{"id":"https://openalex.org/W3208325319","doi":"https://doi.org/10.1007/s13300-021-01176-x","title":"Effects of Dapagliflozin Compared with Sitagliptin and Metformin in Drug-Na\u00efve Japanese Patients with Type 2 Diabetes: A 12-Week, Open-Label, Randomized, Active-Controlled Trial","display_name":"Effects of Dapagliflozin Compared with Sitagliptin and Metformin in Drug-Na\u00efve Japanese Patients with Type 2 Diabetes: A 12-Week, Open-Label, Randomized, Active-Controlled Trial","publication_year":2021,"publication_date":"2021-10-28","ids":{"openalex":"https://openalex.org/W3208325319","doi":"https://doi.org/10.1007/s13300-021-01176-x","mag":"3208325319","pmid":"https://pubmed.ncbi.nlm.nih.gov/34709582","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8586398"},"language":"en","primary_location":{"id":"doi:10.1007/s13300-021-01176-x","doi":"https://doi.org/10.1007/s13300-021-01176-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13300-021-01176-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13300-021-01176-x.pdf","source":{"id":"https://openalex.org/S16535137","display_name":"Diabetes Therapy","issn_l":"1869-6953","issn":["1869-6953","1869-6961"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1007/s13300-021-01176-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101420534","display_name":"Daisuke Ito","orcid":"https://orcid.org/0000-0003-4175-2375","observed_orcids":["https://orcid.org/0000-0003-4175-2375"]},"institutions":[{"id":"https://openalex.org/I4405284634","display_name":"Japanese Red Cross Ogawa Hospital","ror":"https://ror.org/03xm46p63","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4405284634"]},{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Daisuke Ito","raw_affiliation_strings":["Department of Endocrinology and Diabetes, Saitama Medical University, 38, Morohongo, Moroyama, Iruma-gun, Saitama, 350-0495, Japan. dito@saitama-med.ac.jp","Department of Internal Medicine, Ogawa Red Cross Hospital, Saitama, Japan. dito@saitama-med.ac.jp","Department of Endocrinology and Diabetes, Saitama Medical University, 38, Morohongo, Moroyama, Iruma-gun, Saitama, 350-0495, Japan"],"raw_orcid":"https://orcid.org/0000-0003-4175-2375","affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Diabetes, Saitama Medical University, 38, Morohongo, Moroyama, Iruma-gun, Saitama, 350-0495, Japan. dito@saitama-med.ac.jp","institution_ids":["https://openalex.org/I8588240"]},{"raw_affiliation_string":"Department of Internal Medicine, Ogawa Red Cross Hospital, Saitama, Japan. dito@saitama-med.ac.jp","institution_ids":["https://openalex.org/I4405284634"]},{"raw_affiliation_string":"Department of Endocrinology and Diabetes, Saitama Medical University, 38, Morohongo, Moroyama, Iruma-gun, Saitama, 350-0495, Japan","institution_ids":["https://openalex.org/I8588240"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kazuyuki Inoue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuyuki Inoue","raw_affiliation_strings":["Department of Endocrinology and Diabetes, Saitama Medical University, 38, Morohongo, Moroyama, Iruma-gun, Saitama, 350-0495, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Diabetes, Saitama Medical University, 38, Morohongo, Moroyama, Iruma-gun, Saitama, 350-0495, Japan","institution_ids":["https://openalex.org/I8588240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084079409","display_name":"Daigo Saito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daigo Saito","raw_affiliation_strings":["Department of Endocrinology and Diabetes, Saitama Medical University, 38, Morohongo, Moroyama, Iruma-gun, Saitama, 350-0495, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Diabetes, Saitama Medical University, 38, Morohongo, Moroyama, Iruma-gun, Saitama, 350-0495, Japan","institution_ids":["https://openalex.org/I8588240"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Keiko Hamaguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405284634","display_name":"Japanese Red Cross Ogawa Hospital","ror":"https://ror.org/03xm46p63","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4405284634"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiko Hamaguchi","raw_affiliation_strings":["Department of Nursing, Ogawa Red Cross Hospital, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nursing, Ogawa Red Cross