{"id":"https://openalex.org/W3207929673","doi":"https://doi.org/10.1093/eurheartj/ehab724.1365","title":"Relationship between Lactobacillus and prognosis of acute myocardial infarction patients treated by percutaneous coronary intervention and its possible mechanism","display_name":"Relationship between Lactobacillus and prognosis of acute myocardial infarction patients treated by percutaneous coronary intervention and its possible mechanism","publication_year":2021,"publication_date":"2021-10-01","ids":{"openalex":"https://openalex.org/W3207929673","doi":"https://doi.org/10.1093/eurheartj/ehab724.1365","mag":"3207929673"},"language":"en","primary_location":{"id":"doi:10.1093/eurheartj/ehab724.1365","doi":"https://doi.org/10.1093/eurheartj/ehab724.1365","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehab724.1365","pdf_url":"https://academic.oup.com/eurheartj/article-pdf/42/Supplement_1/ehab724.1365/41052401/ehab724.1365.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/eurheartj/article-pdf/42/Supplement_1/ehab724.1365/41052401/ehab724.1365.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101906520","display_name":"Jiasheng Cai","orcid":"https://orcid.org/0000-0001-7417-6728","observed_orcids":["https://orcid.org/0000-0001-7417-6728"]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J.-J Cai","raw_affiliation_strings":["Tianjin Medical University, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Medical University, Tianjin, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045634081","display_name":"Yang Liu","orcid":"https://orcid.org/0000-0003-0070-4094","observed_orcids":["https://orcid.org/0000-0003-0070-4094"]},"institutions":[{"id":"https://openalex.org/I4210150108","display_name":"Tianjin Chest Hospital","ror":"https://ror.org/05r9v1368","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210150108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y Liu","raw_affiliation_strings":["Tianjin Chest Hospital, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Chest Hospital, Tianjin, China","institution_ids":["https://openalex.org/I4210150108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040420677","display_name":"Jiajing Wang","orcid":"https://orcid.org/0009-0000-0627-9370","observed_orcids":["https://orcid.org/0009-0000-0627-9370"]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J Wang","raw_affiliation_strings":["Tianjin Medical University, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Medical University, Tianjin, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020514172","display_name":"J.-X Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J.-X Wang","raw_affiliation_strings":["Tianjin Medical University, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Medical University, Tianjin, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100322938","display_name":"Yan Wang","orcid":"https://orcid.org/0000-0003-2563-255X","observed_orcids":["https://orcid.org/0000-0003-2563-255X","https://orcid.org/0000-0002-0029-2184"]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y Wang","raw_affiliation_strings":["Tianjin Medical University, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Medical University, Tianjin, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109462154","display_name":"Shichao Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"S.-B Xu","raw_affiliation_strings":["Tianjin Medical University, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Medical University, Tianjin, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019761751","display_name":"Zhuang Cui","orcid":"https://orcid.org/0000-0001-6495-766X","observed_orcids":["https://orcid.org/0000-0001-6495-766X"]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Z Cui","raw_affiliation_strings":["Tianjin Medical University, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Medical University, Tianjin, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003714454","display_name":"Jing Gao","orcid":"https://orcid.org/0000-0002-1729-2500","observed_orcids":["https://orcid.org/0000-0002-1729-2500"]},"institutions":[{"id":"https://openalex.org/I4210150108","display_name":"Tianjin Chest Hospital","ror":"https://ror.org/05r9v1368","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210150108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J Gao","raw_affiliation_strings":["Tianjin Chest Hospital, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Chest