{"id":"https://openalex.org/W3207970844","doi":"https://doi.org/10.1080/13880209.2021.1979052","title":"Genistein alleviates H 2 O 2 -induced senescence of human umbilical vein endothelial cells via regulating the TXNIP/NLRP3 axis","display_name":"Genistein alleviates H 2 O 2 -induced senescence of human umbilical vein endothelial cells via regulating the TXNIP/NLRP3 axis","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3207970844","doi":"https://doi.org/10.1080/13880209.2021.1979052","mag":"3207970844","pmid":"https://pubmed.ncbi.nlm.nih.gov/34663173","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8526007"},"language":"en","primary_location":{"id":"doi:10.1080/13880209.2021.1979052","doi":"https://doi.org/10.1080/13880209.2021.1979052","is_oa":true,"landing_page_url":"https://doi.org/10.1080/13880209.2021.1979052","pdf_url":null,"source":{"id":"https://openalex.org/S130009153","display_name":"Pharmaceutical Biology","issn_l":"0925-1618","issn":["0925-1618","1388-0209","1744-5116"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1080/13880209.2021.1979052","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091877534","display_name":"Guihua Wu","orcid":"https://orcid.org/0009-0005-1445-0402","observed_orcids":["https://orcid.org/0009-0005-1445-0402"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guihua Wu","raw_affiliation_strings":["Department of Geriatrics, Nantong First Geriatric Hospital, Nantong City, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, Nantong First Geriatric Hospital, Nantong City, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100670857","display_name":"Siming Li","orcid":"https://orcid.org/0000-0001-7077-0404","observed_orcids":["https://orcid.org/0000-0001-7077-0404"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Siming Li","raw_affiliation_strings":["Department of Geriatrics, Harbin Second Hospital, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, Harbin Second Hospital, Harbin, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080451899","display_name":"Guangjin Qu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210156501","display_name":"First Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/05vy2sc54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guangjin Qu","raw_affiliation_strings":["Cadre Ward of The First Affiliated Hospital of Harbin Medical University, Harbin City, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cadre Ward of The First Affiliated Hospital of Harbin Medical University, Harbin City, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210156501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010204147","display_name":"Jiajia Hua","orcid":"https://orcid.org/0000-0002-9152-7013","observed_orcids":["https://orcid.org/0000-0002-9152-7013"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiajia Hua","raw_affiliation_strings":["Department of Traditional Chinese Medicine, Nantong First Elderly Hospital, Nantong City, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Traditional Chinese Medicine, Nantong First Elderly Hospital, Nantong City, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jing Zong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Zong","raw_affiliation_strings":["Department of Geriatrics, Nantong First Geriatric Hospital, Nantong City, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, Nantong First Geriatric Hospital, Nantong City, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100347687","display_name":"Xiaofeng Li","orcid":"https://orcid.org/0000-0002-3946-5791","observed_orcids":["https://orcid.org/0000-0002-3946-5791"]},"institutions":[{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaofeng Li","raw_affiliation_strings":["Department of Otolaryngology, East Hospital, Shanghai Sixth People's Hospital, Nanhui New City, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, East Hospital, Shanghai Sixth People's Hospital, Nanhui New City, China","institution_ids":["https://openalex.org/I4210144482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021359427","display_name":"Fanghui Xu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fanghui Xu","raw_affiliation_strings":["Department of Geriatrics, Harbin Second Hospital, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, Harbin Second Hospital, Harbin, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5021359427"],"corresponding_institution_ids":[],"apc_list":{"value":2085,"currency":"GBP","value_usd":2557},"apc_paid":{"value":2085,"currency":"GBP","value_usd":2557},"fwci":1.6754,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.81699652,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"59","issue":"1","first_page":"1386","last_page":"1399"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.030300000682473183,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genistein","display_name":"genistein","score":0.9929999709129333},{"id":"https://openalex.org/keywords/endothelial-senescence","display_name":"endothelial