{"id":"https://openalex.org/W3207717469","doi":"https://doi.org/10.1186/s13046-021-02141-z","title":"Targeting strategies for oxaliplatin-induced peripheral neuropathy: clinical syndrome, molecular basis, and drug development","display_name":"Targeting strategies for oxaliplatin-induced peripheral neuropathy: clinical syndrome, molecular basis, and drug development","publication_year":2021,"publication_date":"2021-10-22","ids":{"openalex":"https://openalex.org/W3207717469","doi":"https://doi.org/10.1186/s13046-021-02141-z","mag":"3207717469","pmid":"https://pubmed.ncbi.nlm.nih.gov/34686205"},"language":"en","primary_location":{"id":"doi:10.1186/s13046-021-02141-z","doi":"https://doi.org/10.1186/s13046-021-02141-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13046-021-02141-z","pdf_url":"https://jeccr.biomedcentral.com/track/pdf/10.1186/s13046-021-02141-z","source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental &amp; Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jeccr.biomedcentral.com/track/pdf/10.1186/s13046-021-02141-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060273427","display_name":"Yang Yang","orcid":"https://orcid.org/0000-0002-5923-8270","observed_orcids":["https://orcid.org/0000-0002-5923-8270"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]},{"id":"https://openalex.org/I4210135979","display_name":"Yangtze River Pharmaceutical Group (China)","ror":"https://ror.org/03n5f7689","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210135979"]},{"id":"https://openalex.org/I4405271966","display_name":"Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica","ror":"https://ror.org/03bhw7672","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271966"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yang Yang","raw_affiliation_strings":["Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 100#, Hongshan Road, Nanjing, 210028, Jiangsu, China. young1570@126.com","Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China. young1570@126.com","Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China. young1570@126.com","Yangtze River Pharmaceutical Group, Taizhou, 225321, China. young1570@126.com","Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 100#, Hongshan Road, Nanjing, 210028, Jiangsu, China"],"raw_orcid":"https://orcid.org/0000-0002-5923-8270","affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 100#, Hongshan Road, Nanjing, 210028, Jiangsu, China. young1570@126.com","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China. young1570@126.com","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China. young1570@126.com","institution_ids":["https://openalex.org/I131434179","https://openalex.org/I4405271966"]},{"raw_affiliation_string":"Yangtze River Pharmaceutical Group, Taizhou, 225321, China. young1570@126.com","institution_ids":["https://openalex.org/I4210135979"]},{"raw_affiliation_string":"Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 100#, Hongshan Road, Nanjing, 210028, Jiangsu, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103217641","display_name":"Bing Zhao","orcid":"https://orcid.org/0000-0002-1594-5504","observed_orcids":["https://orcid.org/0000-0002-1594-5504"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing Zhao","raw_affiliation_strings":["Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 100#, Hongshan Road, Nanjing, 210028, Jiangsu, China","Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 100#, Hongshan Road, Nanjing, 210028, Jiangsu, China","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103243926","display_name":"Xuejiao Gao","orcid":"https://orcid.org/0000-0001-5269-812X","observed_orcids":["https://orcid.org/0000-0001-5269-812X"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuejiao Gao","raw_affiliation_strings":["Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 100#, Hongshan Road, Nanjing, 210028, Jiangsu, China","Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 100#, Hongshan Road, Nanjing, 210028, Jiangsu, China","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060131319","display_name":"Jinbing Sun","orcid":"https://orcid.org/0000-0002-3400-6035","observed_orcids":["https://orcid.org/0000-0002-3400-6035"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210125581","display_name":"Changshu No.1 People's Hospital","ror":"https://ror.org/032hk6448","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125581"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinbing Sun","raw_affiliation_strings":["Changshu No.1 People's Hospital Affiliated to Soochow University, Changshu, 