{"id":"https://openalex.org/W3208670974","doi":"https://doi.org/10.14309/01.ajg.0000784628.86661.12","title":"S2774 A Rare Case of Passenger Lymphocyte Syndrome","display_name":"S2774 A Rare Case of Passenger Lymphocyte Syndrome","publication_year":2021,"publication_date":"2021-10-01","ids":{"openalex":"https://openalex.org/W3208670974","doi":"https://doi.org/10.14309/01.ajg.0000784628.86661.12","mag":"3208670974"},"language":"en","primary_location":{"id":"doi:10.14309/01.ajg.0000784628.86661.12","doi":"https://doi.org/10.14309/01.ajg.0000784628.86661.12","is_oa":false,"landing_page_url":"https://doi.org/10.14309/01.ajg.0000784628.86661.12","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044765206","display_name":"Kanika Garg","orcid":"https://orcid.org/0009-0002-4613-6803","observed_orcids":["https://orcid.org/0009-0002-4613-6803"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kanika Garg","raw_affiliation_strings":["Rush University Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush University Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071019175","display_name":"Dharani Guttikonda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dharani Guttikonda","raw_affiliation_strings":["Rush University Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush University Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104091571","display_name":"Edie Y. Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edie Chan","raw_affiliation_strings":["Rush University Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush University Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113877124","display_name":"Sheila L. Eswaran","orcid":"https://orcid.org/0000-0002-8210-6276","observed_orcids":["https://orcid.org/0000-0002-8210-6276"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheila Eswaran","raw_affiliation_strings":["Rush University Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush University Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I1285301757"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1285301757"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"116","issue":"1","first_page":"S1157","last_page":"S1157"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.8773999810218811,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.8773999810218811,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.0421999990940094,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.03920000046491623,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/passenger-lymphocyte-syndrome","display_name":"passenger lymphocyte syndrome","score":0.9959999918937683},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.9599999785423279},{"id":"https://openalex.org/keywords/abo-incompatible-transplantation","display_name":"ABO-incompatible transplantation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/combined-liver-kidney-transplantation","display_name":"combined liver-kidney transplantation","score":0.875},{"id":"https://openalex.org/keywords/hemolytic-anemia","display_name":"hemolytic anemia","score":0.7730000019073486},{"id":"https://openalex.org/keywords/postoperative-anemia","display_name":"postoperative anemia","score":0.6060000061988831},{"id":"https://openalex.org/keywords/direct-antiglobulin-test","display_name":"direct antiglobulin test","score":0.7990000247955322},{"id":"https://openalex.org/keywords/c3d","display_name":"C3d","score":0.6570000052452087},{"id":"https://openalex.org/keywords/blood-type-b","display_name":"blood type B","score":0.5590000152587891},{"id":"https://openalex.org/keywords/blood-transfusion","display_name":"blood transfusion","score":0.3880000114440918},{"id":"https://openalex.org/keywords/plasmapheresis","display_name":"plasmapheresis","score":0.7360000014305115},{"id":"https://openalex.org/keywords/steroids","display_name":"steroids","score":0.5720000267028809},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.6940000057220459},{"id":"https://openalex.org/keywords/alcoholic-cirrhosis","display_name":"alcoholic cirrhosis","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9025499820709229},{"id":"https://openalex.org/C176080213","wikidata":"https://www.wikidata.org/wiki/Q188010","display_name":"ABO blood group system","level":2,"score":0.7770516276359558},{"id":"https://openalex.org/C2779902561","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Hemolysis","level":2,"score":0.6566128730773926},{"id":"https://openalex.org/C65245452","wikidata":"https://www.wikidata.org/wiki/Q623225","display_name":"Schistocyte","level":4,"score":0.6424688100814819},{"id":"https://openalex.org/C2780920261","wikidata":"https://www.wikidata.org/wiki/Q1363810","display_name":"Packed red blood cells","level":3,"score":0.5510264039039612},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5201706886291504},{"id":"https://openalex.org/C184113351","wikidata":"https://www.wikidata.org/wiki/Q55588","display_name":"Blood type (non-human)","level":3,"score":0.5081679821014404},{"id":"https://openalex.org/C206396517","wikidata":"https://www.wikidata.org/wiki/Q422025","display_name":"Haptoglobin","level":2,"score":0.47121185064315796},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.46670934557914734},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4613390862941742},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.42640790343284607},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39960020780563354},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3816732168197632},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35435235500335693},{"id":"https://openalex.org/C2780014101","wikidata":"https://www.wikidata.org/wiki/Q183605","display_name":"Blood