{"id":"https://openalex.org/W3208340281","doi":"https://doi.org/10.1101/2021.10.23.465590","title":"A Prion that regulates genome diversification","display_name":"A Prion that regulates genome diversification","publication_year":2021,"publication_date":"2021-10-24","ids":{"openalex":"https://openalex.org/W3208340281","doi":"https://doi.org/10.1101/2021.10.23.465590","mag":"3208340281"},"language":"en","primary_location":{"id":"doi:10.1101/2021.10.23.465590","doi":"https://doi.org/10.1101/2021.10.23.465590","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.10.23.465590","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/10/24/2021.10.23.465590.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2021/10/24/2021.10.23.465590.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053169078","display_name":"James S. Byers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James S. Byers","raw_affiliation_strings":["Department of Developmental Biology, Stanford University School of Medicine","Department of Developmental Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, Stanford University School of Medicine","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Developmental Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047613295","display_name":"Raymond A. Futia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond A. Futia","raw_affiliation_strings":["Department of Biology, Stanford University","Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Stanford University","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116651947","display_name":"Alexandria Van Elgort","orcid":"https://orcid.org/0000-0001-8429-7275","observed_orcids":["https://orcid.org/0000-0001-8429-7275"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex Van Elgort","raw_affiliation_strings":["Department of Chemical and Systems Biology, Stanford University School of Medicine","Department of Chemical and Systems Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 9405"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Systems Biology, Stanford University School of Medicine","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Chemical and Systems Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 9405","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023196495","display_name":"Thomas M. Lozanoski","orcid":"https://orcid.org/0000-0002-5659-7032","observed_orcids":["https://orcid.org/0000-0002-5659-7032"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas M. Lozanoski","raw_affiliation_strings":["Department of Bioengineering, Stanford University, Shriram Center 443 Via Ortega","Department of Bioengineering, Stanford University, Shriram Center 3 Via Ortega, Stanford, CA 9305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Stanford University, Shriram Center 443 Via Ortega","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Bioengineering, Stanford University, Shriram Center 3 Via Ortega, Stanford, CA 9305","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057674835","display_name":"David M. Garcia","orcid":"https://orcid.org/0000-0003-0600-9527","observed_orcids":["https://orcid.org/0000-0003-0600-9527"]},"institutions":[{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Garcia","raw_affiliation_strings":["Institute of Molecular Biology, University of Oregon","Institute of Molecular Biology, University of Oregon, 1318 Franklin Blvd., Eugene, OR 97403"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, University of Oregon","institution_ids":["https://openalex.org/I181233156"]},{"raw_affiliation_string":"Institute of Molecular Biology, University of Oregon, 1318 Franklin Blvd., Eugene, OR 97403","institution_ids":["https://openalex.org/I181233156"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066860900","display_name":"Daniel F. Jarosz","orcid":"https://orcid.org/0000-0003-3497-5888","observed_orcids":["https://orcid.org/0000-0003-3497-5888"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel F. Jarosz","raw_affiliation_strings":["Department of Chemical and Systems Biology, Stanford University School of Medicine","Department of Developmental Biology, Stanford University School of Medicine","Department of Chemical and Systems Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 9405","Department of Developmental Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Systems Biology, Stanford University School of Medicine","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Developmental Biology, Stanford University School of Medicine","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Chemical and Systems Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 9405","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Developmental Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5066860900"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.46000000834465027,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.46000000834465027,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.1737000048160553,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.0763000026345253,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prions","display_name":"prions","score":0.6930000185966492},{"id":"https://openalex.org/keywords/dna-helicase","display_name":"DNA helicase","score":0.9490000009536743},{"id":"https://openalex.org/keywords/epigenetic-inheritance","display_name":"epigenetic inheritance","score":0.9049999713897705},{"id":"https://openalex.org/keywords/dna-damage-resistance","display_name":"DNA damage resistance","score":0.8360000252723694},{"id":"https://openalex.org/keywords/meiotic-crossover","display_name":"meiotic