{"id":"https://openalex.org/W3208296707","doi":"https://doi.org/10.1016/s1875-5364(22)60152-3","title":"Screening of the ubiquitin-proteasome system activators for anti-Alzheimer's disease by the high-content fluorescence imaging system","display_name":"Screening of the ubiquitin-proteasome system activators for anti-Alzheimer's disease by the high-content fluorescence imaging system","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W3208296707","doi":"https://doi.org/10.1016/s1875-5364(22)60152-3","mag":"3208296707","pmid":"https://pubmed.ncbi.nlm.nih.gov/35101248"},"language":"en","primary_location":{"id":"doi:10.1016/s1875-5364(22)60152-3","doi":"https://doi.org/10.1016/s1875-5364(22)60152-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1875-5364(22)60152-3","pdf_url":null,"source":{"id":"https://openalex.org/S114839437","display_name":"Chinese Journal of Natural Medicines","issn_l":"1672-3651","issn":["1672-3651","1875-5364","2095-6975"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Journal of Natural Medicines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100653311","display_name":"Yiling Wang","orcid":"https://orcid.org/0000-0002-0358-0851","observed_orcids":["https://orcid.org/0000-0002-0358-0851"]},"institutions":[{"id":"https://openalex.org/I3017480383","display_name":"Southwest Medical University","ror":"https://ror.org/00g2rqs52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3017480383"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi-Ling WANG","raw_affiliation_strings":["Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China","Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China","Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China","institution_ids":["https://openalex.org/I3017480383"]},{"raw_affiliation_string":"Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China","institution_ids":["https://openalex.org/I3017480383"]},{"raw_affiliation_string":"Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy","institution_ids":["https://openalex.org/I3017480383"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jing YOU","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3017480383","display_name":"Southwest Medical University","ror":"https://ror.org/00g2rqs52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3017480383"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing YOU","raw_affiliation_strings":["Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China; Luzhou New Drug Evaluation and Research Center, Luzhou 646000, China","Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China","Luzhou New Drug Evaluation and Research Center, Luzhou 646000, China","Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China; Luzhou New Drug Evaluation and Research Center, Luzhou 646000, China","institution_ids":["https://openalex.org/I3017480383"]},{"raw_affiliation_string":"Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China","institution_ids":["https://openalex.org/I3017480383"]},{"raw_affiliation_string":"Luzhou New Drug Evaluation and Research Center, Luzhou 646000, China","institution_ids":[]},{"raw_affiliation_string":"Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy","institution_ids":["https://openalex.org/I3017480383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100560665","display_name":"Jing-Jie CAO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3017480383","display_name":"Southwest Medical University","ror":"https://ror.org/00g2rqs52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3017480383"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing-Jie CAO","raw_affiliation_strings":["Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China; Luzhou New Drug Evaluation and Research Center, Luzhou 646000, China","Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China","Luzhou New Drug Evaluation and Research Center, Luzhou 646000, China","Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China; Luzhou New Drug Evaluation and Research Center, Luzhou 646000, China","institution_ids":["https://openalex.org/I3017480383"]},{"raw_affiliation_string":"Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China","institution_ids":["https://openalex.org/I3017480383"]},{"raw_affiliation_string":"Luzhou New Drug Evaluation and Research Center, Luzhou 646000, China","institution_ids":[]},{"raw_affiliation_string":"Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy","institution_ids":["https://openalex.org/I3017480383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100317967","display_name":"Wei Li","orcid":"https://orcid.org/0000-0001-5696-4309","observed_orcids":["https://orcid.org/0000-0001-5696-4309"]},"institutions":[{"id":"https://openalex.org/I3017480383","display_name":"Southwest Medical University","ror":"https://ror.org/00g2rqs52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3017480383"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei LI","raw_affiliation_strings":["Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China","Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China","Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China","institution_ids":["https://openalex.org/I3017480383"]},{"raw_affiliation_string":"Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China","institution_ids":["https://openalex.org/I3017480383"]},{"raw_affiliation_string":"Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy","institution_ids":["https://openalex.org/I3017480383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104006834","display_name":"Liu-Yang JING","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3017480383","display_name":"Southwest Medical University","ror":"https://ror.org/00g2rqs52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3017480383"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liu-Yang JING","raw_affiliation_strings":["Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China","Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China","Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China","institution_ids":["https://openalex.org/I3017480383"]},{"raw_affiliation_string":"Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China","institution_ids":["https://openalex.org/I3017480383"]},{"raw_affiliation_string":"Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy","institution_ids":["https://openalex.org/I3017480383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055309139","display_name":"Qibing Mei","orcid":"https://orcid.org/0000-0001-7460-5115","observed_orcids":["https://orcid.org/0000-0001-7460-5115"]},"institutions":[{"id":"https://openalex.org/I3017480383","display_name":"Southwest Medical University","ror":"https://ror.org/00g2rqs52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3017480383"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qi-Bing MEI","raw_affiliation_strings":["Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China; Luzhou New Drug Evaluation and Research Center, Luzhou 646000, China. Electronic address: qbmei@swmu.edu.cn","Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China","Luzhou New Drug Evaluation and Research