{"id":"https://openalex.org/W3207784019","doi":"https://doi.org/10.1093/infdis/jiab531","title":"Angiotensin-Converting Enzyme 2 Genetic Variants Are Associated With Coronavirus Disease 2019","display_name":"Angiotensin-Converting Enzyme 2 Genetic Variants Are Associated With Coronavirus Disease 2019","publication_year":2021,"publication_date":"2021-10-11","ids":{"openalex":"https://openalex.org/W3207784019","doi":"https://doi.org/10.1093/infdis/jiab531","mag":"3207784019","pmid":"https://pubmed.ncbi.nlm.nih.gov/34644391"},"language":"en","primary_location":{"id":"doi:10.1093/infdis/jiab531","doi":"https://doi.org/10.1093/infdis/jiab531","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jiab531","pdf_url":"https://academic.oup.com/jid/article-pdf/224/12/2181/41771782/jiab531.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jid/article-pdf/224/12/2181/41771782/jiab531.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004300211","display_name":"Abhijit Pati","orcid":"https://orcid.org/0000-0002-4070-0007","observed_orcids":["https://orcid.org/0000-0002-4070-0007"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abhijit Pati","raw_affiliation_strings":["Department of Bioscience and Bioinformatics, Khallikote University, Berhampur, Odisha, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioscience and Bioinformatics, Khallikote University, Berhampur, Odisha, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110088422","display_name":"Sunali Padhi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sunali Padhi","raw_affiliation_strings":["Department of Bioscience and Bioinformatics, Khallikote University, Berhampur, Odisha, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioscience and Bioinformatics, Khallikote University, Berhampur, Odisha, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tapan Kumar Singh Nayak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tapan Kumar Singh Nayak","raw_affiliation_strings":["Department of Bioscience and Bioinformatics, Khallikote University, Berhampur, Odisha, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioscience and Bioinformatics, Khallikote University, Berhampur, Odisha, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047135932","display_name":"Aditya K. Panda","orcid":"https://orcid.org/0000-0002-1192-1978","observed_orcids":["https://orcid.org/0000-0002-1192-1978"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Aditya K Panda","raw_affiliation_strings":["Department of Bioscience and Bioinformatics, Khallikote University, Berhampur, Odisha, India"],"raw_orcid":"https://orcid.org/0000-0002-1192-1978","affiliations":[{"raw_affiliation_string":"Department of Bioscience and Bioinformatics, Khallikote University, Berhampur, Odisha, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5047135932"],"corresponding_institution_ids":[],"apc_list":{"value":4052,"currency":"USD","value_usd":4052},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"224","issue":"12","first_page":"2181","last_page":"2183"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.6601999998092651,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.6601999998092651,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.2728999853134155,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.03889999911189079,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-converting-enzyme-2","display_name":"angiotensin-converting enzyme 2","score":0.9399999976158142},{"id":"https://openalex.org/keywords/ace2-gene","display_name":"ACE2 gene","score":0.9070000052452087},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9020000100135803},{"id":"https://openalex.org/keywords/covid-19-susceptibility","display_name":"COVID-19 susceptibility","score":0.824999988079071},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.8930000066757202},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.7829999923706055},{"id":"https://openalex.org/keywords/rs2285666","display_name":"rs2285666","score":0.9980000257492065},{"id":"https://openalex.org/keywords/allele-frequency","display_name":"allele frequency","score":0.5540000200271606},{"id":"https://openalex.org/keywords/covid-19-mortality","display_name":"COVID-19 