{"id":"https://openalex.org/W3207701835","doi":"https://doi.org/10.1021/jacs.1c08898","title":"An Activatable Near-Infrared Fluorescence Probe for in Vivo Imaging of Acute Kidney Injury by Targeting Phosphatidylserine and Caspase-3","display_name":"An Activatable Near-Infrared Fluorescence Probe for in Vivo Imaging of Acute Kidney Injury by Targeting Phosphatidylserine and Caspase-3","publication_year":2021,"publication_date":"2021-10-21","ids":{"openalex":"https://openalex.org/W3207701835","doi":"https://doi.org/10.1021/jacs.1c08898","mag":"3207701835","pmid":"https://pubmed.ncbi.nlm.nih.gov/34672197"},"language":"en","primary_location":{"id":"doi:10.1021/jacs.1c08898","doi":"https://doi.org/10.1021/jacs.1c08898","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jacs.1c08898","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024006567","display_name":"Jianhui Weng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391768173","display_name":"State Key Laboratory of Analytical Chemistry for Life Science","ror":"https://ror.org/01xnz3256","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768173","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianhui Weng","raw_affiliation_strings":["State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China","institution_ids":["https://openalex.org/I4391768173","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100451687","display_name":"Yuqi Wang","orcid":"https://orcid.org/0000-0002-9793-6002","observed_orcids":["https://orcid.org/0000-0002-9793-6002","https://orcid.org/0009-0003-9580-6145","https://orcid.org/0009-0004-8224-4689","https://orcid.org/0009-0008-9122-6086","https://orcid.org/0009-0007-7862-2570"]},"institutions":[{"id":"https://openalex.org/I4391768173","display_name":"State Key Laboratory of Analytical Chemistry for Life Science","ror":"https://ror.org/01xnz3256","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768173","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqi Wang","raw_affiliation_strings":["State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China","institution_ids":["https://openalex.org/I4391768173","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100456400","display_name":"Yan Zhang","orcid":"https://orcid.org/0000-0002-8858-8894","observed_orcids":["https://orcid.org/0000-0002-8858-8894"]},"institutions":[{"id":"https://openalex.org/I4391768173","display_name":"State Key Laboratory of Analytical Chemistry for Life Science","ror":"https://ror.org/01xnz3256","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768173","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Zhang","raw_affiliation_strings":["State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China"],"raw_orcid":"https://orcid.org/0000-0002-8858-8894","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China","institution_ids":["https://openalex.org/I4391768173","https://openalex.org/I881766915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027509703","display_name":"Deju Ye","orcid":"https://orcid.org/0000-0002-9887-0914","observed_orcids":["https://orcid.org/0000-0002-9887-0914"]},"institutions":[{"id":"https://openalex.org/I4391768173","display_name":"State Key Laboratory of Analytical Chemistry for Life Science","ror":"https://ror.org/01xnz3256","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768173","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Deju Ye","raw_affiliation_strings":["State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China"],"raw_orcid":"https://orcid.org/0000-0002-9887-0914","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China","institution_ids":["https://openalex.org/I4391768173","https://openalex.org/I881766915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5027509703"],"corresponding_institution_ids":["https://openalex.org/I4391768173","https://openalex.org/I881766915"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":9.959,"has_fulltext":false,"cited_by_count":173,"citation_normalized_percentile":{"value":0.99566953,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"143","issue":"43","first_page":"18294","last_page":"18304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10532","display_name":"Molecular Sensors and Ion Detection","score":0.7445999979972839,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10532","display_name":"Molecular Sensors and Ion Detection","score":0.7445999979972839,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.16220000386238098,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11240","display_name":"Luminescence and Fluorescent