Hospital, Saitama, Japan","institution_ids":["https://openalex.org/I4405284634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043178061","display_name":"Kimie Kaneko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405284634","display_name":"Japanese Red Cross Ogawa Hospital","ror":"https://ror.org/03xm46p63","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4405284634"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kimie Kaneko","raw_affiliation_strings":["Department of Nursing, Ogawa Red Cross Hospital, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nursing, Ogawa Red Cross Hospital, Saitama, Japan","institution_ids":["https://openalex.org/I4405284634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045090490","display_name":"Takashi Sumita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405284634","display_name":"Japanese Red Cross Ogawa Hospital","ror":"https://ror.org/03xm46p63","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4405284634"]},{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Sumita","raw_affiliation_strings":["Department of Endocrinology and Diabetes, Saitama Medical University, 38, Morohongo, Moroyama, Iruma-gun, Saitama, 350-0495, Japan","Department of Internal Medicine, Ogawa Red Cross Hospital, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Diabetes, Saitama Medical University, 38, Morohongo, Moroyama, Iruma-gun, Saitama, 350-0495, Japan","institution_ids":["https://openalex.org/I8588240"]},{"raw_affiliation_string":"Department of Internal Medicine, Ogawa Red Cross Hospital, Saitama, Japan","institution_ids":["https://openalex.org/I4405284634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043984865","display_name":"Kouichi Inukai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kouichi Inukai","raw_affiliation_strings":["Department of Diabetes and Endocrinology, Higashiyamato Hospital, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diabetes and Endocrinology, Higashiyamato Hospital, Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066182280","display_name":"Ikuo Inoue","orcid":"https://orcid.org/0000-0002-4633-4765","observed_orcids":["https://orcid.org/0000-0002-4633-4765"]},"institutions":[{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ikuo Inoue","raw_affiliation_strings":["Department of Endocrinology and Diabetes, Saitama Medical University, 38, Morohongo, Moroyama, Iruma-gun, Saitama, 350-0495, Japan","Department of Health Service Center, Saitama Medical University, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Diabetes, Saitama Medical University, 38, Morohongo, Moroyama, Iruma-gun, Saitama, 350-0495, Japan","institution_ids":["https://openalex.org/I8588240"]},{"raw_affiliation_string":"Department of Health Service Center, Saitama Medical University, Saitama, Japan","institution_ids":["https://openalex.org/I8588240"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059378687","display_name":"Akira Shimada","orcid":"https://orcid.org/0000-0002-3954-4983","observed_orcids":["https://orcid.org/0000-0002-3954-4983"]},"institutions":[{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Shimada","raw_affiliation_strings":["Department of Endocrinology and Diabetes, Saitama Medical University, 38, Morohongo, Moroyama, Iruma-gun, Saitama, 350-0495, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Diabetes, Saitama Medical University, 38, Morohongo, Moroyama, Iruma-gun, Saitama, 350-0495, Japan","institution_ids":["https://openalex.org/I8588240"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101420534"],"corresponding_institution_ids":["https://openalex.org/I4405284634","https://openalex.org/I8588240"],"apc_list":{"value":6000,"currency":"USD","value_usd":6000},"apc_paid":{"value":6000,"currency":"USD","value_usd":6000},"fwci":1.7168,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.84365024,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"12","issue":"12","first_page":"3201","last_page":"3215"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sitagliptin","display_name":"sitagliptin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":1.0},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9919999837875366},{"id":"https://openalex.org/keywords/drug-naive-patients","display_name":"drug-naive