cell senescence","score":0.9309999942779541},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.847000002861023},{"id":"https://openalex.org/keywords/txnip","display_name":"TXNIP","score":0.8989999890327454},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9929999709129333},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5519999861717224},{"id":"https://openalex.org/keywords/p16","display_name":"p16","score":0.6819999814033508},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.996999979019165},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.8730000257492065},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.652999997138977},{"id":"https://openalex.org/keywords/g1-cell-cycle-arrest","display_name":"G1 cell cycle arrest","score":0.6430000066757202},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.8230000138282776},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C2779076967","wikidata":"https://www.wikidata.org/wiki/Q21122281","display_name":"TXNIP","level":4,"score":0.9452146291732788},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.8447132110595703},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6234010457992554},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.5787546634674072},{"id":"https://openalex.org/C2777834122","wikidata":"https://www.wikidata.org/wiki/Q5939177","display_name":"Human umbilical vein endothelial cell","level":4,"score":0.5571564435958862},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5299811363220215},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48837512731552124},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4573930501937866},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4231521189212799},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.421707421541214},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35027098655700684},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32471996545791626},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3117024302482605},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25064635276794434},{"id":"https://openalex.org/C3623737","wikidata":"https://www.wikidata.org/wiki/Q421219","display_name":"Thioredoxin","level":3,"score":0.18018725514411926},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11532413959503174},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019833","descriptor_name":"Genistein","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019833","descriptor_name":"Genistein","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1080/13880209.2021.1979052","doi":"https://doi.org/10.1080/13880209.2021.1979052","is_oa":true,"landing_page_url":"https://doi.org/10.1080/13880209.2021.1979052","pdf_url":null,"source":{"id":"https://openalex.org/S130009153","display_name":"Pharmaceutical Biology","issn_l":"0925-1618","issn":["0925-1618","1388-0209","1744-5116"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8526007","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8526007/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8526007/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharm Biol","raw_type":"Text"},{"id":"pmid:34663173","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34663173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:05d58202343a474b96f4a03e0a52be49","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/05d58202343a474b96f4a03e0a52be49","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutical Biology, Vol 59, Iss 1, Pp 1388-1401 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/13880209.2021.1979052","doi":"https://doi.org/10.1080/13880209.2021.1979052","is_oa":true,"landing_page_url":"https://doi.org/10.1080/13880209.2021.1979052","pdf_url":null,"source":{"id":"https://openalex.org/S130009153","display_name":"Pharmaceutical Biology","issn_l":"0925-1618","issn":["0925-1618","1388-0209","1744-5116"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3207970844.pdf","grobid_xml":"https://content.openalex.org/works/W3207970844.