{"id":"https://openalex.org/W3207668409","doi":"https://doi.org/10.3390/ijms222011224","title":"Histone Deacetylase Inhibition Regulates Lipid Homeostasis in a Mouse Model of Amyotrophic Lateral Sclerosis","display_name":"Histone Deacetylase Inhibition Regulates Lipid Homeostasis in a Mouse Model of Amyotrophic Lateral Sclerosis","publication_year":2021,"publication_date":"2021-10-18","ids":{"openalex":"https://openalex.org/W3207668409","doi":"https://doi.org/10.3390/ijms222011224","mag":"3207668409","pmid":"https://pubmed.ncbi.nlm.nih.gov/34681883","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8541517"},"language":"en","primary_location":{"id":"doi:10.3390/ijms222011224","doi":"https://doi.org/10.3390/ijms222011224","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms222011224","pdf_url":"https://www.mdpi.com/1422-0067/22/20/11224/pdf?version=1634637100","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/22/20/11224/pdf?version=1634637100","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082536763","display_name":"Thibaut Burg","orcid":"https://orcid.org/0000-0002-8788-2936","observed_orcids":["https://orcid.org/0000-0002-8788-2936"]},"institutions":[{"id":"https://openalex.org/I4210153928","display_name":"VIB-KU Leuven Center for Brain & Disease Research","ror":"https://ror.org/045c7t348","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210153928","https://openalex.org/I99464096"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Thibaut Burg","raw_affiliation_strings":["Center for Brain & Disease Research, Laboratory of Neurobiology, VIB, 3000 Leuven, Belgium","Department of Neurosciences, Experimental Neurology, Leuven Brain Institute, KU Leuven\u2014University of Leuven, 3000 Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-8788-2936","affiliations":[{"raw_affiliation_string":"Center for Brain & Disease Research, Laboratory of Neurobiology, VIB, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I4210153928"]},{"raw_affiliation_string":"Department of Neurosciences, Experimental Neurology, Leuven Brain Institute, KU Leuven\u2014University of Leuven, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059143032","display_name":"Elisabeth Rossaert","orcid":"https://orcid.org/0000-0002-6924-4631","observed_orcids":["https://orcid.org/0000-0002-6924-4631","https://orcid.org/0000-0002-9894-2586"]},"institutions":[{"id":"https://openalex.org/I4210153928","display_name":"VIB-KU Leuven Center for Brain & Disease Research","ror":"https://ror.org/045c7t348","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210153928","https://openalex.org/I99464096"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Elisabeth Rossaert","raw_affiliation_strings":["Center for Brain & Disease Research, Laboratory of Neurobiology, VIB, 3000 Leuven, Belgium","Department of Neurosciences, Experimental Neurology, Leuven Brain Institute, KU Leuven\u2014University of Leuven, 3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Brain & Disease Research, Laboratory of Neurobiology, VIB, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I4210153928"]},{"raw_affiliation_string":"Department of Neurosciences, Experimental Neurology, Leuven Brain Institute, KU Leuven\u2014University of Leuven, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011958849","display_name":"Matthieu Moisse","orcid":"https://orcid.org/0000-0001-8880-9311","observed_orcids":["https://orcid.org/0000-0001-8880-9311"]},"institutions":[{"id":"https://openalex.org/I4210153928","display_name":"VIB-KU Leuven Center for Brain & Disease Research","ror":"https://ror.org/045c7t348","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210153928","https://openalex.org/I99464096"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Matthieu Moisse","raw_affiliation_strings":["Center for Brain & Disease Research, Laboratory of Neurobiology, VIB, 3000 Leuven, Belgium","Department of Neurosciences, Experimental Neurology, Leuven Brain Institute, KU Leuven\u2014University of Leuven, 3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Brain & Disease Research, Laboratory of Neurobiology, VIB, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I4210153928"]},{"raw_affiliation_string":"Department of Neurosciences, Experimental Neurology, Leuven Brain Institute, KU Leuven\u2014University of Leuven, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013023361","display_name":"Philip