{"id":"https://openalex.org/W3207656302","doi":"https://doi.org/10.1080/15592294.2021.1992911","title":"Direct bisulphite conversion of cervical samples for DNA methylation analysis","display_name":"Direct bisulphite conversion of cervical samples for DNA methylation analysis","publication_year":2021,"publication_date":"2021-10-17","ids":{"openalex":"https://openalex.org/W3207656302","doi":"https://doi.org/10.1080/15592294.2021.1992911","mag":"3207656302","pmid":"https://pubmed.ncbi.nlm.nih.gov/34652264","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9542276"},"language":"en","primary_location":{"id":"doi:10.1080/15592294.2021.1992911","doi":"https://doi.org/10.1080/15592294.2021.1992911","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15592294.2021.1992911","pdf_url":null,"source":{"id":"https://openalex.org/S203437305","display_name":"Epigenetics","issn_l":"1559-2294","issn":["1559-2294","1559-2308"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epigenetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1080/15592294.2021.1992911","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009839543","display_name":"Lisanne Verhoef","orcid":"https://orcid.org/0000-0001-9877-0297","observed_orcids":["https://orcid.org/0000-0001-9877-0297"]},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4387152927","display_name":"Cancer Center Amsterdam","ror":"https://ror.org/0286p1c86","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4387152927"]},{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Lisanne Verhoef","raw_affiliation_strings":["Amsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, De Boelelaan Amsterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-9877-0297","affiliations":[{"raw_affiliation_string":"Amsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, De Boelelaan Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I4387152927","https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008438893","display_name":"Arno N. Floore","orcid":"https://orcid.org/0000-0002-5835-2688","observed_orcids":["https://orcid.org/0000-0002-5835-2688"]},"institutions":[{"id":"https://openalex.org/I4405267965","display_name":"Self-screen BV (Netherlands)","ror":"https://ror.org/056rwfj39","country_code":"NL","type":"company","lineage":["https://openalex.org/I4405267965"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A. N Floore","raw_affiliation_strings":["Self-screen B.v., Amsterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-5835-2688","affiliations":[{"raw_affiliation_string":"Self-screen B.v., Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405267965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103845068","display_name":"Saskia Doorn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267965","display_name":"Self-screen BV (Netherlands)","ror":"https://ror.org/056rwfj39","country_code":"NL","type":"company","lineage":["https://openalex.org/I4405267965"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Saskia Doorn","raw_affiliation_strings":["Self-screen B.v., Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Self-screen B.v., Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405267965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038399735","display_name":"Kate S. Cuschieri","orcid":"https://orcid.org/0000-0002-2604-3928","observed_orcids":["https://orcid.org/0000-0002-2604-3928"]},"institutions":[{"id":"https://openalex.org/I2802789809","display_name":"Edinburgh Royal Infirmary","ror":"https://ror.org/009bsy196","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802789809"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kate Cuschieri","raw_affiliation_strings":["Scottish Human Papilloma Virus Reference Laboratory, Royal Infirmary of Edinburgh, Edinburgh, UK"],"raw_orcid":"https://orcid.org/0000-0002-2604-3928","affiliations":[{"raw_affiliation_string":"Scottish Human Papilloma Virus Reference Laboratory, Royal Infirmary of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I2802789809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077845396","display_name":"Ramya Bhatia","orcid":"https://orcid.org/0000-0001-5294-0668","observed_orcids":["https://orcid.org/0000-0001-5294-0668"]},"institutions":[{"id":"https://openalex.org/I2802789809","display_name":"Edinburgh Royal Infirmary","ror":"https://ror.org/009bsy196","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802789809"]},{"id":"https://openalex.org/I4210116174","display_name":"MRC Centre for Reproductive Health","ror":"https://ror.org/02f4tsf92","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210116174","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ramya Bhatia","raw_affiliation_strings":["Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK","Scottish Human Papilloma Virus Reference Laboratory, Royal Infirmary of Edinburgh, Edinburgh, UK"],"raw_orcid":"https://orcid.org/0000-0001-5294-0668","affiliations":[{"raw_affiliation_string":"Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I4210116174","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Scottish Human Papilloma Virus Reference Laboratory, Royal Infirmary of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I2802789809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044757320","display_name":"Albertus T. Hesselink","orcid":"https://orcid.org/0000-0002-4282-4417","observed_orcids":["https://orcid.org/0000-0002-4282-4417"]},"institutions":[{"id":"https://openalex.org/I4405267965","display_name":"Self-screen BV (Netherlands)","ror":"https://ror.org/056rwfj39","country_code":"NL","type":"company","lineage":["https://openalex.org/I4405267965"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A. T Hesselink","raw_affiliation_strings":["Self-screen B.v., Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Self-screen B.v., Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4405267965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056537893","display_name":"Chris