{"id":"https://openalex.org/W3208917795","doi":"https://doi.org/10.1002/pbc.29401","title":"Bromodomain 4 inhibition leads to MYCN downregulation in Wilms tumor","display_name":"Bromodomain 4 inhibition leads to MYCN downregulation in Wilms tumor","publication_year":2021,"publication_date":"2021-10-24","ids":{"openalex":"https://openalex.org/W3208917795","doi":"https://doi.org/10.1002/pbc.29401","mag":"3208917795","pmid":"https://pubmed.ncbi.nlm.nih.gov/34693628"},"language":"en","primary_location":{"id":"doi:10.1002/pbc.29401","doi":"https://doi.org/10.1002/pbc.29401","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pbc.29401","pdf_url":null,"source":{"id":"https://openalex.org/S119714264","display_name":"Pediatric Blood & Cancer","issn_l":"1545-5009","issn":["1545-5009","1545-5017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Blood &amp; Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9450910","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068846996","display_name":"Andrew D. Woods","orcid":"https://orcid.org/0000-0002-7036-4796","observed_orcids":["https://orcid.org/0000-0002-7036-4796"]},"institutions":[{"id":"https://openalex.org/I4210137443","display_name":"Children's Cancer Therapy Development Institute","ror":"https://ror.org/04netx779","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210137443"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew D. Woods","raw_affiliation_strings":["Children's Cancer Therapy Development Institute  Beaverton Oregon USA","Children's Cancer Therapy Development Institute, Beaverton, Oregon, USA"],"raw_orcid":"https://orcid.org/0000-0002-7036-4796","affiliations":[{"raw_affiliation_string":"Children's Cancer Therapy Development Institute  Beaverton Oregon USA","institution_ids":["https://openalex.org/I4210137443"]},{"raw_affiliation_string":"Children's Cancer Therapy Development Institute, Beaverton, Oregon, USA","institution_ids":["https://openalex.org/I4210137443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089263262","display_name":"Noah Berlow","orcid":"https://orcid.org/0000-0001-8666-3152","observed_orcids":["https://orcid.org/0000-0001-8666-3152"]},"institutions":[{"id":"https://openalex.org/I4210137443","display_name":"Children's Cancer Therapy Development Institute","ror":"https://ror.org/04netx779","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210137443"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noah E. Berlow","raw_affiliation_strings":["Children's Cancer Therapy Development Institute  Beaverton Oregon USA","Children's Cancer Therapy Development Institute, Beaverton, Oregon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Cancer Therapy Development Institute  Beaverton Oregon USA","institution_ids":["https://openalex.org/I4210137443"]},{"raw_affiliation_string":"Children's Cancer Therapy Development Institute, Beaverton, Oregon, USA","institution_ids":["https://openalex.org/I4210137443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083681305","display_name":"Michael Vincent Ortiz","orcid":"https://orcid.org/0000-0001-9379-314X","observed_orcids":["https://orcid.org/0000-0001-9379-314X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael V. Ortiz","raw_affiliation_strings":["Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York New York USA","Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA"],"raw_orcid":"https://orcid.org/0000-0001-9379-314X","affiliations":[{"raw_affiliation_string":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York New York USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062320984","display_name":"Filemon S. Dela Cruz","orcid":"https://orcid.org/0000-0002-8356-5191","observed_orcids":["https://orcid.org/0000-0002-8356-5191"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Filemon Dela Cruz","raw_affiliation_strings":["Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York New York USA","Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York New York USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040331260","display_name":"Armaan H. Siddiquee","orcid":"https://orcid.org/0009-0007-1464-3786","observed_orcids":["https://orcid.org/0009-0007-1464-3786"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Armaan Siddiquee","raw_affiliation_strings":["Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York New York USA","Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York New York USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090089940","display_name":"Diego F. Coutinho","orcid":"https://orcid.org/0000-0002-7944-1284","observed_orcids":["https://orcid.org/0000-0002-7944-1284","https://orcid.org/0000-0001-6413-7186"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diego F. Coutinho","raw_affiliation_strings":["Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York New York USA","Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York New York USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022388365","display_name":"Reshma Purohit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137443","display_name":"Children's Cancer Therapy Development Institute","ror":"https://ror.org/04netx779","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210137443"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reshma Purohit","raw_affiliation_strings":["Children's Cancer Therapy Development Institute  Beaverton Oregon USA","Children's Cancer Therapy Development Institute, Beaverton, Oregon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Cancer Therapy Development Institute  Beaverton Oregon USA","institution_ids":["https://openalex.org/I4210137443"]},{"raw_affiliation_string":"Children's