{"id":"https://openalex.org/W3208308314","doi":"https://doi.org/10.3390/life11111132","title":"Activity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons","display_name":"Activity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons","publication_year":2021,"publication_date":"2021-10-24","ids":{"openalex":"https://openalex.org/W3208308314","doi":"https://doi.org/10.3390/life11111132","mag":"3208308314","pmid":"https://pubmed.ncbi.nlm.nih.gov/34833008","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8621972"},"language":"en","primary_location":{"id":"doi:10.3390/life11111132","doi":"https://doi.org/10.3390/life11111132","is_oa":true,"landing_page_url":"https://doi.org/10.3390/life11111132","pdf_url":"https://www.mdpi.com/2075-1729/11/11/1132/pdf?version=1635066324","source":{"id":"https://openalex.org/S4210200765","display_name":"Life","issn_l":"2075-1729","issn":["2075-1729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2075-1729/11/11/1132/pdf?version=1635066324","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036845831","display_name":"Rui Dong","orcid":"https://orcid.org/0000-0001-6782-1186","observed_orcids":["https://orcid.org/0000-0001-6782-1186"]},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Rui Dong","raw_affiliation_strings":["Department of Neuroscience, City University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, City University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I168719708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000807944","display_name":"Xuejun Li","orcid":"https://orcid.org/0000-0002-1214-7443","observed_orcids":["https://orcid.org/0000-0002-1214-7443"]},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Xuejun Li","raw_affiliation_strings":["Department of Neuroscience, City University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, City University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I168719708"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060404648","display_name":"Kwok\u2010On Lai","orcid":"https://orcid.org/0000-0002-4069-054X","observed_orcids":["https://orcid.org/0000-0002-4069-054X"]},"institutions":[{"id":"https://openalex.org/I168719708","display_name":"City University of Hong Kong","ror":"https://ror.org/03q8dnn23","country_code":"HK","type":"education","lineage":["https://openalex.org/I168719708"]}],"countries":["HK"],"is_corresponding":true,"raw_author_name":"Kwok-On Lai","raw_affiliation_strings":["Department of Neuroscience, City University of Hong Kong, Hong Kong, China"],"raw_orcid":"https://orcid.org/0000-0002-4069-054X","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, City University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I168719708"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5060404648"],"corresponding_institution_ids":["https://openalex.org/I168719708"],"apc_list":{"value":1600,"currency":"CHF","value_usd":1728},"apc_paid":{"value":1600,"currency":"CHF","value_usd":1728},"fwci":0.4332,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.37031614,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"11","issue":"11","first_page":"1132","last_page":"1132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prmt8","display_name":"PRMT8","score":1.0},{"id":"https://openalex.org/keywords/protein-arginine-methyltransferase","display_name":"protein arginine methyltransferase","score":0.9070000052452087},{"id":"https://openalex.org/keywords/neurons","display_name":"neurons","score":0.6370000243186951},{"id":"https://openalex.org/keywords/dendrite-growth","display_name":"dendritic growth","score":0.9819999933242798},{"id":"https://openalex.org/keywords/synaptic-maturation","display_name":"synapse maturation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":1.0},{"id":"https://openalex.org/keywords/neurological-disorders","display_name":"neurological disorders","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.7112225294113159},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.662962019443512},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5957585573196411},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.5886055827140808},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.5803088545799255},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5718532204627991},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.5193411111831665},{"id":"https://openalex.org/C111819275","wikidata":"https://www.wikidata.org/wiki/Q18035368","display_name":"Protein arginine methyltransferase 5","level":5,"score":0.5040980577468872},{"id":"https://openalex.org/C2993191138","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Structural plasticity","level":2,"score":0.495583176612854},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.47578155994415283},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44310688972473145},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.43505048751831055},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31616121530532837},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.15918651223182678},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.11870533227920532},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/life11111132","doi":"https://doi.org/10.3390/life11111132","is_oa":true,"landing_page_url":"https://doi.org/10.3390/life11111132","pdf_url":"https://www.mdpi.com/2075-1729/11/11/1132/pdf?version=1635066324","source":{"id":"https://openalex.org/S4210200765","display_name":"Life","issn_l":"2075-1729","issn":["2075-1729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life","raw_type":"journal-article"},{"id":"pmid:34833008","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34833008","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8621972","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8621972/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:d698f958ba154a6cadb35054e532f620","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d698f958ba154a6cadb35054e532f620","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Life, Vol 