{"id":"https://openalex.org/W3208545828","doi":"https://doi.org/10.1515/med-2021-0326","title":"Superenhancer\u2013transcription factor regulatory network in malignant tumors","display_name":"Superenhancer\u2013transcription factor regulatory network in malignant tumors","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3208545828","doi":"https://doi.org/10.1515/med-2021-0326","mag":"3208545828","pmid":"https://pubmed.ncbi.nlm.nih.gov/34722892","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8525661"},"language":"en","primary_location":{"id":"doi:10.1515/med-2021-0326","doi":"https://doi.org/10.1515/med-2021-0326","is_oa":true,"landing_page_url":"https://doi.org/10.1515/med-2021-0326","pdf_url":"https://www.degruyter.com/document/doi/10.1515/med-2021-0326/pdf","source":{"id":"https://openalex.org/S4210213140","display_name":"Open Medicine","issn_l":"1895-1058","issn":["1895-1058","1644-3640","2391-5463"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.degruyter.com/document/doi/10.1515/med-2021-0326/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102794374","display_name":"Yuan Liang","orcid":"https://orcid.org/0000-0002-6387-4579","observed_orcids":["https://orcid.org/0000-0002-6387-4579"]},"institutions":[{"id":"https://openalex.org/I4210161255","display_name":"Liaoning Cancer Hospital & Institute","ror":"https://ror.org/05d659s21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161255"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Liang","raw_affiliation_strings":["Medical Oncology Department of Thoracic Cancer (2), Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute , Shenyang 110042 , People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Department of Thoracic Cancer (2), Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute , Shenyang 110042 , People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210161255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318926","display_name":"Linlin Li","orcid":"https://orcid.org/0000-0003-2432-8433","observed_orcids":["https://orcid.org/0000-0003-2432-8433"]},"institutions":[{"id":"https://openalex.org/I4210161255","display_name":"Liaoning Cancer Hospital & Institute","ror":"https://ror.org/05d659s21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161255"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linlin Li","raw_affiliation_strings":["Medical Oncology Department of Thoracic Cancer (2), Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute , Shenyang 110042 , People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Department of Thoracic Cancer (2), Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute , Shenyang 110042 , People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210161255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100584150","display_name":"Xin Tian","orcid":"https://orcid.org/0009-0000-7308-1807","observed_orcids":["https://orcid.org/0009-0000-7308-1807"]},"institutions":[{"id":"https://openalex.org/I4210161255","display_name":"Liaoning Cancer Hospital & Institute","ror":"https://ror.org/05d659s21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161255"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tian Xin","raw_affiliation_strings":["Medical Oncology Department of Thoracic Cancer (2), Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute , Shenyang 110042 , People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Department of Thoracic Cancer (2), Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute , Shenyang 110042 , People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210161255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005403061","display_name":"Binru Li","orcid":"https://orcid.org/0000-0001-7393-5796","observed_orcids":["https://orcid.org/0000-0001-7393-5796"]},"institutions":[{"id":"https://openalex.org/I4210161255","display_name":"Liaoning Cancer Hospital & Institute","ror":"https://ror.org/05d659s21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161255"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Binru Li","raw_affiliation_strings":["Medical Oncology Department of Thoracic Cancer (2), Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute , Shenyang 110042 , People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Department of Thoracic Cancer (2), Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute , Shenyang 110042 , People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210161255"]}]},{"author_position":"last","author":{"id":null,"display_name":"Dalin Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dalin Zhang","raw_affiliation_strings":["Department of Thyroid Surgery, The First Hospital of China Medical University , No. 155, Nanjing North Street , Shenyang 110001 , Liaoning Province , People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thyroid Surgery, The First Hospital of China Medical University , No. 155, Nanjing North Street , Shenyang 110001 , Liaoning Province , People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210140515"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210140515"],"apc_list":{"value":2000,"currency":"EUR","value_usd":2366},"apc_paid":{"value":2000,"currency":"EUR","value_usd":2366},"fwci":0.1398,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.31893882,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"16","issue":"1","first_page":"1564","last_page":"1582"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/super-enhancers","display_name":"super-enhancers","score":0.8790000081062317},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.847000002861023},{"id":"https://openalex.org/keywords/h3k27ac","display_name":"H3K27ac","score":0.8460000157356262},{"id":"https://openalex.org/keywords/smad3","display_name":"Smad3","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.6309999823570251},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.8190000057220459},{"id":"https://openalex.org/keywords/enhancer-regulation","display_name":"enhancer