{"id":"https://openalex.org/W3207698455","doi":"https://doi.org/10.3233/rnn-211169","title":"Dynamics of biomarkers across the stages of traumatic spinal cord injury - implications for neural plasticity and repair","display_name":"Dynamics of biomarkers across the stages of traumatic spinal cord injury - implications for neural plasticity and repair","publication_year":2021,"publication_date":"2021-02-05","ids":{"openalex":"https://openalex.org/W3207698455","doi":"https://doi.org/10.3233/rnn-211169","mag":"3207698455","pmid":"https://pubmed.ncbi.nlm.nih.gov/34657853"},"language":"en","primary_location":{"id":"doi:10.3233/rnn-211169","doi":"https://doi.org/10.3233/rnn-211169","is_oa":false,"landing_page_url":"https://doi.org/10.3233/rnn-211169","pdf_url":null,"source":{"id":"https://openalex.org/S6182497","display_name":"Restorative Neurology and Neuroscience","issn_l":"0922-6028","issn":["0922-6028","1878-3627"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Restorative Neurology and Neuroscience","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026981083","display_name":"Tatjana Begenisic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Tatjana Begenisic","raw_affiliation_strings":["Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021567206","display_name":"Chiara Pavese","orcid":"https://orcid.org/0000-0002-2061-0346","observed_orcids":["https://orcid.org/0000-0002-2061-0346"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]},{"id":"https://openalex.org/I4210091499","display_name":"Istituti Clinici Scientifici Maugeri","ror":"https://ror.org/00mc77d93","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091499","https://openalex.org/I4210105320","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Pavese","raw_affiliation_strings":["Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy","Neurorehabilitation and Spinal Units, ICS Maugeri SPA SB, Institute of Pavia, IRCCS, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]},{"raw_affiliation_string":"Neurorehabilitation and Spinal Units, ICS Maugeri SPA SB, Institute of Pavia, IRCCS, Pavia, Italy","institution_ids":["https://openalex.org/I4210091499"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015319117","display_name":"Beatrice Aiachini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091499","display_name":"Istituti Clinici Scientifici Maugeri","ror":"https://ror.org/00mc77d93","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091499","https://openalex.org/I4210105320","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Beatrice Aiachini","raw_affiliation_strings":["Neurorehabilitation and Spinal Units, ICS Maugeri SPA SB, Institute of Pavia, IRCCS, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurorehabilitation and Spinal Units, ICS Maugeri SPA SB, Institute of Pavia, IRCCS, Pavia, Italy","institution_ids":["https://openalex.org/I4210091499"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006505751","display_name":"Antonio Nardone","orcid":"https://orcid.org/0000-0002-9547-1774","observed_orcids":["https://orcid.org/0000-0002-9547-1774","https://orcid.org/0009-0008-4088-5698","https://orcid.org/0000-0003-0509-7465"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]},{"id":"https://openalex.org/I4210091499","display_name":"Istituti Clinici Scientifici Maugeri","ror":"https://ror.org/00mc77d93","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091499","https://openalex.org/I4210105320","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Antonio Nardone","raw_affiliation_strings":["Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy","Neurorehabilitation and Spinal Units, ICS Maugeri SPA SB, Institute of Pavia, IRCCS, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]},{"raw_affiliation_string":"Neurorehabilitation and Spinal Units, ICS Maugeri SPA SB, Institute of Pavia, IRCCS, Pavia, Italy","institution_ids":["https://openalex.org/I4210091499"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071586379","display_name":"Daniela Rossi","orcid":"https://orcid.org/0000-0002-3346-1327","observed_orcids":["https://orcid.org/0000-0002-3346-1327"]},"institutions":[{"id":"https://openalex.org/I4210091499","display_name":"Istituti Clinici Scientifici Maugeri","ror":"https://ror.org/00mc77d93","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091499","https://openalex.org/I4210105320","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniela Rossi","raw_affiliation_strings":["Laboratory for Research on Neurodegenerative Disorders, ICS Maugeri SPA SB, Institute of Pavia, IRCCS, Pavia, Italy","E-mails:"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Research on Neurodegenerative Disorders, ICS Maugeri SPA SB, Institute of Pavia, IRCCS, Pavia, Italy","institution_ids":["https://openalex.org/I4210091499"]},{"raw_affiliation_string":"E-mails:","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006505751"],"corresponding_institution_ids":["https://openalex.org/I25217355","https://openalex.org/I4210091499"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.1427,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.1495098,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"39","issue":"5","first_page":"339","last_page":"366"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traumatic-spinal-cord-injury","display_name":"traumatic