{"id":"https://openalex.org/W3208641663","doi":"https://doi.org/10.1136/ijgc-2021-igcs.286","title":"EPV215/#519 SOX4 drives ovarian cancer stemness via transcriptionally activating HDAC1","display_name":"EPV215/#519 SOX4 drives ovarian cancer stemness via transcriptionally activating HDAC1","publication_year":2021,"publication_date":"2021-11-01","ids":{"openalex":"https://openalex.org/W3208641663","doi":"https://doi.org/10.1136/ijgc-2021-igcs.286","mag":"3208641663"},"language":"en","primary_location":{"id":"doi:10.1136/ijgc-2021-igcs.286","doi":"https://doi.org/10.1136/ijgc-2021-igcs.286","is_oa":true,"landing_page_url":"https://doi.org/10.1136/ijgc-2021-igcs.286","pdf_url":"https://ijgc.bmj.com/content/ijgc/31/Suppl_4/A114.2.full.pdf","source":{"id":"https://openalex.org/S41026820","display_name":"International Journal of Gynecological Cancer","issn_l":"1048-891X","issn":["1048-891X","1525-1438"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Gynecological Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ijgc.bmj.com/content/ijgc/31/Suppl_4/A114.2.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038083082","display_name":"J Liu","orcid":"https://orcid.org/0000-0002-1289-4422","observed_orcids":["https://orcid.org/0000-0002-1289-4422","https://orcid.org/0000-0002-1541-2222","https://orcid.org/0000-0002-2514-6570","https://orcid.org/0009-0006-1172-5375"]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I4210154480","display_name":"Chongqing Cancer Hospital","ror":"https://ror.org/047d8yx24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J. Liu","raw_affiliation_strings":["Chongqing University Cancer Hospital, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing, China","Chongqing University Cancer Hospital, Department of Gynecologic Oncology, Chongqing, China","Chongqing University, College of Bioengineering, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing University Cancer Hospital, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing, China","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210154480"]},{"raw_affiliation_string":"Chongqing University Cancer Hospital, Department of Gynecologic Oncology, Chongqing, China","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210154480"]},{"raw_affiliation_string":"Chongqing University, College of Bioengineering, Chongqing, China","institution_ids":["https://openalex.org/I158842170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014538004","display_name":"Tingyuan Lang","orcid":"https://orcid.org/0000-0001-6457-6736","observed_orcids":["https://orcid.org/0000-0001-6457-6736"]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I4210154480","display_name":"Chongqing Cancer Hospital","ror":"https://ror.org/047d8yx24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"T. Lang","raw_affiliation_strings":["Chongqing University Cancer Hospital, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing, China","Chongqing University Cancer Hospital, Department of Gynecologic Oncology, Chongqing, China","Chongqing University, College of Bioengineering, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing University Cancer Hospital, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing, China","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210154480"]},{"raw_affiliation_string":"Chongqing University Cancer Hospital, Department of Gynecologic Oncology, Chongqing, China","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210154480"]},{"raw_affiliation_string":"Chongqing University, College of Bioengineering, Chongqing, China","institution_ids":["https://openalex.org/I158842170"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D. Zou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I4210154480","display_name":"Chongqing Cancer Hospital","ror":"https://ror.org/047d8yx24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"D. Zou","raw_affiliation_strings":["Chongqing University Cancer Hospital, Department of Gynecologic Oncology, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing University Cancer Hospital, Department of Gynecologic Oncology, Chongqing, China","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210154480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006991839","display_name":"D Wang","orcid":"https://orcid.org/0009-0001-3441-6122","observed_orcids":["https://orcid.org/0009-0001-3441-6122"]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I4210154480","display_name":"Chongqing Cancer Hospital","ror":"https://ror.org/047d8yx24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"D. Wang","raw_affiliation_strings":["Chongqing University Cancer Hospital, Department of Gynecologic Oncology, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing University Cancer Hospital, Department of Gynecologic Oncology, Chongqing, China","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210154480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100638974","display_name":"Yingying Tang","orcid":"https://orcid.org/0000-0002-8522-1456","observed_orcids":["https://orcid.org/0000-0002-8522-1456"]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I4210154480","display_name":"Chongqing Cancer Hospital","ror":"https://ror.org/047d8yx24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y. Tang","raw_affiliation_strings":["Chongqing University Cancer Hospital, Department of Gynecologic Oncology, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing University Cancer Hospital, Department of Gynecologic Oncology, Chongqing, China","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210154480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079559121","display_name":"Renyan Li","orcid":"https://orcid.org/0000-0002-8843-5185","observed_orcids":["https://orcid.org/0000-0002-8843-5185"]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I4210154480","display_name":"Chongqing Cancer Hospital","ror":"https://ror.org/047d8yx24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"R. Li","raw_affiliation_strings":["Chongqing University Cancer Hospital, Department of Gynecologic Oncology, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing University Cancer Hospital, Department of Gynecologic Oncology, Chongqing, China","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210154480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051843964","display_name":"Y