mortality","score":0.8109999895095825},{"id":"https://openalex.org/keywords/host-genetic-susceptibility","display_name":"host genetic susceptibility","score":0.49300000071525574}],"concepts":[{"id":"https://openalex.org/C2775946041","wikidata":"https://www.wikidata.org/wiki/Q14875321","display_name":"Angiotensin-converting enzyme 2","level":5,"score":0.7818609476089478},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.5918400287628174},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.5852550864219666},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.5145675539970398},{"id":"https://openalex.org/C2910482119","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Peptidyl-Dipeptidase A","level":4,"score":0.5130337476730347},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.45501509308815},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.4468199908733368},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4305681884288788},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.4298032820224762},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.42141997814178467},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4183320701122284},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39728033542633057},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3338494896888733},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3182719945907593},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29823026061058044},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23635509610176086},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.16931414604187012},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.11403629183769226},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08810004591941833},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.06026381254196167},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.05734768509864807}],"mesh":[{"descriptor_ui":"D000085962","descriptor_name":"Angiotensin-Converting Enzyme 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012084","descriptor_name":"Renin-Angiotensin System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057911","descriptor_name":"Angiotensin Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/infdis/jiab531","doi":"https://doi.org/10.1093/infdis/jiab531","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jiab531","pdf_url":"https://academic.oup.com/jid/article-pdf/224/12/2181/41771782/jiab531.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:34644391","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34644391","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of infectious diseases","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/infdis/jiab531","doi":"https://doi.org/10.1093/infdis/jiab531","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jiab531","pdf_url":"https://academic.oup.com/jid/article-pdf/224/12/2181/41771782/jiab531.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320720","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3207784019.pdf","grobid_xml":"https://content.openalex.org/works/W3207784019.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W3004280078","https://openalex.org/W3014571869","https://openalex.org/W3130896424","https://openalex.org/W3164646585","https://openalex.org/W3183717985"],"related_works":["https://openalex.org/W4281669174","https://openalex.org/W3175374188","https://openalex.org/W4286843592","https://openalex.org/W4389131945","https://openalex.org/W4312176840","https://openalex.org/W4292978060","https://openalex.org/W3208162236","https://openalex.org/W3185636606","https://openalex.org/W3165381336","https://openalex.org/W3084461088"],"abstract_inverted_index":{"To":[0],"The":[1,96,184,238,313,411,432,760,782,788],"Editor\u2014In":[2],"a":[3,76,101,161,319,600,638],"recent":[4,635],"article,":[5],"Li":[6],"et":[7],"al":[8],"[1]":[9],"investigated":[10],"angiotensin-converting":[11,391],"enzyme":[12,392],"2":[13,54,393,405,517],"(ACE2)":[14,394],"expression":[15,47,92,97,602],"in":[16,35,78,90,100,141,166,268,441,608,618,630,677,688,692,746],"primary":[17],"epithelial":[18],"cells":[19