spinal cord injury","score":0.9919999837875366},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7940000295639038},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neurotrophic-factors","display_name":"neurotrophic factors","score":0.9599999785423279},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9729999899864197},{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.996999979019165},{"id":"https://openalex.org/keywords/neurotrophin-3","display_name":"neurotrophin-3","score":0.9300000071525574},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9869999885559082},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":1.0},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.9980000257492065},{"id":"https://openalex.org/keywords/maladaptive-plasticity","display_name":"maladaptive plasticity","score":0.824999988079071},{"id":"https://openalex.org/keywords/functional-recovery","display_name":"functional recovery","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.6920837759971619},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.649745523929596},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.5918957591056824},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5736629962921143},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4907137155532837},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.4574829936027527},{"id":"https://openalex.org/C2778423431","wikidata":"https://www.wikidata.org/wiki/Q417782","display_name":"Nerve growth factor","level":3,"score":0.44676530361175537},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.43883827328681946},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3646160364151001},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.3081355392932892},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18878889083862305},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020127","descriptor_name":"Recovery of Function","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3233/rnn-211169","doi":"https://doi.org/10.3233/rnn-211169","is_oa":false,"landing_page_url":"https://doi.org/10.3233/rnn-211169","pdf_url":null,"source":{"id":"https://openalex.org/S6182497","display_name":"Restorative Neurology and Neuroscience","issn_l":"0922-6028","issn":["0922-6028","1878-3627"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Restorative Neurology and Neuroscience","raw_type":"journal-article"},{"id":"pmid:34657853","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34657853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Restorative neurology and neuroscience","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":238,"referenced_works":["https://openalex.org/W141774154","https://openalex.org/W1491554136","https://openalex.org/W1491908576","https://openalex.org/W1496877897","https://openalex.org/W1503318173","https://openalex.org/W1508264626","https://openalex.org/W1522339923","https://openalex.org/W1528086783","https://openalex.org/W1539896698","https://openalex.org/W1548862642","https://openalex.org/W1555862556","https://openalex.org/W1583337372","https://openalex.org/W1605889901","https://openalex.org/W1632883247","https://openalex.org/W1651777585","https://openalex.org/W1752426110","https://openalex.org/W1783549171","https://openalex.org/W1863551998","https://openalex.org/W1869847930","https://openalex.org/W1880716631","https://openalex.org/W1899468091","https://openalex.org/W1905113423","https://openalex.org/W1908112684","https://openalex.org/W1911664005","https://openalex.org/W1964679305","https://openalex.org/W1965352187","https://openalex.org/W1966424136","https://openalex.org/W1966537571","https://openalex.org/W1967054754","https://openalex.org/W1968300632","https://openalex.org/W1968664743","https://openalex.org/W1976674400","https://openalex.org/W1976870104","https://openalex.org/W1977637789","https://openalex.org/W1978337436","https://openalex.org/W1978540694","https://openalex.org/W1978951493","https://openalex.org/W1979082679","https://openalex.org/W1979962409","https://openalex.org/W1980771080","https://openalex.org/W1983273933","https://openalex.org/W1986327151","https://openalex.org/W1986472833","https://openalex.org/W1987897015","https://openalex.org/W1989301603","https://openalex.org/W1989783048","https://openalex.org/W1991550693","https://openalex.org/W1991660337","https://openalex.org/W1992682827","https://openalex.org/W1993713261","https://openalex.org/W1993774985","https://openalex.org/W1994874844","https://openalex.org/W1995269583","https://openalex.org/W1995405296","https://openalex.org/W1997218140","https://openalex.org/W1999810771","https://openalex.org/W2002008252","https://openalex.org/W2002108875","https://openalex.org/W2003432669","https://openalex.org/W2003552158","