{"id":"https://openalex.org/W3207660993","doi":"https://doi.org/10.1038/s41598-021-00122-y","title":"Comparative of meibomian gland morphology in patients with evaporative dry eye disease versus non-dry eye disease","display_name":"Comparative of meibomian gland morphology in patients with evaporative dry eye disease versus non-dry eye disease","publication_year":2021,"publication_date":"2021-10-20","ids":{"openalex":"https://openalex.org/W3207660993","doi":"https://doi.org/10.1038/s41598-021-00122-y","mag":"3207660993","pmid":"https://pubmed.ncbi.nlm.nih.gov/34671059","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8528818"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-021-00122-y","doi":"https://doi.org/10.1038/s41598-021-00122-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-00122-y","pdf_url":"https://www.nature.com/articles/s41598-021-00122-y.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-021-00122-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113388276","display_name":"Ricaurte Crespo Trevino","orcid":"https://orcid.org/0000-0001-8553-1617","observed_orcids":["https://orcid.org/0000-0001-8553-1617"]},"institutions":[{"id":"https://openalex.org/I894135719","display_name":"University of Monterrey","ror":"https://ror.org/02arnxw97","country_code":"MX","type":"education","lineage":["https://openalex.org/I894135719"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Ricaurte Ramiro Crespo-Trevi\u00f1o","raw_affiliation_strings":["Department of Clinical Sciences, Division of Health Sciences, University of Monterrey, San Pedro Garza Garc\u00eda, Nuevo Le\u00f3n, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Division of Health Sciences, University of Monterrey, San Pedro Garza Garc\u00eda, Nuevo Le\u00f3n, Mexico","institution_ids":["https://openalex.org/I894135719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075440690","display_name":"Anna Karen Salinas-S\u00e1nchez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I894135719","display_name":"University of Monterrey","ror":"https://ror.org/02arnxw97","country_code":"MX","type":"education","lineage":["https://openalex.org/I894135719"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Anna Karen Salinas-S\u00e1nchez","raw_affiliation_strings":["Department of Clinical Sciences, Division of Health Sciences, University of Monterrey, San Pedro Garza Garc\u00eda, Nuevo Le\u00f3n, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Division of Health Sciences, University of Monterrey, San Pedro Garza Garc\u00eda, Nuevo Le\u00f3n, Mexico","institution_ids":["https://openalex.org/I894135719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010663780","display_name":"Francisco Amparo","orcid":"https://orcid.org/0000-0001-5146-7901","observed_orcids":["https://orcid.org/0000-0001-5146-7901"]},"institutions":[{"id":"https://openalex.org/I1287163989","display_name":"Massachusetts Eye and Ear Infirmary","ror":"https://ror.org/04g3dn724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287163989"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I894135719","display_name":"University of Monterrey","ror":"https://ror.org/02arnxw97","country_code":"MX","type":"education","lineage":["https://openalex.org/I894135719"]}],"countries":["MX","US"],"is_corresponding":false,"raw_author_name":"Francisco Amparo","raw_affiliation_strings":["Cornea Service, Mass Eye, and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA","Department of Clinical Sciences, Division of Health Sciences, University of Monterrey, San Pedro Garza Garc\u00eda, Nuevo Le\u00f3n, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cornea Service, Mass Eye, and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Clinical Sciences, Division of Health Sciences, University of Monterrey, San Pedro Garza Garc\u00eda, Nuevo Le\u00f3n, Mexico","institution_ids":["https://openalex.org/I894135719"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060637929","display_name":"Manuel Garza-Le\u00f3n","orcid":"https://orcid.org/0000-0001-9515-1992","observed_orcids":["https://orcid.org/0000-0001-9515-1992"]},"institutions":[{"id":"https://openalex.org/I894135719","display_name":"University of Monterrey","ror":"https://ror.org/02arnxw97","country_code":"MX","type":"education","lineage":["https://openalex.org/I894135719"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Manuel Garza-Leon","raw_affiliation_strings":["Department of