J.L.M. Meijer","orcid":"https://orcid.org/0000-0002-2758-9463","observed_orcids":["https://orcid.org/0000-0002-2758-9463","https://orcid.org/0000-0001-8058-1404"]},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4387152927","display_name":"Cancer Center Amsterdam","ror":"https://ror.org/0286p1c86","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4387152927"]},{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Chris J.L.M. Meijer","raw_affiliation_strings":["Amsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, De Boelelaan Amsterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-2758-9463","affiliations":[{"raw_affiliation_string":"Amsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, De Boelelaan Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I4387152927","https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082492592","display_name":"Renske D.M. Steenbergen","orcid":"https://orcid.org/0000-0002-2327-9839","observed_orcids":["https://orcid.org/0000-0002-2327-9839"]},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4387152927","display_name":"Cancer Center Amsterdam","ror":"https://ror.org/0286p1c86","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4387152927"]},{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Renske D.M. Steenbergen","raw_affiliation_strings":["Amsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, De Boelelaan Amsterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-2327-9839","affiliations":[{"raw_affiliation_string":"Amsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, De Boelelaan Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I4387152927","https://openalex.org/I865915315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057813082","display_name":"Dani\u00eblle A.M. Heideman","orcid":"https://orcid.org/0000-0001-6463-7391","observed_orcids":["https://orcid.org/0000-0001-6463-7391"]},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4387152927","display_name":"Cancer Center Amsterdam","ror":"https://ror.org/0286p1c86","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4387152927"]},{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Dani\u00eblle A.M. Heideman","raw_affiliation_strings":["Amsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, De Boelelaan Amsterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-6463-7391","affiliations":[{"raw_affiliation_string":"Amsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, De Boelelaan Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I4387152927","https://openalex.org/I865915315"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5057813082"],"corresponding_institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I4387152927","https://openalex.org/I865915315"],"apc_list":null,"apc_paid":null,"fwci":0.4194,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.49034986,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"17","issue":"10","first_page":"1173","last_page":"1179"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/cervical-samples","display_name":"cervical samples","score":0.9430000185966492},{"id":"https://openalex.org/keywords/fam19a4","display_name":"FAM19A4","score":0.859000027179718},{"id":"https://openalex.org/keywords/methylation-specific-pcr","display_name":"methylation-specific PCR","score":0.7860000133514404},{"id":"https://openalex.org/keywords/genomic-dna-extraction","display_name":"genomic DNA extraction","score":0.6499999761581421},{"id":"https://openalex.org/keywords/epigenetic-biomarkers","display_name":"epigenetic biomarkers","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7301596403121948},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6926939487457275},{"id":"https://openalex.org/C189235521","wikidata":"https://www.wikidata.org/wiki/Q4087270","display_name":"Bisulfite sequencing","level":5,"score":0.6467117071151733},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6312708854675293},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46873220801353455},{"id":"https://openalex.org/C17757408","wikidata":"https://www.wikidata.org/wiki/Q4135516","display_name":"genomic DNA","level":3,"score":0.4618121385574341},{"id":"https://openalex.org/C136953436","wikidata":"https://www.wikidata.org/wiki/Q6000286","display_name":"Illumina Methylation Assay","level":5,"score":0.45084550976753235},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.39083337783813477},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34487685561180115},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3336866497993469},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.14744868874549866}],"mesh":[{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013447","descriptor_name":"Sulfites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1080/15592294.2021.1992911","doi":"https://doi.org/10.1080/15592294.2021.1992911","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15592294.2021.1992911","pdf_url":null,"source":{"id":"https://openalex.org/S203437305","display_name":"Epigenetics","issn_l":"1559-2294","issn":["1559-2294","1559-2308"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epigenetics","raw_type":"journal-article"},{"id":"pmid:34652264","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34652264","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epigenetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9542276","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9542276/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epigenetics","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire/9802f66d-8602-4be1-babe-0b1342d8d13a","doi":null,"is_oa":true,"landing_page_url":"https://research.vumc.nl/en/publications/9802f66d-8602-4be1-babe-0b1342d8d13a","pdf_url":null,"source":{"id":"https://openalex.org/S7407055350","display_name":"Amsterdam UMC (VU Amsterdam) - Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Verhoef, L, Floore, A, Doorn, S, Cuschieri, K, Bhatia, R, Hesselink, B, Meijer, C J L M, Steenbergen, R D M & Heideman, D A M 2021, 'Direct bisulphite conversion of cervical samples for DNA methylation analysis', Epigenetics. https://doi.org/10.1080/15592294.2021.1992911","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/dc1497a9-76a3-4ef4-aefb-1b9a47ca6894","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/files/157532421/Direct-bisulphite-conversion-of-cervical-samples-for-dna-methylation-analysis.pdf","pdf_url":"https://pure.amsterdamumc.nl/ws/files/157532421/Direct-bisulphite-conversion-of-cervical-samples-for-dna-methylation-analysis.