{"id":"https://openalex.org/W3208094274","doi":"https://doi.org/10.1002/pbc.29384","title":"Early stool microbiome and metabolome signatures in pediatric patients undergoing allogeneic hematopoietic cell transplantation","display_name":"Early stool microbiome and metabolome signatures in pediatric patients undergoing allogeneic hematopoietic cell transplantation","publication_year":2021,"publication_date":"2021-10-28","ids":{"openalex":"https://openalex.org/W3208094274","doi":"https://doi.org/10.1002/pbc.29384","mag":"3208094274","pmid":"https://pubmed.ncbi.nlm.nih.gov/34709713","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8629955"},"language":"en","primary_location":{"id":"doi:10.1002/pbc.29384","doi":"https://doi.org/10.1002/pbc.29384","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pbc.29384","pdf_url":null,"source":{"id":"https://openalex.org/S119714264","display_name":"Pediatric Blood & Cancer","issn_l":"1545-5009","issn":["1545-5009","1545-5017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Blood & Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2021/06/11/2021.06.08.21258499.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066301849","display_name":"Caitlin W. Elgarten","orcid":"https://orcid.org/0000-0002-2474-3031","observed_orcids":["https://orcid.org/0000-0002-2474-3031"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caitlin W. Elgarten","raw_affiliation_strings":["Center for Pediatric Clinical Effectiveness Research Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA","Division of Oncology, Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"],"raw_orcid":"https://orcid.org/0000-0002-2474-3031","affiliations":[{"raw_affiliation_string":"Center for Pediatric Clinical Effectiveness Research Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Division of Oncology, Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014500013","display_name":"Ceylan Tanes","orcid":"https://orcid.org/0000-0002-5823-4059","observed_orcids":["https://orcid.org/0000-0002-5823-4059"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ceylan Tanes","raw_affiliation_strings":["PennCHOP Microbiome Program Children's Hospital of Philadelphia Research Institute  Philadelphia Pennsylvania USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PennCHOP Microbiome Program Children's Hospital of Philadelphia Research Institute  Philadelphia Pennsylvania USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101667988","display_name":"Jung\u2010Jin Lee","orcid":"https://orcid.org/0000-0003-1025-8980","observed_orcids":["https://orcid.org/0000-0003-1025-8980"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jung\u2010Jin Lee","raw_affiliation_strings":["PennCHOP Microbiome Program Children's Hospital of Philadelphia Research Institute  Philadelphia Pennsylvania USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PennCHOP Microbiome Program Children's Hospital of Philadelphia Research Institute  Philadelphia Pennsylvania USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077564846","display_name":"Lara A. Danziger\u2010Isakov","orcid":"https://orcid.org/0000-0002-5691-5221","observed_orcids":["https://orcid.org/0000-0002-5691-5221"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lara A. Danziger\u2010Isakov","raw_affiliation_strings":["Division of Infectious Diseases, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati  Cincinnati Ohio USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati  Cincinnati Ohio USA","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031592776","display_name":"Michael S. Grimley","orcid":"https://orcid.org/0000-0003-2056-5167","observed_orcids":["https://orcid.org/0000-0003-2056-5167"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael S. Grimley","raw_affiliation_strings":["Division of Bone Marrow Transplantation and Immune Deficiency, Department of Pediatrics Cincinnati Children's Hospital  Cincinnati Ohio USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Bone Marrow Transplantation and Immune Deficiency, Department of Pediatrics Cincinnati Children's Hospital  Cincinnati Ohio USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100628988","display_name":"Michael Green","orcid":"https://orcid.org/0000-0002-6011-2894","observed_orcids":["https://orcid.org/0000-0002-6011-2894"]},"institutions":[{"id":"https://openalex.org/I4210098814","display_name":"UPMC Health System","ror":"https://ror.org/011htkb76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814"]},{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Green","raw_affiliation_strings":["Division of Infectious Diseases UPMC Children's Hospital of Pittsburgh  Pittsburgh Pennsylvania USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases UPMC Children's Hospital of Pittsburgh  Pittsburgh Pennsylvania USA","institution_ids":["https://openalex.org/I4210098814","https://openalex.org/I4210130600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070892473","display_name":"Marian