,520,525,598],"derived":[20],"from":[21,195,220,229,422,445,450,822],"the":[22,40,62,66,79,113,142,158,167,181,187,221,235,250,302,359,423,461,501,531,609,655,661,673,678,682,711,723,773,780,795,799,810,846],"lungs":[23],"of":[24,45,81,87,98,110,127,163,186,226,295,326,362,387,390,463,561,580,603,641,664,681,726,762,769,790,798,825,833,840,851,854],"58":[25],"human":[26,519],"subjects":[27,443,576],"and":[28,57,73,176,214,242,264,297,329,341,345,354,368,382,398,408,414,439,470,478,480,487,510,570,588,627,647,653,685,715,731,738,743],"observed":[29,377],"no":[30,373],"significant":[31,320,374,639],"alteration":[32],"between":[33,323],"genders":[34],"different":[36,446,747],"age":[37],"groups.":[38],"Furthermore,":[39],"authors":[41,67,843],"highlighted":[42],"minimal":[43],"effects":[44],"ACE2":[46,74,91,99,143,168,384,502,522,527,543,563,581,604,610,666,683,727],"on":[48,133,157,249,306,428,710],"severe":[49,401,568],"acute":[50,402,513],"respiratory":[51,403,514],"syndrome":[52,404,515],"coronavirus":[53,82,516],"(SARS-CoV-2)":[55,406],"replication":[56],"host":[58,71,114],"immune":[59],"response":[60],"against":[61,365,507,585,735],"invading":[63],"virus.":[64],"Although":[65,633],"concluded":[68,721],"that":[69,138,539,596,672,686,701,722,775],"other":[70],"variables":[72],"have":[75,121,129,564,605,844],"role":[77],"etiology":[80],"disease":[83],"2019":[84],"(COVID-19),":[85],"observations":[86],"interindividual":[88],"variance":[89],"cannot":[93],"be":[94,146,537,720,807],"overlooked.":[95],"subject":[102],"has":[103],"been":[104,122,565],"ascribed":[105],"to":[106,150,459,548,594,623,699,706,751,778,809],"various":[107,196,624],"reasons,":[108],"one":[109],"which":[111],"is":[112,498,592,668,697,815],"genetic":[115,703],"makeup.":[116],"Various":[117,254],"single-nucleotide":[118],"polymorphisms":[119,331,395,649,667,728],"(SNPs)":[120],"reported":[123,838],"(https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?locusId=59272);":[124],"however,":[125],"few":[126],"them":[128],"functional":[130,159,662],"relevance.":[131],"Based":[132,156,709],"these":[134,665,702],"observations,":[135,717],"we":[136],"hypothesized":[137],"common":[139],"SNPs":[140,165,192,675],"gene":[144,169,684],"would":[145],"associated":[147,571],"with":[148,332,400,473,541,554,567,599,650,817],"susceptibility":[149],"SARS-CoV-2":[151,239,260,333,412,474,508,550,651,736],"infection":[152,240,261,334,367,407,413,551,652,737],"or":[153,802],"related":[154,346,589],"mortality.":[155,511,590],"relevance,":[160],"total":[162],"7":[164],"(rs4240157,":[170],"rs4646155,":[171,327,437,645],"rs4830542,":[172,380],"rs2074192,":[173,381],"rs233575,":[174,328,397,438,646,730],"rs2158083,":[175],"rs2285666)":[177],"were":[178,193,232,299,420,448],"considered":[179,233,494],"for":[180,190,234,301,378,436,644,849],"present":[182,236,303,712],"investigation.":[183],"prevalence":[185],"alternative":[188,324,363,388,433,464,503,642,724],"alleles":[189,325,364,389,465,504,643,725],"respective":[191],"obtained":[194,421,449],"databases":[197],"such":[198,256],"as":[199,257,495],"1000":[200],"genomes,":[201],"Korean":[202],"Reference":[203],"Genome":[204],"Database,":[205],"Japanese":[206],"whole-genome":[207],"reference":[208,212],"panel":[209],"8.3KJPN,":[210],"Danish":[211],"pan-genome,":[213],"medical":[215],"genome":[216],"project":[217],"healthy":[218,227,442],"control":[219],"Spanish":[222],"population.":[223],"Genomic":[224],"data":[225,255,419,770,793],"controls":[228],"21":[230,269],"countries":[231,270,447],"analysis.":[237],"rate":[241,244,416,482],"death":[243,265,347,481,572],"per":[245,262,266,417,483],"million":[246,267,418,484],"are":[247,545,582,676,749,757,776,785,794],"available":[248,758],"Worldometer":[251,424],"website":[252,425],"(https://www.worldometers.info/coronavirus/).":[253],"countries\u2019":[258],"name,":[259],"million,":[263],"(Bangladesh,":[271],"China,":[272],"Colombia,":[273],"Denmark,":[274],"Finland,":[275],"Gambia,":[276],"India,":[277],"Italy,":[278],"Japan,":[279],"Kenya,":[280],"Korea,":[281],"Mexico,":[282],"Nigeria,":[283],"Pakistan,":[284],"Peru,":[285],"Sierra":[286],"Leone,":[287],"Spain,":