Center, Luzhou 646000, China","Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China; Luzhou New Drug Evaluation and Research Center, Luzhou 646000, China. Electronic address: qbmei@swmu.edu.cn","institution_ids":["https://openalex.org/I3017480383"]},{"raw_affiliation_string":"Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China","institution_ids":["https://openalex.org/I3017480383"]},{"raw_affiliation_string":"Luzhou New Drug Evaluation and Research Center, Luzhou 646000, China","institution_ids":[]},{"raw_affiliation_string":"Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy","institution_ids":["https://openalex.org/I3017480383"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047119468","display_name":"Anguo Wu","orcid":"https://orcid.org/0000-0002-9850-7576","observed_orcids":["https://orcid.org/0000-0002-9850-7576"]},"institutions":[{"id":"https://openalex.org/I3017480383","display_name":"Southwest Medical University","ror":"https://ror.org/00g2rqs52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3017480383"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"An-Guo WU","raw_affiliation_strings":["Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China. Electronic address: wuanguo@swmu.edu.cn","Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China","Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy; Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China. Electronic address: wuanguo@swmu.edu.cn","institution_ids":["https://openalex.org/I3017480383"]},{"raw_affiliation_string":"Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou 646000, China","institution_ids":["https://openalex.org/I3017480383"]},{"raw_affiliation_string":"Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy","institution_ids":["https://openalex.org/I3017480383"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5047119468","https://openalex.org/A5055309139"],"corresponding_institution_ids":["https://openalex.org/I3017480383"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.6904,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.59922874,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"20","issue":"1","first_page":"33","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.017400000244379044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.9559999704360962},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9879999756813049},{"id":"https://openalex.org/keywords/ht22-cells","display_name":"HT22 cells","score":0.8209999799728394},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.8299999833106995},{"id":"https://openalex.org/keywords/salvianolic-acid-a","display_name":"salvianolic acid A","score":0.9779999852180481},{"id":"https://openalex.org/keywords/salvianolic-acid-b","display_name":"salvianolic acid B","score":1.0},{"id":"https://openalex.org/keywords/ellagic-acid","display_name":"ellagic acid","score":1.0},{"id":"https://openalex.org/keywords/amyloid-beta-clearance","display_name":"amyloid-beta clearance","score":0.5809999704360962},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.800000011920929},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.6479894518852234},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6461207866668701},{"id":"https://openalex.org/C2778067846","wikidata":"https://www.wikidata.org/wiki/Q575416","display_name":"Yellow fluorescent protein","level":3,"score":0.6344982385635376},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5343047380447388},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.49244436621665955},{"id":"https://openalex.org/C157044486","wikidata":"https://www.wikidata.org/wiki/Q5754482","display_name":"High-content screening","level":3,"score":0.4750090539455414},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.45884761214256287},{"id":"https://openalex.org/C57477423","wikidata":"https://www.wikidata.org/wiki/Q1434196","display_name":"Fluorescence-lifetime imaging microscopy","level":3,"score":0.4486801028251648},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.4344324767589569},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4187045693397522},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3857738971710205},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3775859475135803},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.34237056970596313},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30762404203414917},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.22881954908370972},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061848","descriptor_name":"Optical Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s1875-5364(22)60152-3","doi":"https://doi.org/10.1016/s1875-5364(22)60152-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1875-5364(22)60152-3","pdf_url":null,"source":{"id":"https://openalex.org/S114839437","display_name":"Chinese Journal of Natural Medicines","issn_l":"1672-3651","issn":["1672-3651","1875-5364","2095-6975"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Journal of Natural Medicines","raw_type":"journal-article"},{"id":"pmid:35101248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35101248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese journal of natural medicines","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1892456310","https://openalex.org/W1901837091","https://openalex.org/W1966695604","https://openalex.org/W1975940799","https://openalex.org/W1991157753","https://openalex.org/W2000881295","https://openalex.org/W2011195206","https://openalex.org/W2031978571","https://openalex.org/W2055522359","https://openalex.org/W2066011396","https://openalex.org/W2088733194","https://openalex.org/W2093761069","https://openalex.org/W2115211381","https://openalex.org/W2116384106","https://openalex.org/W2125534260","https://openalex.org/W2129805026","https://openalex.org/W2140031122","https://openalex.org/W2154419144","https://openalex.org/W2172238326","https://openalex.org/W2213821184","https://openalex.org/W2406301238","https://openalex.org/W2408147065","https://openalex.org/W2410128585","https://openalex.org/W2529372108","https://openalex.org/W2550544546","https://openalex.org/W2561790794","https://openalex.org/W2624139848","https://openalex.org/W2770653741","https://openalex.org/W2782908288","https://openalex.org/W2792609242","https://openalex.org/W2917147174","https://openalex.org/W2972088539","https://openalex.org/W2974541699","https://openalex.org/W2984743962","https://openalex.org/W3022029286","https://openalex.org/W3044388571","https://openalex.org/W3047235413","https://openalex.org/W3082406428","https://openalex.org/W3088340380","https://openalex.org/W3090170642","https://openalex.org/W6714124763","https://openalex.org/W6780786839"],"related_works":["https://openalex.org/W2333535617","https://openalex.org/W2106142655","https://openalex.org/W3022029286","https://openalex.org/W7131119055","https://openalex.org/W4416935947","https://openalex.org/W7117259158","https://openalex.org/W4406225094","https://openalex.org/W2090896183","https://openalex.org/W3088340380","https://openalex.org/W2041988771"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-11-08T00:00:00"}