G. Michaels","orcid":"https://orcid.org/0000-0002-2556-0544","observed_orcids":["https://orcid.org/0000-0002-2556-0544"]},"institutions":[{"id":"https://openalex.org/I4210098814","display_name":"UPMC Health System","ror":"https://ror.org/011htkb76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814"]},{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marian G. Michaels","raw_affiliation_strings":["Division of Infectious Diseases UPMC Children's Hospital of Pittsburgh  Pittsburgh Pennsylvania USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases UPMC Children's Hospital of Pittsburgh  Pittsburgh Pennsylvania USA","institution_ids":["https://openalex.org/I4210098814","https://openalex.org/I4210130600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084553742","display_name":"Jessie L. Barnum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098814","display_name":"UPMC Health System","ror":"https://ror.org/011htkb76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814"]},{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessie L. Barnum","raw_affiliation_strings":["Division of Blood and Marrow Transplantation UPMC Children's Hospital of Pittsburgh  Pittsburgh Pennsylvania USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Blood and Marrow Transplantation UPMC Children's Hospital of Pittsburgh  Pittsburgh Pennsylvania USA","institution_ids":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050623352","display_name":"Monica I. Ardura","orcid":"https://orcid.org/0000-0002-2853-2581","observed_orcids":["https://orcid.org/0000-0002-2853-2581"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica I. Ardura","raw_affiliation_strings":["Division of Infectious Diseases Nationwide Children's Hospital  Columbus Ohio USA"],"raw_orcid":"https://orcid.org/0000-0002-2853-2581","affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases Nationwide Children's Hospital  Columbus Ohio USA","institution_ids":["https://openalex.org/I1314135232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085657767","display_name":"Jeffery James Auletta","orcid":"https://orcid.org/0000-0002-1515-2141","observed_orcids":["https://orcid.org/0000-0002-1515-2141"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]},{"id":"https://openalex.org/I1318116459","display_name":"National Marrow Donor Program","ror":"https://ror.org/016cke005","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1318116459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffery J. Auletta","raw_affiliation_strings":["Division of Hematology/Oncology/BMT Nationwide Children's Hospital  Columbus Ohio USA","Division of Infectious Diseases Nationwide Children's Hospital  Columbus Ohio USA","National Marrow Donor Program/Be The Match  Minneapolis Minnesota USA"],"raw_orcid":"https://orcid.org/0000-0002-1515-2141","affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology/BMT Nationwide Children's Hospital  Columbus Ohio USA","institution_ids":["https://openalex.org/I1314135232"]},{"raw_affiliation_string":"Division of Infectious Diseases Nationwide Children's Hospital  Columbus Ohio USA","institution_ids":["https://openalex.org/I1314135232"]},{"raw_affiliation_string":"National Marrow Donor Program/Be The Match  Minneapolis Minnesota USA","institution_ids":["https://openalex.org/I1318116459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084619811","display_name":"Jesse A. Blumenstock","orcid":"https://orcid.org/0000-0001-7185-0705","observed_orcids":["https://orcid.org/0000-0001-7185-0705"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesse Blumenstock","raw_affiliation_strings":["Center for Pediatric Clinical Effectiveness Research Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Pediatric Clinical Effectiveness Research Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041739266","display_name":"Alix Eden Seif","orcid":"https://orcid.org/0000-0002-1799-2582","observed_orcids":["https://orcid.org/0000-0002-1799-2582"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alix E. Seif","raw_affiliation_strings":["Center for Pediatric Clinical Effectiveness Research Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA","Division of Oncology, Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"],"raw_orcid":"https://orcid.org/0000-0002-1799-2582","affiliations":[{"raw_affiliation_string":"Center for Pediatric Clinical Effectiveness Research Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Division of Oncology, Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066967353","display_name":"Kyle L. Bittinger","orcid":"https://orcid.org/0000-0003-3472-5934","observed_orcids":["https://orcid.org/0000-0003-3472-5934"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle L. Bittinger","raw_affiliation_strings":["Division of Gastroenterology, Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA","PennCHOP Microbiome Program Children's