11, Iss 11, p 1132 (2021)","raw_type":"article"},{"id":"pmh:oai:pure.atira.dk:publications/318272e2-a9b3-43b7-ad52-e9a3bc58c20e","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2031/318272e2-a9b3-43b7-ad52-e9a3bc58c20e","pdf_url":null,"source":{"id":"https://openalex.org/S7407055387","display_name":"CityU Scholars","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dong, R, Li, X & Lai, K-O 2021, 'Activity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons', Life, vol. 11, no. 11, 1132. https://doi.org/10.3390/life11111132","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/life11111132","doi":"https://doi.org/10.3390/life11111132","is_oa":true,"landing_page_url":"https://doi.org/10.3390/life11111132","pdf_url":"https://www.mdpi.com/2075-1729/11/11/1132/pdf?version=1635066324","source":{"id":"https://openalex.org/S4210200765","display_name":"Life","issn_l":"2075-1729","issn":["2075-1729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321019","display_name":"University Grants Committee","ror":"https://ror.org/00djwmt25"},{"id":"https://openalex.org/F4320323291","display_name":"Food and Health Bureau","ror":"https://ror.org/03qh32912"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3208308314.pdf","grobid_xml":"https://content.openalex.org/works/W3208308314.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W163733949","https://openalex.org/W1524259538","https://openalex.org/W1534780647","https://openalex.org/W1608099415","https://openalex.org/W1964303494","https://openalex.org/W1967554461","https://openalex.org/W1970215478","https://openalex.org/W1973222984","https://openalex.org/W1973744740","https://openalex.org/W1978514466","https://openalex.org/W1980581068","https://openalex.org/W1980586443","https://openalex.org/W1981188079","https://openalex.org/W1995223777","https://openalex.org/W1995657253","https://openalex.org/W1998553495","https://openalex.org/W2004207754","https://openalex.org/W2004922568","https://openalex.org/W2005140272","https://openalex.org/W2010778459","https://openalex.org/W2013961818","https://openalex.org/W2016640096","https://openalex.org/W2024380057","https://openalex.org/W2025277638","https://openalex.org/W2025801062","https://openalex.org/W2027621038","https://openalex.org/W2028149832","https://openalex.org/W2032059333","https://openalex.org/W2035247356","https://openalex.org/W2035536565","https://openalex.org/W2035946761","https://openalex.org/W2041706699","https://openalex.org/W2044921355","https://openalex.org/W2048564333","https://openalex.org/W2050018606","https://openalex.org/W2051909860","https://openalex.org/W2060254862","https://openalex.org/W2064794127","https://openalex.org/W2065169750","https://openalex.org/W2071921711","https://openalex.org/W2072731237","https://openalex.org/W2074726646","https://openalex.org/W2076142854","https://openalex.org/W2078779212","https://openalex.org/W2086157862","https://openalex.org/W2092809155","https://openalex.org/W2096104522","https://openalex.org/W2097356145","https://openalex.org/W2099035207","https://openalex.org/W2103762808","https://openalex.org/W2108191354","https://openalex.org/W2117399884","https://openalex.org/W2120192934","https://openalex.org/W2127861463","https://openalex.org/W2132585055","https://openalex.org/W2137395087","https://openalex.org/W2142258451","https://openalex.org/W2148714108","https://openalex.org/W2149733880","https://openalex.org/W2151026975","https://openalex.org/W2161507125","https://openalex.org/W2166612636","https://openalex.org/W2170699481","https://openalex.org/W2183547519","https://openalex.org/W2247530002","https://openalex.org/W2292132642","https://openalex.org/W2508160565","https://openalex.org/W2509062642","https://openalex.org/W2516365506","https://openalex.org/W2560750450","https://openalex.org/W2585941395","https://openalex.org/W2593404947","https://openalex.org/W2735573858","https://openalex.org/W2742471016","https://openalex.org/W2767324723","https://openalex.org/W2802066007","https://openalex.org/W2803025553","https://openalex.org/W2883888632","https://openalex.org/W2982683082","https://openalex.org/W3001462302","https://openalex.org/W3033980913","https://openalex.org/W3119334688","https://openalex.org/W3126536193","https://openalex.org/W3155880568","https://openalex.org/W3158719940","https://openalex.org/W3163513997"],"related_works":["https://openalex.org/W2276107618","https://openalex.org/W2911780180","https://openalex.org/W7112035082","https://openalex.org/W2742471016","https://openalex.org/W2041706699","https://openalex.org/W2035536565","https://openalex.org/W2247530002","https://openalex.org/W2036758026","https://openalex.org/W3033980913","https://openalex.org/W3175148158"],"abstract_inverted_index":{"Among":[0],"the":[1,17,22,45,72],"nine":[2],"mammalian":[3],"protein":[4],"arginine":[5],"methyltransferases":[6],"(PRMTs),":[7],"PRMT8":[8,50,76],"is":[9,21],"unusual":[10],"because":[11],"it":[12,54],"has":[13],"restricted":[14],"expression":[15],"in":[16,36,39,56,78],"nervous":[18],"system":[19],"and":[20,51,66],"only":[23],"membrane-bound":[24],"PRMT.":[25],"Emerging":[26],"studies":[27],"have":[28],"demonstrated":[29],"that":[30],"this":[31],"enzyme":[32],"plays":[33],"multifaceted":[34],"roles":[35],"diverse":[37],"processes":[38],"neurons.":[40],"Here":[41],"we":[42],"will":[43,81],"summarize":[44],"unique":[46],"structural":[47],"features":[48],"of":[49,75],"describe":[52],"how":[53],"participates":[55],"various":[57],"neuronal":[58],"functions":[59],"such":[60],"as":[61],"dendritic":[62],"growth,":[63],"synapse":[64],"maturation,":[65],"synaptic":[67],"plasticity.":[68],"Recent":[69],"evidence":[70],"suggesting":[71],"potential":[73],"role":[74],"function":[77],"neurological":[79],"diseases":[80],"also":[82],"be":[83],"discussed.":[84]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-11-08T00:00:00"}