Van Damme","orcid":"https://orcid.org/0000-0002-4010-2357","observed_orcids":["https://orcid.org/0000-0002-4010-2357","https://orcid.org/0000-0001-6384-0611"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I4210153928","display_name":"VIB-KU Leuven Center for Brain & Disease Research","ror":"https://ror.org/045c7t348","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210153928","https://openalex.org/I99464096"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Philip Van Damme","raw_affiliation_strings":["Center for Brain & Disease Research, Laboratory of Neurobiology, VIB, 3000 Leuven, Belgium","Department of Neurology, University Hospitals Leuven, 3000 Leuven, Belgium","Department of Neurosciences, Experimental Neurology, Leuven Brain Institute, KU Leuven\u2014University of Leuven, 3000 Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-4010-2357","affiliations":[{"raw_affiliation_string":"Center for Brain & Disease Research, Laboratory of Neurobiology, VIB, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I4210153928"]},{"raw_affiliation_string":"Department of Neurology, University Hospitals Leuven, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306"]},{"raw_affiliation_string":"Department of Neurosciences, Experimental Neurology, Leuven Brain Institute, KU Leuven\u2014University of Leuven, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069828577","display_name":"Ludo Van Den Bosch","orcid":"https://orcid.org/0000-0003-0104-4067","observed_orcids":["https://orcid.org/0000-0003-0104-4067","https://orcid.org/0000-0001-9277-6524"]},"institutions":[{"id":"https://openalex.org/I4210153928","display_name":"VIB-KU Leuven Center for Brain & Disease Research","ror":"https://ror.org/045c7t348","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210153928","https://openalex.org/I99464096"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Ludo Van Den Bosch","raw_affiliation_strings":["Center for Brain & Disease Research, Laboratory of Neurobiology, VIB, 3000 Leuven, Belgium","Department of Neurosciences, Experimental Neurology, Leuven Brain Institute, KU Leuven\u2014University of Leuven, 3000 Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-0104-4067","affiliations":[{"raw_affiliation_string":"Center for Brain & Disease Research, Laboratory of Neurobiology, VIB, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I4210153928"]},{"raw_affiliation_string":"Department of Neurosciences, Experimental Neurology, Leuven Brain Institute, KU Leuven\u2014University of Leuven, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5069828577"],"corresponding_institution_ids":["https://openalex.org/I4210153928","https://openalex.org/I99464096"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2160},"fwci":4.6466,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.96460606,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"22","issue":"20","first_page":"11224","last_page":"11224"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.984000027179718},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibition","display_name":"histone deacetylase inhibition","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lipid-homeostasis","display_name":"lipid homeostasis","score":0.8989999890327454},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.7919999957084656},{"id":"https://openalex.org/keywords/glycerophospholipids","display_name":"glycerophospholipids","score":0.8989999890327454},{"id":"https://openalex.org/keywords/sphingolipids","display_name":"sphingolipids","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cholesteryl-esters","display_name":"cholesterol esters","score":0.8889999985694885},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.9319999814033508},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.7630000114440918},{"id":"https://openalex.org/keywords/treatment-strategy","display_name":"treatment