{"id":"https://openalex.org/W3208795162","doi":"https://doi.org/10.1038/s41586-021-04145-3","title":"A conserved mechanism for regulating replisome disassembly in eukaryotes","display_name":"A conserved mechanism for regulating replisome disassembly in eukaryotes","publication_year":2021,"publication_date":"2021-10-26","ids":{"openalex":"https://openalex.org/W3208795162","doi":"https://doi.org/10.1038/s41586-021-04145-3","mag":"3208795162","pmid":"https://pubmed.ncbi.nlm.nih.gov/34700328","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8695382"},"language":"en","primary_location":{"id":"doi:10.1038/s41586-021-04145-3","doi":"https://doi.org/10.1038/s41586-021-04145-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41586-021-04145-3","pdf_url":"https://www.nature.com/articles/s41586-021-04145-3.pdf","source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s41586-021-04145-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051426057","display_name":"Michael Jenkyn-Bedford","orcid":"https://orcid.org/0000-0003-2335-8278","observed_orcids":["https://orcid.org/0000-0003-2335-8278"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael Jenkyn-Bedford","raw_affiliation_strings":["MRC Laboratory of Molecular Biology, Cambridge, UK"],"raw_orcid":"https://orcid.org/0000-0003-2335-8278","affiliations":[{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Cambridge, UK","institution_ids":["https://openalex.org/I170203145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076424245","display_name":"Morgan L. Jones","orcid":"https://orcid.org/0000-0003-1948-4925","observed_orcids":["https://orcid.org/0000-0003-1948-4925"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Morgan L. Jones","raw_affiliation_strings":["MRC Laboratory of Molecular Biology, Cambridge, UK"],"raw_orcid":"https://orcid.org/0000-0003-1948-4925","affiliations":[{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Cambridge, UK","institution_ids":["https://openalex.org/I170203145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042038518","display_name":"Yasemin Baris","orcid":"https://orcid.org/0000-0003-2791-5588","observed_orcids":["https://orcid.org/0000-0003-2791-5588"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yasemin Baris","raw_affiliation_strings":["MRC Laboratory of Molecular Biology, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Cambridge, UK","institution_ids":["https://openalex.org/I170203145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073735040","display_name":"Karim P. M. Labib","orcid":"https://orcid.org/0000-0001-8861-379X","observed_orcids":["https://orcid.org/0000-0001-8861-379X"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I4210110201","display_name":"MRC Protein Phosphorylation and Ubiquitylation Unit","ror":"https://ror.org/01zg1tt02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I177639307","https://openalex.org/I4210087105","https://openalex.org/I4210110201","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Karim P. M. Labib","raw_affiliation_strings":["MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, UK","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I4210110201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019379073","display_name":"Giuseppe Cannone","orcid":"https://orcid.org/0000-0002-4381-2522","observed_orcids":["https://orcid.org/0000-0002-4381-2522"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Giuseppe Cannone","raw_affiliation_strings":["MRC Laboratory of Molecular Biology, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Cambridge, UK","institution_ids":["https://openalex.org/I170203145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089523004","display_name":"Joseph T.P. Yeeles","orcid":"https://orcid.org/0000-0002-2255-2119","observed_orcids":["https://orcid.org/0000-0002-2255-2119"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Joseph T. P. Yeeles","raw_affiliation_strings":["MRC Laboratory of Molecular Biology, Cambridge, UK. jyeeles@mrc-lmb.cam.ac.uk","MRC Laboratory of Molecular Biology, Cambridge, UK"],"raw_orcid":"https://orcid.org/0000-0002-2255-2119","affiliations":[{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Cambridge, UK. jyeeles@mrc-lmb.cam.ac.uk","institution_ids":["https://openalex.org/I170203145"]},{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Cambridge, UK","institution_ids":["https://openalex.org/I170203145"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079736311","display_name":"Tom