{"id":"https://openalex.org/W3208917200","doi":"https://doi.org/10.1200/po.21.00011","title":"Therapeutic Actionability of Circulating Cell-Free DNA Alterations in Carcinoma of Unknown Primary","display_name":"Therapeutic Actionability of Circulating Cell-Free DNA Alterations in Carcinoma of Unknown Primary","publication_year":2021,"publication_date":"2021-11-01","ids":{"openalex":"https://openalex.org/W3208917200","doi":"https://doi.org/10.1200/po.21.00011","mag":"3208917200","pmid":"https://pubmed.ncbi.nlm.nih.gov/34778692"},"language":"en","primary_location":{"id":"doi:10.1200/po.21.00011","doi":"https://doi.org/10.1200/po.21.00011","is_oa":true,"landing_page_url":"https://doi.org/10.1200/po.21.00011","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/PO.21.00011?role=tab","source":{"id":"https://openalex.org/S4210227748","display_name":"JCO Precision Oncology","issn_l":"2473-4284","issn":["2473-4284"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Precision Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ascopubs.org/doi/pdfdirect/10.1200/PO.21.00011?role=tab","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086626483","display_name":"Shumei Kato","orcid":"https://orcid.org/0000-0003-1193-1815","observed_orcids":["https://orcid.org/0000-0003-1193-1815"]},"institutions":[{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shumei Kato","raw_affiliation_strings":["Center for Personalized Cancer Therapy, University of California San Diego Moores Cancer Center, La Jolla, CA"],"raw_orcid":"https://orcid.org/0000-0003-1193-1815","affiliations":[{"raw_affiliation_string":"Center for Personalized Cancer Therapy, University of California San Diego Moores Cancer Center, La Jolla, CA","institution_ids":["https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074681480","display_name":"Caroline M. Weipert","orcid":"https://orcid.org/0000-0002-0069-882X","observed_orcids":["https://orcid.org/0000-0002-0069-882X"]},"institutions":[{"id":"https://openalex.org/I4210100465","display_name":"Guardant (United States)","ror":"https://ror.org/013z4s422","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline Weipert","raw_affiliation_strings":["Guardant Health, Redwood City, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guardant Health, Redwood City, CA","institution_ids":["https://openalex.org/I4210100465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064576709","display_name":"Sophia Gumas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sophia Gumas","raw_affiliation_strings":["Center for Personalized Cancer Therapy, University of California San Diego Moores Cancer Center, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Personalized Cancer Therapy, University of California San Diego Moores Cancer Center, La Jolla, CA","institution_ids":["https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018234365","display_name":"Ryosuke Okamura","orcid":"https://orcid.org/0000-0001-7352-8621","observed_orcids":["https://orcid.org/0000-0001-7352-8621"]},"institutions":[{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryosuke Okamura","raw_affiliation_strings":["Center for Personalized Cancer Therapy, University of California San Diego Moores Cancer Center, La Jolla, CA","Department of Surgery, Kyoto University Hospital, Kyoto, Japan"],"raw_orcid":"https://orcid.org/0000-0001-7352-8621","affiliations":[{"raw_affiliation_string":"Center for Personalized Cancer Therapy, University of California San Diego Moores Cancer Center, La Jolla, CA","institution_ids":["https://openalex.org/I4390039236"]},{"raw_affiliation_string":"Department of Surgery, Kyoto University Hospital, Kyoto, Japan","institution_ids":["https://openalex.org/I4210150196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059459442","display_name":"Suzanna Lee","orcid":"https://orcid.org/0000-0002-9502-4907","observed_orcids":["https://orcid.org/0000-0002-9502-4907"]},"institutions":[{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanna Lee","raw_affiliation_strings":["Center for Personalized Cancer Therapy, University of California San Diego Moores Cancer Center, La Jolla, CA"],"raw_orcid":"https://orcid.org/0000-0002-9502-4907","affiliations":[{"raw_affiliation_string":"Center for Personalized Cancer Therapy, University of California San Diego Moores Cancer Center, La Jolla, CA","institution_ids":["https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005618779","display_name":"Jason Keith Sicklick","orcid":"https://orcid.org/0000-0003-4403-0271","observed_orcids":["https://orcid.org/0000-0003-4403-0271"]},"institutions":[{"id":"https://openalex.org/I2800935791","display_name":"UC San Diego Health System","ror":"https://ror.org/01kbfgm16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason K. Sicklick","raw_affiliation_strings":["Center for Personalized Cancer Therapy, University of California San Diego Moores Cancer Center, La Jolla, CA","Department of Surgery, Division of Surgical Oncology, UC San Diego School of Medicine, San Diego, CA"],"raw_orcid":"https://orcid.org/0000-0003-4403-0271","affiliations":[{"raw_affiliation_string":"Center for Personalized Cancer Therapy, University of California San Diego Moores Cancer Center, La Jolla, CA","institution_ids":["https://openalex.org/I4390039236"]},{"raw_affiliation_string":"Department of Surgery, Division of Surgical Oncology, UC San Diego School of Medicine, San Diego, CA","institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059108650","display_name":"Jennifer R. Saam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100465","display_name":"Guardant (United States)","ror":"https://ror.org/013z4s422","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Saam","raw_affiliation_strings":["Guardant Health, Redwood City, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guardant Health, Redwood City, CA","institution_ids":["https://openalex.org/I4210100465"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053481267","display_name":"Razelle Kurzrock","orcid":"https://orcid.org/0000-0003-4110-1214","observed_orcids":["https://orcid.org/0000-0003-4110-1214"]},"institutions":[{"id":"https://openalex.org/I4391012559","display_name":"WIN Consortium","ror":"https://ror.org/03r6bpj37","country_code":null,"type":"nonprofit","lineage":["https://openalex.org/I4391012559"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Razelle Kurzrock","raw_affiliation_strings":["WIN Consortium for Precision Medicine, Villejuif, France"],"raw_orcid":"https://orcid.org/0000-0003-4110-1214","affiliations":[{"raw_affiliation_string":"WIN Consortium for Precision Medicine, Villejuif, France","institution_ids":["https://openalex.org/I4391012559"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5086626483"],"corresponding_institution_ids":["https://openalex.org/I4390039236"],"apc_list":null,"apc_paid":null,"fwci":1.3027,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.83778982,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"5","issue":"5","first_page":"1687","last_page":"1698"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment","score":0.6699000000953674,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment","score":0.6699000000953674,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.32010000944137573,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-of-unknown-primary","display_name":"cancer of unknown primary","score":0.878000020980835},{"id":"https://openalex.org/keywords/cell-free-dna","display_name":"cell-free DNA","score":0.9440000057220459},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.9779999852180481},{"id":"https://openalex.org/keywords/actionable-mutations","display_name":"actionable mutations","score":0.5879999995231628},{"id":"https://openalex.org/keywords/oncokb","display_name":"OncoKB","score":0.7390000224113464},{"id":"https://openalex.org/keywords/treatment-matching","display_name":"treatment matching","score":0.45500001311302185},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8389999866485596},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.968999981880188},{"id":"https://openalex.org/keywords/clinical-benefit-rate","display_name":"clinical benefit rate","score":0.8090000152587891},{"id":"https://openalex.org/keywords/metastatic-carcinoma","display_name":"metastatic carcinoma","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6623457074165344},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6325883269309998},{"id":"https://openalex.org/C152110520","wikidata":"https://www.wikidata.org/wiki/Q14225730","display_name":"Cell-free fetal DNA","level":5,"score":0.6277334690093994},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5789746046066284},{"id":"https://openalex.org/C17923572","wikidata":"https://www.wikidata.org/wiki/Q7250160","display_name":"Propensity score matching","level":2,"score":0.5175685286521912},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.44791918992996216},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.4447343349456787},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.43818947672843933},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4132488965988159},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3971748352050781},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3655152916908264},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3461337089538574},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.1625548005104065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14751261472702026},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11639189720153809},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.0},{"id":"https://openalex.org/C2778258057","wikidata":"https://www.wikidata.org/wiki/Q1136569","display_name":"Prenatal diagnosis","level":4,"score":0.0},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000073888","descriptor_name":"Cell-Free Nucleic Acids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000073888","descriptor_name":"Cell-Free Nucleic Acids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000073888","descriptor_name":"Cell-Free Nucleic Acids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000073890","descriptor_name":"Liquid Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000073890","descriptor_name":"Liquid Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000073890","descriptor_name":"Liquid Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009382","descriptor_name":"Neoplasms, Unknown Primary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009382","descriptor_name":"Neoplasms, Unknown Primary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009382","descriptor_name":"Neoplasms, Unknown Primary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009382","descriptor_name":"Neoplasms, Unknown Primary","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009382","descriptor_name":"Neoplasms, Unknown Primary","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009382","descriptor_name":"Neoplasms, Unknown Primary","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009382","descriptor_name":"Neoplasms, Unknown Primary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009382","descriptor_name":"Neoplasms, Unknown Primary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009382","descriptor_name":"Neoplasms, Unknown Primary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009382","descriptor_name":"Neoplasms, Unknown Primary","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009382","descriptor_name":"Neoplasms, Unknown