{"id":"https://openalex.org/W3207927474","doi":"https://doi.org/10.1002/ppul.25740","title":"Comparison of inhaled mannitol/dornase alfa combination and daily dornase alfa alone in children with cystic fibrosis","display_name":"Comparison of inhaled mannitol/dornase alfa combination and daily dornase alfa alone in children with cystic fibrosis","publication_year":2021,"publication_date":"2021-10-23","ids":{"openalex":"https://openalex.org/W3207927474","doi":"https://doi.org/10.1002/ppul.25740","mag":"3207927474","pmid":"https://pubmed.ncbi.nlm.nih.gov/34687284"},"language":"en","primary_location":{"id":"doi:10.1002/ppul.25740","doi":"https://doi.org/10.1002/ppul.25740","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ppul.25740","pdf_url":null,"source":{"id":"https://openalex.org/S144578311","display_name":"Pediatric Pulmonology","issn_l":"1099-0496","issn":["1099-0496","8755-6863"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Pulmonology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020944729","display_name":"Dilber Ademhan Tural","orcid":"https://orcid.org/0000-0002-0334-6336","observed_orcids":["https://orcid.org/0000-0002-0334-6336"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Dilber Ademhan Tural","raw_affiliation_strings":["Department of Pediatric Pulmonology, Ihsan Dogramaci Children's Hospital, School of Medicine Hacettepe University Ankara Turkey"],"raw_orcid":"https://orcid.org/0000-0002-0334-6336","affiliations":[{"raw_affiliation_string":"Department of Pediatric Pulmonology, Ihsan Dogramaci Children's Hospital, School of Medicine Hacettepe University Ankara Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101501162","display_name":"Ebru Yal\u00e7\u0131n","orcid":"https://orcid.org/0000-0002-7325-1981","observed_orcids":["https://orcid.org/0000-0002-7325-1981"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ebru Yal\u00e7\u0131n","raw_affiliation_strings":["Department of Pediatric Pulmonology, Ihsan Dogramaci Children's Hospital, School of Medicine Hacettepe University Ankara Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Pulmonology, Ihsan Dogramaci Children's Hospital, School of Medicine Hacettepe University Ankara Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023361115","display_name":"Nagehan Emiralio\u011flu","orcid":"https://orcid.org/0000-0002-1405-8401","observed_orcids":["https://orcid.org/0000-0002-1405-8401"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Nagehan Emiralioglu","raw_affiliation_strings":["Department of Pediatric Pulmonology, Ihsan Dogramaci Children's Hospital, School of Medicine Hacettepe University Ankara Turkey"],"raw_orcid":"https://orcid.org/0000-0002-1405-8401","affiliations":[{"raw_affiliation_string":"Department of Pediatric Pulmonology, Ihsan Dogramaci Children's Hospital, School of Medicine Hacettepe University Ankara Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088130435","display_name":"Beste \u00d6zsezen","orcid":"https://orcid.org/0000-0002-0052-8361","observed_orcids":["https://orcid.org/0000-0002-0052-8361"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Beste Ozsezen","raw_affiliation_strings":["Department of Pediatric Pulmonology, Ihsan Dogramaci Children's Hospital, School of Medicine Hacettepe University Ankara Turkey"],"raw_orcid":"https://orcid.org/0000-0002-0052-8361","affiliations":[{"raw_affiliation_string":"Department of Pediatric Pulmonology, Ihsan Dogramaci Children's Hospital, School of Medicine Hacettepe University Ankara Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047379730","display_name":"Birce Sunman","orcid":"https://orcid.org/0000-0001-9818-8782","observed_orcids":["https://orcid.org/0000-0001-9818-8782"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Birce Sunman","raw_affiliation_strings":["Department of Pediatric Pulmonology, Ihsan Dogramaci Children's Hospital, School of Medicine Hacettepe University Ankara Turkey"],"raw_orcid":"https://orcid.org/0000-0001-9818-8782","affiliations":[{"raw_affiliation_string":"Department of Pediatric Pulmonology, Ihsan Dogramaci Children's Hospital, School of Medicine Hacettepe University