{"id":"https://openalex.org/W3207790843","doi":"https://doi.org/10.30895/2221-996x-2021-21-3-178-192","title":"Assessment of T-cell immunity to SARS-CoV-2 in COVID-19 convalescents and vaccinated subjects, using TigraTest\u00ae SARS-CoV-2 ELISPOT kit","display_name":"Assessment of T-cell immunity to SARS-CoV-2 in COVID-19 convalescents and vaccinated subjects, using TigraTest\u00ae SARS-CoV-2 ELISPOT kit","publication_year":2021,"publication_date":"2021-10-02","ids":{"openalex":"https://openalex.org/W3207790843","doi":"https://doi.org/10.30895/2221-996x-2021-21-3-178-192","mag":"3207790843"},"language":"en","primary_location":{"id":"doi:10.30895/2221-996x-2021-21-3-178-192","doi":"https://doi.org/10.30895/2221-996x-2021-21-3-178-192","is_oa":true,"landing_page_url":"https://doi.org/10.30895/2221-996x-2021-21-3-178-192","pdf_url":"https://www.biopreparations.ru/jour/article/download/374/438","source":{"id":"https://openalex.org/S4210169820","display_name":"Biological Products Prevention Diagnosis Treatment","issn_l":"2221-996X","issn":["2221-996X","2619-1156"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Products. Prevention, Diagnosis, Treatment","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.biopreparations.ru/jour/article/download/374/438","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063696712","display_name":"Dmitry A. Poteryaev","orcid":"https://orcid.org/0000-0003-2695-8869","observed_orcids":["https://orcid.org/0000-0003-2695-8869"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. A. Poteryaev","raw_affiliation_strings":["International Biotechnology Center \u201cGENERIUM\u201d"],"raw_orcid":"https://orcid.org/0000-0003-2695-8869","affiliations":[{"raw_affiliation_string":"International Biotechnology Center \u201cGENERIUM\u201d","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071080340","display_name":"S. G. Abbasova","orcid":"https://orcid.org/0000-0001-5841-7587","observed_orcids":["https://orcid.org/0000-0001-5841-7587"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. G. Abbasova","raw_affiliation_strings":["International Biotechnology Center \u201cGENERIUM\u201d"],"raw_orcid":"https://orcid.org/0000-0001-5841-7587","affiliations":[{"raw_affiliation_string":"International Biotechnology Center \u201cGENERIUM\u201d","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032190960","display_name":"P. E. Ignatyeva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. E. Ignatyeva","raw_affiliation_strings":["International Biotechnology Center \u201cGENERIUM\u201d"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Biotechnology Center \u201cGENERIUM\u201d","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061156021","display_name":"Olga M. Strizhakova","orcid":"https://orcid.org/0000-0003-0023-0028","observed_orcids":["https://orcid.org/0000-0003-0023-0028"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O. M. Strizhakova","raw_affiliation_strings":["International Biotechnology Center \u201cGENERIUM\u201d"],"raw_orcid":"https://orcid.org/0000-0003-0023-0028","affiliations":[{"raw_affiliation_string":"International Biotechnology Center \u201cGENERIUM\u201d","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079883898","display_name":"\u0421. \u0412. \u041a\u043e\u043b\u0435\u0441\u043d\u0438\u043a","orcid":"https://orcid.org/0000-0003-2398-4615","observed_orcids":["https://orcid.org/0000-0003-2398-4615"]},"institutions":[{"id":"https://openalex.org/I4405272539","display_name":"Generium Pharmaceuticals (Russia)","ror":"https://ror.org/04anvdv29","country_code":"RU","type":"company","lineage":["https://openalex.org/I4405272539"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"S. V. Kolesnik","raw_affiliation_strings":["GENERIUM JSC"],"raw_orcid":"https://orcid.org/0000-0003-2398-4615","affiliations":[{"raw_affiliation_string":"GENERIUM JSC","institution_ids":["https://openalex.org/I4405272539"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015374870","display_name":"\u0425\u0430\u043c\u0438\u0442\u043e\u0432 \u0420\u0430\u0432\u0438\u043b\u044c \u0410\u0432\u0433\u0430\u0442\u043e\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0002-1314-894X","observed_orcids":["https://orcid.org/0000-0002-1314-894X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. A. Khamitov","raw_affiliation_strings":["International Biotechnology Center \u201cGENERIUM\u201d"],"raw_orcid":"https://orcid.org/0000-0002-1314-894X","affiliations":[{"raw_affiliation_string":"International Biotechnology Center \u201cGENERIUM\u201d","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1908,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.82733055,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"21","issue":"3","first_page":"178","last_page":"192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/covid-19-survivors","display_name":"COVID-19 