options","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.8224974870681763},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.7438854575157166},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.6657915711402893},{"id":"https://openalex.org/C2776262904","wikidata":"https://www.wikidata.org/wiki/Q905901","display_name":"Vorinostat","level":5,"score":0.5907538533210754},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46296122670173645},{"id":"https://openalex.org/C2909310144","wikidata":"https://www.wikidata.org/wiki/Q7553358","display_name":"Phenylbutyrate","level":2,"score":0.4596942961215973},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.42355069518089294},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3465430438518524},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32281672954559326},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2654568552970886},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23245897889137268},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.21402955055236816},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1601884961128235},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15407469868659973},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1366928517818451},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000081362","descriptor_name":"Lipidomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006877","descriptor_name":"Hydroxamic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D034702","descriptor_name":"RNA-Binding Protein FUS","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.3390/ijms222011224","doi":"https://doi.org/10.3390/ijms222011224","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms222011224","pdf_url":"https://www.mdpi.com/1422-0067/22/20/11224/pdf?version=1634637100","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:7429623","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8541517","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8541517","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8541517","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:34681883","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34681883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/682942","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/682942","pdf_url":"https://lirias.kuleuven.be/retrieve/6d7139b2-614f-4391-ae75-e89a81099a59","source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal Of Molecular Sciences, vol. 22 (20), Art.No. ARTN 11224","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:6a25160c15474faca0ab8b87b0174d9c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6a25160c15474faca0ab8b87b0174d9c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 22, Iss 11224, p 11224 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms222011224","doi":"https://doi.org/10.3390/ijms222011224","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms222011224","pdf_url":"https://www.mdpi.com/1422-0067/22/20/11224/pdf?version=1634637100","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3143014879","display_name":null,"funder_award_id":"00099187","funder_id":"https://openalex.org/F4320311132","funder_display_name":"Fondation Thierry Latran"},{"id":"https://openalex.org/G4785366879","display_name":null,"funder_award_id":"577668","funder_id":"https://openalex.org/F4320308306","funder_display_name":"Muscular Dystrophy Association"}],"funders":[{"id":"https://openalex.org/F4320308306","display_name":"Muscular Dystrophy Association","ror":"https://ror.org/01frxsf98"},{"id":"https://openalex.org/F4320311132","display_name":"Fondation Thierry Latran","ror":"https://ror.org/03jf78g10"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3207668409.pdf","grobid_xml":"https://content.openalex.org/works/W3207668409.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W1576723774","https://openalex.org/W1942622409","https://openalex.org/W1968659767","https://openalex.org/W1973617509","https://openalex.org/W1984954439","https://openalex.org/W1989378845","https://openalex.org/W1991567522","https://openalex.org/W1995049733","https://openalex.org/W1998707569","https://openalex.org/W2003205286","https://openalex.org/W2008274837","https://openalex.org/W2011078603","https://openalex.org/W2016509332","https://openalex.org/W2047702883","https://openalex.org/W2052141092","https://openalex.org/W2053863700","https://openalex.org/W2066088939","https://openalex.org/W2071683292","https://openalex.org/W2076386951","https://openalex.org/W2078190587","https://openalex.org/W2082283120","https://openalex.org/W2082996556","https://openalex.org/W2087863751","https://openalex.org/W2096717747","https://openalex.org/W2100168825","https://openalex.org/W2110256992","https://openalex.org/W2112710669","https://openalex.org/W2116687544","https://openalex