{"id":"https://openalex.org/W3207338596","doi":"https://doi.org/10.1590/fst.78621","title":"Anti-neuroinflammatory activity of Humulus japonicus extract and its active compound luteolin on lipopolysaccharide-induced inflammatory response in SIM-A9 microglia via NF-\u03baB and MAPK signaling pathways","display_name":"Anti-neuroinflammatory activity of Humulus japonicus extract and its active compound luteolin on lipopolysaccharide-induced inflammatory response in SIM-A9 microglia via NF-\u03baB and MAPK signaling pathways","publication_year":2021,"publication_date":"2021-10-20","ids":{"openalex":"https://openalex.org/W3207338596","doi":"https://doi.org/10.1590/fst.78621","mag":"3207338596"},"language":"en","primary_location":{"id":"doi:10.1590/fst.78621","doi":"https://doi.org/10.1590/fst.78621","is_oa":true,"landing_page_url":"https://doi.org/10.1590/fst.78621","pdf_url":"https://www.scielo.br/j/cta/a/sW9PfJLkHP7mgt6hRyVgrzC/?lang=en&format=pdf","source":{"id":"https://openalex.org/S4210223135","display_name":"Food Science and Technology","issn_l":"0101-2061","issn":["0101-2061","1678-457X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20"],"host_organization":"https://openalex.org/P4310312337","host_organization_name":"Sociedade Brasileira de Ci\u00eancia e Tecnologia de Alimentos","host_organization_lineage":["https://openalex.org/P4310312337"],"host_organization_lineage_names":["Sociedade Brasileira de Ci\u00eancia e Tecnologia de Alimentos"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Science and Technology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.scielo.br/j/cta/a/sW9PfJLkHP7mgt6hRyVgrzC/?lang=en&format=pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105820349","display_name":"Feng Wang","orcid":"https://orcid.org/0009-0002-4040-2015","observed_orcids":["https://orcid.org/0009-0002-4040-2015"]},"institutions":[{"id":"https://openalex.org/I110262843","display_name":"Yuncheng University","ror":"https://ror.org/03qt1g669","country_code":"CN","type":"education","lineage":["https://openalex.org/I110262843"]},{"id":"https://openalex.org/I70591777","display_name":"Jeonju University","ror":"https://ror.org/015v9d997","country_code":"KR","type":"education","lineage":["https://openalex.org/I70591777"]}],"countries":["CN","KR"],"is_corresponding":false,"raw_author_name":"Feng WANG","raw_affiliation_strings":["Jeonju University,  Republic of Korea; Yuncheng University,  PR, China","Department of Health Management, Jeonju University, Jeonju-si, Jeollabuk-do, Republic of KoreaDepartment of Life Sciences, Yuncheng University, Yuncheng, Shanxi Province, PR, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jeonju University,  Republic of Korea; Yuncheng University,  PR, China","institution_ids":["https://openalex.org/I110262843","https://openalex.org/I70591777"]},{"raw_affiliation_string":"Department of Health Management, Jeonju University, Jeonju-si, Jeollabuk-do, Republic of KoreaDepartment of Life Sciences, Yuncheng University, Yuncheng, Shanxi Province, PR, China","institution_ids":["https://openalex.org/I110262843","https://openalex.org/I70591777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062462909","display_name":"Byoung Ok Cho","orcid":"https://orcid.org/0000-0001-8272-2282","observed_orcids":["https://orcid.org/0000-0001-8272-2282"]},"institutions":[{"id":"https://openalex.org/I70591777","display_name":"Jeonju University","ror":"https://ror.org/015v9d997","country_code":"KR","type":"education","lineage":["https://openalex.org/I70591777"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byoung Ok CHO","raw_affiliation_strings":["Jeonju University,  Republic of Korea; Ato Q&A Co., LTD,  Republic of Korea","Institute of Health Science, Jeonju University, Jeonju-si, Jeollabuk-do, Republic of KoreaResearch Institute, Ato