regulation","score":0.5270000100135803},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9210000038146973}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5790868401527405},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.5559588670730591},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5496408343315125},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5343847274780273},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5124369263648987},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5120242238044739},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.4152825176715851},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3948611617088318},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3276195526123047},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2474079132080078},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.24458497762680054},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1501811444759369},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1414262056350708},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.12944740056991577}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1515/med-2021-0326","doi":"https://doi.org/10.1515/med-2021-0326","is_oa":true,"landing_page_url":"https://doi.org/10.1515/med-2021-0326","pdf_url":"https://www.degruyter.com/document/doi/10.1515/med-2021-0326/pdf","source":{"id":"https://openalex.org/S4210213140","display_name":"Open Medicine","issn_l":"1895-1058","issn":["1895-1058","1644-3640","2391-5463"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:7439304","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8525661","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:34722892","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34722892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open medicine (Warsaw, Poland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8525661","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8525661/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Med (Wars)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:6a46785b4db64d48bb07bc8d22b74050","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6a46785b4db64d48bb07bc8d22b74050","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Medicine, Vol 16, Iss 1, Pp 1564-1582 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1515/med-2021-0326","doi":"https://doi.org/10.1515/med-2021-0326","is_oa":true,"landing_page_url":"https://doi.org/10.1515/med-2021-0326","pdf_url":"https://www.degruyter.com/document/doi/10.1515/med-2021-0326/pdf","source":{"id":"https://openalex.org/S4210213140","display_name":"Open Medicine","issn_l":"1895-1058","issn":["1895-1058","1644-3640","2391-5463"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3208545828.pdf","grobid_xml":"https://content.openalex.org/works/W3208545828.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W897563747","https://openalex.org/W1523117612","https://openalex.org/W1971578941","https://openalex.org/W2004966039","https://openalex.org/W2014677321","https://openalex.org/W2043304374","https://openalex.org/W2061096783","https://openalex.org/W2102619694","https://openalex.org/W2108234281","https://openalex.org/W2132344184","https://openalex.org/W2133465414","https://openalex.org/W2153056550","https://openalex.org/W2157164705","https://openalex.org/W2158217645","https://openalex.org/W2158789637","https://openalex.org/W2158934466","https://openalex.org/W2171808845","https://openalex.org/W2262709833","https://openalex.org/W2468495646","https://openalex.org/W2495793061","https://openalex.org/W2523668277","https://openalex.org/W2534008312","https://openalex.org/W2593459113","https://openalex.org/W2607363971","https://openalex.org/W2809250494","https://openalex.org/W2889051002","https://openalex.org/W2892397277","https://openalex.org/W2908255744","https://openalex.org/W2914775587","https://openalex.org/W2921841818","https://openalex.org/W2931202164","https://openalex.org/W2955964880","https://openalex.org/W2972263821","https://openalex.org/W2979081539","https://openalex.org/W3007397831","https://openalex.org/W3012674294","https://openalex.org/W3014830213","https://openalex.org/W3016557714"],"related_works":["https://openalex.org/W3157872380","https://openalex.org/W3207889514","https://openalex.org/W4360604611","https://openalex.org/W3083213584","https://openalex.org/W7147226295","https://openalex.org/W4411991605","https://openalex.org/W2752877137","https://openalex.org/W2941993016","https://openalex.org/W4391677541","https://openalex.org/W2980417691"],"abstract_inverted_index":{"Abstract":[0],"Objective":[1],"This":[2],"study":[3],"aims":[4],"to":[5,14,53],"identify":[6],"superenhancer":[7],"(SE)\u2013transcriptional":[8],"factor":[9],"(TF)":[10],"regulatory":[11,71,166,173,186],"network":[12,167,174,187],"related":[13],"eight":[15,40,114,151],"common":[16,41,115,152],"malignant":[17,42,75,101,116,125,135,153,177,200],"tumors":[18,102],"based":[19],"on":[20],"ChIP-seq":[21,37],"data":[22,38,87,159],"modified":[23],"by":[24,63,85],"histone":[25],"H3K27ac":[26,36,108,148],"in":[27,74,88,94,113,150,168,196],"the":[28,32,48,56,107,132,161,176,191,197],"enhancer":[29],"region":[30],"of":[31,39,134,163,179,199],"SRA":[33,49],"database.":[34],"Methods":[35],"tumor":[43,76,117,154],"samples":[44,77],"were":[45,65,92,122],"downloaded":[46],"from":[47],"database":[50],"and":[51,83,143,171],"subjected":[52],"comparison":[54],"with":[55,67,188],"human":[57],"reference":[58],"genome":[59],"hg19.":[60],"TFs":[61,129],"regulated":[62],"SEs":[64],"screened":[66],"HOMER":[68],"software.":[69],"Core":[70],"circuitry":[72],"(CRC)":[73],"was":[78],"defined":[79,123],"through":[80,106],"CRCmapper":[81],"software":[82],"validated":[84],"RNA-seq":[86],"TCGA.":[89],"The":[90,184],"findings":[91],"substantiated":[93],"bladder":[95,169,180],"cancer":[96,181],"cell":[97],"experiments.":[98],"Results":[99],"Different":[100],"could":[103],"be":[104],"distinguished":[105,131],"signal.":[109],"After":[110],"SE":[111],"identification":[112],"samples,":[118],"35":[119],"SE-regulated":[120,127],"genes":[121],"as":[124,190],"tumor-specific.":[126],"specific":[128],"effectively":[130],"types":[133],"tumors.":[136,201],"Finally,":[137],"we":[138],"obtained":[139],"60":[140],"CRC":[141],"TFs,":[142],"SMAD3":[144,189],"exhibited":[145],"a":[146,164],"strong":[147],"signal":[149],"samples.":[155],"In":[156],"vitro":[157],"experimental":[158],"verified":[160],"presence":[162],"SE\u2013TF":[165,172,185],"cancer,":[170],"enhanced":[175],"phenotype":[178],"cells.":[182],"Conclusion":[183],"core":[192],"TF":[193],"may":[194],"participate":[195],"carcinogenesis":[198]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-11-08T00:00:00"}