215500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changshu No.1 People's Hospital Affiliated to Soochow University, Changshu, 215500, China","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210125581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100682480","display_name":"Juan Ye","orcid":"https://orcid.org/0000-0002-1948-2500","observed_orcids":["https://orcid.org/0000-0002-1948-2500","https://orcid.org/0009-0001-5741-4867"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Ye","raw_affiliation_strings":["Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 100#, Hongshan Road, Nanjing, 210028, Jiangsu, China","Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 100#, Hongshan Road, Nanjing, 210028, Jiangsu, China","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108047719","display_name":"Jun Li","orcid":"https://orcid.org/0000-0002-8623-0581","observed_orcids":["https://orcid.org/0000-0002-8623-0581"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Li","raw_affiliation_strings":["Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, P.R. China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047259641","display_name":"Peng Cao","orcid":"https://orcid.org/0000-0002-2044-3074","observed_orcids":["https://orcid.org/0000-0002-2044-3074","https://orcid.org/0009-0003-9510-9091"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Peng Cao","raw_affiliation_strings":["Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 100#, Hongshan Road, Nanjing, 210028, Jiangsu, China. cao_peng@njucm.edu.cn","Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China. cao_peng@njucm.edu.cn","Zhenjiang Hospital of Chinese Traditional and Western Medicine, Zhenjiang, 212002, Jiangsu, China. cao_peng@njucm.edu.cn","Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 100#, Hongshan Road, Nanjing, 210028, Jiangsu, China. cao_peng@njucm.edu.cn","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China. cao_peng@njucm.edu.cn","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"Zhenjiang Hospital of Chinese Traditional and Western Medicine, Zhenjiang, 212002, Jiangsu, China. cao_peng@njucm.edu.cn","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China","institution_ids":["https://openalex.org/I131434179"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5047259641","https://openalex.org/A5060273427"],"corresponding_institution_ids":["https://openalex.org/I131434179","https://openalex.org/I4210135979","https://openalex.org/I4405271966"],"apc_list":{"value":3380,"currency":"USD","value_usd":3380},"apc_paid":{"value":3380,"currency":"USD","value_usd":3380},"fwci":4.016,"has_fulltext":true,"cited_by_count":94,"citation_normalized_percentile":{"value":0.96187591,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"40","issue":"1","first_page":"331","last_page":"331"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxaliplatin","display_name":"oxaliplatin","score":0.8799999952316284},{"id":"https://openalex.org/keywords/peripheral-neuropathy","display_name":"peripheral neuropathy","score":0.8330000042915344},{"id":"https://openalex.org/keywords/chemotherapy-induced-neurotoxicity","display_name":"chemotherapy-induced neurotoxicity","score":0.8849999904632568},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.781000018119812},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6000000238418579},{"id":"https://openalex.org/keywords/molecular-mechanisms","display_name":"molecular mechanisms","score":0.7490000128746033},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.5559999942779541},{"id":"https://openalex.org/keywords/duloxetine","display_name":"duloxetine","score":0.7910000085830688},{"id":"https://openalex.org/keywords/prevention","display_name":"prevention","score":0.5090000033378601},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6909999847412109},{"id":"https://openalex.org/keywords/cancer-pain-management","display_name":"cancer pain management","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8353354930877686},{"id":"https://openalex.org/C2779901536","wikidata":"https://www.wikidata.org/wiki/Q945238","display_name":"Peripheral