Clinical Sciences, Division of Health Sciences, University of Monterrey, San Pedro Garza Garc\u00eda, Nuevo Le\u00f3n, Mexico. manuel.garza@udem.edu","Department of Clinical Sciences, Division of Health Sciences, University of Monterrey, San Pedro Garza Garc\u00eda, Nuevo Le\u00f3n, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Division of Health Sciences, University of Monterrey, San Pedro Garza Garc\u00eda, Nuevo Le\u00f3n, Mexico. manuel.garza@udem.edu","institution_ids":["https://openalex.org/I894135719"]},{"raw_affiliation_string":"Department of Clinical Sciences, Division of Health Sciences, University of Monterrey, San Pedro Garza Garc\u00eda, Nuevo Le\u00f3n, Mexico","institution_ids":["https://openalex.org/I894135719"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5060637929"],"corresponding_institution_ids":["https://openalex.org/I894135719"],"apc_list":{"value":1990,"currency":"USD","value_usd":1990},"apc_paid":{"value":1990,"currency":"USD","value_usd":1990},"fwci":3.6161,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.93909922,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"11","issue":"1","first_page":"20729","last_page":"20729"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meibomian-gland-morphology","display_name":"meibomian gland morphology","score":0.902999997138977},{"id":"https://openalex.org/keywords/evaporative-dry-eye-disease","display_name":"evaporative dry eye disease","score":0.9549999833106995},{"id":"https://openalex.org/keywords/meibomian-gland-dysfunction","display_name":"meibomian gland dysfunction","score":0.8709999918937683},{"id":"https://openalex.org/keywords/meibography","display_name":"meibography","score":0.9020000100135803},{"id":"https://openalex.org/keywords/meibum-quality","display_name":"meibum quality","score":0.7269999980926514},{"id":"https://openalex.org/keywords/meibum-expressibility","display_name":"meibum expressibility","score":0.9629999995231628},{"id":"https://openalex.org/keywords/lower-eyelid","display_name":"lower eyelid","score":0.640999972820282},{"id":"https://openalex.org/keywords/tear-film-break-up-time","display_name":"tear film break-up time","score":0.8130000233650208},{"id":"https://openalex.org/keywords/dry-eye-prevalence","display_name":"dry eye prevalence","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C2777165675","wikidata":"https://www.wikidata.org/wiki/Q1425513","display_name":"Meibomian gland","level":3,"score":0.968669056892395},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7376095056533813},{"id":"https://openalex.org/C50965678","wikidata":"https://www.wikidata.org/wiki/Q2724302","display_name":"Abnormality","level":2,"score":0.5918155908584595},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5854161977767944},{"id":"https://openalex.org/C2776883082","wikidata":"https://www.wikidata.org/wiki/Q1162694","display_name":"Dry eyes","level":2,"score":0.5331185460090637},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5254244804382324},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.46181026101112366},{"id":"https://openalex.org/C2776148792","wikidata":"https://www.wikidata.org/wiki/Q3041498","display_name":"Eye disease","level":2,"score":0.4151201844215393},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34680524468421936},{"id":"https://openalex.org/C2781302119","wikidata":"https://www.wikidata.org/wiki/Q48228","display_name":"Eyelid","level":2,"score":0.17189782857894897},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000080343","descriptor_name":"Meibomian Gland Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005141","descriptor_name":"Eyelid Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008537","descriptor_name":"Meibomian Glands","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013666","descriptor_name":"Tears","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015352","descriptor_name":"Dry Eye Syndromes","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-021-00122-y","doi":"https://doi.org/10.1038/s41598-021-00122-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-00122-y","pdf_url":"https://www.nature.com/articles/s41598-021-00122-y.