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Verhoef, L, Floore, A, Doorn, S, Cuschieri, K, Bhatia, R, Hesselink, B, Meijer, C J L M, Steenbergen, R D M & Heideman, D A M 2021, 'Direct bisulphite conversion of cervical samples for DNA methylation analysis', EPIGENETICS. https://doi.org/10.1080/15592294.2021.1992911","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:1e33e333d096402e8f72d9240b3b64ad","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/1e33e333d096402e8f72d9240b3b64ad","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Epigenetics, Vol 17, Iss 10, Pp 1173-1179 (2022)","raw_type":"article"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/9802f66d-8602-4be1-babe-0b1342d8d13a","doi":null,"is_oa":true,"landing_page_url":"https://research.vumc.nl/en/publications/9802f66d-8602-4be1-babe-0b1342d8d13a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Epigenetics. Landes Bioscience","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1080/15592294.2021.1992911","doi":"https://doi.org/10.1080/15592294.2021.1992911","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15592294.2021.1992911","pdf_url":null,"source":{"id":"https://openalex.org/S203437305","display_name":"Epigenetics","issn_l":"1559-2294","issn":["1559-2294","1559-2308"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epigenetics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3760528189","display_name":null,"funder_award_id":"666800","funder_id":"https://openalex.org/F4320335254","funder_display_name":"Horizon 2020"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6740006344","display_name":"DNA-methylatie-biomerkers binnen het bevolkingsonderzoek naar baarmoederhalskanker: de eerste complete moleculaire oplossing compatibel met zelfafname","funder_award_id":"11337","funder_id":"https://openalex.org/F4320322777","funder_display_name":"KWF Kankerbestrijding"},{"id":"https://openalex.org/G934511114","display_name":"Validation of PreCursor-M for enhanced Cervical (Pre)Cancer detection","funder_award_id":"666800","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320322777","display_name":"KWF Kankerbestrijding","ror":"https://ror.org/0368jnd28"},{"id":"https://openalex.org/F4320335254","display_name":"Horizon 2020","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3207656302.pdf","grobid_xml":"https://content.openalex.org/works/W3207656302.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1963744267","https://openalex.org/W2015795623","https://openalex.org/W2028087631","https://openalex.org/W2064302386","https://openalex.org/W2082901248","https://openalex.org/W2121732950","https://openalex.org/W2151501050","https://openalex.org/W2152656267","https://openalex.org/W2895926103","https://openalex.org/W2904346106","https://openalex.org/W2911784962","https://openalex.org/W2912944499","https://openalex.org/W2948335898","https://openalex.org/W2970079004","https://openalex.org/W2981289376","https://openalex.org/W3013213019","https://openalex.org/W3090192533","https://openalex.org/W3092906323"],"related_works":["https://openalex.org/W2182425122","https://openalex.org/W2413063824","https://openalex.org/W3080631201","https://openalex.org/W1528657886","https://openalex.org/W2793268473","https://openalex.org/W2805216920","https://openalex.org/W4241482787","https://openalex.org/W2076234267","https://openalex.org/W1770941044","https://openalex.org/W7214702969"],"abstract_inverted_index":{"Sodium":[0],"bisulphite":[1,60,126],"conversion":[2,23,46,84,135],"of":[3,72,102],"DNA":[4,33,50],"to":[5,30,43],"separate":[6],"methylated":[7],"from":[8],"unmethylated":[9],"cytosines":[10],"is":[11],"a":[12,20,44,54,87,96,145],"standard":[13],"for":[14,58,66,148],"methylation":[15,71,149],"analysis.":[16,150],"This":[17],"study":[18],"evaluated":[19],"direct":[21,45,133],"cell":[22,134],"protocol":[24,136],"on":[25],"cervical":[26,36],"samples":[27,37,63,94],"as":[28,34],"alternative":[29],"isolated":[31,52],"genomic":[32,49],"input.Clinician-collected":[35],"(n":[38],"=":[39,120],"120)":[40],"were":[41,64,106],"subjected":[42],"protocol,":[47],"or":[48],"was":[51,128],"with":[53],"fixed":[55],"amount":[56],"used":[57],"subsequent":[59],"conversion.":[61],"Converted":[62],"compared":[65],"ACTB":[67],"control":[68],"gene":[69],"and":[70,74,104,115,140,143],"FAM19A4":[73,103],"miR124-2":[75,105],"genes":[76],"using":[77],"quantitative":[78],"methylation-specific":[79],"PCR":[80],"(QIAsure":[81],"Methylation":[82],"Test).Direct":[83],"resulted":[85],"in":[86],"high":[88],"success":[89],"rate,":[90],"i.e.,":[91],"119/120":[92],"(99.2%)":[93],"reported":[95],"valid":[97],"test":[98],"result.":[99],"\u0394\u0394Cq":[100],"values":[101],"significantly":[107],"correlated":[108],"between":[109,123],"both":[110,124],"protocols":[111,127],"(Spearman":[112],"Rho":[113],"0.708":[114],"0.763,":[116],"respectively,":[117],"all":[118],"p-values":[119],"0.000).":[121],"Agreement":[122],"the":[125],"demonstrated":[129],"by":[130],"Bland\u2013Altman":[131],"plots.A":[132],"shows":[137],"good":[138],"technical":[139],"analytical":[141],"performance":[142],"offers":[144],"streamlined":[146],"workflow":[147]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-10-25T00:00:00"}