Hospital, Tianjin, China","institution_ids":["https://openalex.org/I4210150108"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3918,"currency":"EUR","value_usd":4592},"apc_paid":null,"fwci":0.1398,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.31893882,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"42","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.7089999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.7089999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.19259999692440033,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.04540000110864639,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lactobacillus","display_name":"Lactobacillus","score":0.9890000224113464},{"id":"https://openalex.org/keywords/acute-myocardial-infarction","display_name":"acute myocardial infarction","score":0.9900000095367432},{"id":"https://openalex.org/keywords/percutaneous-coronary-intervention","display_name":"percutaneous coronary intervention","score":0.9649999737739563},{"id":"https://openalex.org/keywords/major-adverse-cardiac-events","display_name":"major adverse cardiac events","score":0.8939999938011169},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.6110000014305115},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9150000214576721},{"id":"https://openalex.org/keywords/fecal-microbiota","display_name":"fecal microbiota","score":0.5479999780654907},{"id":"https://openalex.org/keywords/st-elevation-myocardial-infarction","display_name":"ST-elevation myocardial infarction","score":0.6159999966621399},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.460999995470047},{"id":"https://openalex.org/keywords/brain-natriuretic-peptide","display_name":"brain natriuretic peptide","score":0.5350000262260437},{"id":"https://openalex.org/keywords/high-sensitivity-c-reactive-protein","display_name":"high-sensitivity C-reactive protein","score":0.6290000081062317},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.42100000381469727},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.414000004529953},{"id":"https://openalex.org/keywords/serum-lipids","display_name":"serum lipids","score":0.6320000290870667},{"id":"https://openalex.org/keywords/cardiac-injury","display_name":"cardiac injury","score":0.3230000138282776},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.5400000214576721},{"id":"https://openalex.org/keywords/16s-rrna-gene-sequencing","display_name":"16S rRNA gene sequencing","score":0.640999972820282},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.949364185333252},{"id":"https://openalex.org/C2780739214","wikidata":"https://www.wikidata.org/wiki/Q6723023","display_name":"Mace","level":4,"score":0.8714613914489746},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.7746627926826477},{"id":"https://openalex.org/C2780400711","wikidata":"https://www.wikidata.org/wiki/Q2008344","display_name":"Percutaneous coronary intervention","level":3,"score":0.7610918879508972},{"id":"https://openalex.org/C45393284","wikidata":"https://www.wikidata.org/wiki/Q191012","display_name":"Conventional PCI","level":3,"score":0.7383872866630554},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7090765833854675},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.5648557543754578},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5026917457580566},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.4787249267101288},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.43733906745910645},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36066365242004395},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.29226595163345337},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/eurheartj/ehab724.1365","doi":"https://doi.org/10.1093/eurheartj/ehab724.1365","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehab724.1365","pdf_url":"https://academic.oup.com/eurheartj/article-pdf/42/Supplement_1/ehab724.1365/41052401/ehab724.1365.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/eurheartj/ehab724.1365","doi":"https://doi.org/10.1093/eurheartj/ehab724.1365","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehab724.1365","pdf_url":"https://academic.oup.com/eurheartj/article-pdf/42/Supplement_1/ehab724.1365/41052401/ehab724.1365.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W3207929673.