Ankara Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019135951","display_name":"Halime Nay\u0131r B\u00fcy\u00fck\u015fahin","orcid":"https://orcid.org/0000-0002-6909-7993","observed_orcids":["https://orcid.org/0000-0002-6909-7993"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Halime Nayir Buyuksahin","raw_affiliation_strings":["Department of Pediatric Pulmonology, Ihsan Dogramaci Children's Hospital, School of Medicine Hacettepe University Ankara Turkey"],"raw_orcid":"https://orcid.org/0000-0002-6909-7993","affiliations":[{"raw_affiliation_string":"Department of Pediatric Pulmonology, Ihsan Dogramaci Children's Hospital, School of Medicine Hacettepe University Ankara Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028114293","display_name":"\u0130smail G\u00fczelka\u015f","orcid":"https://orcid.org/0000-0001-7628-7253","observed_orcids":["https://orcid.org/0000-0001-7628-7253"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ismail Guzelkas","raw_affiliation_strings":["Department of Pediatric Pulmonology, Ihsan Dogramaci Children's Hospital, School of Medicine Hacettepe University Ankara Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Pulmonology, Ihsan Dogramaci Children's Hospital, School of Medicine Hacettepe University Ankara Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011266391","display_name":"Deni\u0307z Do\u011fru","orcid":"https://orcid.org/0000-0001-9931-9473","observed_orcids":["https://orcid.org/0000-0001-9931-9473"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Deniz Dogru","raw_affiliation_strings":["Department of Pediatric Pulmonology, Ihsan Dogramaci Children's Hospital, School of Medicine Hacettepe University Ankara Turkey"],"raw_orcid":"https://orcid.org/0000-0001-9931-9473","affiliations":[{"raw_affiliation_string":"Department of Pediatric Pulmonology, Ihsan Dogramaci Children's Hospital, School of Medicine Hacettepe University Ankara Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088197160","display_name":"U\u011fur \u00d6z\u00e7elik","orcid":"https://orcid.org/0000-0003-1587-5216","observed_orcids":["https://orcid.org/0000-0003-1587-5216"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ugur Ozcelik","raw_affiliation_strings":["Department of Pediatric Pulmonology, Ihsan Dogramaci Children's Hospital, School of Medicine Hacettepe University Ankara Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Pulmonology, Ihsan Dogramaci Children's Hospital, School of Medicine Hacettepe University Ankara Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059794005","display_name":"Nural Ki\u0307per","orcid":"https://orcid.org/0000-0003-1261-7393","observed_orcids":["https://orcid.org/0000-0003-1261-7393"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Nural Kiper","raw_affiliation_strings":["Department of Pediatric Pulmonology, Ihsan Dogramaci Children's Hospital, School of Medicine Hacettepe University Ankara Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Pulmonology, Ihsan Dogramaci Children's Hospital, School of Medicine Hacettepe University Ankara Turkey","institution_ids":["https://openalex.org/I66514158"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I66514158"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":2.2694,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.89185279,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"57","issue":"1","first_page":"142","last_page":"151"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dornase-alfa","display_name":"dornase alfa","score":0.8920000195503235},{"id":"https://openalex.org/keywords/mannitol","display_name":"mannitol","score":0.7649999856948853},{"id":"https://openalex.org/keywords/dry-powder-inhaler","display_name":"dry powder inhaler","score":0.902999997138977},{"id":"https://openalex.org/keywords/osmotic-agents","display_name":"osmotic agents","score":0.671999990940094},{"id":"https://openalex.org/keywords/airway-clearance","display_name":"airway clearance","score":0.6140000224113464},{"id":"https://openalex.org/keywords/fev1","display_name":"FEV1","score":0.628000020980835},{"id":"https://openalex.org/keywords/lung-function","display_name":"lung