neuropathy","level":3,"score":0.6192097663879395},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.5668347477912903},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.5448501110076904},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4971208870410919},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.43033719062805176},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3872191309928894},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34756630659103394},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3299620449542999},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3105851411819458},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2548922300338745},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.11424115300178528},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.07596752047538757},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013577","descriptor_name":"Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013577","descriptor_name":"Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013577","descriptor_name":"Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019468","descriptor_name":"Disease Management","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019468","descriptor_name":"Disease Management","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019468","descriptor_name":"Disease Management","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s13046-021-02141-z","doi":"https://doi.org/10.1186/s13046-021-02141-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13046-021-02141-z","pdf_url":"https://jeccr.biomedcentral.com/track/pdf/10.1186/s13046-021-02141-z","source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental &amp; Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:34686205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34686205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of experimental & clinical cancer research : CR","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:7431513","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8532307","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8532307","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8532307","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Exp Clin Cancer Res","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:722ae5da3725440684ae0c7c17a471c7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/722ae5da3725440684ae0c7c17a471c7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-25 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13046-021-02141-z","doi":"https://doi.org/10.1186/s13046-021-02141-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13046-021-02141-z","pdf_url":"https://jeccr.biomedcentral.com/track/pdf/10.1186/s13046-021-02141-z","source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental &amp; Clinical Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4399999976158142,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2144716447","display_name":null,"funder_award_id":"81973498","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2809573382","display_name":null,"funder_award_id":"82125037","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3643099709","display_name":null,"funder_award_id":"81774283","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7257804239","display_name":null,"funder_award_id":"82125037","funder_id":"https://openalex.org/F4320336125","funder_display_name":"National Science Fund for Distinguished Young Scholars"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335687","display_name":"Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica","ror":"https://ror.org/03bhw7672"},{"id":"https://openalex.org/F4320336125","display_name":"National Science Fund for Distinguished Young Scholars","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3207717469.pdf","grobid_xml":"https://content.openalex.org/works/W3207717469.grobid-xml"},"referenced_works_count":212,"referenced_works":["https://openalex.org/W1051008347","https://openalex.org/W1561971247","https://openalex.org/W1629196859","https://openalex.org/W1778762198","https://openalex.org/W1883489645","https://openalex.org/W1963663378","https://openalex.org/W1965715834","https://openalex.org/W1966667955","https://openalex.org/W1968626722","https://openalex.org/W1969076414","https://openalex.org/W1973839513","https://openalex.org/W1975520592","https://openalex.org/W1976085931","https://openalex.org/W1977663897","https://openalex.org/W1980450602","https://openalex.org/W1980562969","https://openalex.org/W1981465968","https://openalex.org/W1992063739","https://openalex.org/W1992372874","https://openalex.org/W1993397541","https://openalex.org/W1995300665","https://openalex.org/W1997980896","https://openalex.org/W1998043521","https://openalex.org/W1998507857","https://openalex.org/W2005692725","https://openalex.org/W2007302872","https://openalex.org/W2008902622","https://openalex.org/W2009046911","https://openalex.org/W2009707259","https://openalex.org/W2011033166","https://openalex.org/W2012