{"id":"https://openalex.org/W3208565145","doi":"https://doi.org/10.3390/polym13213808","title":"Isoniazid\u2014Loaded Albumin Nanoparticles: Taguchi Optimization Method","display_name":"Isoniazid\u2014Loaded Albumin Nanoparticles: Taguchi Optimization Method","publication_year":2021,"publication_date":"2021-11-04","ids":{"openalex":"https://openalex.org/W3208565145","doi":"https://doi.org/10.3390/polym13213808","mag":"3208565145","pmid":"https://pubmed.ncbi.nlm.nih.gov/34771365","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8588201"},"language":"en","primary_location":{"id":"doi:10.3390/polym13213808","doi":"https://doi.org/10.3390/polym13213808","is_oa":true,"landing_page_url":"https://doi.org/10.3390/polym13213808","pdf_url":"https://www.mdpi.com/2073-4360/13/21/3808/pdf?version=1636009118","source":{"id":"https://openalex.org/S123288148","display_name":"Polymers","issn_l":"2073-4360","issn":["2073-4360"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polymers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-4360/13/21/3808/pdf?version=1636009118","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088334217","display_name":"Yerkeblan M. Tazhbayev","orcid":"https://orcid.org/0000-0003-4828-2521","observed_orcids":["https://orcid.org/0000-0003-4828-2521","https://orcid.org/0000-0003-2043-6672"]},"institutions":[{"id":"https://openalex.org/I2800164252","display_name":"Karaganda Buketov University","ror":"https://ror.org/00eq8hh49","country_code":"KZ","type":"education","lineage":["https://openalex.org/I2800164252"]}],"countries":["KZ"],"is_corresponding":true,"raw_author_name":"Yerkeblan Tazhbayev","raw_affiliation_strings":["Department of Organic Chemistry and Polymers, Buketov Karaganda University, Karaganda 100028, Kazakhstan"],"raw_orcid":"https://orcid.org/0000-0003-4828-2521","affiliations":[{"raw_affiliation_string":"Department of Organic Chemistry and Polymers, Buketov Karaganda University, Karaganda 100028, Kazakhstan","institution_ids":["https://openalex.org/I2800164252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091585434","display_name":"Aldana R. Galiyeva","orcid":"https://orcid.org/0000-0002-8551-6297","observed_orcids":["https://orcid.org/0000-0002-8551-6297"]},"institutions":[{"id":"https://openalex.org/I2800164252","display_name":"Karaganda Buketov University","ror":"https://ror.org/00eq8hh49","country_code":"KZ","type":"education","lineage":["https://openalex.org/I2800164252"]}],"countries":["KZ"],"is_corresponding":true,"raw_author_name":"Aldana Galiyeva","raw_affiliation_strings":["Department of Organic Chemistry and Polymers, Buketov Karaganda University, Karaganda 100028, Kazakhstan"],"raw_orcid":"https://orcid.org/0000-0002-8551-6297","affiliations":[{"raw_affiliation_string":"Department of Organic Chemistry and Polymers, Buketov Karaganda University, Karaganda 100028, Kazakhstan","institution_ids":["https://openalex.org/I2800164252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110177106","display_name":"Tolkyn Zhumagaliyeva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800164252","display_name":"Karaganda Buketov University","ror":"https://ror.org/00eq8hh49","country_code":"KZ","type":"education","lineage":["https://openalex.org/I2800164252"]}],"countries":["KZ"],"is_corresponding":false,"raw_author_name":"Tolkyn Zhumagaliyeva","raw_affiliation_strings":["Department of Organic Chemistry and Polymers, Buketov Karaganda University, Karaganda 100028, Kazakhstan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organic Chemistry and Polymers, Buketov Karaganda University, Karaganda 100028, Kazakhstan","institution_ids":["https://openalex.org/I2800164252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026619331","display_name":"Meiram Burkeyev","orcid":"https://orcid.org/0000-0001-8084-4825","observed_orcids":["https://orcid.org/0000-0001-8084-4825"]},"institutions":[{"id":"https://openalex.org/I2800164252","display_name":"Karaganda Buketov University","ror":"https://ror.org/00eq8hh49","country_code":"KZ","type":"education","lineage":["https://openalex.org/I2800164252"]}],"countries":["KZ"],"is_corresponding":false,"raw_author_name":"Meiram Burkeyev","raw_affiliation_strings":["Department of Organic Chemistry and Polymers, Buketov Karaganda University, Karaganda 100028, Kazakhstan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organic Chemistry and Polymers, Buketov Karaganda University, Karaganda 100028, Kazakhstan","institution_ids":["https://openalex.org/I2800164252"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054067338","display_name":"Bakhytgul Karimova","orcid":"https://orcid.org/0000-0001-6548-3179","observed_orcids":["https://orcid.org/0000-0001-6548-3179"]},"institutions":[{"id":"https://openalex.org/I2800164252","display_name":"Karaganda