Li","orcid":"https://orcid.org/0000-0001-7648-5671","observed_orcids":["https://orcid.org/0000-0001-7648-5671","https://orcid.org/0000-0002-4082-4261","https://orcid.org/0000-0003-3299-505X","https://orcid.org/0000-0001-5412-2028","https://orcid.org/0000-0001-5887-3937","https://orcid.org/0000-0001-6605-4069","https://orcid.org/0000-0002-0478-0177","https://orcid.org/0000-0002-2079-9484","https://orcid.org/0000-0002-9190-4755","https://orcid.org/0000-0003-2175-9449","https://orcid.org/0009-0005-2457-2964"]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I4210154480","display_name":"Chongqing Cancer Hospital","ror":"https://ror.org/047d8yx24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y. Li","raw_affiliation_strings":["Chongqing University Cancer Hospital, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing, China","Chongqing University Cancer Hospital, Department of Gynecologic Oncology, Chongqing, China","Chongqing University, College of Bioengineering, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing University Cancer Hospital, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing, China","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210154480"]},{"raw_affiliation_string":"Chongqing University Cancer Hospital, Department of Gynecologic Oncology, Chongqing, China","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210154480"]},{"raw_affiliation_string":"Chongqing University, College of Bioengineering, Chongqing, China","institution_ids":["https://openalex.org/I158842170"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D. Ding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I4210154480","display_name":"Chongqing Cancer Hospital","ror":"https://ror.org/047d8yx24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"D. Ding","raw_affiliation_strings":["Chongqing University Cancer Hospital, Department of Gynecologic Oncology, Chongqing, China","Chongqing University, College of Bioengineering, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing University Cancer Hospital, Department of Gynecologic Oncology, Chongqing, China","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210154480"]},{"raw_affiliation_string":"Chongqing University, College of Bioengineering, Chongqing, China","institution_ids":["https://openalex.org/I158842170"]}]},{"author_position":"last","author":{"id":null,"display_name":"Q. Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I4210154480","display_name":"Chongqing Cancer Hospital","ror":"https://ror.org/047d8yx24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Q. Zhou","raw_affiliation_strings":["Chongqing University Cancer Hospital, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing, China","Chongqing University Cancer Hospital, Department of Gynecologic Oncology, Chongqing, China","Chongqing University, College of Bioengineering, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing University Cancer Hospital, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing, China","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210154480"]},{"raw_affiliation_string":"Chongqing University Cancer Hospital, Department of Gynecologic Oncology, Chongqing, China","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210154480"]},{"raw_affiliation_string":"Chongqing University, College of Bioengineering, Chongqing, China","institution_ids":["https://openalex.org/I158842170"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17700298,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":null,"first_page":"A114","last_page":"A114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.022299999371170998,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sox4","display_name":"SOX4","score":1.0},{"id":"https://openalex.org/keywords/hdac1","display_name":"HDAC1","score":0.8960000276565552},{"id":"https://openalex.org/keywords/ovarian-cancer-stem-cells","display_name":"ovarian cancer stem cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.8709999918937683},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6507722735404968},{"id":"https://openalex.org/C139259183","wikidata":"https://www.wikidata.org/wiki/Q18031651","display_name":"SOX4","level":5,"score":0.6490830779075623},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.558790922164917},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5450109243392944},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4668470323085785},{"id":"https://openalex.org/C85240754","wikidata":"https://www.wikidata.org/wiki/Q14914420","display_name":"HDAC1","level":5,"score":0.4549207389354706},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.4241424798965454},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32415348291397095},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32140570878982544},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32067418098449707},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.20820140838623047},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.190891295671463},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13563686609268188},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10768070816993713},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.0},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/ijgc-2021-igcs.286","doi":"https://doi.org/10.1136/ijgc-2021-igcs.286","is_oa":true,"landing_page_url":"https://doi.org/10.1136/ijgc-2021-igcs.286","pdf_url":"https://ijgc.bmj.com/content/ijgc/31/Suppl_4/A114.2.full.pdf","source":{"id":"https://openalex.org/S41026820","display_name":"International Journal of Gynecological Cancer","issn_l":"1048-891X","issn":["1048-891X","1525-1438"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Gynecological Cancer","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1136/ijgc-2021-igcs.286","doi":"https://doi.org/10.1136/ijgc-2021-igcs.286","is_oa":true,"landing_page_url":"https://doi.org/10.1136/ijgc-2021-igcs.286","pdf_url":"https://ijgc.bmj.com/content/ijgc/31/Suppl_4/A114.2.full.pdf","source":{"id":"https://openalex.org/S41026820","display_name":"International Journal of Gynecological Cancer","issn_l":"1048-891X","issn":["1048-891X","1525-1438"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Gynecological Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7799999713897705,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3208641663.pdf","grobid_xml":"https://content.openalex.org/works/W3208641663.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2368682957","https://openalex.org/W2005566060","https://openalex.org/W2783652815","https://openalex.org/W2564946823","https://openalex.org/W2351542508","https://openalex.org/W2762455533","https://openalex.org/W2389465834","https://openalex.org/W4394739755","https://openalex.org/W4223629701","https://openalex.org/W2526778509"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}