D Deegan","orcid":"https://orcid.org/0000-0001-9639-7636","observed_orcids":["https://orcid.org/0000-0001-9639-7636"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I4210110201","display_name":"MRC Protein Phosphorylation and Ubiquitylation Unit","ror":"https://ror.org/01zg1tt02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I177639307","https://openalex.org/I4210087105","https://openalex.org/I4210110201","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210158898","display_name":"Institute of Genetics and Cancer","ror":"https://ror.org/05hygey35","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210158898","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I4387154614","display_name":"MRC Human Genetics Unit","ror":"https://ror.org/011jsc803","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4387154614","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Tom D. Deegan","raw_affiliation_strings":["MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK. tdeegan@ed.ac.uk","MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, UK. tdeegan@ed.ac.uk","MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, UK"],"raw_orcid":"https://orcid.org/0000-0001-9639-7636","affiliations":[{"raw_affiliation_string":"MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK. tdeegan@ed.ac.uk","institution_ids":["https://openalex.org/I2800150677","https://openalex.org/I4210158898","https://openalex.org/I4387154614","https://openalex.org/I98677209"]},{"raw_affiliation_string":"MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, UK. tdeegan@ed.ac.uk","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I4210110201"]},{"raw_affiliation_string":"MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, UK","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I4210110201"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5079736311","https://openalex.org/A5089523004"],"corresponding_institution_ids":["https://openalex.org/I170203145","https://openalex.org/I177639307","https://openalex.org/I2800150677","https://openalex.org/I4210110201","https://openalex.org/I4210158898","https://openalex.org/I4387154614","https://openalex.org/I98677209"],"apc_list":{"value":11390,"currency":"USD","value_usd":11390},"apc_paid":{"value":11390,"currency":"USD","value_usd":11390},"fwci":4.2044,"has_fulltext":true,"cited_by_count":110,"citation_normalized_percentile":{"value":0.96660372,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"600","issue":"7890","first_page":"743","last_page":"747"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.6279000043869019,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.6279000043869019,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.25220000743865967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.060600001364946365,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cmg-helicase","display_name":"CMG helicase","score":0.7549999952316284},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.9520000219345093},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.8799999952316284},{"id":"https://openalex.org/keywords/replication-termination","display_name":"replication termination","score":0.7820000052452087},{"id":"https://openalex.org/keywords/leucine-rich-repeat-domain","display_name":"leucine-rich repeat domain","score":0.828000009059906},{"id":"https://openalex.org/keywords/replication-fork-collapse","display_name":"replication fork collapse","score":0.6620000004768372},{"id":"https://openalex.org/keywords/eukaryotic-dna-replication","display_name":"eukaryotic DNA replication","score":0.8700000047683716}],"concepts":[{"id":"https://openalex.org/C149187182","wikidata":"https://www.wikidata.org/wiki/Q22325217","display_name":"Replisome","level":5,"score":0.976618766784668},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.6500835418701172},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6470012068748474},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6444928050041199},{"id":"https://openalex.org/C161223559","wikidata":"https://www.wikidata.org/wiki/Q138864","display_name":"Helicase","level":4,"score":0.620723307132721},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.5612695217132568},{"id":"https://openalex.org/C104690221","wikidata":"https://www.wikidata.org/wiki/Q5165872","display_name":"Control of chromosome duplication","level":4,"score":0.46429356932640076},{"id":"https://openalex.org/C98086919","wikidata":"https://www.wikidata.org/wiki/Q118019","display_name":"Eukaryotic