{"id":"https://openalex.org/W3207603071","doi":"https://doi.org/10.1101/2021.10.12.463902","title":"The mechanochemical origins of the microtubule sliding motility within the kinesin-5 domain organization","display_name":"The mechanochemical origins of the microtubule sliding motility within the kinesin-5 domain organization","publication_year":2021,"publication_date":"2021-10-13","ids":{"openalex":"https://openalex.org/W3207603071","doi":"https://doi.org/10.1101/2021.10.12.463902","mag":"3207603071"},"language":"en","primary_location":{"id":"doi:10.1101/2021.10.12.463902","doi":"https://doi.org/10.1101/2021.10.12.463902","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.10.12.463902","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/10/13/2021.10.12.463902.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2021/10/13/2021.10.12.463902.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054327416","display_name":"Stanley Nithianantham","orcid":"https://orcid.org/0000-0001-6238-647X","observed_orcids":["https://orcid.org/0000-0001-6238-647X"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanley Nithianantham","raw_affiliation_strings":["Dept. of Molecular and Cellular Biology, University of California, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Molecular and Cellular Biology, University of California, Davis, CA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073217882","display_name":"Malina K. Iwanski","orcid":"https://orcid.org/0000-0002-4903-9796","observed_orcids":["https://orcid.org/0000-0002-4903-9796"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Malina K. Iwanski","raw_affiliation_strings":["Dept. of Biology, Dept. of Bioengineering, McGill University, Montreal, QC"],"raw_orcid":"https://orcid.org/0000-0002-4903-9796","affiliations":[{"raw_affiliation_string":"Dept. of Biology, Dept. of Bioengineering, McGill University, Montreal, QC","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066906855","display_name":"Ignas R. Gaska","orcid":"https://orcid.org/0009-0005-2569-0751","observed_orcids":["https://orcid.org/0009-0005-2569-0751"]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]},{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["IL","US"],"is_corresponding":false,"raw_author_name":"Ignas Gaska","raw_affiliation_strings":["Dept. of Biology, Rensselaer Polytechnic Institute, Troy","Dept. of Chemistry, The Ben Gurion University, Ber Sheva, Israel","Dept. of Molecular and Cellular Biology, University of California, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Biology, Rensselaer Polytechnic Institute, Troy","institution_ids":["https://openalex.org/I165799507"]},{"raw_affiliation_string":"Dept. of Chemistry, The Ben Gurion University, Ber Sheva, Israel","institution_ids":["https://openalex.org/I124227911"]},{"raw_affiliation_string":"Dept. of Molecular and Cellular Biology, University of California, Davis, CA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051512752","display_name":"Himanshu Pandey","orcid":"https://orcid.org/0000-0002-0629-7525","observed_orcids":["https://orcid.org/0000-0002-0629-7525","https://orcid.org/0009-0001-3336-0729"]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]},{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["IL","US"],"is_corresponding":false,"raw_author_name":"Himanshu Pandey","raw_affiliation_strings":["Dept. of Biology, Rensselaer Polytechnic Institute, Troy","Dept. of Chemistry, The Ben Gurion University, Ber Sheva, Israel","Dept. of Molecular and Cellular Biology, University of California, Davis, CA"],"raw_orcid":"https://orcid.org/0000-0002-0629-7525","affiliations":[{"raw_affiliation_string":"Dept. of Biology, Rensselaer Polytechnic Institute, Troy","institution_ids":["https://openalex.org/I165799507"]},{"raw_affiliation_string":"Dept. of Chemistry, The Ben Gurion University, Ber Sheva, Israel","institution_ids":["https://openalex.org/I124227911"]},{"raw_affiliation_string":"Dept. of Molecular and Cellular Biology, University of California, Davis, CA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030961057","display_name":"Tatyana Bodrug","orcid":"https://orcid.org/0000-0001-9017-962X","observed_orcids":["https://orcid.org/0000-0001-9017-962X"]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]},{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["IL","US"],"is_corresponding":false,"raw_author_name":"Tatyana Bodrug","raw_affiliation_strings":["Dept. of Biology, Rensselaer Polytechnic Institute, Troy","Dept. of Chemistry, The Ben Gurion University, Ber Sheva, Israel","Dept. of Molecular and Cellular Biology, University of California, Davis, CA"],"raw_orcid":"https://orcid.org/0000-0001-9017-962X","affiliations":[{"raw_affiliation_string":"Dept. of Biology, Rensselaer Polytechnic Institute, Troy","institution_ids":["https://openalex.org/I165799507"]},{"raw_affiliation_string":"Dept. of Chemistry, The