https://openalex.org/W2004179558","https://openalex.org/W2004538934","https://openalex.org/W2004552741","https://openalex.org/W2005378461","https://openalex.org/W2005705586","https://openalex.org/W2006173799","https://openalex.org/W2007326167","https://openalex.org/W2008461178","https://openalex.org/W2009725257","https://openalex.org/W2010215681","https://openalex.org/W2011070917","https://openalex.org/W2011874194","https://openalex.org/W2012299945","https://openalex.org/W2013092651","https://openalex.org/W2014256027","https://openalex.org/W2014533960","https://openalex.org/W2014754503","https://openalex.org/W2015290511","https://openalex.org/W2018807442","https://openalex.org/W2020244870","https://openalex.org/W2020935490","https://openalex.org/W2023476837","https://openalex.org/W2024476573","https://openalex.org/W2025118259","https://openalex.org/W2025388917","https://openalex.org/W2026570544","https://openalex.org/W2027858580","https://openalex.org/W2027887897","https://openalex.org/W2030032536","https://openalex.org/W2030076800","https://openalex.org/W2030313245","https://openalex.org/W2030578080","https://openalex.org/W2030635546","https://openalex.org/W2031419550","https://openalex.org/W2032051864","https://openalex.org/W2032743208","https://openalex.org/W2033132847","https://openalex.org/W2034099577","https://openalex.org/W2034226385","https://openalex.org/W2034540486","https://openalex.org/W2035311358","https://openalex.org/W2036475002","https://openalex.org/W2036498908","https://openalex.org/W2036743679","https://openalex.org/W2039141638","https://openalex.org/W2040528920","https://openalex.org/W2040738889","https://openalex.org/W2045975412","https://openalex.org/W2046358031","https://openalex.org/W2046570168","https://openalex.org/W2046773304","https://openalex.org/W2047159816","https://openalex.org/W2047239398","https://openalex.org/W2050066016","https://openalex.org/W2050541834","https://openalex.org/W2050839683","https://openalex.org/W2051332981","https://openalex.org/W2051600135","https://openalex.org/W2053684855","https://openalex.org/W2054190000","https://openalex.org/W2056200351","https://openalex.org/W2057192508","https://openalex.org/W2057974205","https://openalex.org/W2058524634","https://openalex.org/W2058650902","https://openalex.org/W2060446687","https://openalex.org/W2062818758","https://openalex.org/W2063153146","https://openalex.org/W2063695629","https://openalex.org/W2065778432","https://openalex.org/W2066577103","https://openalex.org/W2067132959","https://openalex.org/W2067243932","https://openalex.org/W2067302534","https://openalex.org/W2068181807","https://openalex.org/W2070648258","https://openalex.org/W2071289799","https://openalex.org/W2071359561","https://openalex.org/W2072347484","https://openalex.org/W2073775732","https://openalex.org/W2074480115","https://openalex.org/W2075931967","https://openalex.org/W2076492394","https://openalex.org/W2077847097","https://openalex.org/W2079476808","https://openalex.org/W2083070797","https://openalex.org/W2085486418","https://openalex.org/W2085878479","https://openalex.org/W2086013222","https://openalex.org/W2087090756","https://openalex.org/W2087454645","https://openalex.org/W2089302208","https://openalex.org/W2089454493","https://openalex.org/W2090459889","https://openalex.org/W2091738135","https://openalex.org/W2091812306","https://openalex.org/W2093738970","https://openalex.org/W2094835614","https://openalex.org/W2096603652","https://openalex.org/W2102146294","https://openalex.org/W2102252670","https://openalex.org/W2103420764","https://openalex.org/W2104792456","https://openalex.org/W2105028929","https://openalex.org/W2107470225","https://openalex.org/W2108835750","https://openalex.org/W2110724392","https://openalex.org/W2111189129","https://openalex.org/W2113390309","https://openalex.org/W2114894842","https://openalex.org/W2115199304","https://openalex.org/W2116447863","https://openalex.org/W2117308838","https://openalex.org/W2120143347","https://openalex.org/W2122190640","https://openalex.org/W2123473800","https://openalex.org/W2127581110","https://openalex.org/W2128049766","https://openalex.org/W2133138877","https://openalex.org/W2133968430","https://openalex.org/W2138182618","https://openalex.org/W2138293945","https://openalex.org/W2139137961","https://openalex.org/W2139488193","https://openalex.org/W2139714668","https://openalex.org/W2140844751","https://openalex.org/W2142721059","https://openalex.org/W2144164400","https://openalex.org/W2146046495","https://openalex.org/W2148575622","https://openalex.org/W2149270017","https://openalex.org/W2152518380","https://openalex.org/W2155749005","https://openalex.org/W2156869534","https://openalex.org/W2159414274","https://openalex.org/W2159640450","https://openalex.org/W2163169629","https://openalex.org/W2163347971","https://openalex.org/W2164301024","https://openalex.org/W2165801181","https://openalex.org/W2166287038","https://openalex.org/W2168127946","https://openalex.org/W2236369785","https://openalex.org/W2266209009","https://openalex.