function","score":0.6679999828338623},{"id":"https://openalex.org/keywords/pulmonary-exacerbations","display_name":"pulmonary exacerbations","score":0.9049999713897705},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.7979999780654907},{"id":"https://openalex.org/keywords/sputum-microbiology","display_name":"sputum microbiology","score":0.9210000038146973},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.7509999871253967},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7440000176429749},{"id":"https://openalex.org/keywords/long-term-treatment-outcomes","display_name":"long-term treatment outcomes","score":0.593999981880188},{"id":"https://openalex.org/keywords/fev1-fvc-ratio","display_name":"FEV1/FVC ratio","score":0.7279999852180481},{"id":"https://openalex.org/keywords/fev1-z-score","display_name":"FEV1 z-score","score":0.6579999923706055},{"id":"https://openalex.org/keywords/oxygen-saturation","display_name":"oxygen saturation","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9271204471588135},{"id":"https://openalex.org/C2778445172","wikidata":"https://www.wikidata.org/wiki/Q407646","display_name":"Mannitol","level":2,"score":0.8629751205444336},{"id":"https://openalex.org/C2776938444","wikidata":"https://www.wikidata.org/wiki/Q178194","display_name":"Cystic fibrosis","level":2,"score":0.7922981977462769},{"id":"https://openalex.org/C2780333948","wikidata":"https://www.wikidata.org/wiki/Q653305","display_name":"Spirometry","level":3,"score":0.5129084587097168},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.49354732036590576},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49158892035484314},{"id":"https://openalex.org/C2776301714","wikidata":"https://www.wikidata.org/wiki/Q259346","display_name":"Sputum","level":3,"score":0.4411933124065399},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.37042462825775146},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.28986087441444397},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05940425395965576},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003850","descriptor_name":"Deoxyribonuclease I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008353","descriptor_name":"Mannitol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/ppul.25740","doi":"https://doi.org/10.1002/ppul.25740","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ppul.25740","pdf_url":null,"source":{"id":"https://openalex.org/S144578311","display_name":"Pediatric Pulmonology","issn_l":"1099-0496","issn":["1099-0496","8755-6863"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Pulmonology","raw_type":"journal-article"},{"id":"pmid:34687284","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34687284","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric pulmonology","raw_type":"Journal Article"},{"id":"pmh:1685f69f-d1e1-4c48-b600-fee3f04b64f3","doi":null,"is_oa":false,"landing_page_url":"https://avesis.aybu.edu.tr/publication/details/1685f69f-d1e1-4c48-b600-fee3f04b64f3/oai","pdf_url":null,"source":{"id":"https://openalex.org/S7407055213","display_name":"AYBU AVESIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1772669508","https://openalex.org/W1920811724","https://openalex.org/W1970252373","https://openalex.org/W1970431627","https://openalex.org/W1986733730","https://openalex.org/W1987048335","https://openalex.org/W2007479478","https://openalex.org/W2045827836","https://openalex.org/W2047080603","https://openalex.org/W2047381800","https://openalex.org/W2048431484","https://openalex.org/W2078805297","https://openalex.org/W2091042844","https://openalex.org/W2099449365","https://openalex.org/W2104379296","https://openalex.org/W2114494355","https://openalex.org/W2117559755","https://openalex.org/W2124747901","https://openalex.org/W2124798883","https://openalex.org/W2125078269","https://openalex.org/W2125364344","https://openalex.org/W2126762232","https://openalex.org/W2132665778","https://openalex.org/W2133653432","https://openalex.org/W2134260485","https://openalex.org/W2140243233","https://openalex.org/W2182271449","https://openalex.org/W2312654759","https://openalex.org/W2333398204","https://openalex.org/W2584373275","https://openalex.org/W2592166454","https://openalex.org/W2981067716","https://openalex.org/W4242635816","https://openalex.org/W4248775771","https://openalex.org/W4256199455","https://openalex.org/W6720634416"],"related_works":["https://openalex.org/W2125364344","https://openalex.org/W4221079914","https://openalex.org/W2067761480","https://openalex.org/W4292497486","https://openalex.org/W2104379296","https://openalex.org/W2948397211","https://openalex.org/W2338015468","https://openalex.org/W2592166454","https://openalex.org/W2001492346","https://openalex.org/W2124798883"],"abstract_inverted_index":{"Abstract":[0],"Objectives":[1],"Inhaled":[2],"recombinant":[3],"human":[4],"deoxyribonuclease":[5],"(dornase":[6],"alfa)":[7],"and":[8,75,112,115,131,160,201,221,225,227,288,344],"osmotic":[9],"agents":[10],"such":[11],"as":[12],"inhaled":[13,40],"mannitol":[14,42,68,74,146,159,169,181,189,195,236,274,343],"are":[15,48,249],"used":[16,206],"for":[17,196],"improving":[18],"the":[19,32,97,116,149,168,177,188,210,222,228,235,247,263,273,285,299,302,309,324],"clearance":[20],"of":[21,23,36,66,96,127,138,173,179,265,301],"secretions":[22],"cystic":[24],"fibrosis":[25],"(CF)":[26],"patients.":[27,175],"We":[28,54],"aimed":[29],"to":[30,143,253,298],"evaluate":[31],"long\u2010term":[33,337],"clinical":[34],"effects":[35],"adding":[37],"dry":[38],"powder":[39],"(DPI)":[41],"in":[43,84,102,108,187,217,234,272,323,332,350,362],"subjects":[44,61],"with":[45,62,79,86,157,251,341,358,364],"CF":[46,87],"who":[47,141,192,204,335],"taking":[49],"daily":[50,80],"dornase":[51,76,81,207,345,359],"alfa.":[52],"Method":[53],"conducted":[55],"a":[56,89,136,154],"retrospective":[57],"case\u2013control":[58],"study":[59,98,150,286,303,329],"on":[60],"CF.":[63,365],"The":[64,92,213],"effect":[65,178],"DPI":[67,73,145,158,180,194,342],"was":[69,182],"assessed":[70],"by":[71],"comparing":[72],"alfa":[77,82,208,346,360],"combination":[78],"alone":[83,361],"children":[85,363],"during":[88,148,284],"12\u2010month":[90],"period.":[91],"primary":[93],"outcome":[94],"measures":[95],"were":[99,162,231,321],"absolute":[100,215,254,290],"changes":[101,295,320],"percent":[103],"predicted":[104],"forced":[105],"expiratory":[106],"volume":[107],"1":[109],"s":[110],"(FEV1)":[111],"FEV1":[113,218],"z\u2010scores":[114,355],"secondary":[117,278],"outcomes":[118,279],"included":[119],"other":[120],"spirometry":[121,258],"indices,":[122,259],"body":[123,291],"mass":[124,292],"index,":[125],"frequency":[126,283],"pulmonary":[128,281],"exacerbations,":[129],"SPO2,":[130],"sputum":[132],"microbiology.":[133],"Result":[134],"Of":[135],"total":[137],"28":[139],"patients":[140,186,203,334],"committed":[142],"use":[144],"treatments":[147],"period,":[151],"five":[152],"had":[153],"positive":[155],"challenge":[156],"two":[161],"aged":[163],"over":[164],"18":[165,202],"years.":[166],"Therefore,":[167],"treatment":[170,190,237,275,325,340,357],"group":[171,191,238],"consisted":[172],"21":[174],"However,":[176],"analyzed":[183],"using":[184],"15":[185],"received":[193],"at":[197,262],"least":[198],"12":[199],"months,":[200,267],"only":[205],"constituted":[209],"control":[211],"group.":[212,276,326],"median":[214,289],"change":[216],"between":[219,308],"baseline":[220,226,297],"third":[223],"month;":[224],"12th":[229],"month":[230],"significantly":[232],"higher":[233],"(p":[239,311],"=":[240,243,312,315],"0.038,":[241],"p":[242,314],"0.004,":[244],"respectively).":[245,317],"When":[246],"groups":[248,310],"compared":[250],"respect":[252],"z\u2010score":[255,294],"changes,":[256],"all":[257],"except":[260],"FVC":[261],"end":[264,300],"3":[266],"showed":[268,304,330],"statistically":[269],"significant":[270,306],"improvements":[271,349],"Some":[277],"like":[280],"exacerbation":[282],"year":[287],"index":[293],"from":[296],"no":[305],"differences":[307],"0.735,":[313],"0.161,":[316],"No":[318],"colonization":[319],"observed":[322],"Conclusions":[327],"This":[328],"that":[331],"those":[333],"tolerated":[336],"(12":[338],"months)":[339],"made":[347],"greater":[348],"FEV1,":[351],"FVC,":[352],"FEV1/FVC,":[353],"FEF25\u201375":[354],"than":[356]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-10-25T00:00:00"}