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:34671059","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34671059","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8528818","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8528818/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:733386762a744d32a9a377632fab58cd","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/733386762a744d32a9a377632fab58cd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-021-00122-y","doi":"https://doi.org/10.1038/s41598-021-00122-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-00122-y","pdf_url":"https://www.nature.com/articles/s41598-021-00122-y.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3207660993.pdf","grobid_xml":"https://content.openalex.org/works/W3207660993.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1021001934","https://openalex.org/W1969801895","https://openalex.org/W1981351886","https://openalex.org/W1983667404","https://openalex.org/W1996620460","https://openalex.org/W2005800753","https://openalex.org/W2017695421","https://openalex.org/W2026786052","https://openalex.org/W2034719862","https://openalex.org/W2057038561","https://openalex.org/W2082837804","https://openalex.org/W2085793457","https://openalex.org/W2091075844","https://openalex.org/W2321299560","https://openalex.org/W2406110349","https://openalex.org/W2416309465","https://openalex.org/W2529717042","https://openalex.org/W2737787547","https://openalex.org/W2739359388","https://openalex.org/W2757918035","https://openalex.org/W2789407936","https://openalex.org/W2791498502","https://openalex.org/W2795368310","https://openalex.org/W2809298347","https://openalex.org/W2890827676","https://openalex.org/W2902594458","https://openalex.org/W2906052212","https://openalex.org/W2942285677","https://openalex.org/W2972561368","https://openalex.org/W2994911509","https://openalex.org/W3003126704","https://openalex.org/W3007278825","https://openalex.org/W3080263371","https://openalex.org/W3080393580","https://openalex.org/W3085519673","https://openalex.org/W3183749799","https://openalex.org/W4229073835","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W4252647355","https://openalex.org/W4362692516","https://openalex.org/W3182200104","https://openalex.org/W1936526137","https://openalex.org/W2999473029","https://openalex.org/W4410764906","https://openalex.org/W4205668848","https://openalex.org/W3080263371","https://openalex.org/W2906052212","https://openalex.org/W4285031853"],"abstract_inverted_index":{"Many":[0],"recent":[1],"studies":[2],"have":[3],"showed":[4],"that":[5,169],"morphological":[6,66],"changes":[7,20],"are":[8],"one":[9],"of":[10,14,32,45,63,83,161],"the":[11,30,43,61,129,145,165,174,195],"key":[12],"signs":[13],"meibomian":[15,46],"gland":[16,47],"disease":[17,75],"(MGD).":[18],"These":[19],"can":[21],"be":[22],"seen":[23],"even":[24],"before":[25],"symptom":[26],"onset,":[27],"potentially":[28],"underestimating":[29],"prevalence":[31,62],"MGD;":[33],"however,":[34],"until":[35],"now,":[36],"there":[37],"is":[38],"no":[39],"conclusive":[40],"information":[41],"about":[42],"impact":[44],"(MG)":[48],"morphology":[49],"in":[50,125,128,144,173,177,181,194],"tear":[51,113],"film":[52,114],"physiology":[53],"and":[54,65,77,89,117,134],"disease.":[55],"This":[56],"study":[57],"aimed":[58],"to":[59],"investigate":[60],"anatomical":[64],"MG":[67,126,142,167],"alterations":[68,127,143,193],"between":[69,132],"patients":[70,85,179],"with":[71,86,138,188],"evaporative":[72,87,139,189],"dry":[73,94],"eye":[74,95],"(DED)":[76],"healthy":[78,90,133,151,182,199],"controls.":[79],"Retrospective":[80],"chart":[81],"review":[82],"seventy-five":[84],"DED":[88,135,140,190],"individuals":[91],"who":[92],"had":[93],"assessments":[96],"included":[97],"Ocular":[98],"Surface":[99],"Disease":[100],"Index":[101],"questionnaire,":[102],"meibum":[103,105],"quality,":[104],"expressibility,":[106],"lid":[107,131,147,176,197],"margin":[108],"abnormality,":[109],"ocular":[110],"staining,":[111],"non-invasive":[112],"break-up":[115],"time,":[116],"meibography.":[118],"We":[119],"did":[120],"not":[121],"find":[122],"significant":[123],"differences":[124],"upper":[130],"subjects.":[136,200],"Patients":[137],"presented":[141,191],"lower":[146,175,196],"more":[148,171,192],"frequently":[149],"than":[150,180,198],"subjects":[152,183],"(54.8":[153],"vs.":[154],"30.3%;":[155],"p":[156],"=":[157],"0.03).":[158],"The":[159],"presence":[160],"shortened":[162],"glands":[163],"was":[164,170],"only":[166],"alteration":[168],"prevalent":[172],"dry-eye":[178],"(p":[184],"<":[185],"0.05).":[186],"Subjects":[187]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-10-25T00:00:00"}
