{"id":"https://openalex.org/W3207545918","doi":"https://doi.org/10.3390/cancers13215279","title":"Sulfatase-2 Regulates Liver Fibrosis through the TGF-\u03b2 Signaling Pathway","display_name":"Sulfatase-2 Regulates Liver Fibrosis through the TGF-\u03b2 Signaling Pathway","publication_year":2021,"publication_date":"2021-10-21","ids":{"openalex":"https://openalex.org/W3207545918","doi":"https://doi.org/10.3390/cancers13215279","mag":"3207545918","pmid":"https://pubmed.ncbi.nlm.nih.gov/34771445","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8582359"},"language":"en","primary_location":{"id":"doi:10.3390/cancers13215279","doi":"https://doi.org/10.3390/cancers13215279","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13215279","pdf_url":"https://www.mdpi.com/2072-6694/13/21/5279/pdf?version=1634811409","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/13/21/5279/pdf?version=1634811409","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102917396","display_name":"Ikuo Nakamura","orcid":"https://orcid.org/0000-0003-4536-9023","observed_orcids":["https://orcid.org/0000-0003-4536-9023"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ikuo Nakamura","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic and Mayo Clinic Cancer Center, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic and Mayo Clinic Cancer Center, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044670195","display_name":"Faizal Z. Asumda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Faizal Z. Asumda","raw_affiliation_strings":["Department of Clinical Genomics, Mayo Clinic, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Genomics, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042449797","display_name":"Catherine D. Moser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine D. Moser","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic and Mayo Clinic Cancer Center, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic and Mayo Clinic Cancer Center, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008542359","display_name":"Yoo Na Kang","orcid":"https://orcid.org/0000-0003-3634-9127","observed_orcids":["https://orcid.org/0000-0003-3634-9127"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]},{"id":"https://openalex.org/I52010207","display_name":"Keimyung University","ror":"https://ror.org/00tjv0s33","country_code":"KR","type":"education","lineage":["https://openalex.org/I52010207"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Yoo Na N. Kang","raw_affiliation_strings":["Department of Pathology, Keimyung University School of Medicine, Daegu 42601, Korea","Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic and Mayo Clinic Cancer Center, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Keimyung University School of Medicine, Daegu 42601, Korea","institution_ids":["https://openalex.org/I52010207"]},{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic and Mayo Clinic Cancer Center, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002738255","display_name":"Jinping Lai","orcid":"https://orcid.org/0000-0002-4234-5096","observed_orcids":["https://orcid.org/0000-0002-4234-5096"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin-Ping Lai","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic and Mayo Clinic Cancer Center, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic and Mayo Clinic Cancer Center, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038949267","display_name":"Lewis Rowland Roberts","orcid":"https://orcid.org/0000-0001-7885-8574","observed_orcids":["https://orcid.org/0000-0001-7885-8574"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lewis R. Roberts","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic and Mayo Clinic Cancer Center, Rochester, MN 55905, USA"],"raw_orcid":"https://orcid.org/0000-0001-7885-8574","affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic and Mayo Clinic Cancer Center, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5038949267"],"corresponding_institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2376},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2376},"fwci":1.3914,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.8108247,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"13","issue":"21","first_page":"5279","last_page":"5279"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sulfatase-2","display_name":"SULF2","score":0.9350000023841858},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9580000042915344},{"id":"https://openalex.org/keywords/hepatic-stellate-cells","display_name":"hepatic