Cancer Therapy Development Institute, Beaverton, Oregon, USA","institution_ids":["https://openalex.org/I4210137443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031348733","display_name":"Katherine E. Tranbarger Freier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137443","display_name":"Children's Cancer Therapy Development Institute","ror":"https://ror.org/04netx779","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210137443"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine E. Tranbarger Freier","raw_affiliation_strings":["Children's Cancer Therapy Development Institute  Beaverton Oregon USA","Children's Cancer Therapy Development Institute, Beaverton, Oregon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Cancer Therapy Development Institute  Beaverton Oregon USA","institution_ids":["https://openalex.org/I4210137443"]},{"raw_affiliation_string":"Children's Cancer Therapy Development Institute, Beaverton, Oregon, USA","institution_ids":["https://openalex.org/I4210137443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019498881","display_name":"Joel Edmund Michalek","orcid":"https://orcid.org/0000-0003-3021-773X","observed_orcids":["https://orcid.org/0000-0003-3021-773X"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel E. Michalek","raw_affiliation_strings":["Department of Population Health Sciences, Joe R. &amp; Teresa Lozano Long School of Medicine University of Texas Health Science Center  San Antonio Texas USA","Department of Population Health Sciences, Joe R. & Teresa Lozano Long School of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population Health Sciences, Joe R. &amp; Teresa Lozano Long School of Medicine University of Texas Health Science Center  San Antonio Texas USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Population Health Sciences, Joe R. & Teresa Lozano Long School of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089889303","display_name":"Melvin Lathara","orcid":"https://orcid.org/0009-0006-1919-6244","observed_orcids":["https://orcid.org/0009-0006-1919-6244"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melvin Lathara","raw_affiliation_strings":["Omics Data Automation Inc.  Beaverton Oregon USA","Omics Data Automation Inc., Beaverton, Oregon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Omics Data Automation Inc.  Beaverton Oregon USA","institution_ids":[]},{"raw_affiliation_string":"Omics Data Automation Inc., Beaverton, Oregon, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090860214","display_name":"Kevin Matlock","orcid":"https://orcid.org/0000-0003-1658-7427","observed_orcids":["https://orcid.org/0000-0003-1658-7427"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin Matlock","raw_affiliation_strings":["Omics Data Automation Inc.  Beaverton Oregon USA","Omics Data Automation Inc., Beaverton, Oregon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Omics Data Automation Inc.  Beaverton Oregon USA","institution_ids":[]},{"raw_affiliation_string":"Omics Data Automation Inc., Beaverton, Oregon, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030175149","display_name":"Ganapati Srivivasa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ganapati Srivivasa","raw_affiliation_strings":["Omics Data Automation Inc.  Beaverton Oregon USA","Omics Data Automation Inc., Beaverton, Oregon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Omics Data Automation Inc.  Beaverton Oregon USA","institution_ids":[]},{"raw_affiliation_string":"Omics Data Automation Inc., Beaverton, Oregon, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011160875","display_name":"Brigitte Royer\u2010Pokora","orcid":"https://orcid.org/0000-0001-5114-7801","observed_orcids":["https://orcid.org/0000-0001-5114-7801"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Brigitte Royer\u2010Pokora","raw_affiliation_strings":["Institute of Human Genetics, Medical Faculty Heinrich Heine University Duesseldorf  Duesseldorf Germany","Institute of Human Genetics, Medical Faculty, Heinrich Heine University Duesseldorf, Duesseldorf, Germany"],"raw_orcid":"https://orcid.org/0000-0001-5114-7801","affiliations":[{"raw_affiliation_string":"Institute of Human Genetics, Medical Faculty Heinrich Heine University Duesseldorf  Duesseldorf Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Institute of Human Genetics, Medical Faculty, Heinrich Heine University Duesseldorf, Duesseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075042319","display_name":"Renata Veselsk\u00e1","orcid":"https://orcid.org/0000-0002-0048-9913","observed_orcids":["https://orcid.org/0000-0002-0048-9913"]},"institutions":[{"id":"https://openalex.org/I21449261","display_name":"Masaryk University","ror":"https://ror.org/02j46qs45","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21449261"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Renata Veselska","raw_affiliation_strings":["Department of Experimental Biology, Faculty of Science Masaryk University  Brno Czech Republic","Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic"],"raw_orcid":"https://orcid.org/0000-0002-0048-9913","affiliations":[{"raw_affiliation_string":"Department of Experimental Biology, Faculty of Science Masaryk University  Brno Czech Republic","institution_ids":["https://openalex.org/I21449261"]},{"raw_affiliation_string":"Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic","institution_ids":["https://openalex.org/I21449261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059247439","display_name":"Andrew