Hospital of Philadelphia Research Institute  Philadelphia Pennsylvania USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"PennCHOP Microbiome Program Children's Hospital of Philadelphia Research Institute  Philadelphia Pennsylvania USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055721856","display_name":"Brian T. Fisher","orcid":"https://orcid.org/0000-0002-8224-4281","observed_orcids":["https://orcid.org/0000-0002-8224-4281"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian T. Fisher","raw_affiliation_strings":["Center for Pediatric Clinical Effectiveness Research Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA","Division of Infectious Diseases, Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Pediatric Clinical Effectiveness Research Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Division of Infectious Diseases, Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA","institution_ids":["https://openalex.org/I1335321130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":0.7845,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.67981862,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"69","issue":"1","first_page":"e29384","last_page":"e29384"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7649999856948853},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.9300000071525574},{"id":"https://openalex.org/keywords/dysbiosis","display_name":"dysbiosis","score":0.9300000071525574},{"id":"https://openalex.org/keywords/bacteroides","display_name":"Bacteroides","score":0.8180000185966492},{"id":"https://openalex.org/keywords/ruminococcaceae","display_name":"Ruminococcaceae","score":0.9150000214576721},{"id":"https://openalex.org/keywords/butyrate-production","display_name":"butyrate production","score":0.9309999942779541},{"id":"https://openalex.org/keywords/gammaproteobacteria","display_name":"Gammaproteobacteria","score":0.9380000233650208},{"id":"https://openalex.org/keywords/alpha-diversity","display_name":"alpha diversity","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.8225721120834351},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.770646870136261},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6821104884147644},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.6090648770332336},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5753785371780396},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.43626153469085693},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.42560383677482605},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4170231521129608},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3855617344379425},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.3370462656021118},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26234695315361023},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2462041974067688},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.1555686593055725},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10104101896286011},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09991931915283203}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/pbc.29384","doi":"https://doi.org/10.1002/pbc.29384","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pbc.29384","pdf_url":null,"source":{"id":"https://openalex.org/S119714264","display_name":"Pediatric Blood & Cancer","issn_l":"1545-5009","issn":["1545-5009","1545-5017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Blood & Cancer","raw_type":"journal-article"},{"id":"doi:10.1101/2021.06.08.21258499","doi":"https://doi.org/10.1101/2021.06.08.21258499","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.06.08.21258499","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2021/06/11/2021.06.08.21258499.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:34709713","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34709713","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric blood & cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8629955","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8629955","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Pediatr Blood Cancer","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2021.06.08.21258499","doi":"https://doi.org/10.1101/2021.06.08.21258499","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.06.08.21258499","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2021/06/11/2021.06.08.21258499.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G6248468932","display_name":null,"funder_award_id":"HHSN272201600014C","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3208094274.pdf","grobid_xml":"https://content.openalex.org/works/W3208094274.