.org/W2131177410","https://openalex.org/W2131678573","https://openalex.org/W2147621341","https://openalex.org/W2149370967","https://openalex.org/W2153825225","https://openalex.org/W2164604342","https://openalex.org/W2174288164","https://openalex.org/W2175312206","https://openalex.org/W2188399911","https://openalex.org/W2220264637","https://openalex.org/W2473774898","https://openalex.org/W2552888741","https://openalex.org/W2561022367","https://openalex.org/W2562967686","https://openalex.org/W2605431828","https://openalex.org/W2619183966","https://openalex.org/W2738143624","https://openalex.org/W2763212735","https://openalex.org/W2765471780","https://openalex.org/W2775539932","https://openalex.org/W2781754183","https://openalex.org/W2791472194","https://openalex.org/W2896272078","https://openalex.org/W2900703673","https://openalex.org/W2913740672","https://openalex.org/W2914870314","https://openalex.org/W2926710975","https://openalex.org/W2949923941","https://openalex.org/W2955720946","https://openalex.org/W2955740693","https://openalex.org/W2959056005","https://openalex.org/W2968765313","https://openalex.org/W2974361058","https://openalex.org/W2998724136","https://openalex.org/W3000061011","https://openalex.org/W3011959425","https://openalex.org/W3024743006","https://openalex.org/W3034958546","https://openalex.org/W3045291328","https://openalex.org/W3045860601","https://openalex.org/W3087092516","https://openalex.org/W3092427287","https://openalex.org/W3092829285","https://openalex.org/W3133026938","https://openalex.org/W3133763219","https://openalex.org/W3135010503","https://openalex.org/W3153329097","https://openalex.org/W3157142085","https://openalex.org/W3159107545","https://openalex.org/W3163255909","https://openalex.org/W3173709405","https://openalex.org/W3174757911","https://openalex.org/W3190595512","https://openalex.org/W3190994775","https://openalex.org/W3196317695","https://openalex.org/W3196485281","https://openalex.org/W6686773071"],"related_works":["https://openalex.org/W2955740693","https://openalex.org/W4414368248","https://openalex.org/W2968765313","https://openalex.org/W3196485281","https://openalex.org/W3109268037","https://openalex.org/W3092427287","https://openalex.org/W3212730460","https://openalex.org/W4320497439","https://openalex.org/W2175312206","https://openalex.org/W4306247611"],"abstract_inverted_index":{"Amyotrophic":[0],"lateral":[1],"sclerosis":[2],"(ALS)":[3],"is":[4,18,152],"an":[5],"incurable":[6],"and":[7,70,114,122,140,165],"fatal":[8],"neurodegenerative":[9,168],"disorder":[10],"of":[11,52,57,80,98],"the":[12,16,31,49,67,77,95,116],"motor":[13,68],"system.":[14],"While":[15],"etiology":[17],"still":[19],"incompletely":[20],"understood,":[21],"defects":[22,134,162],"in":[23,48,94,111,115,163],"metabolism":[24,85,139,161],"act":[25],"as":[26],"a":[27,53,63,153],"major":[28],"contributor":[29],"to":[30,44,158],"disease":[32],"progression.":[33],"Recently,":[34],"histone":[35],"deacetylase":[36],"(HDAC)":[37],"inhibition":[38,82,130,151],"using":[39,86],"ACY-738":[40],"has":[41],"been":[42],"shown":[43],"restore":[45],"metabolic":[46],"alterations":[47,109],"spinal":[50,96],"cord":[51,97],"FUS":[54,99,105],"mouse":[55,118],"model":[56],"ALS,":[58],"which":[59],"was":[60],"accompanied":[61],"by":[62,135],"beneficial":[64],"effect":[65],"on":[66,83],"phenotype":[69],"survival.":[71],"In":[72],"this":[73],"study,":[74],"we":[75],"investigated":[76],"specific":[78],"effects":[79],"HDAC":[81,129,150],"lipid":[84,108,132,160],"untargeted":[87],"lipidomic":[88],"analysis":[89,93],"combined":[90],"with":[91],"transcriptomic":[92],"mice.":[100],"We":[101],"discovered":[102],"that":[103,149],"symptomatic":[104],"mice":[106],"recapitulate":[107],"found":[110],"ALS":[112,164],"patients":[113],"SOD1":[117],"model.":[119],"Glycerophospholipids,":[120],"sphingolipids,":[121],"cholesterol":[123],"esters":[124,143],"were":[125],"most":[126],"affected.":[127],"Strikingly,":[128],"mitigated":[131],"homeostasis":[133],"selectively":[136],"targeting":[137],"glycerophospholipid":[138],"reducing":[141],"cholesteryl":[142],"accumulation.":[144],"Therefore,":[145],"our":[146],"data":[147],"suggest":[148],"potential":[154],"new":[155],"therapeutic":[156],"strategy":[157],"modulate":[159],"potentially":[166],"other":[167],"diseases.":[169]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-10-25T00:00:00"}