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4220934932","https://openalex.org/W3196348154","https://openalex.org/W6902207065","https://openalex.org/W3107902908","https://openalex.org/W4323565797","https://openalex.org/W4312941556","https://openalex.org/W2390326293","https://openalex.org/W1991320853","https://openalex.org/W4415818789","https://openalex.org/W3210887660"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Our":[2],"previous":[3],"study":[4],"had":[5,315],"found":[6],"that":[7,25,213,250,277,351],"the":[8,28,45,140,153,156,173,189,256,297,324,349,374],"abundance":[9],"of":[10,14,30,51,83,158,183,222,299,326,367,377,383],"Lactobacillaceae":[11],"in":[12,81,188,240,328,385,392],"stool":[13,119],"acute":[15,52],"coronary":[16,60],"syndrome":[17],"patients":[18,56,185,214,231,330,394],"was":[19,149,193,204,237,252,258,279],"significantly":[20,322],"decreased.":[21],"Experiments":[22],"have":[23],"confirmed":[24],"Lactobacillus":[26,48,120,143,161,176,216,233,251,278,320,352],"has":[27],"effects":[29],"anti-inflammation,":[31],"regulating":[32],"blood":[33,88],"lipids":[34],"and":[35,49,63,87,106,113,132,144,160,166,177,268,289,307,360,379],"improving":[36],"cardiac":[37,128,358,362],"injury":[38,359],"after":[39],"myocardial":[40,53],"infarction.":[41],"Purpose":[42],"To":[43],"explore":[44],"relationship":[46,141,174],"between":[47,142,155,175,389],"prognosis":[50],"infarction":[54],"(AMI)":[55],"treated":[57,331],"by":[58,332],"percutaneous":[59],"intervention":[61],"(PCI)":[62],"its":[64],"possible":[65],"mechanism.":[66],"Methods":[67],"Patients":[68],"with":[69,215,232,282,294],"AMI":[70],"who":[71],"received":[72],"emergency":[73],"PCI":[74],"from":[75,92,102],"July":[76],"2017":[77],"to":[78,118,138,151,171,230,348],"December":[79],"2018":[80],"department":[82],"CCU":[84],"were":[85,90,104,108,125,136,169,186,199],"enrolled.Stool":[86],"samples":[89],"collected":[91],"all":[93],"patients.":[94],"The":[95,122,191,201,342],"fecal":[96],"16S":[97],"rDNA":[98],"gene":[99],"sequencing":[100],"data":[101],"subjects":[103,107],"analyzed":[105],"categorized":[109],"into":[110],"Low,":[111],"Medium":[112],"High":[114],"level":[115],"groups":[116],"according":[117],"measurements.":[121],"primary":[123],"endpoints":[124],"major":[126],"adverse":[127],"events":[129],"(MACE).":[130],"Univariate":[131],"multivariate":[133],"Cox":[134,210],"regression":[135,211],"used":[137,150,170],"analyze":[139],"prognosis.":[145],"Kaplan-Meier":[146],"survival":[147],"curve":[148],"characterize":[152],"association":[154],"risk":[157,221,325],"MACE":[159,223,327],"levels.":[162],"Spearman":[163],"correlation":[164,274],"analysis":[165,248,275,388,391],"trend":[167],"test":[168],"assess":[172],"Clinical":[178],"index.":[179],"Results":[180],"A":[181],"total":[182],"254":[184],"included":[187],"analysis.":[190],"age":[192],"65.90\u00b111.56":[194],"years":[195,266,340],"old,and":[196],"152":[197],"(59.84%)":[198],"male.":[200],"follow-up":[202],"time":[203],"652":[205],"(548.25,":[206],"753)":[207],"days.":[208],"Multivariate":[209],"showed":[212,276,309],">7.1":[217],"copies/g":[218],"presented":[219],"lower":[220],"(HR=0.179,":[224],"95%":[225,243],"CI":[226,244],"0.076\u20130.422,":[227],"P<0.001),":[228],"compared":[229],"\u22643.6":[234],"copies/g.This":[235],"difference":[236],"statistically":[238],"significant":[239],"STEMI":[241,329],"(HR=0.210,":[242],"0.082\u20130.542,":[245],"P=0.001).":[246],"Subgroup":[247],"indicated":[249],"a":[253,310],"protective":[254],"factor,whereas":[255],"value":[257],"more":[259],"evident":[260],"for":[261,335],"male":[262,336],"smokers":[263,337],"over":[264,271,338],"60":[265,339],"old":[267],"whose":[269],"BNP":[270,308],"1000":[272],"pg/mL.Spearman":[273],"negatively":[280],"correlated":[281,293],"WBC,":[283,301],"NEUT,":[284,302],"hs-CRP,":[285,303],"TNT,":[286,304],"CK,":[287,305],"CK-MB":[288,306],"BNP,":[290],"while":[291,313],"positively":[292],"LVEF.":[295],"With":[296],"increasing":[298],"Lactobacillus,":[300],"downward":[311],"trend,":[312],"LVEF":[314],"an":[316],"upward":[317],"trend.":[318],"Conclusion":[319],"can":[321,353],"reduce":[323,354],"PCI,":[333],"especially":[334],"old.":[341],"underlying":[343],"mechanism":[344],"may":[345],"be":[346],"related":[347],"fact":[350],"inflammatory":[355],"reaction,":[356],"lessen":[357],"improve":[361],"function.":[363],"Funding":[364],"Acknowledgement":[365],"Type":[366],"funding":[368,372],"sources:":[369],"Foundation.":[370],"Main":[371],"source(s):":[373],"Key":[375],"Project":[376],"Scientific":[378],"Technological":[380],"Support":[381],"Plan":[382],"Tianjin":[384],"2020":[386],"Correlation":[387],"LactobacillSubgroup":[390],"different":[393]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2021-10-25T00:00:00"}