survivors","score":0.9359999895095825},{"id":"https://openalex.org/keywords/covid-19-vaccination","display_name":"COVID-19 vaccination","score":0.8889999985694885},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.578000009059906},{"id":"https://openalex.org/keywords/elispot-assay","display_name":"ELISPOT assay","score":0.8510000109672546},{"id":"https://openalex.org/keywords/t-cell-response","display_name":"T cell response","score":0.5220000147819519},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.7590000033378601},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C2779053233","wikidata":"https://www.wikidata.org/wiki/Q731235","display_name":"ELISPOT","level":4,"score":0.9157747030258179},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.67341548204422},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.6472154855728149},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.6346824169158936},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5758859515190125},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5288459062576294},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5024337768554688},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.4981517791748047},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4698067307472229},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.46580037474632263},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.46377888321876526},{"id":"https://openalex.org/C3017875465","wikidata":"https://www.wikidata.org/wiki/Q189146","display_name":"Cellular immunity","level":3,"score":0.4498330056667328},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.44849562644958496},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.4379420578479767},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.4237544536590576},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3437284529209137},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3350484371185303},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10008111596107483},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.08300340175628662},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.30895/2221-996x-2021-21-3-178-192","doi":"https://doi.org/10.30895/2221-996x-2021-21-3-178-192","is_oa":true,"landing_page_url":"https://doi.org/10.30895/2221-996x-2021-21-3-178-192","pdf_url":"https://www.biopreparations.ru/jour/article/download/374/438","source":{"id":"https://openalex.org/S4210169820","display_name":"Biological Products Prevention Diagnosis Treatment","issn_l":"2221-996X","issn":["2221-996X","2619-1156"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Products. Prevention, Diagnosis, Treatment","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:4cb802dafa41407c80ad4f74e8dacd73","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4cb802dafa41407c80ad4f74e8dacd73","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0411\u0438\u043e\u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u044b: \u041f\u0440\u043e\u0444\u0438\u043b\u0430\u043a\u0442\u0438\u043a\u0430, \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430, \u043b\u0435\u0447\u0435\u043d\u0438\u0435, Vol 21, Iss 3, Pp 178-192 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.30895/2221-996x-2021-21-3-178-192","doi":"https://doi.org/10.30895/2221-996x-2021-21-3-178-192","is_oa":true,"landing_page_url":"https://doi.org/10.30895/2221-996x-2021-21-3-178-192","pdf_url":"https://www.biopreparations.ru/jour/article/download/374/438","source":{"id":"https://openalex.org/S4210169820","display_name":"Biological Products Prevention Diagnosis Treatment","issn_l":"2221-996X","issn":["2221-996X","2619-1156"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Products. Prevention, Diagnosis, Treatment","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3207790843.pdf","grobid_xml":"https://content.openalex.org/works/W3207790843.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W2025080738","https://openalex.org/W2087813773","https://openalex.org/W2092563148","https://openalex.org/W2106247702","https://openalex.org/W2769549108","https://openalex.org/W3015060295","https://openalex.org/W3018274661","https://openalex.org/W3018517500","https://openalex.org/W3027204812","https://openalex.org/W3037718428","https://openalex.org/W3042183476","https://openalex.org/W3043559115","https://openalex.org/W3044311014","https://openalex.org/W3047159181","https://openalex.org/W3048775784","https://openalex.org/W3082438395","https://openalex.org/W3083285583","https://openalex.org/W3083750089","https://openalex.org/W3087225540","https://openalex.org/W3087265144","https://openalex.org/W3093824751","https://openalex.org/W3095375824","https://openalex.