{"id":"https://openalex.org/W3207955017","doi":"https://doi.org/10.1111/jvim.16293","title":"Leukocyte and cytokine variables in asymptomatic Pugs at genetic risk of necrotizing meningoencephalitis","display_name":"Leukocyte and cytokine variables in asymptomatic Pugs at genetic risk of necrotizing meningoencephalitis","publication_year":2021,"publication_date":"2021-10-23","ids":{"openalex":"https://openalex.org/W3207955017","doi":"https://doi.org/10.1111/jvim.16293","mag":"3207955017","pmid":"https://pubmed.ncbi.nlm.nih.gov/34687084","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8692191"},"language":"en","primary_location":{"id":"doi:10.1111/jvim.16293","doi":"https://doi.org/10.1111/jvim.16293","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jvim.16293","pdf_url":null,"source":{"id":"https://openalex.org/S69093139","display_name":"Journal of Veterinary Internal Medicine","issn_l":"0891-6640","issn":["0891-6640","1939-1676"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1111/jvim.16293","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033974019","display_name":"Rebecca Windsor","orcid":"https://orcid.org/0000-0001-7443-2912","observed_orcids":["https://orcid.org/0000-0001-7443-2912"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rebecca Windsor","raw_affiliation_strings":["Ethos Discovery (501c3) , San Diego, California,","Ethos Veterinary Health , Woburn, Massachusetts,","Ethos Discovery (501c3), San Diego, California, USA","Ethos Veterinary Health, Woburn, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ethos Discovery (501c3) , San Diego, California,","institution_ids":[]},{"raw_affiliation_string":"Ethos Veterinary Health , Woburn, Massachusetts,","institution_ids":[]},{"raw_affiliation_string":"Ethos Discovery (501c3), San Diego, California, USA","institution_ids":[]},{"raw_affiliation_string":"Ethos Veterinary Health, Woburn, Massachusetts, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001275135","display_name":"Samuel D. Stewart","orcid":"https://orcid.org/0000-0003-1148-2589","observed_orcids":["https://orcid.org/0000-0003-1148-2589"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Samuel D. Stewart","raw_affiliation_strings":["Ethos Discovery (501c3) , San Diego, California,","Ethos Veterinary Health , Woburn, Massachusetts,","Ethos Discovery (501c3), San Diego, California, USA","Ethos Veterinary Health, Woburn, Massachusetts, USA"],"raw_orcid":"https://orcid.org/0000-0003-1148-2589","affiliations":[{"raw_affiliation_string":"Ethos Discovery (501c3) , San Diego, California,","institution_ids":[]},{"raw_affiliation_string":"Ethos Veterinary Health , Woburn, Massachusetts,","institution_ids":[]},{"raw_affiliation_string":"Ethos Discovery (501c3), San Diego, California, USA","institution_ids":[]},{"raw_affiliation_string":"Ethos Veterinary Health, Woburn, Massachusetts, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015978195","display_name":"Joshua S. Talboom","orcid":"https://orcid.org/0000-0002-4327-4103","observed_orcids":["https://orcid.org/0000-0002-4327-4103"]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Talboom","raw_affiliation_strings":["Neurogenomics Division, Translational Genomics Research Institute , Phoenix, Arizona,","Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurogenomics Division, Translational Genomics Research Institute , Phoenix, Arizona,","institution_ids":["https://openalex.org/I1284308235"]},{"raw_affiliation_string":"Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035160894","display_name":"Candace R. Lewis","orcid":"https://orcid.org/0000-0001-5253-9989","observed_orcids":["https://orcid.org/0000-0001-5253-9989"]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Candace Lewis","raw_affiliation_strings":["Neurogenomics Division, Translational Genomics Research Institute , Phoenix, Arizona,","Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurogenomics Division, Translational Genomics Research Institute , Phoenix, Arizona,","institution_ids":["https://openalex.org/I1284308235"]},{"raw_affiliation_string":"Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113351320","display_name":"Marcus Naymik","orcid":"https://orcid.org/0009-0007-7727-8851","observed_orcids":["https://orcid.org/0009-0007-7727-8851"]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcus Naymik","raw_affiliation_strings":["Neurogenomics Division, Translational Genomics Research Institute , Phoenix, Arizona,","Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurogenomics Division, Translational Genomics Research Institute , Phoenix, Arizona,","institution_ids":["https://openalex.org/I1284308235"]},{"raw_affiliation_string":"Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081542125","display_name":"Ignazio Stefano Piras","orcid":"https://orcid.org/0000-0003-4024-3368","observed_orcids":["https://orcid.org/0000-0003-4024-3368"]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ignazio S. Piras","raw_affiliation_strings":["Neurogenomics Division, Translational Genomics Research Institute , Phoenix, Arizona,","Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurogenomics Division, Translational Genomics Research Institute , Phoenix, Arizona,","institution_ids":["https://openalex.org/I1284308235"]},{"raw_affiliation_string":"Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012714468","display_name":"Stefan M. Keller","orcid":"https://orcid.org/0000-0002-5428-2985","observed_orcids":["https://orcid.org/0000-0002-5428-2985"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan Keller","raw_affiliation_strings":["Microbiology, Immunology, University of California, Davis Department of Pathology, , Davis, California,","Department of