[288],"Sri":[289],"Lanka,":[290],"United":[291,293],"Kingdom,":[292],"States":[294],"America,":[296],"Vietnam)":[298],"extracted":[300],"analysis":[304,317,456,636],"(assessed":[305],"August":[307,429],"19,":[308,430],"2021)":[309],"(Supplementary":[310],"Table":[311],"1).":[312,371],"Spearman":[314,453],"rank":[315,454],"correlation":[316,375,462],"revealed":[318],"inverse":[321],"link":[322],"rs2158083":[330,440,648],"(rs4646155:":[335,348,466],"r=\u22120.617,":[336],"P=.003;":[337],"rs233575:":[338,351,468],"r=\u22120.786,":[339],"P<.0001;":[340],"rs2158083:":[342,355,471],"r=\u22120.663,":[343],"P=.001)":[344],"r=\u22120.569,":[349],"P=.008;":[350],"r=\u22120.725,":[352],"P=.0002;":[353],"r=\u22120.553,":[356],"P=.009),":[357],"indicating":[358],"protective":[360],"nature":[361],"COVID-19":[366,569,586,631,707],"mortality":[369,409,415],"(Figure":[370],"However,":[372,740],"was":[376,457,493],"rs4240157,":[379],"rs2285666":[383],"polymorphisms.":[385],"Correlation":[386],"(rs4646155,":[396,729],"rs2158083)":[399,732],"rate.":[410],"(https://www.worldometers.info/coronavirus/,":[426],"assessed":[427],"2021).":[431],"allele":[434],"frequencies":[435],"hailed":[444],"online":[451],"databases.":[452],"coefficient":[455],"performed":[458],"investigate":[460],"T;":[467],"A;":[469],"T)":[472],"infection/million":[475],"(A,":[476],"C,":[477],"E)":[479],"(B,":[485],"D,":[486],"F).":[488],"A":[489],"P":[490],"<":[491],".05":[492],"significant.":[496],"It":[497,591],"unclear":[499],"how":[500],"provide":[505],"protection":[506,734],"infections":[509],"Severe":[512],"infects":[518],"via":[521],"receptors,":[523],"whereas":[524],"lacking":[526],"remain":[528],"uninfected":[529],"by":[530,772],"virus":[532],"[2].":[533],"Thus,":[534,575],"it":[535,696,718],"can":[536,719],"assumed":[538],"people":[540],"lower":[542,578],"levels":[544,560,579],"less":[546],"likely":[547],"contract":[549],"than":[552],"those":[553],"elevated":[555],"ACE2.":[556],"In":[557],"addition,":[558],"higher":[559],"soluble":[562],"linked":[566],"[3,":[573],"4].":[574],"expressing":[577],"possibly":[583],"protected":[584],"severity":[587,629],"interesting":[593],"note":[595],"SARS-CoV-infected":[597],"diminished":[601],"an":[606],"imbalance":[607],"angiotensin":[611,615],"II":[612,616],"axis.":[613],"Elevated":[614],"results":[617],"greater":[619],"inflammatory":[620],"molecules,":[621],"leading":[622],"organ":[625],"failures":[626],"clinical":[628],"[5].":[632],"our":[634,753],"indicated":[637],"association":[640],"death,":[654],"possible":[656],"mechanism":[657],"remained":[658],"unexplored,":[659],"because":[660],"significance":[663],"largely":[669],"unknown.":[670],"Given":[671],"3":[674],"intronic":[679],"region":[680],"variation":[687],"introns":[689],"might":[690],"result":[691],"altered":[693],"transcription":[694],"[3],":[695],"reasonable":[698],"assume":[700],"variants":[704],"contribute":[705],"pathogenesis.":[708],"study\u2019s":[713],"findings":[714],"earlier":[716],"confer":[733],"death.":[739],"additional":[741],"case-control":[742],"mechanistic":[744],"studies":[745],"populations":[748],"necessary":[750],"validate":[752],"findings.":[754],"Supplementary":[755,766],"materials":[756,767,784],"at":[759],"Journal":[761],"Infectious":[763],"Diseases":[764],"online.":[765],"consist":[768],"provided":[771],"author":[774],"published":[777],"benefit":[779],"reader.":[781],"posted":[783],"not":[786],"copyedited.":[787],"contents":[789],"all":[791],"supplementary":[792],"sole":[796],"responsibility":[797],"authors.":[800],"Questions":[801],"messages":[803],"regarding":[804],"errors":[805],"should":[806],"addressed":[808],"author.":[811],"Financial":[812],"support.":[813],"A.P.":[814],"supported":[816],"Senior":[818],"Research":[819,827],"Fellowship":[820],"(SRF)":[821],"Indian":[823],"Council":[824],"Medical":[826],"(ICMR)":[828],"New":[829],"Delhi.":[830],"Potential":[831,852],"conflicts":[832,839],"interest.":[834,841],"All":[835,842],"authors:":[836],"No":[837],"submitted":[845],"ICMJE":[847],"Form":[848],"Disclosure":[850],"Conflicts":[853],"Interest.":[855]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-10-25T00:00:00"}