330364","https://openalex.org/W2014969455","https://openalex.org/W2020833122","https://openalex.org/W2022836457","https://openalex.org/W2025968906","https://openalex.org/W2026423509","https://openalex.org/W2027642651","https://openalex.org/W2032609740","https://openalex.org/W2040595891","https://openalex.org/W2049899770","https://openalex.org/W2051114387","https://openalex.org/W2052278699","https://openalex.org/W2057662279","https://openalex.org/W2058983865","https://openalex.org/W2059074940","https://openalex.org/W2059786204","https://openalex.org/W2065478958","https://openalex.org/W2067898251","https://openalex.org/W2071620144","https://openalex.org/W2072022627","https://openalex.org/W2076296281","https://openalex.org/W2079719679","https://openalex.org/W2080382070","https://openalex.org/W2081877352","https://openalex.org/W2084893146","https://openalex.org/W2087838893","https://openalex.org/W2089729192","https://openalex.org/W2090519636","https://openalex.org/W2091378110","https://openalex.org/W2092340811","https://openalex.org/W2100418754","https://openalex.org/W2102674981","https://openalex.org/W2103209607","https://openalex.org/W2103447688","https://openalex.org/W2103602375","https://openalex.org/W2104476156","https://openalex.org/W2106201634","https://openalex.org/W2106712365","https://openalex.org/W2109054243","https://openalex.org/W2114458368","https://openalex.org/W2117045578","https://openalex.org/W2121368761","https://openalex.org/W2124634039","https://openalex.org/W2127740872","https://openalex.org/W2127933589","https://openalex.org/W2128519670","https://openalex.org/W2129155568","https://openalex.org/W2129632445","https://openalex.org/W2137634045","https://openalex.org/W2138474390","https://openalex.org/W2145689186","https://openalex.org/W2148570600","https://openalex.org/W2149527926","https://openalex.org/W2149603226","https://openalex.org/W2154159423","https://openalex.org/W2155770121","https://openalex.org/W2156409369","https://openalex.org/W2158499547","https://openalex.org/W2161160099","https://openalex.org/W2161636334","https://openalex.org/W2162730620","https://openalex.org/W2164998622","https://openalex.org/W2166443941","https://openalex.org/W2167571044","https://openalex.org/W2170802167","https://openalex.org/W2175773713","https://openalex.org/W2176841557","https://openalex.org/W2191527115","https://openalex.org/W2191831187","https://openalex.org/W2216726856","https://openalex.org/W2237245576","https://openalex.org/W2255650972","https://openalex.org/W2310218110","https://openalex.org/W2397657947","https://openalex.org/W2397961238","https://openalex.org/W2399389980","https://openalex.org/W2511631274","https://openalex.org/W2514093340","https://openalex.org/W2517340225","https://openalex.org/W2519510195","https://openalex.org/W2528348279","https://openalex.org/W2561650646","https://openalex.org/W2566839157","https://openalex.org/W2571321248","https://openalex.org/W2572784602","https://openalex.org/W2576404523","https://openalex.org/W2577605944","https://openalex.org/W2580584788","https://openalex.org/W2595493677","https://openalex.org/W2598773833","https://openalex.org/W2618483800","https://openalex.org/W2620036274","https://openalex.org/W2621825389","https://openalex.org/W2637410905","https://openalex.org/W2724969245","https://openalex.org/W2726036270","https://openalex.org/W2730708157","https://openalex.org/W2734623137","https://openalex.org/W2734713643","https://openalex.org/W2736312583","https://openalex.org/W2737110054","https://openalex.org/W2743582201","https://openalex.org/W2747807556","https://openalex.org/W2750084680","https://openalex.org/W2750983142","https://openalex.org/W2754964191","https://openalex.org/W2758315038","https://openalex.org/W2761809679","https://openalex.org/W2766552310","https://openalex.org/W2767154219","https://openalex.org/W2768996399","https://openalex.org/W2773429266","https://openalex.org/W2775754599","https://openalex.org/W2783215140","https://openalex.org/W2783534816","https://openalex.org/W2783968535","https://openalex.org/W2786883050","https://openalex.org/W2793239171","https://openalex.org/W2793592230","https://openalex.org/W2795004340","https://openalex.org/W2799442274","https://openalex.org/W2804818935","https://openalex.org/W2805466009","https://openalex.org/W2807968746","https://openalex.org/W2808700523","https://openalex.org/W2883443875","https://openalex.org/W2883523160","https://openalex.org/W2887794732","https://openalex.org/W2887926439","https://openalex.org/W2889628754","https://openalex.org/W2896668430","https://openalex.org/W2897123913","https://openalex.org/W2898151937","https://openalex.org/W2898447103","https://openalex.org/W2901646746","https://openalex.org/W2902202470","https://openalex.org/W2902281143","https://openalex.org/W2906588216","https://openalex.org/W2909588616","https://openalex.org/W2911971051","https://openalex.org/W2912194533","https://openalex.org/W2913006758","https://openalex.org/W2913507404","https://openalex.org/W2918157483","https://openalex.org/W2921679047","https://openalex.org/W2925040389","https://openalex.org/W2936355305","https://openalex.org/W2939152062","https://openalex.org/W2941263613","https://openalex.org/W2944942536","https://openalex.org/W2946373148","https://openalex.org/W2946642995","https://openalex.org/W2950957862","https://openalex.org/W2951119702","https://openalex.org/W2958317599","https://openalex.org/W2961510098","https://openalex.org/W2962968022","https://openalex.org/W2966970992","https://openalex.org/W2967175822","https://openalex.org/W2970300816","https://openalex.org/W2975826307","https://openalex.org/W2980420668","https://openalex.org/W2981122688","https://openalex.org/W2981758984","https://openalex.org/W2982135574","https://openalex.org/W2982503761","https://openalex.org/W2987816669","https://openalex.org/W2989310232","https://openalex.org/W2990658298","https://openalex.org/W2990768607","https://openalex.org/W2993626006","https://openalex.org/W2994512974","https://openalex.org/W2997239061","https://openalex.org/W2998890161","https://openalex.org/W2999195703","https://openalex.org/W3008993913","https://openalex.org/W3010594119","https://openalex.org/W3017572093","https://openalex.org/W3043680095","https://openalex.org/W3047874730","https://openalex.org/W3092435124","https://openalex.org/W4233910316"],"related_works":["https://openalex.org/W2219306646","https://openalex.org/W3207726620","https://openalex.org/W2917879708","https://openalex.org/W2207317950","https://openalex.org/W2767691688","https://openalex.org/W2922208794","https://openalex.org/W2152181158","https://openalex.org/W1992155514","https://openalex.org/W2730598197","https://openalex.org/W1585256759"],"abstract_inverted_index":{"Oxaliplatin":[0],"(OHP)-induced":[1],"peripheral":[2],"neurotoxicity":[3],"(OIPN)":[4],"is":[5,113,116],"a":[6],"severe":[7],"clinical":[8,96,104,148,164,185],"problem":[9],"and":[10,25,42,54,67,80,95,106,154,168,177,184,194],"potentially":[11],"permanent":[12],"side":[13],"effect":[14],"of":[15,21,27,44,56,74,126,140,146,156,174,191],"cancer":[16],"treatment.":[17],"For":[18],"the":[19,40,52,107,117,123,133,138,144,147,172,178,189],"management":[20,166],"OIPN,":[22,143],"accurate":[23],"diagnosis":[24],"understanding":[26],"significant":[28,103],"risk":[29],"factors":[30],"including":[31],"genetic":[32],"vulnerability":[33],"are":[34,63],"essential":[35],"to":[36],"improve":[37],"knowledge":[38],"regarding":[39],"prevalence":[41],"incidence":[43],"OIPN":[45,62,75,112,175],"as":[46,48],"well":[47],"enhance":[49],"strategies":[50],"for":[51,86,110,196],"prevention":[53,193],"treatment":[55,109],"OIPN.":[57,197],"The":[58,129],"molecular":[59,150],"mechanisms":[60,73],"underlying":[61],"complex,":[64],"with":[65],"multi-targets":[66],"various":[68],"cells":[69],"causing":[70],"neuropathy.":[71],"Furthermore,":[72],"can":[76],"reinforce":[77],"each":[78],"other,":[79],"combination":[81],"therapies":[82,100],"may":[83],"be":[84],"required":[85],"effective":[87],"management.":[88],"However,":[89],"despite":[90],"intense":[91],"investigation":[92],"in":[93,137],"preclinical":[94,183],"studies,":[97],"no":[98],"preventive":[99],"have":[101],"shown":[102],"efficacy,":[105],"established":[108],"painful":[111],"limited.":[114],"Duloxetine":[115],"only":[118],"agent":[119],"currently":[120],"recommended":[121],"by":[122],"American":[124],"Society":[125],"Clinical":[127],"Oncology.":[128],"present":[130],"article":[131],"summarizes":[132],"most":[134],"recent":[135],"advances":[136],"field":[139],"studies":[141],"on":[142],"overview":[145],"syndrome,":[149],"basis,":[151],"therapy":[152],"development,":[153],"outlook":[155],"future":[157],"drug":[158],"candidates.":[159],"Importantly,":[160],"closer":[161],"links":[162],"between":[163,182],"pain":[165],"teams":[167],"oncology":[169],"will":[170,187],"advance":[171],"effectiveness":[173],"treatment,":[176],"continued":[179],"close":[180],"collaboration":[181],"research":[186],"facilitate":[188],"development":[190],"novel":[192],"treatments":[195]},"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":24},{"year":2024,"cited_by_count":26},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}