L. Kung","orcid":"https://orcid.org/0000-0002-9091-488X","observed_orcids":["https://orcid.org/0000-0002-9091-488X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew L. Kung","raw_affiliation_strings":["Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York New York USA","Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York New York USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009653245","display_name":"Charles Keller","orcid":"https://orcid.org/0000-0003-2505-7487","observed_orcids":["https://orcid.org/0000-0003-2505-7487"]},"institutions":[{"id":"https://openalex.org/I4210137443","display_name":"Children's Cancer Therapy Development Institute","ror":"https://ror.org/04netx779","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210137443"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Charles Keller","raw_affiliation_strings":["Children's Cancer Therapy Development Institute  Beaverton Oregon USA","Children's Cancer Therapy Development Institute, Beaverton, Oregon, USA"],"raw_orcid":"https://orcid.org/0000-0003-2505-7487","affiliations":[{"raw_affiliation_string":"Children's Cancer Therapy Development Institute  Beaverton Oregon USA","institution_ids":["https://openalex.org/I4210137443"]},{"raw_affiliation_string":"Children's Cancer Therapy Development Institute, Beaverton, Oregon, USA","institution_ids":["https://openalex.org/I4210137443"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5009653245"],"corresponding_institution_ids":["https://openalex.org/I4210137443"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":0.6697,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.63829684,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"69","issue":"2","first_page":"e29401","last_page":"e29401"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.6509000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.6509000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.2379000037908554,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.06719999760389328,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wilms-tumor","display_name":"Wilms tumor","score":0.9580000042915344},{"id":"https://openalex.org/keywords/brd4-inhibition","display_name":"BRD4 inhibition","score":0.7670000195503235},{"id":"https://openalex.org/keywords/anaplastic-wilms-tumor","display_name":"anaplastic Wilms tumor","score":0.9350000023841858},{"id":"https://openalex.org/keywords/azd5153","display_name":"AZD5153","score":0.9679999947547913},{"id":"https://openalex.org/keywords/bromodomain-inhibitors","display_name":"bromodomain inhibitors","score":0.6629999876022339},{"id":"https://openalex.org/keywords/mycn","display_name":"MYCN","score":0.44699999690055847},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.8659999966621399},{"id":"https://openalex.org/keywords/pediatric-kidney-tumors","display_name":"pediatric kidney cancer","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C2780263296","wikidata":"https://www.wikidata.org/wiki/Q486082","display_name":"Anaplasia","level":2,"score":0.9251554012298584},{"id":"https://openalex.org/C2775999222","wikidata":"https://www.wikidata.org/wiki/Q756289","display_name":"Wilms' tumor","level":2,"score":0.8851855993270874},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6877409815788269},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6821022033691406},{"id":"https://openalex.org/C2993561819","wikidata":"https://www.wikidata.org/wiki/Q5097977","display_name":"Pediatric cancer","level":3,"score":0.4786840081214905},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4494395852088928},{"id":"https://openalex.org/C2779744173","wikidata":"https://www.wikidata.org/wiki/Q15269707","display_name":"Palbociclib","level":5,"score":0.4179789423942566},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.41034477949142456},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2930026650428772},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2626160979270935},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2071084976196289},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000071447","descriptor_name":"N-Myc Proto-Oncogene Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071447","descriptor_name":"N-Myc Proto-Oncogene Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071447","descriptor_name":"N-Myc Proto-Oncogene Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000092468","descriptor_name":"Bromodomain Containing Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000708","descriptor_name":"Anaplasia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000708","descriptor_name":"Anaplasia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000708","descriptor_name":"Anaplasia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009396","descriptor_name":"Wilms Tumor","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009396","descriptor_name":"Wilms Tumor","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009396","descriptor_name":"Wilms Tumor","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009396","descriptor_name":"Wilms Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009396","descriptor_name":"Wilms Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009396","descriptor_name":"Wilms Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009396","descriptor_name":"Wilms Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009396","descriptor_name":"Wilms Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009396","descriptor_name":"Wilms Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/pbc.29401","doi":"https://doi.org/10.1002/pbc.29401","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pbc.29401","pdf_url":null,"source":{"id":"https://openalex.org/S119714264","display_name":"Pediatric