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W602304908","https://openalex.org/W1531916091","https://openalex.org/W1590760212","https://openalex.org/W1964440144","https://openalex.org/W1964712513","https://openalex.org/W1968884794","https://openalex.org/W1976268751","https://openalex.org/W1978772332","https://openalex.org/W2011763511","https://openalex.org/W2052411122","https://openalex.org/W2057204948","https://openalex.org/W2067655785","https://openalex.org/W2080290533","https://openalex.org/W2082942776","https://openalex.org/W2107277218","https://openalex.org/W2114360920","https://openalex.org/W2124411435","https://openalex.org/W2159665335","https://openalex.org/W2266344911","https://openalex.org/W2291707735","https://openalex.org/W2333497814","https://openalex.org/W2474737012","https://openalex.org/W2524081832","https://openalex.org/W2550169656","https://openalex.org/W2550560946","https://openalex.org/W2569107931","https://openalex.org/W2578699488","https://openalex.org/W2584322210","https://openalex.org/W2607546792","https://openalex.org/W2607662251","https://openalex.org/W2609968886","https://openalex.org/W2618696265","https://openalex.org/W2776511822","https://openalex.org/W2788870748","https://openalex.org/W2798059234","https://openalex.org/W2888882541","https://openalex.org/W2892283506","https://openalex.org/W2901136059","https://openalex.org/W2916538909","https://openalex.org/W2948831997","https://openalex.org/W2961784779","https://openalex.org/W3000623168","https://openalex.org/W4211217520"],"related_works":["https://openalex.org/W4388422454","https://openalex.org/W2354894074","https://openalex.org/W2067655785","https://openalex.org/W2381925019","https://openalex.org/W2092834979","https://openalex.org/W2041415712","https://openalex.org/W2330275543","https://openalex.org/W2325664315","https://openalex.org/W1998317015","https://openalex.org/W3001200283"],"abstract_inverted_index":{"Context":[0],"Genistein":[1],"(Gen)":[2],"has":[3],"shown":[4],"protective":[5],"effects":[6],"against":[7],"ageing":[8],"process.Objective":[9],"To":[10],"explore":[11],"the":[12,17,29,77,92,132,143,171,206,237,258,278],"role":[13],"of":[14,19,40,79,94,134,138,155,173,188,209,216,219,280],"Gen":[15,52,80,157,182,210,255],"on":[16,81,211],"senescence":[18,154,169,213,251,271],"H2O2-induced":[20,82,167,212,249],"human":[21],"umbilical":[22],"vein":[23],"endothelial":[24],"cells":[25],"(HUVECs)":[26],"and":[27,32,45,57,70,101,109,123,128,151,170,175,184,190,214,226,247,272],"investigate":[28],"possible":[30],"mechanism.Materials":[31],"methods":[33],"HUVECs":[34,85,113,163,178,193,231],"were":[35,73,86,114,179,194,232],"treated":[36],"with":[37,88],"different":[38],"concentrations":[39,137],"H2O2":[41,126,141,197],"(50,":[42],"100,":[43],"200":[44],"400":[46,129],"\u03bcmol/L)":[47,130],"for":[48,60,268,277],"1":[49],"h":[50],"or":[51],"administration":[53],"(20,":[54],"40,":[55],"80":[56,185],"160":[58,165],"\u03bcg/mL)":[59],"24":[61],"h.":[62],"Functional":[63],"experiments":[64],"(cell":[65],"counting":[66],"kit-8,":[67],"\u03b2-galactosidase":[68],"staining":[69],"flow":[71],"cytometry)":[72],"used":[74],"to":[75,162],"detect":[76],"effect":[78,208],"HUVECs.":[83,135,156,217],"After":[84],"transfected":[87],"TXNIP":[89,174,189,203],"overexpression":[90],"plasmids,":[91],"expression":[93,172],"p16,":[95,220],"p21,":[96,221],"thioredoxin-interacting":[97],"protein":[98],"(TXNIP),":[99],"nucleotide-binding":[100],"oligomerization":[102],"domain-like":[103],"receptor":[104],"3":[105],"(NLRP3),":[106],"cleaved":[107,110,224,227],"caspase-3":[108,225],"caspase-1":[111,228],"in":[112,148,177,192,229],"detected":[115],"by":[116,181,196,200,234,244,254],"quantitative":[117],"real-time":[118],"polymerase":[119],"chain":[120],"reaction":[121],"(qRT-PCR)":[122],"western":[124],"blot.Results":[125],"(200":[127],"inhibited":[131,233],"proliferation":[133],"At":[136],">50":[139],"\u03bcmol/L,":[140],"induced":[142],"cell":[144,153],"cycle":[145],"progression":[146],"arrests":[147],"G1":[149],"phase":[150],"promoted":[152],"had":[158],"no":[159],"obvious":[160],"cytotoxicity":[161],"below":[164],"\u00b5g/mL.":[166],"HUVEC":[168,250,270],"NLRP3":[176,191],"down-regulated":[180,199],"(40":[183],"\u00b5g/mL).":[186],"Expressions":[187,218],"up-regulated":[195],"but":[198],"Gen.":[201],"Overexpressed":[202],"partially":[204,242],"reversed":[205,243],"suppressive":[207],"apoptosis":[215],"TXNIP,":[222],"NLRP3,":[223],"H2O2-treated":[230],"Gen,":[235],"while":[236],"inhibition":[238],"as":[239],"such":[240],"was":[241,252],"overexpressed":[245],"TXNIP.Discussion":[246],"conclusions":[248],"alleviated":[253],"via":[256],"suppressing":[257],"TXNIP/NLRP3":[259],"axis,":[260],"which":[261],"may":[262],"offer":[263],"a":[264,274],"potential":[265],"therapeutic":[266],"approach":[267],"improving":[269],"provide":[273],"new":[275],"direction":[276],"treatment":[279],"cardiovascular":[281],"disease.":[282]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-10-25T00:00:00"}