patients","score":0.8289999961853027},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.8939999938011169},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.9509999752044678},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.3959999978542328},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.8500000238418579},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.8949999809265137},{"id":"https://openalex.org/keywords/dpp-4-inhibitors","display_name":"DPP-4 inhibitors","score":0.9470000267028809},{"id":"https://openalex.org/keywords/meal-tolerance-test","display_name":"meal tolerance test","score":0.6349999904632568},{"id":"https://openalex.org/keywords/japanese-patients","display_name":"Japanese patients","score":0.7590000033378601},{"id":"https://openalex.org/keywords/drug-comparison","display_name":"drug comparison","score":0.5},{"id":"https://openalex.org/keywords/tolerability","display_name":"tolerability","score":0.9100000262260437},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.9079999923706055}],"concepts":[{"id":"https://openalex.org/C2777422806","wikidata":"https://www.wikidata.org/wiki/Q409898","display_name":"Dapagliflozin","level":4,"score":0.9671885967254639},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.9169862270355225},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9080936312675476},{"id":"https://openalex.org/C2779284873","wikidata":"https://www.wikidata.org/wiki/Q419832","display_name":"Sitagliptin","level":4,"score":0.8643029928207397},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6744507551193237},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.6469070911407471},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6364544034004211},{"id":"https://openalex.org/C2778199505","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Postprandial","level":3,"score":0.6182849407196045},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.5947319269180298},{"id":"https://openalex.org/C2778763485","wikidata":"https://www.wikidata.org/wiki/Q419770","display_name":"Dipeptidyl peptidase-4 inhibitor","level":4,"score":0.5821143388748169},{"id":"https://openalex.org/C2777538456","wikidata":"https://www.wikidata.org/wiki/Q311213","display_name":"Glycated hemoglobin","level":4,"score":0.5790875554084778},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.47111061215400696},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.45844152569770813},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4334750771522522},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3906790018081665},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3284831643104553},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.312580406665802},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1007/s13300-021-01176-x","doi":"https://doi.org/10.1007/s13300-021-01176-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13300-021-01176-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13300-021-01176-x.pdf","source":{"id":"https://openalex.org/S16535137","display_name":"Diabetes Therapy","issn_l":"1869-6953","issn":["1869-6953","1869-6961"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8586398","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8586398","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Ther","raw_type":"Text"},{"id":"pmid:34709582","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34709582","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes therapy : research, treatment and education of diabetes and related disorders","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s13300-021-01176-x","doi":"https://doi.org/10.1007/s13300-021-01176-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13300-021-01176-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13300-021-01176-x.pdf","source":{"id":"https://openalex.org/S16535137","display_name":"Diabetes Therapy","issn_l":"1869-6953","issn":["1869-6953","1869-6961"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3208325319.pdf","grobid_xml":"https://content.openalex.org/works/W3208325319.