Blood & Cancer","issn_l":"1545-5009","issn":["1545-5009","1545-5017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Blood &amp; Cancer","raw_type":"journal-article"},{"id":"pmid:34693628","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34693628","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric blood & cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9450910","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9450910","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pediatr Blood Cancer","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9450910","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9450910","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pediatr Blood Cancer","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5099999904632568,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3343554601","display_name":null,"funder_award_id":"K12CA184746","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1482784375","https://openalex.org/W1523117612","https://openalex.org/W1546505563","https://openalex.org/W1838829111","https://openalex.org/W1964186082","https://openalex.org/W1968674166","https://openalex.org/W1973462980","https://openalex.org/W1993186884","https://openalex.org/W1995541594","https://openalex.org/W1996210502","https://openalex.org/W1996949194","https://openalex.org/W2002395443","https://openalex.org/W2002419133","https://openalex.org/W2006035096","https://openalex.org/W2020365958","https://openalex.org/W2048838478","https://openalex.org/W2056377340","https://openalex.org/W2062121228","https://openalex.org/W2062348957","https://openalex.org/W2063583146","https://openalex.org/W2068575863","https://openalex.org/W2081785076","https://openalex.org/W2082571806","https://openalex.org/W2091988355","https://openalex.org/W2098282574","https://openalex.org/W2100335940","https://openalex.org/W2103648100","https://openalex.org/W2105723991","https://openalex.org/W2109378990","https://openalex.org/W2112309180","https://openalex.org/W2117559539","https://openalex.org/W2118428599","https://openalex.org/W2120572492","https://openalex.org/W2124514136","https://openalex.org/W2129129812","https://openalex.org/W2132546867","https://openalex.org/W2157030129","https://openalex.org/W2183670742","https://openalex.org/W2226721679","https://openalex.org/W2263799391","https://openalex.org/W2307422613","https://openalex.org/W2516657620","https://openalex.org/W2519390626","https://openalex.org/W2529309126","https://openalex.org/W2735902464","https://openalex.org/W2794385660","https://openalex.org/W2806421539","https://openalex.org/W2898199771","https://openalex.org/W2913323028","https://openalex.org/W3010105342","https://openalex.org/W3022464154"],"related_works":["https://openalex.org/W2063583146","https://openalex.org/W2351007721","https://openalex.org/W2261357522","https://openalex.org/W2371815150","https://openalex.org/W2184337485","https://openalex.org/W2762217692","https://openalex.org/W3028606754","https://openalex.org/W2895783306","https://openalex.org/W3208917795","https://openalex.org/W2048791809"],"abstract_inverted_index":{"BACKGROUND:":[0],"Wilms":[1,15,76,98,127,146,165,190,198],"tumor":[2,16,128,147,162,166,191,195,199],"is":[3],"the":[4],"most":[5],"common":[6],"childhood":[7],"kidney":[8],"cancer.":[9],"Two":[10],"distinct":[11],"histological":[12],"subtypes":[13],"of":[14,72,136],"have":[17,39],"been":[18,67],"described:":[19],"tumors":[20,27],"lacking":[21],"anaplasia":[22,47],"(the":[23,31],"favorable":[24,36],"subtype)":[25],"and":[26,54,102,125,138,155,188,201],"displaying":[28],"anaplastic":[29,97,124,187],"features":[30],"unfavorable":[32],"subtype).":[33],"Children":[34],"with":[35,46,69,96],"disease":[37],"generally":[38],"a":[40,70,84,133,177],"very":[41],"good":[42],"prognosis,":[43],"whereas":[44],"those":[45,94],"are":[48],"oftentimes":[49],"refractory":[50],"to":[51,59,88,152],"standard":[52],"treatments":[53],"suffer":[55],"poor":[56],"outcomes,":[57],"leading":[58],"an":[60],"unmet":[61],"clinical":[62],"need.":[63],"MYCN":[64,115,137,183],"dysregulation":[65],"has":[66],"associated":[68],"number":[71],"pediatric":[73],"cancers":[74],"including":[75],"tumor.":[77,99],"PROCEDURES:":[78],"In":[79],"this":[80],"context,":[81],"we":[82],"undertook":[83],"functional":[85],"genomics":[86],"approach":[87],"uncover":[89],"novel":[90,178],"therapeutic":[91,208],"strategies":[92],"for":[93,206],"patients":[95],"Genomic":[100],"analysis":[101],"in":[103,122,145,164,185,197],"vitro":[104],"experimentation":[105],"demonstrate":[106],"that":[107,175],"cell":[108,148,153,192],"growth":[109],"can":[110,181],"be":[111,203],"reduced":[112,161],"by":[113],"modulating":[114],"overexpression":[116],"via":[117],"bromodomain":[118],"4":[119],"(BRD4)":[120],"inhibition":[121,144,159],"both":[123,186],"nonanaplastic":[126,189],"models.":[129,171],"RESULTS:":[130],"We":[131,173],"observed":[132],"time-dependent":[134],"reduction":[135],"MYCC":[139],"protein":[140],"levels":[141,184],"upon":[142],"BRD4":[143,158],"lines,":[149,193],"which":[150],"led":[151],"death":[154],"proliferation":[156],"suppression.":[157],"significantly":[160],"volumes":[163],"patient-derived":[167],"xenograft":[168],"(PDX)":[169],"mouse":[170],"CONCLUSIONS:":[172],"suggest":[174],"AZD5153,":[176],"dual-BRD4":[179],"inhibitor,":[180],"reduce":[182],"reduces":[194],"volume":[196],"PDXs,":[200],"should":[202],"further":[204],"explored":[205],"its":[207],"potential.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2021-11-08T00:00:00"}
