{"id":"https://openalex.org/W3208960287","doi":"https://doi.org/10.1016/bs.mcb.2021.06.004","title":"Strategies for targeting cell surface proteins using multivalent conjugates and chemical biology","display_name":"Strategies for targeting cell surface proteins using multivalent conjugates and chemical biology","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3208960287","doi":"https://doi.org/10.1016/bs.mcb.2021.06.004","mag":"3208960287","pmid":"https://pubmed.ncbi.nlm.nih.gov/34752333","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8895325"},"language":"en","primary_location":{"id":"doi:10.1016/bs.mcb.2021.06.004","doi":"https://doi.org/10.1016/bs.mcb.2021.06.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/bs.mcb.2021.06.004","pdf_url":null,"source":{"id":"https://openalex.org/S177811526","display_name":"Methods in cell biology","issn_l":"0091-679X","issn":["0091-679X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Cell Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4252731853","display_name":"Biomolecular Interactions Part A"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8895325","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027767206","display_name":"Shivani Sachdev","orcid":"https://orcid.org/0000-0003-2514-9189","observed_orcids":["https://orcid.org/0000-0003-2514-9189"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shivani Sachdev","raw_affiliation_strings":["National Institutes of Health, National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK), Laboratory of Bioorganic Chemistry, Bethesda, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK), Laboratory of Bioorganic Chemistry, Bethesda, MD, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034227606","display_name":"Chino C. Cabalteja","orcid":"https://orcid.org/0000-0002-7935-560X","observed_orcids":["https://orcid.org/0000-0002-7935-560X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chino C. Cabalteja","raw_affiliation_strings":["National Institutes of Health, National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK), Laboratory of Bioorganic Chemistry, Bethesda, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK), Laboratory of Bioorganic Chemistry, Bethesda, MD, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018356508","display_name":"Ross W. Cheloha","orcid":"https://orcid.org/0000-0001-9871-8333","observed_orcids":["https://orcid.org/0000-0001-9871-8333"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ross W. Cheloha","raw_affiliation_strings":["National Institutes of Health, National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK), Laboratory of Bioorganic Chemistry, Bethesda, MD, United States. Electronic address: ross.cheloha@nih.gov","National Institutes of Health, National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK), Laboratory of Bioorganic Chemistry, Bethesda, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK), Laboratory of Bioorganic Chemistry, Bethesda, MD, United States. Electronic address: ross.cheloha@nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]},{"raw_affiliation_string":"National Institutes of Health, National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK), Laboratory of Bioorganic Chemistry, Bethesda, MD, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018356508"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"],"apc_list":null,"apc_paid":null,"fwci":5.7268,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.96845832,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"166","issue":null,"first_page":"205","last_page":"222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.4011000096797943,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.4011000096797943,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.259799987077713,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.210099995136261,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-surface-receptors","display_name":"cell surface receptors","score":0.9639999866485596},{"id":"https://openalex.org/keywords/antibody-conjugation","display_name":"antibody conjugation","score":0.6140000224113464},{"id":"https://openalex.org/keywords/conjugation-chemistry","display_name":"chemical conjugation","score":0.4749999940395355},{"id":"https://openalex.org/keywords/receptor-specificity","display_name":"receptor specificity","score":0.5559999942779541},{"id":"https://openalex.org/keywords/pharmacological-targeting","display_name":"pharmacological targeting","score":0.5070000290870667},{"id":"https://openalex.org/keywords/receptor-modulation","display_name":"receptor modulation","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7902920842170715},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6442251205444336},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5276502370834351},{"id":"https://openalex.org/C197462201","wikidata":"https://www.wikidata.org/wiki/Q2476074","display_name":"Cell surface