crossover","score":0.859000027179718},{"id":"https://openalex.org/keywords/genome-diversification","display_name":"genome diversification","score":0.8610000014305115},{"id":"https://openalex.org/keywords/phenotypic-diversification","display_name":"phenotypic diversification","score":0.847000002861023},{"id":"https://openalex.org/keywords/lamarckian-inheritance","display_name":"Lamarckian inheritance","score":0.875}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.8238072991371155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6830572485923767},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5500136017799377},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5094762444496155},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.504775881767273},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.49738457798957825},{"id":"https://openalex.org/C161223559","wikidata":"https://www.wikidata.org/wiki/Q138864","display_name":"Helicase","level":4,"score":0.4873984456062317},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4673115909099579},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3469046354293823},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.24298155307769775},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.09811049699783325}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2021.10.23.465590","doi":"https://doi.org/10.1101/2021.10.23.465590","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.10.23.465590","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/10/24/2021.10.23.465590.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2021.10.23.465590","doi":"https://doi.org/10.1101/2021.10.23.465590","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.10.23.465590","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/10/24/2021.10.23.465590.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3208340281.pdf","grobid_xml":"https://content.openalex.org/works/W3208340281.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W184600276","https://openalex.org/W966608475","https://openalex.org/W1503622815","https://openalex.org/W1571724913","https://openalex.org/W1970140322","https://openalex.org/W1972399884","https://openalex.org/W1979914496","https://openalex.org/W1982893758","https://openalex.org/W1998491954","https://openalex.org/W1999665216","https://openalex.org/W2006037039","https://openalex.org/W2006952692","https://openalex.org/W2018085822","https://openalex.org/W2025096207","https://openalex.org/W2028490462","https://openalex.org/W2031202740","https://openalex.org/W2043676526","https://openalex.org/W2046147149","https://openalex.org/W2058301426","https://openalex.org/W2062210712","https://openalex.org/W2073533352","https://openalex.org/W2080183225","https://openalex.org/W2086660631","https://openalex.org/W2086991973","https://openalex.org/W2088631165","https://openalex.org/W2095674609","https://openalex.org/W2101784201","https://openalex.org/W2107546215","https://openalex.org/W2107861779","https://openalex.org/W2110451776","https://openalex.org/W2110519712","https://openalex.org/W2121150109","https://openalex.org/W2127403065","https://openalex.org/W2130937633","https://openalex.org/W2132641227","https://openalex.org/W2141165131","https://openalex.org/W2141566674","https://openalex.org/W2144939475","https://openalex.org/W2147984622","https://openalex.org/W2149441684","https://openalex.org/W2154518311","https://openalex.org/W2162357575","https://openalex.org/W2162980545","https://openalex.org/W2167844213","https://openalex.org/W2193760529","https://openalex.org/W2222627402","https://openalex.org/W2270112503","https://openalex.org/W2295695175","https://openalex.org/W2524788592","https://openalex.org/W2784457786","https://openalex.org/W3007420340"],"related_works":["https://openalex.org/W2636297872","https://openalex.org/W2150234014","https://openalex.org/W2769292253","https://openalex.org/W2883758471","https://openalex.org/W1995748666","https://openalex.org/W4408509297","https://openalex.org/W2735744795","https://openalex.org/W4213420059","https://openalex.org/W3021095473","https://openalex.org/W2011163535"],"abstract_inverted_index":{"ABSTRACT":[0],"Epigenetic":[1],"mechanisms":[2],"mediate":[3],"diverse":[4],"gene":[5],"expression":[6],"programs":[7],"in":[8,79,93],"growth":[9],"and":[10,116],"development.":[11],"Here":[12],"we":[13],"report":[14],"a":[15,19,33,56,104],"protein-based":[16],"epigenetic":[17],"element,":[18],"prion,":[20],"formed":[21],"by":[22,40,90],"the":[23,41,113,119],"conserved":[24],"DNA":[25,54],"helicase":[26,61],"Mph1/FANCM.":[27],"[":[28,47,63,83,99],"MIX":[29,48,64,84,100],"+":[30,49,65,85,101],"]":[31,50,66,86,102],"is":[32,96],"cytoplasmically":[34],"inherited":[35],"state":[36],"with":[37],"propagation":[38],"driven":[39],"non-amyloid":[42],"prion":[43],"templating":[44],"of":[45,107,112,118],"Mph1.":[46],"provides":[51],"resistance":[52],"to":[53],"damage,":[55],"gain-of-function":[57],"trait":[58],"that":[59,109],"requires":[60],"activity.":[62],"reduces":[67],"mitotic":[68],"mutation":[69],"rates,":[70],"but":[71],"promotes":[72,110],"meiotic":[73],"crossovers,":[74],"driving":[75],"measurable":[76],"phenotypic":[77],"diversification":[78,117],"wild":[80],"outcrosses.":[81],"Remarkably,":[82],"can":[87],"be":[88],"induced":[89],"DNA-damaging":[91],"stresses":[92],"which":[94],"it":[95],"beneficial.":[97],"Thus,":[98],"fuels":[103],"quasi-Lamarckian":[105],"form":[106],"inheritance":[108],"survival":[111],"current":[114],"generation":[115],"next.":[120]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2021-11-08T00:00:00"}