transfusion","level":2,"score":0.2783885896205902},{"id":"https://openalex.org/C2778585876","wikidata":"https://www.wikidata.org/wiki/Q1426491","display_name":"Thrombotic thrombocytopenic purpura","level":3,"score":0.1470508575439453},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14309/01.ajg.0000784628.86661.12","doi":"https://doi.org/10.14309/01.ajg.0000784628.86661.12","is_oa":false,"landing_page_url":"https://doi.org/10.14309/01.ajg.0000784628.86661.12","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7161501470","https://openalex.org/W4403720705","https://openalex.org/W2920812196","https://openalex.org/W2667390490","https://openalex.org/W4401892900","https://openalex.org/W4297503844","https://openalex.org/W7163736079","https://openalex.org/W3045161558","https://openalex.org/W4416066826","https://openalex.org/W1589538576"],"abstract_inverted_index":{"Introduction:":[0],"Passenger":[1,404],"Lymphocyte":[2,405],"Syndrome":[3],"(PLS)":[4],"is":[5,49,71,117,291,311],"a":[6,67,74,87,95,118,165,401],"subtype":[7],"of":[8,25,34,47,90,144,147,167,260,322,343,357,362,378,397],"graft-versus-host":[9],"disease":[10,132],"that":[11,92,313],"can":[12,301,382],"occur":[13],"days":[14,245],"to":[15,73,152,180,238,272,386],"weeks":[16],"after":[17,101,222,230,281,325],"stem":[18],"cell":[19],"transplants":[20],"or":[21,56],"solid":[22],"organ":[23,70,328],"transplantation":[24],"an":[26,201],"ABO-mismatched":[27],"organ.":[28],"Antibodies":[29],"produced":[30],"from":[31],"the":[32,137,191,318,363,391],"transfer":[33],"donor":[35,364],"B-lymphocytes":[36],"target":[37],"recipient":[38,75],"red":[39,149,359],"cells":[40,151,361],"and":[41,128,206,278,330,355,388],"cause":[42],"hemolysis.":[43,216],"The":[44,115],"true":[45],"incidence":[46],"PLS":[48,60,91,290,316,344,381],"unknown,":[50],"as":[51,257,367],"many":[52],"cases":[53,321],"are":[54],"subclinical":[55],"go":[57],"undetected.":[58],"Classically,":[59],"develops":[61],"with":[62,76,80,97,107,123,187,242,296,306,352,403],"minor":[63],"ABO-incompatible":[64],"transplantation,":[65],"when":[66,174],"type":[68,77,99,188,261,264,298,308],"O":[69,265],"donated":[72],"A":[78,375],"blood,":[79,190,263],"ABO":[81,326],"antibodies":[82],"being":[83,268],"formed.":[84],"We":[85],"present":[86],"rare":[88],"case":[89,286],"developed":[93],"in":[94,294,304,320,349,369,400],"patient":[96,116,138],"blood":[98,140,150,185,211,266,297,307,360,365],"B":[100,189,262],"simultaneous":[102,409],"liver":[103,126,410],"kidney":[104,411],"transplant":[105,329],"(SLKT)":[106],"initial":[108],"negative":[109,337],"testing":[110,333],"for":[111,215,270,380,384],"PLS.":[112],"Case":[113],"Description/Methods:":[114],"45":[119],"year":[120],"old":[121],"male":[122],"hypertension,":[124],"alcoholic":[125],"cirrhosis,":[127],"end":[129],"stage":[130],"renal":[131],"who":[133],"underwent":[134],"SLKT.":[135],"Intraoperatively,":[136],"had":[139,224],"loss":[141],"requiring":[142],"transfusion":[143,356],"5":[145],"units":[146,179],"packed":[148,358],"which":[153,251,273],"his":[154,160,231,247,274],"hemoglobin":[155,161,193,232,275],"responded":[156,276],"appropriately.":[157],"After":[158],"surgery,":[159],"remained":[162,194,279],"stable":[163,280],"at":[164],"level":[166],"9-10":[168],"g/dL":[169],"until":[170],"postoperative":[171,323,415],"day":[172,229],"8":[173],"it":[175,235,300],"dropped":[176],"about":[177],"3":[178],"6.7":[181],"g/dL.":[182],"Despite":[183],"further":[184],"transfusions":[186],"patient\u2019s":[192],"persistently":[195],"below":[196],"7g/dL.":[197],"Other":[198],"labs":[199],"including":[200],"elevated":[202],"LDH,":[203],"low":[204],"haptoglobin,":[205],"schistocytes":[207],"seen":[208,368],"on":[209,317],"peripheral":[210],"smear":[212],"were":[213],"suspicious":[214],"Initial":[217],"direct":[218,422],"antiglobulin":[219,423],"test":[220],"(DAT)":[221],"surgery":[223],"been":[225,346,373],"negative,":[226,254],"however":[227],"one":[228],"started":[233],"dropping":[234],"was":[236,252],"found":[237],"be":[239],"positive":[240,256],"along":[241],"C3d.":[243],"Three":[244],"later,":[246],"immunoglobulin":[248,427],"G":[249],"(IgG),":[250],"initially":[253],"became":[255],"well.":[258],"Instead":[259],"began":[267],"used":[269],"transfusions,":[271],"appropriately":[277,387],"6":[282],"days.":[283],"Discussion:":[284],"This":[285],"demonstrates":[287],"how":[288],"although":[289],"more":[292],"common":[293],"recipients":[295],"A,":[299],"still":[302],"develop":[303],"those":[305],"B.":[309],"It":[310],"prudent":[312],"clinicians":[314],"keep":[315],"differential":[319],"anemia":[324,351],"mismatched":[327],"continue":[331],"serologic":[332],"even":[334],"despite":[335],"early":[336],"results.":[338],"While":[339],"no":[340],"definitive":[341],"treatment":[342],"has":[345],"established,":[347],"improvement":[348],"hemolytic":[350],"steroids,":[353],"plasmapheresis,":[354],"type,":[366],"this":[370],"case,":[371],"have":[372],"documented.":[374],"high":[376],"index":[377],"suspicion":[379],"allow":[383],"patients":[385],"quickly":[389],"receive":[390],"support":[392],"they":[393],"need.Table":[394],"1.:":[395],"Progression":[396],"Blood":[398],"Tests":[399],"Patient":[402],"Syndrome.":[406],"OLT":[407],"=":[408,414,418,421,426],"transplant,":[412],"POD":[413],"day,":[416],"Hbg":[417],"hemoglobin,":[419],"DAT":[420],"test,":[424],"IgG":[425],"G.":[428]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2021-11-08T00:00:00"}