Pathology, Microbiology, Immunology, University of California, Davis, Davis, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology, Immunology, University of California, Davis Department of Pathology, , Davis, California,","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Pathology, Microbiology, Immunology, University of California, Davis, Davis, California, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007969802","display_name":"Dori L. Borjesson","orcid":"https://orcid.org/0000-0002-5705-534X","observed_orcids":["https://orcid.org/0000-0002-5705-534X"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dori L. Borjesson","raw_affiliation_strings":["Microbiology, Immunology, University of California, Davis Department of Pathology, , Davis, California,","Department of Pathology, Microbiology, Immunology, University of California, Davis, Davis, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology, Immunology, University of California, Davis Department of Pathology, , Davis, California,","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Pathology, Microbiology, Immunology, University of California, Davis, Davis, California, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102732578","display_name":"Gary M. Clark","orcid":"https://orcid.org/0000-0002-2265-6743","observed_orcids":["https://orcid.org/0000-0002-2265-6743"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary Clark","raw_affiliation_strings":["Gary Clark Statistical Consulting LLC , Superior, Colorado,","Gary Clark Statistical Consulting LLC, Superior, Colorado, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gary Clark Statistical Consulting LLC , Superior, Colorado,","institution_ids":[]},{"raw_affiliation_string":"Gary Clark Statistical Consulting LLC, Superior, Colorado, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112077722","display_name":"Chand Khanna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chand Khanna","raw_affiliation_strings":["Ethos Discovery (501c3) , San Diego, California,","Ethos Veterinary Health , Woburn, Massachusetts,","Ethos Discovery (501c3), San Diego, California, USA","Ethos Veterinary Health, Woburn, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ethos Discovery (501c3) , San Diego, California,","institution_ids":[]},{"raw_affiliation_string":"Ethos Veterinary Health , Woburn, Massachusetts,","institution_ids":[]},{"raw_affiliation_string":"Ethos Discovery (501c3), San Diego, California, USA","institution_ids":[]},{"raw_affiliation_string":"Ethos Veterinary Health, Woburn, Massachusetts, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037628555","display_name":"Matthew J. Huentelman","orcid":"https://orcid.org/0000-0001-7390-9918","observed_orcids":["https://orcid.org/0000-0001-7390-9918"]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Huentelman","raw_affiliation_strings":["Neurogenomics Division, Translational Genomics Research Institute , Phoenix, Arizona,","Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurogenomics Division, Translational Genomics Research Institute , Phoenix, Arizona,","institution_ids":["https://openalex.org/I1284308235"]},{"raw_affiliation_string":"Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA","institution_ids":["https://openalex.org/I1284308235"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001275135"],"corresponding_institution_ids":[],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":2.5695,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.88531267,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"35","issue":"6","first_page":"2846","last_page":"2852"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12249","display_name":"Veterinary Orthopedics and Neurology","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12249","display_name":"Veterinary Orthopedics and Neurology","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12322","display_name":"Animal health and immunology","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/necrotizing-meningoencephalitis","display_name":"necrotizing meningoencephalitis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/pug","display_name":"Pug","score":0.7559999823570251},{"id":"https://openalex.org/keywords/genetic-risk","display_name":"genetic risk","score":0.8109999895095825},{"id":"https://openalex.org/keywords/chromosome-12","display_name":"chromosome 12","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8610000014305115},{"id":"https://openalex.org/keywords/leukocyte-subsets","display_name":"leukocyte subsets","score":0.7940000295639038},{"id":"https://openalex.org/keywords/plasma-cytokine-levels","display_name":"plasma cytokines","score":0.8090000152587891},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9129999876022339},{"id":"https://openalex.org/keywords/asymptomatic-dogs","display_name":"asymptomatic dogs","score":0.8059999942779541},{"id":"https://openalex.org/keywords/canine-immunology","display_name":"canine immunology","score":0.6510000228881836},{"id":"https://openalex.org/keywords/immunomodulatory-therapy","display_name":"immunomodulatory therapy","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8730259537696838},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.6866333484649658},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5475219488143921},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.4638056755065918},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42272526025772095},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4114452302455902},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.17217713594436646},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07338011264801025},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0718424916267395},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008590","descriptor_name":"Meningoencephalitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008590","descriptor_name":"Meningoencephalitis","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1111/jvim.16293","doi":"https://doi.org/10.1111/jvim.16293","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jvim.16293","pdf_url":null,"source":{"id":"https://openalex.org/S69093139","display_name":"Journal