Materials","score":0.03060000017285347,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9319999814033508},{"id":"https://openalex.org/keywords/near-infrared-fluorescent-probe","display_name":"near-infrared fluorescent probe","score":0.9269999861717224},{"id":"https://openalex.org/keywords/phosphatidylserine-exposure","display_name":"phosphatidylserine exposure","score":0.9710000157356262},{"id":"https://openalex.org/keywords/caspase-3-activation","display_name":"caspase-3 activation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/renal-clearance","display_name":"renal clearance","score":0.625},{"id":"https://openalex.org/keywords/cisplatin-induced-nephrotoxicity","display_name":"cisplatin nephrotoxicity","score":0.8629999756813049},{"id":"https://openalex.org/keywords/apoptosis-imaging","display_name":"apoptosis imaging","score":0.671999990940094},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.8460000157356262},{"id":"https://openalex.org/keywords/drug-induced-nephrotoxicity","display_name":"drug-induced nephrotoxicity","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7743539810180664},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.773486852645874},{"id":"https://openalex.org/C2779637612","wikidata":"https://www.wikidata.org/wiki/Q2354337","display_name":"Phosphatidylserine","level":4,"score":0.7293440103530884},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.6829424500465393},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.5997275710105896},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.49051207304000854},{"id":"https://openalex.org/C29331040","wikidata":"https://www.wikidata.org/wiki/Q7239554","display_name":"Preclinical imaging","level":3,"score":0.4709552228450775},{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.46098220348358154},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4555765688419342},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.43661969900131226},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.4265809953212738},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.4208180904388428},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.357163667678833},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22086504101753235},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.14789432287216187},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12096509337425232},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.1190195083618164},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09388437867164612},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09025463461875916},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007259","descriptor_name":"Infrared Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010718","descriptor_name":"Phosphatidylserines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056831","descriptor_name":"Coordination Complexes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D056831","descriptor_name":"Coordination Complexes","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D056831","descriptor_name":"Coordination Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061848","descriptor_name":"Optical Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jacs.1c08898","doi":"https://doi.org/10.1021/jacs.1c08898","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jacs.1c08898","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:34672197","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34672197","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2578377983","display_name":null,"funder_award_id":"BK20190055","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G2840854422","display_name":null,"funder_award_id":"020514380251","funder_id":"https://openalex.org/F4320321106","funder_display_name":"Ministry of Education of the People's Republic of China"},{"id":"https://openalex.org/G3704078530","display_name":null,"funder_award_id":"22137003","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5092617870","display_name":null,"funder_award_id":"BK20200301","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G5451633068","display_name":null,"funder_award_id":"21922406","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8572505451","display_name":null,"funder_award_id":"22004067","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321106","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1972664118","https://openalex.org/W1991945497","https://openalex.org/W1999891600","https://openalex.org/W2033435759","https://openalex.org/W2033917903","https://openalex.org/W2057708711","https://openalex.org/W2074267914","https://openalex.org/W2077967941","