org/W2292619439","https://openalex.org/W2293360927","https://openalex.org/W2307194507","https://openalex.org/W2330537790","https://openalex.org/W2330956224","https://openalex.org/W2333386541","https://openalex.org/W2345530086","https://openalex.org/W2410244603","https://openalex.org/W2417139078","https://openalex.org/W2460837672","https://openalex.org/W2499736488","https://openalex.org/W2514255391","https://openalex.org/W2515324474","https://openalex.org/W2522599246","https://openalex.org/W2584289628","https://openalex.org/W2589856153","https://openalex.org/W2608640383","https://openalex.org/W2610023532","https://openalex.org/W2624853583","https://openalex.org/W2746575140","https://openalex.org/W2767078245","https://openalex.org/W2782414823","https://openalex.org/W2783262082","https://openalex.org/W2790767158","https://openalex.org/W2794351872","https://openalex.org/W2804643499","https://openalex.org/W2807990765","https://openalex.org/W2900330948","https://openalex.org/W2907714486","https://openalex.org/W2913249489","https://openalex.org/W2944160948","https://openalex.org/W2955503221","https://openalex.org/W3104682194","https://openalex.org/W4235281330"],"related_works":["https://openalex.org/W4396980626","https://openalex.org/W2913249489","https://openalex.org/W3200983596","https://openalex.org/W4396599185","https://openalex.org/W2035904405","https://openalex.org/W1976870104","https://openalex.org/W2516751212","https://openalex.org/W3180273863","https://openalex.org/W2955503221","https://openalex.org/W3001027940"],"abstract_inverted_index":{"BACKGROUND:":[0],"Traumatic":[1],"spinal":[2,21,295],"cord":[3,22],"injury":[4],"(SCI)":[5],"is":[6,23,34],"a":[7],"complex":[8],"medical":[9],"condition":[10],"causing":[11],"significant":[12],"physical":[13],"disability":[14],"and":[15,100,111,118,198,215,232,244],"psychological":[16],"distress.":[17],"While":[18],"the":[19,49,55,67,77,83,107,144,256,264,270,279,285],"adult":[20],"characterized":[24],"by":[25,105,241],"poor":[26],"regenerative":[27],"potential,":[28],"some":[29],"recovery":[30],"of":[31,39,51,70,72,76,86,92,132,137,174,178,251,253,258,272,287],"neurological":[32],"function":[33],"still":[35,44],"possible":[36],"through":[37],"activation":[38,50],"neural":[40,98,153,179,273],"plasticity":[41,78,99,138,154,180,282],"mechanisms.":[42],"We":[43],"have":[45],"limited":[46],"knowledge":[47,277],"about":[48,278],"these":[52,222],"mechanisms":[53,79,280],"in":[54,123,152,266],"different":[56,84],"stages":[57,257],"after":[58,139,161,181],"human":[59],"SCI.":[60,87,247],"OBJECTIVE:":[61],"In":[62],"this":[63],"review,":[64],"we":[65,169],"discuss":[66],"potential":[68,175],"role":[69,236],"biomarkers":[71,102,136,177,223,254],"SCI":[73,96,115,119,140,162,259],"as":[74],"indicators":[75],"at":[80],"work":[81],"during":[82,246],"phases":[85],"METHODS:":[88],"An":[89],"extensive":[90],"review":[91,112],"literature":[93],"related":[94],"to":[95,238,262,292],"pathophysiology,":[97],"humoral":[101,135,176],"was":[103,141],"conducted":[104],"consulting":[106],"PubMed":[108],"database.":[109],"Research":[110],"articles":[113],"from":[114],"animal":[116],"models":[117],"clinical":[120],"trials":[121],"published":[122],"English":[124],"until":[125],"January":[126],"2021":[127],"were":[128],"reviewed.":[129],"The":[130],"selection":[131,286],"candidates":[133],"for":[134],"based":[142],"on":[143,166],"following":[145],"criteria:":[146],"1)":[147,183],"strong":[148],"evidence":[149,157],"supporting":[150,158],"involvement":[151],"(mandatory);":[155],"2)":[156,204],"altered":[159],"expression":[160],"(optional).":[163],"RESULTS:":[164],"Based":[165],"selected":[167],"findings,":[168],"identified":[170],"two":[171],"main":[172],"groups":[173],"SCI:":[182],"neurotrophic":[184,189],"factors":[185,206],"including:":[186,207],"Brain":[187],"derived":[188],"factor":[190,194,201],"(BDNF),":[191],"Nerve":[192],"growth":[193,200],"(NGF),":[195],"Neurotrofin-3":[196],"(NT-3),":[197],"Insulin-like":[199],"1":[202],"(IGF-1);":[203],"other":[205],"Tumor":[208],"necrosis":[209],"factor-alpha":[210],"(TNF-\u03b1),":[211],"Matrix":[212],"Metalloproteinases":[213],"(MMPs),":[214],"MicroRNAs":[216],"(miRNAs).":[217],"Plasticity":[218],"changes":[219],"associated":[220],"with":[221],"often":[224],"can":[225],"be":[226,239],"both":[227],"adaptive":[228],"(promoting":[229],"functional":[230],"improvement)":[231],"maladaptive.":[233],"This":[234],"dual":[235],"seems":[237],"influenced":[240],"their":[242],"concentrations":[243],"time-window":[245],"CONCLUSIONS:":[248],"Further":[249],"studies":[250],"dynamics":[252],"across":[255],"are":[260],"necessary":[261],"elucidate":[263],"way":[265],"which":[267],"they":[268],"reflect":[269],"remodeling":[271],"pathways.":[274],"A":[275],"better":[276],"underlying":[281],"could":[283],"guide":[284],"more":[288],"appropriate":[289],"therapeutic":[290],"strategies":[291],"enhance":[293],"positive":[294],"network":[296],"reorganization.":[297]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-10-25T00:00:00"}