of Veterinary Internal Medicine","issn_l":"0891-6640","issn":["0891-6640","1939-1676"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Internal Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8692191","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8692191","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Vet Intern Med","raw_type":"Text"},{"id":"pmid:34687084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34687084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of veterinary internal medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5058e92fb8f149508ea5b03aa177743e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5058e92fb8f149508ea5b03aa177743e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Veterinary Internal Medicine, Vol 35, Iss 6, Pp 2846-2852 (2021)","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt7xv9c5vs","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/7xv9c5vs","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Veterinary Internal Medicine, vol 35, iss 6","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1111/jvim.16293","doi":"https://doi.org/10.1111/jvim.16293","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jvim.16293","pdf_url":null,"source":{"id":"https://openalex.org/S69093139","display_name":"Journal of Veterinary Internal Medicine","issn_l":"0891-6640","issn":["0891-6640","1939-1676"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Internal Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1558438182","https://openalex.org/W1964363017","https://openalex.org/W2012417795","https://openalex.org/W2018470874","https://openalex.org/W2035090464","https://openalex.org/W2050413009","https://openalex.org/W2060427517","https://openalex.org/W2075981540","https://openalex.org/W2088035675","https://openalex.org/W2094205468","https://openalex.org/W2107271105","https://openalex.org/W2120670559","https://openalex.org/W2130495662","https://openalex.org/W2138345444","https://openalex.org/W2152664025","https://openalex.org/W2162530578","https://openalex.org/W2560668196","https://openalex.org/W2601140832","https://openalex.org/W2605581028","https://openalex.org/W3037935502","https://openalex.org/W3207955017"],"related_works":["https://openalex.org/W4281781996","https://openalex.org/W2347097712","https://openalex.org/W2075981540","https://openalex.org/W1964363017","https://openalex.org/W7106251500","https://openalex.org/W2070590379","https://openalex.org/W2035090464","https://openalex.org/W2033005830","https://openalex.org/W4388170460","https://openalex.org/W6987533343"],"abstract_inverted_index":{"BACKGROUND:":[0],"Necrotizing":[1],"meningoencephalitis":[2],"(NME,":[3],"aka":[4],"Pug":[5,61],"dog":[6],"encephalitis)":[7],"is":[8,46],"an":[9,183],"inflammatory":[10],"brain":[11],"condition":[12],"associated":[13,47,170],"with":[14,48,171],"advanced":[15],"disease":[16],"at":[17],"initial":[18],"presentation,":[19],"rapid":[20],"progression,":[21],"and":[22,53,85,104,119,142,188,201],"poor":[23],"response":[24],"to":[25,186],"conventional":[26],"immunomodulatory":[27],"therapy.":[28],"HYPOTHESIS/OBJECTIVES:":[29],"That":[30],"genetic":[31],"risk":[32,108,113,121],"for":[33,64,109,192,204],"NME,":[34,110],"defined":[35],"by":[36,82,89],"a":[37,67,112,189],"common":[38],"germline":[39,76],"DNA":[40],"haplotype":[41,114],"located":[42],"on":[43],"chromosome":[44],"12,":[45],"altered":[49],"blood":[50],"cytokine":[51,80],"concentrations":[52,146],"leukocyte":[54,86],"subsets":[55],"in":[56],"asymptomatic":[57,63],"Pugs.":[58],"ANIMALS:":[59],"Forty":[60],"dogs":[62,96],"NME":[65,173,187],"from":[66],"hospital":[68],"sample.":[69],"METHODS:":[70],"Prospective":[71],"observational":[72],"cohort":[73],"study,":[74],"including":[75],"genome-wide":[77],"genotyping,":[78],"plasma":[79,144],"determination":[81],"multiplexed":[83],"profiling,":[84],"subset":[87],"characterization":[88],"flow":[90],"cytometric":[91],"analysis.":[92],"RESULTS:":[93],"Seven":[94],"(18%)":[95],"were":[97,168],"high":[98],"risk,":[99,103],"10":[100],"(25%)":[101],"medium":[102,120],"23":[105],"(58%)":[106],"low":[107],"giving":[111],"frequency":[115],"of":[116,127],"30%.":[117],"High":[118],"Pugs":[122,149],"had":[123],"significantly":[124,169],"lower":[125],"proportion":[126],"CD4+":[128],"T":[129],"cells":[130],"(median":[131,150],"22%":[132],"[range,":[133,137,153,159],"7.3%-38%]":[134],"vs":[135,156],"29%":[136],"16%-41%],":[138],"P":[139,162],"=":[140,163],".03)":[141],"higher":[143],"IL-10":[145],"than":[147],"low-risk":[148],"14.11":[151],"pg/mL":[152,158],"9.66-344.19":[154],"pg/mL]":[155],"12.21":[157],"2.59-18.53":[160],"pg/mL],":[161],".001).":[164],"No":[165],"other":[166],"variables":[167],"the":[172],"haplotype-based":[174],"risk.":[175],"CONCLUSIONS":[176],"AND":[177],"CLINICAL":[178],"IMPORTANCE:":[179],"These":[180],"data":[181],"suggest":[182],"immunological":[184],"underpinning":[185],"biologic":[190],"rationale":[191],"future":[193],"clinical":[194],"trials":[195],"that":[196],"investigate":[197],"novel":[198],"diagnostic,":[199],"preventative,":[200],"therapeutic":[202],"strategies":[203],"this":[205],"disease.":[206]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-10-25T00:00:00"}
