","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2780297707","wikidata":"https://www.wikidata.org/wiki/Q4895393","display_name":"Landmark","level":2,"score":0.5523465871810913},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4903116524219513},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.46078479290008545},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4453674554824829},{"id":"https://openalex.org/C79186407","wikidata":"https://www.wikidata.org/wiki/Q472074","display_name":"Plasticity","level":2,"score":0.4409116506576538},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41250079870224},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4105280339717865},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3939655125141144},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3688110113143921},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3302125632762909},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1987413763999939},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1793140470981598},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11762931942939758},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10563603043556213},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.06744721531867981},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000066670","descriptor_name":"Cell Plasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000066670","descriptor_name":"Cell Plasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000066670","descriptor_name":"Cell Plasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000066670","descriptor_name":"Cell Plasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.52586/4978","doi":"https://doi.org/10.52586/4978","is_oa":true,"landing_page_url":"https://doi.org/10.52586/4978","pdf_url":null,"source":{"id":"https://openalex.org/S4210236708","display_name":"Frontiers in Bioscience-Landmark","issn_l":"2768-6698","issn":["2768-6698","2768-6701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310322753","host_organization_name":"IMR Press","host_organization_lineage":["https://openalex.org/P4310322753"],"host_organization_lineage_names":["IMR Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioscience-Landmark","raw_type":"journal-article"},{"id":"pmid:34719196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34719196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioscience (Landmark edition)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9230141","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9230141","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Biosci (Landmark Ed)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:0bf732c0ef1947c2afd82da5fee424dd","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/0bf732c0ef1947c2afd82da5fee424dd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioscience-Landmark, Vol 26, Iss 10, Pp 678-679 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.52586/4978","doi":"https://doi.org/10.52586/4978","is_oa":true,"landing_page_url":"https://doi.org/10.52586/4978","pdf_url":null,"source":{"id":"https://openalex.org/S4210236708","display_name":"Frontiers in Bioscience-Landmark","issn_l":"2768-6698","issn":["2768-6698","2768-6701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310322753","host_organization_name":"IMR Press","host_organization_lineage":["https://openalex.org/P4310322753"],"host_organization_lineage_names":["IMR Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioscience-Landmark","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.5099999904632568,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3337428404","display_name":"IL-35 inhibits gut microbiota-produced uremic toxin-accelerated endothelial cell activation","funder_award_id":"R01HL147565","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4050894106","display_name":"The roles of miR-155 in regulating atherosclerosis and metabolically healthy obesity","funder_award_id":"R01HL138749","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4899324136","display_name":null,"funder_award_id":"R01 DK113775","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8146487","display_name":null,"funder_award_id":"R01 DK104116","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8603912025","display_name":"IL-35 suppression of endothelial cell activation and atherosclerosis","funder_award_id":"R01HL132399","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W2901827774","https://openalex.org/W3210387898"],"related_works":["https://openalex.org/W2040128205","https://openalex.org/W2060075608","https://openalex.org/W2026444950","https://openalex.org/W2168929838","https://openalex.org/W2012972418","https://openalex.org/W2037024992","https://openalex.org/W2064485034","https://openalex.org/W2140205174","https://openalex.org/W104003022","https://openalex.org/W1971240700"],"abstract_inverted_index":{"No":[0],"abstract":[1],"present.":[2]},"counts_by_year":[],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}