DNA replication","level":4,"score":0.44081810116767883},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4082576334476471},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3597618639469147},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0958399772644043},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004265","descriptor_name":"DNA Helicases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056890","descriptor_name":"Eukaryota","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1038/s41586-021-04145-3","doi":"https://doi.org/10.1038/s41586-021-04145-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41586-021-04145-3","pdf_url":"https://www.nature.com/articles/s41586-021-04145-3.pdf","source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8695382","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8695382","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Text"},{"id":"pmid:34700328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34700328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"},{"id":"pmh:oai:discovery.dundee.ac.uk:openaire/dd9b2eb1-01a7-4e56-9e66-14963fbb4639","doi":null,"is_oa":true,"landing_page_url":"https://discovery.dundee.ac.uk/en/publications/dd9b2eb1-01a7-4e56-9e66-14963fbb4639","pdf_url":null,"source":{"id":"https://openalex.org/S4306400523","display_name":"Discovery Research Portal (University of Dundee)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177639307","host_organization_name":"University of Dundee","host_organization_lineage":["https://openalex.org/I177639307"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jenkyn-Bedford, M, Jones, M L, Baris, Y, Labib, K P M, Cannone, G, Yeeles, J T P & Deegan, T D 2021, 'A Conserved Mechanism for Regulating Replisome Disassembly in Eukaryotes', Nature, vol. 600, pp. 743-747. https://doi.org/10.1038/s41586-021-04145-3","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:nat:nature:v:600:y:2021:i:7890:d:10.1038_s41586-021-04145-3","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41586-021-04145-3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:pure.ed.ac.uk:openaire/c59d45ac-f3b0-45fc-8229-87753c120126","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.11820/c59d45ac-f3b0-45fc-8229-87753c120126","pdf_url":null,"source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Jenkyn-Bedford, M, Jones, M L, Baris, Y, Labib, K P M, Cannone, G, Yeeles, J T P & Deegan, T D 2021, 'A Conserved Mechanism for Regulating Replisome Disassembly in Eukaryotes', Nature. https://doi.org/10.1038/s41586-021-04145-3","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/332081","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/332081","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.17863/cam.79528","doi":"https://doi.org/10.17863/cam.79528","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.79528","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1038/s41586-021-04145-3","doi":"https://doi.org/10.1038/s41586-021-04145-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41586-021-04145-3","pdf_url":"https://www.nature.com/articles/s41586-021-04145-3.pdf","source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1458394169","display_name":null,"funder_award_id":"MC_UU_12016/13","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G1614540307","display_name":null,"funder_award_id":"24558","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G3619684613","display_name":null,"funder_award_id":"MC_UP_1201/12","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5962197380","display_name":"Molecular mechanisms of DNA replication termination","funder_award_id":"204678/Z/16/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6138341811","display_name":null,"funder_award_id":"MC_UU_12016","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8293791796","display_name":null,"funder_award_id":"MC_UP_1201/12","funder_id":"https://openalex.org/F4320314731","funder_display_name":"UK Research and Innovation"},{"id":"https://openalex.org/G8833095207","display_name":"Ubiquitylation pathways controlling the end of chromosome replication","funder_award_id":"MC_UU_00018/4","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320314731","display_name":"UK Research and Innovation","ror":"https://ror.org/001aqnf71"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3208795162.pdf","grobid_xml":"https://content.openalex.org/works/W3208795162.