Ben Gurion University, Ber Sheva, Israel","institution_ids":["https://openalex.org/I124227911"]},{"raw_affiliation_string":"Dept. of Molecular and Cellular Biology, University of California, Davis, CA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039383940","display_name":"Sayaka Inagaki","orcid":"https://orcid.org/0000-0001-9064-0762","observed_orcids":["https://orcid.org/0000-0001-9064-0762"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sayaka Inagaki","raw_affiliation_strings":["Dept. of Pharmacology, Mayo Clinic, Jacksonville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pharmacology, Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102712240","display_name":"Jennifer A. Major","orcid":"https://orcid.org/0000-0003-3140-5046","observed_orcids":["https://orcid.org/0000-0003-3140-5046"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Major","raw_affiliation_strings":["Dept. of Pharmacology, Mayo Clinic, Jacksonville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pharmacology, Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089318397","display_name":"Gary J. Brouhard","orcid":"https://orcid.org/0000-0001-9101-1247","observed_orcids":["https://orcid.org/0000-0001-9101-1247"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gary J. Brouhard","raw_affiliation_strings":["Dept. of Biology, Dept. of Bioengineering, McGill University, Montreal, QC"],"raw_orcid":"https://orcid.org/0000-0001-9101-1247","affiliations":[{"raw_affiliation_string":"Dept. of Biology, Dept. of Bioengineering, McGill University, Montreal, QC","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001101284","display_name":"Larisa Gheber","orcid":"https://orcid.org/0000-0003-3759-4001","observed_orcids":["https://orcid.org/0000-0003-3759-4001"]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]},{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["IL","US"],"is_corresponding":false,"raw_author_name":"Larissa Gheber","raw_affiliation_strings":["Dept. of Biology, Rensselaer Polytechnic Institute, Troy","Dept. of Chemistry, The Ben Gurion University, Ber Sheva, Israel","Dept. of Molecular and Cellular Biology, University of California, Davis, CA"],"raw_orcid":"https://orcid.org/0000-0003-3759-4001","affiliations":[{"raw_affiliation_string":"Dept. of Biology, Rensselaer Polytechnic Institute, Troy","institution_ids":["https://openalex.org/I165799507"]},{"raw_affiliation_string":"Dept. of Chemistry, The Ben Gurion University, Ber Sheva, Israel","institution_ids":["https://openalex.org/I124227911"]},{"raw_affiliation_string":"Dept. of Molecular and Cellular Biology, University of California, Davis, CA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020641571","display_name":"Steven S. Rosenfeld","orcid":"https://orcid.org/0000-0003-1909-7116","observed_orcids":["https://orcid.org/0000-0003-1909-7116"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven S. Rosenfeld","raw_affiliation_strings":["Dept. of Pharmacology, Mayo Clinic, Jacksonville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pharmacology, Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083788897","display_name":"Scott T. Forth","orcid":"https://orcid.org/0000-0002-2630-8017","observed_orcids":["https://orcid.org/0000-0002-2630-8017"]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]},{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["IL","US"],"is_corresponding":true,"raw_author_name":"Scott Forth","raw_affiliation_strings":["Dept. of Biology, Rensselaer Polytechnic Institute, Troy","Dept. of Chemistry, The Ben Gurion University, Ber Sheva, Israel","Dept. of Molecular and Cellular Biology, University of California, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Biology, Rensselaer Polytechnic Institute, Troy","institution_ids":["https://openalex.org/I165799507"]},{"raw_affiliation_string":"Dept. of Chemistry, The Ben Gurion University, Ber Sheva, Israel","institution_ids":["https://openalex.org/I124227911"]},{"raw_affiliation_string":"Dept. of Molecular and Cellular Biology, University of California, Davis, CA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068846727","display_name":"Adam G. Hendricks","orcid":"https://orcid.org/0000-0003-3635-1577","observed_orcids":["https://orcid.org/0000-0003-3635-1577"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Adam G. Hendricks","raw_affiliation_strings":["Dept. of Biology, Dept. of Bioengineering, McGill University, Montreal, QC"],"raw_orcid":"https://orcid.org/0000-0003-3635-1577","affiliations":[{"raw_affiliation_string":"Dept. of Biology, Dept. of Bioengineering, McGill University, Montreal, QC","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020409493","display_name":"Jawdat Al\u2010Bassam","orcid":"https://orcid.org/0000-0001-6625-2102","observed_orcids":["https://orcid.org/0000-0001-6625-2102"]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]},{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["IL","US"],"is_corresponding":true,"raw_author_name":"Jawdat