org/W3103140952","https://openalex.org/W3109331896","https://openalex.org/W3114439193","https://openalex.org/W3121008609","https://openalex.org/W3131926645","https://openalex.org/W3134099704","https://openalex.org/W3136627989","https://openalex.org/W3137307037","https://openalex.org/W4407668627"],"related_works":["https://openalex.org/W4311499194","https://openalex.org/W4295221794","https://openalex.org/W3205500699","https://openalex.org/W4319789637","https://openalex.org/W4410575568","https://openalex.org/W4390888667","https://openalex.org/W3197591755","https://openalex.org/W3112164905","https://openalex.org/W4380204493","https://openalex.org/W4386067810"],"abstract_inverted_index":{"With":[0],"the":[1,4,146,181,190,202,217,229,232,263,268,297,304,311,316,324,327,330,343,353,364,370],"onset":[2],"of":[3,9,39,60,81,92,96,106,117,124,129,145,168,192,205,208,240,257,267,303,326,332,337,340,366,392],"COVID-19":[5,222,347],"pandemic,":[6],"a":[7,36,51,58,104,154,161,358],"number":[8,59,191],"molecular-based":[10],"tests":[11,23],"have":[12,50,62],"been":[13],"developed":[14,185,231],"to":[15,67,84,149,157,171,243,301,342,369,394],"diagnose":[16],"SARS-CoV-2":[17,85,172,183,234,244,355,371],"infection.":[18],"However,":[19],"numerous":[20],"available":[21],"serological":[22],"lack":[24],"sufficient":[25],"sensitivity":[26],"or":[27,126,289],"specificity.":[28],"They":[29],"do":[30],"not":[31,88,141],"detect":[32],"specific":[33,130,170,242,359],"antibodies":[34],"in":[35,136,160,165,174,197,201,216,237,246,271,283,310,315,386],"significant":[37],"proportion":[38],"patients":[40],"with":[41,100,286,290],"PCR-confirmed":[42],"COVID-19.":[43],"There":[44],"is":[45,86,357],"evidence":[46],"that":[47,64,296],"some":[48,284],"convalescents":[49],"relatively":[52],"short-lived":[53],"humoral":[54],"immunity.":[55],"In":[56],"contrast,":[57],"publications":[61],"shown":[63,282],"T-cell":[65,82,131,269,278,299,333,344,367],"response":[66,132,270,279,300,345],"human":[68,175,247],"coronaviruses,":[69],"including":[70],"SARS-CoV-1,":[71],"MERS,":[72],"and":[73,78,94,114,139,151,179,253,265,273,329,360],"SARS-CoV-2,":[74],"can":[75,374],"be":[76,158,376,384],"strong":[77],"long-term.":[79],"Assessment":[80],"immunity":[83,101,368,393],"important":[87],"only":[89],"for":[90,111,164,236,363,378,389],"stratification":[91],"risks":[93],"identification":[95],"potentially":[97],"protected":[98],"populations":[99],"acquired":[102],"as":[103],"result":[105],"previous":[107],"infection,":[108],"but":[109],"also":[110,281,350,375],"determining":[112],"immunogenicity":[113],"potential":[115],"efficacy":[116],"vaccines":[118],"under":[119],"development.":[120],"The":[121,143,260,381],"existing":[122],"methods":[123],"quantitative":[125],"semi-quantitative":[127],"assessment":[128,256,365,391],"are":[133,140],"mainly":[134],"used":[135,159,377,385],"scientific":[137],"research":[138],"standardised.":[142],"aim":[144],"study":[147,261],"was":[148,199,280,294,308,321],"develop":[150],"verify":[152],"experimentally":[153],"test":[155],"kit":[156,184,235,356,382],"standardised":[162],"procedure":[163],"vitro":[166,238],"determination":[167,239],"T-cells":[169,193,241],"antigens,":[173],"peripheral":[176,248],"blood.":[177],"Materials":[178],"methods:":[180],"TigraTest\u00ae":[182,233,354],"by":[186],"GENERIUM,":[187],"which":[188,373],"determines":[189],"secreting":[194],"interferon":[195],"gamma":[196],"vitro,":[198],"tested":[200],"study.":[203],"Samples":[204],"venous":[206],"blood":[207],"volunteers":[209],"from":[210],"three":[211],"different":[212],"groups":[213,339],"were":[214,349],"analysed":[215,262],"study:":[218],"presumably":[219],"healthy":[220],"volunteers;":[221],"convalescents;":[223],"individuals":[224,285,313],"vaccinated":[225,274,312,379],"against":[226],"SARS-CoV-2.":[227,395],"Results:":[228],"authors":[230],"antigens":[245,341],"blood,":[249],"demonstrated":[250],"its":[251,258],"specificity":[252],"performed":[254],"preliminary":[255],"sensitivity.":[259],"range":[264],"magnitude":[266],"convalescent":[272,317],"individuals.":[275,380],"A":[276,319],"pronounced":[277],"no":[287],"symptoms":[288],"unconfirmed":[291],"diagnosis.":[292],"It":[293],"discovered":[295],"mean":[298],"peptides":[302],"spike":[305],"protein":[306],"(S-protein)":[307],"higher":[309],"than":[314],"patients.":[318],"correlation":[320],"determined":[322],"between":[323],"severity":[325],"disease":[328],"level":[331],"response.":[334],"Specific":[335],"contributions":[336],"various":[338],"after":[346],"infection":[348],"determined.":[351],"Conclusions:":[352],"sensitive":[361],"tool":[362],"virus,":[372],"may":[383],"clinical":[387],"practice":[388],"comprehensive":[390]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2021-10-25T00:00:00"}