receptor","level":3,"score":0.513069748878479},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.48442748188972473},{"id":"https://openalex.org/C171852809","wikidata":"https://www.wikidata.org/wiki/Q731154","display_name":"Chemical biology","level":2,"score":0.46613070368766785},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.45695140957832336},{"id":"https://openalex.org/C2994604686","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell function","level":3,"score":0.4495568871498108},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4432026743888855},{"id":"https://openalex.org/C2776620830","wikidata":"https://www.wikidata.org/wiki/Q4919211","display_name":"Bivalent (engine)","level":3,"score":0.4338243007659912},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34285837411880493},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.11130908131599426},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001695","descriptor_name":"Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/bs.mcb.2021.06.004","doi":"https://doi.org/10.1016/bs.mcb.2021.06.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/bs.mcb.2021.06.004","pdf_url":null,"source":{"id":"https://openalex.org/S177811526","display_name":"Methods in cell biology","issn_l":"0091-679X","issn":["0091-679X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Cell Biology","raw_type":"book-chapter"},{"id":"pmid:34752333","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34752333","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8895325","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8895325","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Methods Cell Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8895325","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8895325","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Methods Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2225345073","display_name":null,"funder_award_id":"Z99 DK999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000896420","display_name":"New tools from chemistry and antibodies to address receptor function","funder_award_id":"ZIADK075157","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W1495996409","https://openalex.org/W1989421980","https://openalex.org/W1991787812","https://openalex.org/W1992276619","https://openalex.org/W2027679305","https://openalex.org/W2028636893","https://openalex.org/W2036736151","https://openalex.org/W2038813477","https://openalex.org/W2043023167","https://openalex.org/W2079052124","https://openalex.org/W2079996410","https://openalex.org/W2081231410","https://openalex.org/W2089920783","https://openalex.org/W2114210788","https://openalex.org/W2131556640","https://openalex.org/W2133572151","https://openalex.org/W2165408834","https://openalex.org/W2221707331","https://openalex.org/W2461901476","https://openalex.org/W2478287506","https://openalex.org/W2482833677","https://openalex.org/W2484854673","https://openalex.org/W2511475001","https://openalex.org/W2586914431","https://openalex.org/W2593943479","https://openalex.org/W2734750805","https://openalex.org/W2741191097","https://openalex.org/W2742314046","https://openalex.org/W2765153686","https://openalex.org/W2767376904","https://openalex.org/W2788587230","https://openalex.org/W2792245061","https://openalex.org/W2799734443","https://openalex.org/W2886130158","https://openalex.org/W2888780203","https://openalex.org/W2897168872","https://openalex.org/W2897420794","https://openalex.org/W2899980190","https://openalex.org/W2902933072","https://openalex.org/W2909575520","https://openalex.org/W2912171584","https://openalex.org/W2919234929","https://openalex.org/W2920392315","https://openalex.org/W2948141873","https://openalex.org/W2954367430","https://openalex.org/W2965468477","https://openalex.org/W2973145235","https://openalex.org/W2978834401","https://openalex.org/W2986170540","https://openalex.org/W2999524723","https://openalex.org/W3001942526","https://openalex.org/W3008323409","https://openalex.org/W3011469361","https://openalex.org/W3013193077","https://openalex.org/W3022893071","https://openalex.org/W3032049180","https://openalex.org/W3037419359","https://openalex.org/W3045619116","https://openalex.org/W3047014325","https://openalex.org/W3081528659","https://openalex.org/W3081599094","https://openalex.org/W3081642245","https://openalex.org/W3083802816","https://openalex.org/W3093810618","https://openalex.org/W3094177723","https://openalex.org/W3096284929","https://openalex.org/W3100506610","https://openalex.org/W3111378088","https://openalex.org/W3136546688","https://openalex.org/W3190382466","https://openalex.org/W4281627591"],"related_works":["https://openalex.org/W1964006504","https://openalex.org/W2006083718","https://openalex.org/W2150594488","https://openalex.org/W2184164552","https://openalex.org/W2145061993","https://openalex.org/W2717925384","https://openalex.org/W2098420292","https://openalex.org/W1896676686","https://openalex.org/W2580490691","https://openalex.org/W2899417906"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-11-08T00:00:00"}