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W273955616","https://openalex.org/W1516197597","https://openalex.org/W1530269410","https://openalex.org/W1592407962","https://openalex.org/W1968105193","https://openalex.org/W1974092500","https://openalex.org/W1995355078","https://openalex.org/W2011479207","https://openalex.org/W2032157446","https://openalex.org/W2043442946","https://openalex.org/W2103441770","https://openalex.org/W2131026689","https://openalex.org/W2131271579","https://openalex.org/W2133286612","https://openalex.org/W2134985690","https://openalex.org/W2139284253","https://openalex.org/W2152200355","https://openalex.org/W2155860422","https://openalex.org/W2159954944","https://openalex.org/W2177723893","https://openalex.org/W2230661608","https://openalex.org/W2275502427","https://openalex.org/W2287438430","https://openalex.org/W2310441748","https://openalex.org/W2340304486","https://openalex.org/W2381299150","https://openalex.org/W2407774696","https://openalex.org/W2463548453","https://openalex.org/W2510324998","https://openalex.org/W2559588208","https://openalex.org/W2587332109","https://openalex.org/W2589011865","https://openalex.org/W2601323577","https://openalex.org/W2605052214","https://openalex.org/W2617347465","https://openalex.org/W2736420924","https://openalex.org/W2742423499","https://openalex.org/W2749612575","https://openalex.org/W2764002491","https://openalex.org/W2802205848","https://openalex.org/W2884424911","https://openalex.org/W2895709638","https://openalex.org/W2922175623","https://openalex.org/W2933318385","https://openalex.org/W2952539125","https://openalex.org/W2972909756","https://openalex.org/W3008229386","https://openalex.org/W3013399474","https://openalex.org/W3015086928","https://openalex.org/W3023986475","https://openalex.org/W3025306404","https://openalex.org/W3027773538","https://openalex.org/W3043709758","https://openalex.org/W3063997159","https://openalex.org/W3087184338","https://openalex.org/W3125639254","https://openalex.org/W4247053599"],"related_works":["https://openalex.org/W3198265138","https://openalex.org/W6920940063","https://openalex.org/W6902036037","https://openalex.org/W6939641631","https://openalex.org/W2981496133","https://openalex.org/W2978054192","https://openalex.org/W2952165720","https://openalex.org/W4417014138","https://openalex.org/W4281905638","https://openalex.org/W4414464673"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"contribution":[2],"of":[3,20,102,117,125,144,227],"the":[4,27,42,122,197],"gastrointestinal":[5],"tract":[6],"microbiome":[7,28,45,84,164,182,201,212],"to":[8,40,132,218,223],"outcomes":[9],"after":[10],"allogeneic":[11,97,189],"hematopoietic":[12],"cell":[13],"transplantation":[14],"(HCT)":[15],"is":[16],"increasingly":[17],"recognized.":[18],"Investigations":[19],"larger":[21],"pediatric":[22,47,96,188],"cohorts":[23],"aimed":[24],"at":[25,51],"defining":[26],"state":[29],"and":[30,59,74,86,120,128,147,213,222],"associated":[31],"metabolic":[32,61],"patterns":[33],"pretransplant":[34,43,64],"are":[35,216],"needed.":[36],"METHODS:":[37],"We":[38,54,78,90],"sought":[39],"describe":[41],"stool":[44,65,83,92,108,133,163],"in":[46,121,150,162,196],"allogenic":[48],"HCT":[49,98,139,190],"patients":[50,140,191],"four":[52],"centers.":[53],"performed":[55],"shotgun":[56],"metagenomic":[57],"sequencing":[58],"untargeted":[60],"profiling":[62],"on":[63,115],"samples.":[66],"Samples":[67],"were":[68,154,174],"compared":[69],"with":[70,181,204],"normal":[71],"age-matched":[72],"controls":[73,113],"by":[75,168],"clinical":[76],"characteristics.":[77],"then":[79],"explored":[80],"associations":[81,221],"between":[82],"measurements":[85],"metabolite":[87],"concentrations.":[88],"RESULTS:":[89],"profiled":[91],"samples":[93,109,137,186],"from":[94,111,134,138,187],"88":[95],"patients,":[99,136],"a":[100],"median":[101],"4":[103],"days":[104],"before":[105],"transplant.":[106],"Pretransplant":[107],"differed":[110],"healthy":[112,135],"based":[114],"indices":[116],"alpha":[118],"diversity":[119],"proportional":[123],"abundance":[124],"specific":[126],"taxa":[127],"bacterial":[129],"genes.":[130],"Relative":[131],"had":[141],"decreased":[142],"proportion":[143],"Bacteroides,":[145],"Ruminococcaeae,":[146],"genes":[148],"involved":[149],"butyrate":[151],"production,":[152],"but":[153],"enriched":[155],"for":[156],"gammaproteobacterial":[157],"species.":[158],"No":[159],"systematic":[160],"differences":[161],"or":[165,172],"metabolomic":[166],"profiles":[167],"age,":[169],"transplant":[170,198,206],"indication,":[171],"hospital":[173],"noted.":[175],"Stool":[176,185],"metabolites":[177],"demonstrated":[178],"strong":[179],"correlations":[180],"composition.":[183],"DISCUSSION:":[184],"demonstrate":[192],"substantial":[193],"dysbiosis":[194],"early":[195],"course.":[199],"As":[200],"disruptions":[202],"associate":[203],"adverse":[205],"outcomes,":[207],"pediatric-specific":[208],"analyses":[209],"examining":[210],"longitudinal":[211],"metabolome":[214],"changes":[215],"imperative":[217],"identify":[219],"causal":[220],"inform":[224],"rational":[225],"design":[226],"interventions.":[228]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-11-08T00:00:00"}