Buketov University","ror":"https://ror.org/00eq8hh49","country_code":"KZ","type":"education","lineage":["https://openalex.org/I2800164252"]}],"countries":["KZ"],"is_corresponding":false,"raw_author_name":"Bakhytgul Karimova","raw_affiliation_strings":["Department of Organic Chemistry and Polymers, Buketov Karaganda University, Karaganda 100028, Kazakhstan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organic Chemistry and Polymers, Buketov Karaganda University, Karaganda 100028, Kazakhstan","institution_ids":["https://openalex.org/I2800164252"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088334217","https://openalex.org/A5091585434"],"corresponding_institution_ids":["https://openalex.org/I2800164252"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2376},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2376},"fwci":0.8919,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.63069464,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"13","issue":"21","first_page":"3808","last_page":"3808"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.6723999977111816,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.6723999977111816,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.19480000436306,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.09040000289678574,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isoniazid","display_name":"isoniazid","score":0.9950000047683716},{"id":"https://openalex.org/keywords/bovine-serum-albumin","display_name":"bovine serum albumin","score":0.9539999961853027},{"id":"https://openalex.org/keywords/albumin-nanoparticles","display_name":"albumin nanoparticles","score":0.8610000014305115},{"id":"https://openalex.org/keywords/drug-loaded-nanoparticles","display_name":"drug-loaded nanoparticles","score":0.8240000009536743},{"id":"https://openalex.org/keywords/drug-resistant-tuberculosis","display_name":"drug-resistant tuberculosis","score":0.7450000047683716},{"id":"https://openalex.org/keywords/taguchi-method","display_name":"Taguchi method","score":0.7549999952316284},{"id":"https://openalex.org/keywords/nanoparticle-size","display_name":"nanoparticle size","score":0.7139999866485596},{"id":"https://openalex.org/keywords/polydispersity","display_name":"polydispersity","score":0.9330000281333923},{"id":"https://openalex.org/keywords/drug-loading","display_name":"drug loading","score":0.7300000190734863},{"id":"https://openalex.org/keywords/protein-drug-conjugates","display_name":"protein-drug conjugates","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C2776967927","wikidata":"https://www.wikidata.org/wiki/Q423169","display_name":"Isoniazid","level":3,"score":0.8242337703704834},{"id":"https://openalex.org/C86807702","wikidata":"https://www.wikidata.org/wiki/Q2620381","display_name":"Bovine serum albumin","level":2,"score":0.6484500169754028},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.582112729549408},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.5466599464416504},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5232221484184265},{"id":"https://openalex.org/C11432220","wikidata":"https://www.wikidata.org/wiki/Q1975334","display_name":"Dispersity","level":2,"score":0.5076659917831421},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.4670611321926117},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4102252721786499},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.34998172521591187},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.34050512313842773},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.28388550877571106},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.21061092615127563},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1732896864414215},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.15729933977127075},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09964388608932495},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/polym13213808","doi":"https://doi.org/10.3390/polym13213808","is_oa":true,"landing_page_url":"https://doi.org/10.3390/polym13213808","pdf_url":"https://www.mdpi.com/2073-4360/13/21/3808/pdf?version=1636009118","source":{"id":"https://openalex.org/S123288148","display_name":"Polymers","issn_l":"2073-4360","issn":["2073-4360"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polymers","raw_type":"journal-article"},{"id":"pmid:34771365","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34771365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polymers","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8588201","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8588201/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polymers (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:fa789b672a4d4b8187d1f2a110484491","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fa789b672a4d4b8187d1f2a110484491","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Polymers, Vol 13, Iss 21, p 3808 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/polym13213808","doi":"https://doi.org/10.3390/polym13213808","is_oa":true,"landing_page_url":"https://doi.org/10.3390/polym13213808","pdf_url":"https://www.mdpi.com/2073-4360/13/21/3808/pdf?version=1636009118","source":{"id":"https://openalex.org/S123288148","display_name":"Polymers","issn_l":"2073-4360","issn":["2073-4360"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polymers","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3208565145.pdf","grobid_xml":"https://content.openalex.org/works/W3208565145.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W65039510","https://openalex.org/W1266434244","https://openalex.org/W1965046246","https://openalex.org/W1969990370","https://openalex.org/W1982628018","https://openalex.org/W2002995327","https://openalex.org/W2007192377","https://openalex.org/W2008832211","https://openalex.org/W2041998484","https://openalex.org/W2054750440","https://openalex.org/W2073544886","https://openalex.org/W2090857211","https://openalex.org/W2101245024","https://openalex.org/W2114257996","https://openalex.org/W2337917444","https://openalex.org/W2556176123","https://openalex.org/W2605410679","https://openalex.org/W2939546806","https://openalex.org/W2968639311","https://openalex.org/W3017137707","https://openalex.org/W3033110818","https://openalex.org/W3089651222","https://openalex.org/W3093893434","https://openalex.org/W3111178373","https://openalex.org/W3123634553","https://openalex.org/W3141823543","https://openalex.org/W3148014714","https://openalex.org/W3150177701","https://openalex.org/W3186884229"],"related_works":["https://openalex.org/W4411216937","https://openalex.org/W4392181101","https://openalex.org/W4220972242","https://openalex.org/W4381686592","https://openalex.org/W7220507156","https://openalex.org/W2810490996","https://openalex.org/W3043920380","https://openalex.org/W6963533265","https://openalex.org/W4410832050","https://openalex.org/W4404443410"],"abstract_inverted_index":{"Tuberculosis":[0],"is":[1,28,81,109,155],"one":[2],"of":[3,25,95,106,122,129,140,151,161,169,180,202],"the":[4,23,68,101,107,120,130,138,147,152,158,162,167,170,178,195],"dangerous":[5],"infectious":[6],"diseases,":[7],"killing":[8],"over":[9],"a":[10,85],"million":[11],"people":[12],"worldwide":[13],"each":[14,203],"year.":[15],"The":[16,70,104,127,149],"search":[17],"for":[18,22,119],"new":[19],"dosage":[20],"forms":[21],"treatment":[24],"drug-resistant":[26],"tuberculosis":[27],"an":[29,92,96,206],"actual":[30],"task.":[31],"Biocompatible":[32],"polymer":[33],"nanoparticles,":[34],"in":[35,100,146],"particular":[36],"bovine":[37],"serum":[38],"albumin":[39],"(BSA),":[40],"are":[41,58,117,134,173],"promising":[42],"drug":[43,65,102],"carriers.":[44],"Nanoparticle":[45],"(NP)":[46],"parameters":[47,168],"such":[48],"as":[49,84,190],"diameter,":[50],"polydispersity,":[51],"bioactive":[52],"substance":[53],"loading,":[54],"and":[55,73,115,144,188,193],"NP":[56],"yield":[57],"very":[59],"important":[60,207],"when":[61],"it":[62],"comes":[63],"to":[64,156,198],"transport":[66],"through":[67],"bloodstream.":[69],"most":[71],"well-known":[72],"widely":[74],"used":[75,83,118],"first-line":[76],"anti-tuberculosis":[77],"drug,":[78],"isoniazid":[79],"(INH),":[80],"being":[82],"drug.":[86],"BSA-INH":[87,123,132,210],"NPs":[88,124,133,171,211],"were":[89],"obtained":[90,131],"by":[91,137],"ethanol":[93],"desolvation":[94],"aqueous":[97],"protein":[98],"solution":[99],"presence.":[103],"peculiarity":[105],"method":[108,197],"that":[110,172],"natural":[111],"components,":[112,183],"namely":[113],"urea":[114],"cysteine,":[116,189],"stabilization":[121],"after":[125],"desolvation.":[126],"characteristics":[128],"significantly":[135],"affected":[136],"concentration":[139,159,201],"protein,":[141],"isoniazid,":[142,186],"urea,":[143,187],"cysteine":[145],"solution.":[148],"aim":[150],"present":[153],"study":[154],"investigate":[157],"effect":[160,208],"system":[163],"reacting":[164,182],"components":[165],"on":[166,209],"obtained.":[174],"We":[175],"have":[176],"chosen":[177],"concentrations":[179],"four":[181],"i.e.,":[184],"BSA,":[185],"controlling":[191],"factors":[192],"applied":[194],"Taguchi":[196],"analyze":[199],"which":[200],"component":[204],"has":[205],"characteristics.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-11-08T00:00:00"}