stellate cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tgfbr3","display_name":"TGFBR3","score":0.9380000233650208},{"id":"https://openalex.org/keywords/extracellular-matrix-deposition","display_name":"extracellular matrix deposition","score":0.722000002861023},{"id":"https://openalex.org/keywords/collagen","display_name":"collagen","score":0.6800000071525574},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.8700000047683716},{"id":"https://openalex.org/keywords/bile-duct-ligation","display_name":"bile duct ligation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/carbon-tetrachloride","display_name":"carbon tetrachloride","score":0.9660000205039978},{"id":"https://openalex.org/keywords/thioacetamide","display_name":"thioacetamide","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C2779770810","wikidata":"https://www.wikidata.org/wiki/Q23069155","display_name":"Sirius Red","level":3,"score":0.8368768095970154},{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.7404046058654785},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5716475248336792},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5295000076293945},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5188337564468384},{"id":"https://openalex.org/C2781057625","wikidata":"https://www.wikidata.org/wiki/Q416253","display_name":"Thioacetamide","level":2,"score":0.5069448947906494},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.47497957944869995},{"id":"https://openalex.org/C2993667909","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Hepatic fibrosis","level":3,"score":0.473256379365921},{"id":"https://openalex.org/C2779797417","wikidata":"https://www.wikidata.org/wiki/Q12460151","display_name":"Hydroxyproline","level":2,"score":0.4667898118495941},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.4510577917098999},{"id":"https://openalex.org/C2781080636","wikidata":"https://www.wikidata.org/wiki/Q700000","display_name":"SMAD","level":3,"score":0.4428809583187103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33472535014152527},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2536887228488922}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/cancers13215279","doi":"https://doi.org/10.3390/cancers13215279","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13215279","pdf_url":"https://www.mdpi.com/2072-6694/13/21/5279/pdf?version=1634811409","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:7472668","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8582359","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8582359","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8582359","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmid:34771445","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34771445","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:cc40c55beceb4fb8940093a3f1e36b86","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/cc40c55beceb4fb8940093a3f1e36b86","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancers, Vol 13, Iss 5279, p 5279 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cancers13215279","doi":"https://doi.org/10.3390/cancers13215279","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13215279","pdf_url":"https://www.mdpi.com/2072-6694/13/21/5279/pdf?version=1634811409","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3207545918.pdf","grobid_xml":"https://content.openalex.org/works/W3207545918.