Primary","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009382","descriptor_name":"Neoplasms, Unknown Primary","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1200/po.21.00011","doi":"https://doi.org/10.1200/po.21.00011","is_oa":true,"landing_page_url":"https://doi.org/10.1200/po.21.00011","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/PO.21.00011?role=tab","source":{"id":"https://openalex.org/S4210227748","display_name":"JCO Precision Oncology","issn_l":"2473-4284","issn":["2473-4284"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Precision Oncology","raw_type":"journal-article"},{"id":"pmid:34778692","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34778692","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO precision oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8585281","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8585281","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JCO Precis Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1200/po.21.00011","doi":"https://doi.org/10.1200/po.21.00011","is_oa":true,"landing_page_url":"https://doi.org/10.1200/po.21.00011","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/PO.21.00011?role=tab","source":{"id":"https://openalex.org/S4210227748","display_name":"JCO Precision Oncology","issn_l":"2473-4284","issn":["2473-4284"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCO Precision Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7699999809265137}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3360784914","display_name":null,"funder_award_id":"CA023100","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7810585149","display_name":"Specialized Cancer Center Support Grant","funder_award_id":"P30CA023100","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3208917200.pdf","grobid_xml":"https://content.openalex.org/works/W3208917200.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1864344361","https://openalex.org/W1913120928","https://openalex.org/W1955860674","https://openalex.org/W2007523256","https://openalex.org/W2058087313","https://openalex.org/W2059145105","https://openalex.org/W2060688862","https://openalex.org/W2078276694","https://openalex.org/W2103724490","https://openalex.org/W2111435123","https://openalex.org/W2116737251","https://openalex.org/W2123454509","https://openalex.org/W2145396043","https://openalex.org/W2148094326","https://openalex.org/W2150575159","https://openalex.org/W2156251761","https://openalex.org/W2161179758","https://openalex.org/W2161375781","https://openalex.org/W2200963198","https://openalex.org/W2276287001","https://openalex.org/W2406106220","https://openalex.org/W2408112818","https://openalex.org/W2614443510","https://openalex.org/W2637886930","https://openalex.org/W2752473968","https://openalex.org/W2770162711","https://openalex.org/W2780582854","https://openalex.org/W2800224623","https://openalex.org/W2897177558","https://openalex.org/W2898564840","https://openalex.org/W2911210943","https://openalex.org/W2938206352","https://openalex.org/W2938634307","https://openalex.org/W2963575612","https://openalex.org/W2965346296","https://openalex.org/W2978475373","https://openalex.org/W2991413122","https://openalex.org/W3089562193","https://openalex.org/W3092995520","https://openalex.org/W4240897294"],"related_works":["https://openalex.org/W2026576563","https://openalex.org/W3196761963","https://openalex.org/W2036193982","https://openalex.org/W213628847","https://openalex.org/W2065417422","https://openalex.org/W101468167","https://openalex.org/W4232168831","https://openalex.org/W4253956144","https://openalex.org/W3023923059","https://openalex.org/W2105161754"],"abstract_inverted_index":{"PURPOSE":[0],"Cancer":[1],"of":[2,60,69,92,165],"unknown":[3],"primary":[4,12],"(CUP)":[5],"is":[6],"a":[7,35],"metastatic":[8],"disease":[9,138],"with":[10,32,34,84,170],"unidentifiable":[11],"tumor.":[13],"Somatic":[14],"alterations":[15,96,159],"can":[16],"be":[17],"assessed":[18],"noninvasively":[19],"via":[20],"liquid":[21],"biopsies":[22],"interrogating":[23],"cell-free":[24],"DNA":[25],"(cfDNA).":[26],"METHODS":[27],"We":[28,52],"evaluated":[29],"1,931":[30],"patients":[31,45,67,83],"CUP":[33,85],"cfDNA":[36,50,88,153],"next-generation":[37],"sequencing":[38],"panel":[39],"(73-74":[40],"genes).":[41],"RESULTS":[42],"Overall,":[43],"1,739":[44],"(90%)":[46],"had":[47,71,87],"\u2265":[48,139],"1":[49],"alteration.":[51],"then":[53],"explored":[54],"alteration":[55],"actionability":[56],"(per":[57],"the":[58,63,105],"levels":[59],"evidence":[61],"from":[62],"OncoKB":[64],"database);":[65],"825":[66],"(47.4%":[68],"1,739)":[70],"level":[72,74],"1,":[73],"2,":[75],"or":[76],"resistance/R1":[77],"alterations.":[78],"Among":[79],"40":[80],"clinically":[81],"annotated":[82],"who":[86],"evaluated,":[89],"higher":[90,133],"degrees":[91,164],"matching":[93,166],"treatment":[94],"to":[95,167],"(Matching":[97],"Score":[98],">":[99],"50%":[100],"v":[101,116,125,145],"\u2264":[102],"50%)":[103],"was":[104],"only":[106],"variable":[107],"predicting":[108],"improved":[109],"outcome:":[110],"longer":[111],"median":[112],"progression-free":[113],"survival":[114,123],"(10.4":[115],"2.5":[117],"months;":[118,127],"P":[119,128,147],"=":[120,129,148],".002),":[121],"overall":[122],"(13.4":[124],"5.7":[126],".07,":[130],"trend),":[131],"and":[132,162],"clinical":[134],"benefit":[135],"rate":[136],"(stable":[137],"6":[140],"months/partial":[141],"response/complete":[142],"response;":[143],"83%":[144],"25%;":[146],".003).":[149],"CONCLUSION":[150],"In":[151],"summary,":[152],"frequently":[154],"reveals":[155],"strong":[156],"level-of-evidence":[157],"actionable":[158],"in":[160],"CUP,":[161],"high":[163],"therapy":[168],"correlates":[169],"better":[171],"outcomes.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}