{"id":"https://openalex.org/W320803602","doi":null,"title":"Histopathology and pathogenesis of behaviorally induced gastric lesions in rats.","display_name":"Histopathology and pathogenesis of behaviorally induced gastric lesions in rats.","publication_year":1973,"publication_date":"1973-11-01","ids":{"openalex":"https://openalex.org/W320803602","mag":"320803602","pmid":"https://pubmed.ncbi.nlm.nih.gov/4543311","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1904064"},"language":"en","primary_location":{"id":"pmid:4543311","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4543311","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1904064/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111543486","display_name":"Donald A. Kristt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D A Kristt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059897441","display_name":"Steven J. Freimark","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S J Freimark","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2016,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.86199146,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"73","issue":"2","first_page":"411","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.41769999265670776,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.41769999265670776,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.20090000331401825,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.14839999377727509,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stress-ulcer","display_name":"stress ulcer","score":0.7120000123977661},{"id":"https://openalex.org/keywords/gastric-lesions","display_name":"gastric lesions","score":0.7170000076293945},{"id":"https://openalex.org/keywords/behavioral-stress","display_name":"behavioral stress","score":0.6460000276565552},{"id":"https://openalex.org/keywords/footshock","display_name":"footshock","score":0.8880000114440918},{"id":"https://openalex.org/keywords/gastric-metaplasia","display_name":"gastric metaplasia","score":0.746999979019165},{"id":"https://openalex.org/keywords/ulcer-healing","display_name":"ulcer healing","score":0.828000009059906},{"id":"https://openalex.org/keywords/ulcer-pathogenesis","display_name":"ulcer pathogenesis","score":0.6549999713897705},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7001835703849792},{"id":"https://openalex.org/C2781443798","wikidata":"https://www.wikidata.org/wiki/Q383249","display_name":"Gastric mucosa","level":3,"score":0.6842007637023926},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6663161516189575},{"id":"https://openalex.org/C2779357193","wikidata":"https://www.wikidata.org/wiki/Q660713","display_name":"Metaplasia","level":2,"score":0.6551589369773865},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.6135848164558411},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.559924840927124},{"id":"https://openalex.org/C2777798775","wikidata":"https://www.wikidata.org/wiki/Q207550","display_name":"Infarction","level":3,"score":0.5053003430366516},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.46976423263549805},{"id":"https://openalex.org/C2778456384","wikidata":"https://www.wikidata.org/wiki/Q1508510","display_name":"Perforation","level":3,"score":0.4416941702365875},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.2778134346008301},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24945956468582153},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.07454457879066467},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C2778527123","wikidata":"https://www.wikidata.org/wiki/Q11750728","display_name":"Punching","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004567","descriptor_name":"Electrodes, Implanted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004597","descriptor_name":"Electroshock","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006471","descriptor_name":"Gastrointestinal Hemorrhage","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007238","descriptor_name":"Infarction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008679","descriptor_name":"Metaplasia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010438","descriptor_name":"Peptic Ulcer Hemorrhage","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012201","descriptor_name":"Reward","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013276","descriptor_name":"Stomach Ulcer","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D013276","descriptor_name":"Stomach Ulcer","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:4543311","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4543311","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1904064","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1904064/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"mag:320803602","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4543311","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1904064","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1904064/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1591447100","https://openalex.org/W1892790757","https://openalex.org/W1974894551","https://openalex.org/W1975426922","https://openalex.org/W1982345201","https://openalex.org/W1982753964","https://openalex.org/W2008443954","https://openalex.org/W2034766914","https://openalex.org/W2068379345","https://openalex.org/W2074224361","https://openalex.org/W2077989294","https://openalex.org/W2084518983","https://openalex.org/W2086373761","https://openalex.org/W2107819622","https://openalex.org/W2150755107","https://openalex.org/W2173282500","https://openalex.org/W2180780378","https://openalex.org/W2394997161","https://openalex.org/W2409520786","https://openalex.org/W2414227425","https://openalex.org/W2414808450","https://openalex.org/W2419050177","https://openalex.org/W2419663467","https://openalex.org/W2442214661","https://openalex.org/W2467831880"],"related_works":["https://openalex.org/W1990686016","https://openalex.org/W2378904307","https://openalex.org/W2326935165","https://openalex.org/W2180780378","https://openalex.org/W394716060","https://openalex.org/W2067026426","https://openalex.org/W2029602991","https://openalex.org/W2361191220","https://openalex.org/W2033742007","https://openalex.org/W4405238420"],"abstract_inverted_index":{"The":[0,87,117],"development":[1],"of":[2,30,82,102,106,129],"behaviorally":[3],"induced":[4],"acute":[5,69],"gastric":[6,84,118],"\"stress\"":[7],"ulcers":[8],"was":[9],"studied":[10],"in":[11,112],"rats.":[12],"Rats":[13],"were":[14,39],"first":[15],"trained":[16],"to":[17,34,52,93,125,154],"press":[18],"a":[19,77,123,126],"bar":[20],"for":[21,36,95],"food.":[22],"During":[23],"either":[24],"19":[25],"or":[26],"29":[27],"consecutive":[28],"days":[29],"testing":[31],"they":[32],"continued":[33],"work":[35],"food":[37],"but":[38],"also":[40],"stressed":[41],"by":[42],"mild":[43],"foot":[44],"shock.":[45],"This":[46],"schedule":[47],"has":[48],"previously":[49],"been":[50],"shown":[51],"be":[53],"impressively":[54],"ulcerogenic,":[55],"though":[56],"otherwise":[57],"not":[58],"physically":[59],"traumatic.":[60],"Gastric":[61],"lesions":[62],"fell":[63],"into":[64],"two":[65],"histologic":[66],"classes:":[67],"an":[68],"ulcerative-hemorrhagic":[70],"process":[71],"with":[72],"several":[73],"different":[74],"manifestations":[75],"and":[76,110,141],"focal":[78,113],"clear":[79],"cell":[80],"metaplasia":[81,120],"the":[83,103,107,130,146],"pit":[85,119],"epithelium.":[86],"following":[88],"explanation":[89],"is":[90],"tentatively":[91],"offered":[92],"account":[94],"these":[96],"findings:":[97],"a)":[98],"Stress":[99],"induces":[100],"constriction":[101],"blood":[104],"vessels":[105],"muscularis":[108],"mucosa":[109],"results":[111],"mucosal":[114],"infarction.":[115],"b)":[116],"may":[121],"reflect":[122],"response":[124],"stress-induced":[127],"impairment":[128],"protective":[131],"mucous":[132],"coat.":[133],"In":[134],"addition,":[135],"preliminary":[136],"data":[137],"suggest":[138],"that":[139,150],"ulceration":[140],"healing":[142],"occur":[143],"continuously":[144],"throughout":[145],"test":[147],"period":[148],"so":[149],"no":[151],"ulcer":[152],"progresses":[153],"perforation.":[155]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}