{"id":"https://openalex.org/W3208401101","doi":"https://doi.org/10.1182/blood.2021013630","title":"A viral cause of APL","display_name":"A viral cause of APL","publication_year":2021,"publication_date":"2021-11-04","ids":{"openalex":"https://openalex.org/W3208401101","doi":"https://doi.org/10.1182/blood.2021013630","mag":"3208401101","pmid":"https://pubmed.ncbi.nlm.nih.gov/34734999"},"language":"en","primary_location":{"id":"doi:10.1182/blood.2021013630","doi":"https://doi.org/10.1182/blood.2021013630","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.2021013630","pdf_url":"https://ashpublications.org/blood/article-pdf/138/18/1653/1832886/bloodbld2021013630c.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/138/18/1653/1832886/bloodbld2021013630c.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036550103","display_name":"Rachel E. Rau","orcid":"https://orcid.org/0000-0003-4096-6603","observed_orcids":["https://orcid.org/0000-0003-4096-6603"]},"institutions":[{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rachel E. Rau","raw_affiliation_strings":["Texas Children\u2019s Hospital"],"raw_orcid":"https://orcid.org/0000-0003-4096-6603","affiliations":[{"raw_affiliation_string":"Texas Children\u2019s Hospital","institution_ids":["https://openalex.org/I4210147586"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5036550103"],"corresponding_institution_ids":["https://openalex.org/I4210147586"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"138","issue":"18","first_page":"1653","last_page":"1655"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.23469999432563782,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.23469999432563782,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.2167000025510788,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.05249999836087227,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-promyelocytic-leukemia","display_name":"acute promyelocytic leukemia","score":0.968999981880188},{"id":"https://openalex.org/keywords/viral-etiology","display_name":"viral etiology","score":0.8730000257492065},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.8360000252723694},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.953000009059906},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.8289999961853027},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9940000176429749},{"id":"https://openalex.org/keywords/secondary-infection","display_name":"secondary infection","score":0.921999990940094},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.6349999904632568},{"id":"https://openalex.org/keywords/hyperinflammation","display_name":"hyperinflammation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/clinical-deterioration","display_name":"clinical deterioration","score":0.3869999945163727}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4078351855278015},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40404143929481506}],"mesh":[{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017152","descriptor_name":"Antibodies, Antiphospholipid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1182/blood.2021013630","doi":"https://doi.org/10.1182/blood.2021013630","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.2021013630","pdf_url":"https://ashpublications.org/blood/article-pdf/138/18/1653/1832886/bloodbld2021013630c.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:34734999","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34734999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Editorial"}],"best_oa_location":{"id":"doi:10.1182/blood.2021013630","doi":"https://doi.org/10.1182/blood.2021013630","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.2021013630","pdf_url":"https://ashpublications.org/blood/article-pdf/138/18/1653/1832886/bloodbld2021013630c.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3208401101.pdf","grobid_xml":"https://content.openalex.org/works/W3208401101.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W2129338773","https://openalex.org/W2339658711","https://openalex.org/W2768202893","https://openalex.org/W2884059319","https://openalex.org/W2891476569","https://openalex.org/W2999957329","https://openalex.org/W3005400930","https://openalex.org/W3011245150","https://openalex.org/W3193764108","https://openalex.org/W3217207951"],"related_works":["https://openalex.org/W6939505521","https://openalex.org/W3118685355","https://openalex.org/W3093630651","https://openalex.org/W3197542039","https://openalex.org/W3047987484","https://openalex.org/W4382500663","https://openalex.org/W7222373577","https://openalex.org/W4220820840","https://openalex.org/W4318478956","https://openalex.org/W4402301245"],"abstract_inverted_index":{"in":[0,4,11,55,73,86,104],"hospitalized":[1,75],"patients,":[2],"including":[3],"those":[5,12],"requiring":[6,13],"supplemental":[7],"oxygen,":[8],"but":[9,25],"not":[10],"ICU":[14,42],"level":[15,43],"care,":[16],"may":[17],"reflect":[18],"better":[19],"management":[20],"of":[21,30,33,69],"patients":[22,56,74,87],"over":[23],"time,":[24],"also":[26],"highlight":[27],"the":[28,63,67,82,91],"significance":[29],"early":[31],"introduction":[32],"various":[34],"anti-COVID-19":[35],"therapies":[36],"to":[37,41,94,101],"prevent":[38],"clinical":[39],"deterioration":[40],"care.The":[44],"findings":[45],"that":[46],"corticosteroids":[47,98],"increased":[48],"both":[49],"secondary":[50],"infections":[51],"and":[52,59],"death":[53],"rates":[54],"with":[57,76,88],"CLL":[58,89],"COVID-19":[60,77],"are":[61],"intriguing.In":[62],"RECOV-ERY":[64],"trial,":[65],"8":[66],"use":[68],"dexamethasone":[70],"improved":[71],"survival":[72],"who":[78],"received":[79],"respiratory":[80],"support.Perhaps":[81],"impaired":[83],"immune":[84],"reactions":[85,93],"moderate":[90],"hyperinflammatory":[92],"COVID-19,":[95],"thus":[96],"turning":[97],"beneficial":[99],"effects":[100],"somewhat":[102],"redundant":[103],"this":[105],"frail":[106],"population.":[107]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-11-08T00:00:00"}