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W966906763","https://openalex.org/W1016707613","https://openalex.org/W1565561072","https://openalex.org/W1921804337","https://openalex.org/W1965588383","https://openalex.org/W1975510007","https://openalex.org/W1980755859","https://openalex.org/W1982667179","https://openalex.org/W1983765056","https://openalex.org/W2011826749","https://openalex.org/W2017961355","https://openalex.org/W2019777638","https://openalex.org/W2020960905","https://openalex.org/W2022836663","https://openalex.org/W2028938330","https://openalex.org/W2030881674","https://openalex.org/W2037795068","https://openalex.org/W2048612060","https://openalex.org/W2051399737","https://openalex.org/W2075298915","https://openalex.org/W2079684286","https://openalex.org/W2083533385","https://openalex.org/W2086762583","https://openalex.org/W2088611209","https://openalex.org/W2097876392","https://openalex.org/W2116261308","https://openalex.org/W2117778710","https://openalex.org/W2120394416","https://openalex.org/W2139445236","https://openalex.org/W2145948214","https://openalex.org/W2148367631","https://openalex.org/W2152821878","https://openalex.org/W2157445082","https://openalex.org/W2165062244","https://openalex.org/W2167857818","https://openalex.org/W2256103742","https://openalex.org/W2405064881","https://openalex.org/W2471828796","https://openalex.org/W2551798322","https://openalex.org/W2585223803","https://openalex.org/W2734709214","https://openalex.org/W2793191892","https://openalex.org/W2802260485","https://openalex.org/W2884945282","https://openalex.org/W3003658184"],"related_works":["https://openalex.org/W2803819184","https://openalex.org/W4320915136","https://openalex.org/W4391151293","https://openalex.org/W2171931307","https://openalex.org/W2924876605","https://openalex.org/W4377091788","https://openalex.org/W2383584861","https://openalex.org/W3028142817","https://openalex.org/W3170083204","https://openalex.org/W1891318431"],"abstract_inverted_index":{"Transforming":[0],"growth":[1],"factor-\u03b2":[2],"(TGF-\u03b2)":[3],"activates":[4],"hepatic":[5],"stellate":[6],"cells":[7],"(HSCs),":[8],"which":[9],"drive":[10],"liver":[11,33,40,72,167,232,251],"fibrosis":[12,41,69,233],"via":[13,52,76,234],"the":[14,26,71,95,177,182,210,219,235],"production":[15],"and":[16,45,79,84,91,99,109,114,148,154,196,209],"deposition":[17],"of":[18,29,59,68,128,138,166,174,189,214,221,241],"extracellular":[19],"matrix":[20],"(ECM).":[21],"We":[22,123],"aimed":[23],"to":[24,181,192,249],"elucidate":[25],"mechanistic":[27],"role":[28],"sulfatase-2":[30],"(SULF2)":[31],"in":[32,42,70,157,176,211,216],"fibrosis.":[34,252],"To":[35,93],"this":[36],"end,":[37],"we":[38,101,169],"induced":[39],"wild-type":[43],"(WT)":[44],"SULF2":[46,113,129,190,205,215,230,242],"knockout":[47,127],"(Sulf2-KO)":[48],"mice":[49,179],"(6\u20138":[50],"weeks-old)":[51],"bile":[53],"duct":[54],"ligation":[55],"(BDL),":[56],"intraperitoneal":[57],"injection":[58,156],"carbon":[60],"tetrachloride":[61],"(CCl4)":[62],"or":[63],"thioacetamide":[64],"(TAA).":[65],"The":[66],"levels":[67,173,188],"sections":[73],"were":[74],"assessed":[75],"Sirius":[77,144],"red":[78],"Masson\u2019s":[80,146],"trichrome":[81,147],"staining,":[82],"immunohistochemistry":[83],"immunoblotting":[85],"for":[86],"\u03b1-smooth":[87],"muscle":[88],"actin":[89],"(\u03b1-SMA)":[90],"hydroxyproline.":[92],"evaluate":[94],"interaction":[96],"between":[97],"TGF-\u03b2":[98,236],"SULF2,":[100],"transfected":[102],"human":[103],"HSCs":[104,185,217],"with":[105,120,186,202,207],"scrambled":[106],"control":[107],"shRNA":[108,110],"constructs":[111],"targeting":[112],"measured":[115],"\u03b1-SMA":[116,149,195],"expression":[117],"following":[118,200],"treatment":[119,201],"TGF-\u03b21":[121,222],"ligand.":[122],"show":[124],"here":[125],"that":[126,229],"significantly":[130,171,193],"decreases":[131,218],"collagen":[132,197],"content,":[133],"as":[134,136,141],"well":[135],"bands":[137],"bridging":[139],"fibrosis,":[140,168],"demonstrated":[142],"by":[143],"red,":[145],"staining":[150],"after":[151],"BDL,":[152],"CCl4":[153],"TAA":[155],"Sulf2-KO":[158,178],"versus":[159],"WT":[160,183],"mice.":[161,184],"In":[162],"all":[163],"three":[164],"models":[165],"observed":[170],"lower":[172],"hydroxyproline":[175],"compared":[180],"reduced":[187],"failed":[191],"express":[194],"type":[198],"I":[199],"TGF-\u03b21.":[203],"Furthermore,":[204],"co-localizes":[206],"TGFBR3":[208],"vitro":[212],"knockdown":[213],"release":[220],"from":[223],"TGFBR3.":[224],"Together,":[225],"these":[226],"data":[227],"suggest":[228],"regulates":[231],"signaling":[237],"pathway.":[238],"Pharmacologic":[239],"inhibition":[240],"may":[243],"represent":[244],"a":[245],"novel":[246],"therapeutic":[247],"approach":[248],"improve":[250]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2021-10-25T00:00:00"}