Al-Bassam","raw_affiliation_strings":["Dept. of Biology, Rensselaer Polytechnic Institute, Troy","Dept. of Chemistry, The Ben Gurion University, Ber Sheva, Israel","Dept. of Molecular and Cellular Biology, University of California, Davis, CA"],"raw_orcid":"https://orcid.org/0000-0001-6625-2102","affiliations":[{"raw_affiliation_string":"Dept. of Biology, Rensselaer Polytechnic Institute, Troy","institution_ids":["https://openalex.org/I165799507"]},{"raw_affiliation_string":"Dept. of Chemistry, The Ben Gurion University, Ber Sheva, Israel","institution_ids":["https://openalex.org/I124227911"]},{"raw_affiliation_string":"Dept. of Molecular and Cellular Biology, University of California, Davis, CA","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5020409493","https://openalex.org/A5068846727","https://openalex.org/A5083788897"],"corresponding_institution_ids":["https://openalex.org/I124227911","https://openalex.org/I165799507","https://openalex.org/I5023651","https://openalex.org/I84218800"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinesin-5","display_name":"kinesin-5","score":1.0},{"id":"https://openalex.org/keywords/microtubule-sliding","display_name":"microtubule sliding","score":0.972000002861023},{"id":"https://openalex.org/keywords/processive-motility","display_name":"processive motility","score":0.6819999814033508},{"id":"https://openalex.org/keywords/microtubule-crosslinking","display_name":"microtubule crosslinking","score":0.8939999938011169},{"id":"https://openalex.org/keywords/mitotic-spindle-assembly","display_name":"mitotic spindle assembly","score":0.9279999732971191},{"id":"https://openalex.org/keywords/coiled-coil-dimer","display_name":"coiled-coil dimer","score":0.6039999723434448},{"id":"https://openalex.org/keywords/single-molecule-motility","display_name":"single-molecule motility","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C59006786","wikidata":"https://www.wikidata.org/wiki/Q15319390","display_name":"Kinesin","level":3,"score":0.9553031921386719},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.9094673991203308},{"id":"https://openalex.org/C93126451","wikidata":"https://www.wikidata.org/wiki/Q2383767","display_name":"Motor protein","level":3,"score":0.6731425523757935},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.6603984832763672},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5206477046012878},{"id":"https://openalex.org/C160408235","wikidata":"https://www.wikidata.org/wiki/Q423905","display_name":"Molecular motor","level":2,"score":0.4606132507324219},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4507177770137787},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4482989013195038},{"id":"https://openalex.org/C84425145","wikidata":"https://www.wikidata.org/wiki/Q422492","display_name":"Tubulin","level":3,"score":0.440718412399292},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34790050983428955}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2021.10.12.463902","doi":"https://doi.org/10.1101/2021.10.12.463902","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.10.12.463902","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/10/13/2021.10.12.463902.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2021.10.12.463902","doi":"https://doi.org/10.1101/2021.10.12.463902","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.10.12.463902","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/10/13/2021.10.12.463902.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2271590008","display_name":null,"funder_award_id":"RGPIN 2020","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G4270215162","display_name":null,"funder_award_id":"ISF 386/18","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"},{"id":"https://openalex.org/G5334367339","display_name":null,"funder_award_id":"386/18","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"},{"id":"https://openalex.org/G5485795480","display_name":"Molecular determinants of cell mechanics","funder_award_id":"rgpin-2020-04608","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G6496260398","display_name":"Regulation of microtubule motors in organelle transport","funder_award_id":"159490_1","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G8783922825","display_name":"NSF-MCB/BSF Exploring Kinesin-5 Evolutionary Adaptations for Mitotic Spindle Dynamics","funder_award_id":"1615991","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309500","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3207603071.pdf","grobid_xml":"https://content.openalex.org/works/W3207603071.