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W172609984","https://openalex.org/W1526927233","https://openalex.org/W1990025047","https://openalex.org/W2007374852","https://openalex.org/W2030311010","https://openalex.org/W2060104918","https://openalex.org/W2072040765","https://openalex.org/W2120655733","https://openalex.org/W2142065502","https://openalex.org/W2143239235","https://openalex.org/W2146264128","https://openalex.org/W2150959326","https://openalex.org/W2170271198","https://openalex.org/W2335973015","https://openalex.org/W2337454357","https://openalex.org/W2424539745","https://openalex.org/W2566774342","https://openalex.org/W2586681261","https://openalex.org/W2626446274","https://openalex.org/W2742155329","https://openalex.org/W2767087620","https://openalex.org/W2783931157","https://openalex.org/W2808191170","https://openalex.org/W2894993577","https://openalex.org/W2895533920","https://openalex.org/W2900413769","https://openalex.org/W2939222610","https://openalex.org/W2972938422","https://openalex.org/W3130225195"],"related_works":["https://openalex.org/W2015191704","https://openalex.org/W2177336327","https://openalex.org/W3004109662","https://openalex.org/W2001991301","https://openalex.org/W2122077393","https://openalex.org/W4378801796","https://openalex.org/W4405079874","https://openalex.org/W7099518322","https://openalex.org/W4381377796","https://openalex.org/W2153920846"],"abstract_inverted_index":{"To":[0],"compare":[1],"the":[2,61,74,87,94,102,113,142,156,160,170,175,180,193,208,237,246],"efficacy":[3],"and":[4,12,57,78,82,106,138,145,242,266,278,282],"tolerability":[5],"of":[6,10,72,163],"dapagliflozin":[7,40,176,194,209,220,273],"with":[8,16,304],"those":[9],"sitagliptin":[11,43,265],"metformin":[13,47,146,171,267],"in":[14,76,101,124,141,169,174,192,207,236,239,256],"patients":[15,34,62,303],"type":[17,305],"2":[18,306],"diabetes":[19],"who":[20],"have":[21],"never":[22],"received":[23],"glucose-lowering":[24],"agents.":[25],"In":[26,178,271],"this":[27],"randomized,":[28],"12-week,":[29],"open-label,":[30],"active-controlled":[31],"trial,":[32],"32":[33],"were":[35,98,108,133,232,254],"randomly":[36],"assigned":[37],"to":[38,130,166,264],"receive":[39],"5":[41],"mg,":[42,45],"50":[44],"or":[46],"1000":[48],"mg":[49],"per":[50],"day":[51],"for":[52,300],"12":[53,70,132,188],"weeks.":[54],"At":[55],"baseline":[56,97,129],"at":[58,186],"week":[59,131,187],"12,":[60],"underwent":[63],"a":[64],"meal":[65],"tolerance":[66],"test":[67],"(MTT).":[68],"After":[69],"weeks":[71],"treatment,":[73],"changes":[75,123,238],"fasting":[77],"postprandial":[79],"plasma":[80,83],"glucose":[81,84],"area":[85],"under":[86],"curve":[88],"(AUC)":[89],"0\u2013120":[90,183],"min":[91,184],"levels":[92,185,225,281],"during":[93],"MTT":[95],"from":[96,128],"significantly":[99,189,204,221,274],"improved":[100,222,283],"three":[103,114,157,247,292],"study":[104,115,158,248],"groups,":[105,147,159],"there":[107,150,231],"no":[109,152,233],"significant":[110,153,234],"differences":[111,235],"among":[112,155,245],"groups":[116],"(":[117,196,226],"P":[118,197,216,227],"<":[119],"0.05).":[120],"The":[121],"mean":[122],"glycated":[125],"hemoglobin":[126],"(HbA1c)":[127],"\u2212":[134,136,139],"0.96%,":[135],"1.24%,":[137],"1.40%":[140],"dapagliflozin,":[143],"sitagliptin,":[144],"respectively.":[148],"Although":[149],"was":[151,203],"difference":[154],"lowering":[161],"effect":[162],"HbA1c":[164],"tended":[165],"be":[167,296],"greater":[168],"group":[172,195,210],"than":[173],"group.":[177,258],"contrast,":[179],"insulin":[181,279],"AUC":[182,280],"decreased":[190],"only":[191,206],"=":[198,217,228],"0.049).":[199],"Similarly,":[200],"body":[201,276],"weight":[202,277],"reduced":[205,275],"(\u2212":[211],"2.1":[212],"kg":[213],"[\u2212":[214],"2.7%],":[215],"0.047).":[218],"Moreover,":[219],"serum":[223,284],"adiponectin":[224,285],"0.003).":[229],"However,":[230],"these":[240,291],"glycemic":[241,269],"metabolic":[243],"parameters":[244],"groups.":[249],"No":[250],"serious":[251],"adverse":[252],"events":[253],"documented":[255],"any":[257],"Dapagliflozin":[259],"exerted":[260],"beneficial":[261],"effects":[262],"similar":[263],"on":[268],"parameters.":[270],"addition,":[272],"levels.":[286],"Therefore,":[287],"we":[288],"suggest":[289],"that":[290],"hypoglycemic":[293],"agents":[294],"could":[295],"viable":[297],"first-line":[298],"medications":[299],"drug-na\u00efve":[301],"Japanese":[302],"diabetes.":[307],"University":[308],"Hospital":[309],"Medical":[310],"Information":[311],"Network":[312],"(UMIN000024427).":[313]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-11-08T00:00:00"}