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1136494239","https://openalex.org/W1259155283","https://openalex.org/W1501553911","https://openalex.org/W1599398129","https://openalex.org/W1968074226","https://openalex.org/W1989831269","https://openalex.org/W2007201048","https://openalex.org/W2016628718","https://openalex.org/W2021846401","https://openalex.org/W2062741934","https://openalex.org/W2062830884","https://openalex.org/W2121077625","https://openalex.org/W2122674109","https://openalex.org/W2124221060","https://openalex.org/W2147542927","https://openalex.org/W2258280387","https://openalex.org/W2589901784","https://openalex.org/W2602290490","https://openalex.org/W2604825272","https://openalex.org/W2604886968","https://openalex.org/W2618013191","https://openalex.org/W2624244777","https://openalex.org/W2766127952","https://openalex.org/W2786390877","https://openalex.org/W2919983752","https://openalex.org/W2960549984","https://openalex.org/W2966483144","https://openalex.org/W2971471877","https://openalex.org/W3004470337","https://openalex.org/W3009570400","https://openalex.org/W3021801309","https://openalex.org/W3035859142","https://openalex.org/W3049294857","https://openalex.org/W3087402143","https://openalex.org/W3125609455","https://openalex.org/W3130695509","https://openalex.org/W3165649272","https://openalex.org/W3180688762","https://openalex.org/W3208578918","https://openalex.org/W4248756242","https://openalex.org/W6627288242","https://openalex.org/W6678640366"],"related_works":["https://openalex.org/W3049294857","https://openalex.org/W3183470564","https://openalex.org/W2604886968","https://openalex.org/W1989831269","https://openalex.org/W1599398129","https://openalex.org/W4400883818","https://openalex.org/W2972759678","https://openalex.org/W7128676257","https://openalex.org/W3217123474","https://openalex.org/W2007201048"],"abstract_inverted_index":{"Abstract":[0],"Replisome":[1],"disassembly":[2,50,163,199],"is":[3,12,51,63,79,89,159,166],"the":[4,17,130,150,169,177,181,195],"final":[5],"step":[6],"of":[7,16,61,118,134,183,197],"eukaryotic":[8],"DNA":[9,84,171,209],"replication":[10,66,70,82,174],"and":[11,94,121,136,152,202],"triggered":[13],"by":[14,27,53,81,168],"ubiquitylation":[15,60,185],"CDC45\u2013MCM\u2013GINS":[18],"(CMG)":[19],"replicative":[20],"helicase":[21],"1\u20133":[22],".":[23,86],"Despite":[24],"being":[25],"driven":[26],"evolutionarily":[28],"diverse":[29],"E3":[30],"ubiquitin":[31],"ligases":[32],"in":[33,38,45,58,200,210],"different":[34],"eukaryotes":[35],"(SCF":[36],"Dia2":[37,93,135],"budding":[39,119],"yeast":[40,120],"1":[41],",":[42],"CUL2":[43,95],"LRR1":[44,96,137],"metazoa":[46],"4\u20137":[47],"),":[48],"replisome":[49,162,198,212],"governed":[52],"a":[54,144,191,204],"common":[55,145],"regulatory":[56],"principle,":[57],"which":[59],"CMG":[62,105,184],"suppressed":[64],"before":[65,186],"termination,":[67],"to":[68,102,114,143],"prevent":[69],"fork":[71,83],"collapse.":[72],"Recent":[73],"evidence":[74],"suggests":[75],"that":[76,129],"this":[77],"suppression":[78,182],"mediated":[80],"8\u201310":[85],"However,":[87],"it":[88],"unknown":[90],"how":[91],"SCF":[92],"discriminate":[97],"terminated":[98],"from":[99],"elongating":[100],"replisomes,":[101],"selectively":[103],"ubiquitylate":[104],"only":[106],"after":[107],"termination.":[108,187],"Here":[109],"we":[110],"used":[111],"cryo-electron":[112],"microscopy":[113],"solve":[115],"high-resolution":[116],"structures":[117,127],"human":[122],"replisome\u2013E3":[123],"ligase":[124],"assemblies.":[125],"Our":[126,188],"show":[128],"leucine-rich":[131],"repeat":[132],"domains":[133],"are":[138],"structurally":[139],"distinct,":[140],"but":[141],"bind":[142],"site":[146],"on":[147],"CMG,":[148],"including":[149],"MCM3":[151],"MCM5":[153],"zinc-finger":[154],"domains.":[155],"The":[156],"LRR\u2013MCM":[157],"interaction":[158],"essential":[160],"for":[161,180,194,208],"and,":[164],"crucially,":[165],"occluded":[167],"excluded":[170],"strand":[172],"at":[173],"forks,":[175],"establishing":[176],"structural":[178],"basis":[179],"results":[189],"elucidate":[190],"conserved":[192],"mechanism":[193],"regulation":[196],"eukaryotes,":[201],"reveal":[203],"previously":[205],"unanticipated":[206],"role":[207],"preserving":[211],"integrity.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":33},{"year":2024,"cited_by_count":30},{"year":2023,"cited_by_count":23},{"year":2022,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-11-08T00:00:00"}