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W252082922","https://openalex.org/W1579870485","https://openalex.org/W1970866062","https://openalex.org/W1971204916","https://openalex.org/W1974971179","https://openalex.org/W1984376417","https://openalex.org/W1988678729","https://openalex.org/W2000182851","https://openalex.org/W2009010596","https://openalex.org/W2017760953","https://openalex.org/W2022179322","https://openalex.org/W2022214576","https://openalex.org/W2024962906","https://openalex.org/W2030284682","https://openalex.org/W2037415133","https://openalex.org/W2043629514","https://openalex.org/W2044503653","https://openalex.org/W2052647531","https://openalex.org/W2057400222","https://openalex.org/W2061422791","https://openalex.org/W2061680493","https://openalex.org/W2069582146","https://openalex.org/W2069916404","https://openalex.org/W2090530171","https://openalex.org/W2094358436","https://openalex.org/W2100071228","https://openalex.org/W2118639465","https://openalex.org/W2124026197","https://openalex.org/W2146314877","https://openalex.org/W2148159864","https://openalex.org/W2150332547","https://openalex.org/W2161666528","https://openalex.org/W2164812932","https://openalex.org/W2165712421","https://openalex.org/W2167279371","https://openalex.org/W2171175768","https://openalex.org/W2253382748","https://openalex.org/W2335392465","https://openalex.org/W2402207766","https://openalex.org/W2412269768","https://openalex.org/W2416205039","https://openalex.org/W2464687182","https://openalex.org/W2529052661","https://openalex.org/W2568269004","https://openalex.org/W2883198166","https://openalex.org/W2952969570","https://openalex.org/W2954466294","https://openalex.org/W2973457155","https://openalex.org/W3002484703","https://openalex.org/W3128111468","https://openalex.org/W4253159331"],"related_works":["https://openalex.org/W4386099926","https://openalex.org/W3002484703","https://openalex.org/W2043629514","https://openalex.org/W7034241439","https://openalex.org/W2055750084","https://openalex.org/W2165712421","https://openalex.org/W2090881596","https://openalex.org/W2088848199","https://openalex.org/W4403416006","https://openalex.org/W2164812932"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"conserved":[2,22,242],"kinesin-5":[3,53,67,92,107,118,162,176,243],"bipolar":[4,17,139],"tetrameric":[5,23,50,101,130,252],"motors":[6,68,141],"slide":[7,224],"apart":[8],"microtubules":[9,58,225,265],"during":[10,76,266],"mitotic":[11,267],"spindle":[12,268],"assembly":[13,269],"and":[14,59,64,96,109,144,192,196,247,260,270],"elongation.":[15,271],"Kinesin-5":[16],"organization":[18],"originates":[19],"from":[20,128,142],"its":[21],"helical":[24],"minifilament,":[25,102],"which":[26,147],"position":[27],"the":[28,36,91,97,100,116,122,129,150,241,248,251],"C-terminal":[29],"tail":[30,72,163,183,208],"domains":[31,39,164,209],"of":[32,40,99,106,115,152,250],"two":[33,41,57,88],"subunits":[34,43],"near":[35],"N-terminal":[37,125],"motor":[38,74,185],"anti-parallel":[42],"(Scholey":[44],"et":[45,80],"al,":[46,81],"2014).":[47],"This":[48],"unique":[49],"structure":[51,114],"enables":[52],"to":[54,69,73,184,203,210,232],"simultaneously":[55],"engage":[56],"transmit":[60],"forces":[61],"between":[62],"them,":[63],"for":[65,257],"multiple":[66],"organize":[70],"via":[71,182],"interactions":[75,95],"microtubule":[77,199,212],"sliding":[78,110,258],"(Bodrug":[79],"2020).":[82],"Here,":[83],"we":[84,136,159],"show":[85,160],"how":[86,121],"these":[87],"structural":[89],"adaptations,":[90],"tail-motor":[93],"domain":[94,186],"length":[98,151,249],"determine":[103],"critical":[104,262],"aspects":[105],"motility":[108,157,195,259],"mechanisms.":[111],"An":[112],"x-ray":[113],"34-nm":[117],"minifilament":[119,235,253],"reveals":[120],"dual":[123],"dimeric":[124],"coiled-coils":[126],"emerge":[127],"central":[131],"bundle.":[132],"Using":[133,155],"this":[134],"structure,":[135],"generated":[137],"active":[138],"mini-tetrameric":[140],"Drosophila":[143],"human":[145],"orthologs,":[146],"are":[148,216,254,261],"half":[149],"native":[153,204,229],"kinesin-5.":[154],"single-molecule":[156],"assays,":[158],"that":[161,169,240],"promote":[165],"mini-tetramers":[166,177,206,215],"static":[167],"pauses":[168],"punctuate":[170],"processive":[171,194],"motility.":[172],"During":[173],"such":[174],"pauses,":[175],"form":[178],"multi-motor":[179],"clusters":[180,189],"mediated":[181,245],"cross-interactions.":[187],"These":[188],"undergo":[190],"slow":[191],"highly":[193,217],"accumulate":[197],"at":[198],"plus-ends.":[200],"In":[201],"contrast":[202],"kinesin-5,":[205,230],"require":[207],"initiate":[211],"crosslinking.":[213],"Although":[214],"strained":[218],"in":[219,263],"initially":[220],"aligning":[221],"microtubules,":[222],"they":[223],"more":[226],"efficiently":[227],"than":[228],"due":[231],"their":[233],"decreased":[234],"flexibility.":[236],"Our":[237],"studies":[238],"reveal":[239],"motor-tail":[244],"clustering":[246],"key":[255],"features":[256],"organizing":[264]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2021-10-25T00:00:00"}