https://openalex.org/W2081021553","https://openalex.org/W2104568314","https://openalex.org/W2112639066","https://openalex.org/W2114317477","https://openalex.org/W2114889530","https://openalex.org/W2137240612","https://openalex.org/W2148962636","https://openalex.org/W2152565550","https://openalex.org/W2156746575","https://openalex.org/W2157010451","https://openalex.org/W2162775629","https://openalex.org/W2216095137","https://openalex.org/W2291540813","https://openalex.org/W2293538892","https://openalex.org/W2321043317","https://openalex.org/W2405517316","https://openalex.org/W2586557390","https://openalex.org/W2610260048","https://openalex.org/W2804536290","https://openalex.org/W2891075762","https://openalex.org/W2913372229","https://openalex.org/W2913950891","https://openalex.org/W2946216397","https://openalex.org/W2950811882","https://openalex.org/W2963641856","https://openalex.org/W2971196856","https://openalex.org/W2978073283","https://openalex.org/W2980064070","https://openalex.org/W2999522562","https://openalex.org/W3033189836","https://openalex.org/W3045070210","https://openalex.org/W3048610785","https://openalex.org/W3063952986","https://openalex.org/W3160826957","https://openalex.org/W3164429466","https://openalex.org/W3176290829","https://openalex.org/W3185851404","https://openalex.org/W4211223405"],"related_works":["https://openalex.org/W7152549605","https://openalex.org/W4413889999","https://openalex.org/W7160665922","https://openalex.org/W4362523374","https://openalex.org/W3094362477","https://openalex.org/W7202382231","https://openalex.org/W2946216397","https://openalex.org/W4309706671","https://openalex.org/W4415440467","https://openalex.org/W3045070210"],"abstract_inverted_index":{"Renal-clearable":[0],"and":[1,28,44,54,64,92,107,197,208],"target-responsive":[2],"near-infrared":[3],"(NIR)":[4],"fluorescent":[5,70],"imaging":[6,23,172],"probes":[7],"have":[8],"been":[9],"promising":[10],"for":[11,185,203,210],"in":[12,121,140,159,219],"vivo":[13,220],"diagnosis":[14,205],"of":[15,39,99,118,138,143,156,182,188,206,212,222],"acute":[16],"kidney":[17,142,157],"injury":[18],"(AKI).":[19],"However,":[20],"designing":[21],"an":[22,66],"probe":[24,71],"that":[25],"is":[26,46,201],"renal-clearable":[27],"concurrently":[29,193],"responsive":[30],"toward":[31],"multiple":[32],"molecular":[33],"targets":[34],"to":[35,114],"facilitate":[36],"early":[37,124,204],"detection":[38],"AKI":[40,120,146,160,207],"with":[41,58,129],"improved":[42],"sensitivity":[43],"specificity":[45],"challenging.":[47],"Herein,":[48],"by":[49,173,192],"leveraging":[50],"the":[51,88,116,135,141,153,180],"receptor-mediated":[52],"binding":[53],"retention":[55],"effect":[56],"along":[57],"enzyme-triggered":[59],"fluorescence":[60,106,171],"activation,":[61,199],"we":[62],"design":[63],"synthesize":[65],"activatable":[67],"small-molecule":[68],"NIR":[69,105],"(":[72],"1-DPA":[73,83,174,183],"2":[74,84,175,184],")":[75],"using":[76],"a":[77,108],"\u201cone-pot":[78],"sequential":[79],"click":[80],"reaction\u201d":[81],"approach.":[82],"can":[85,150],"target":[86],"both":[87],"externalized":[89],"phosphatidylserine":[90],"(PS)":[91],"active":[93],"caspase-3":[94],"(Casp-3),":[95],"two":[96],"essential":[97],"biomarkers":[98],"apoptosis,":[100],"producing":[101],"enhanced":[102],"808":[103],"nm":[104],"high":[109],"signal-to-background":[110],"ratio":[111],"(SBR)":[112],"amenable":[113],"detecting":[115],"onset":[117],"cisplatin-induced":[119],"mice":[122,144,161],"as":[123,125,216,218],"24":[126],"h":[127],"post-treatment":[128],"cisplatin.":[130],"We":[131],"not":[132],"only":[133],"monitor":[134],"gradual":[136],"activation":[137],"Casp-3":[139,198],"upon":[145],"progression":[147],"but":[148],"also":[149],"report":[151],"on":[152],"progressive":[154],"recovery":[155],"functions":[158],"following":[162],"N":[163],"-acetyl-":[164],"l":[165],"-cysteine":[166],"(NAC)":[167],"therapy":[168],"via":[169],"real-time":[170],".":[176],"This":[177],"study":[178],"demonstrates":[179],"ability":[181],"longitudinal":[186],"monitoring":[187],"renal":[189],"cell":[190],"apoptosis":[191],"targeting":[194],"PS":[195],"externalization":[196],"which":[200],"efficient":[202],"useful":[209],"prediction":[211],"potential":[213],"drug":[214],"nephrotoxicity":[215],"well":[217],"screening":[221],"anti-AKI":[223],"drugs\u2019":[224],"efficacy.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":26},{"year":2025,"cited_by_count":38},{"year":2024,"cited_by_count":37},{"year":2023,"cited_by_count":33},{"year":2022,"cited_by_count":39}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-10-25T00:00:00"}