Q&A Co., LTD, Jeonju-si, Jeollabuk-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jeonju University,  Republic of Korea; Ato Q&A Co., LTD,  Republic of Korea","institution_ids":["https://openalex.org/I70591777"]},{"raw_affiliation_string":"Institute of Health Science, Jeonju University, Jeonju-si, Jeollabuk-do, Republic of KoreaResearch Institute, Ato Q&A Co., LTD, Jeonju-si, Jeollabuk-do, Republic of Korea","institution_ids":["https://openalex.org/I70591777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082425847","display_name":"Jae Young Shin","orcid":"https://orcid.org/0000-0001-7692-1111","observed_orcids":["https://orcid.org/0000-0001-7692-1111"]},"institutions":[{"id":"https://openalex.org/I70591777","display_name":"Jeonju University","ror":"https://ror.org/015v9d997","country_code":"KR","type":"education","lineage":["https://openalex.org/I70591777"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae Young SHIN","raw_affiliation_strings":["Jeonju University,  Republic of Korea; Ato Q&A Co., LTD,  Republic of Korea","Department of Health Management, Jeonju University, Jeonju-si, Jeollabuk-do, Republic of KoreaResearch Institute, Ato Q&A Co., LTD, Jeonju-si, Jeollabuk-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jeonju University,  Republic of Korea; Ato Q&A Co., LTD,  Republic of Korea","institution_ids":["https://openalex.org/I70591777"]},{"raw_affiliation_string":"Department of Health Management, Jeonju University, Jeonju-si, Jeollabuk-do, Republic of KoreaResearch Institute, Ato Q&A Co., LTD, Jeonju-si, Jeollabuk-do, Republic of Korea","institution_ids":["https://openalex.org/I70591777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113967945","display_name":"Suping Hao","orcid":"https://orcid.org/0009-0002-3417-0043","observed_orcids":["https://orcid.org/0009-0002-3417-0043"]},"institutions":[{"id":"https://openalex.org/I70591777","display_name":"Jeonju University","ror":"https://ror.org/015v9d997","country_code":"KR","type":"education","lineage":["https://openalex.org/I70591777"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Suping HAO","raw_affiliation_strings":["Jeonju University,  Republic of Korea","Department of Health Management, Jeonju University, Jeonju-si, Jeollabuk-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jeonju University,  Republic of Korea","institution_ids":["https://openalex.org/I70591777"]},{"raw_affiliation_string":"Department of Health Management, Jeonju University, Jeonju-si, Jeollabuk-do, Republic of Korea","institution_ids":["https://openalex.org/I70591777"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017308145","display_name":"Seon Il Jang","orcid":"https://orcid.org/0000-0001-6259-5124","observed_orcids":["https://orcid.org/0000-0001-6259-5124"]},"institutions":[{"id":"https://openalex.org/I70591777","display_name":"Jeonju University","ror":"https://ror.org/015v9d997","country_code":"KR","type":"education","lineage":["https://openalex.org/I70591777"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Seon Il JANG","raw_affiliation_strings":["Jeonju University,  Republic of Korea; Jeonju University,  Republic of Korea; Ato Q&A Co., LTD,  Republic of Korea","Department of Health Management, Jeonju University, Jeonju-si, Jeollabuk-do, Republic of KoreaInstitute of Health Science, Jeonju University, Jeonju-si, Jeollabuk-do, Republic of KoreaResearch Institute, Ato Q&A Co., LTD, Jeonju-si, Jeollabuk-do, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-6259-5124","affiliations":[{"raw_affiliation_string":"Jeonju University,  Republic of Korea; Jeonju University,  Republic of Korea; Ato Q&A Co., LTD,  Republic of Korea","institution_ids":["https://openalex.org/I70591777"]},{"raw_affiliation_string":"Department of Health Management, Jeonju University, Jeonju-si, Jeollabuk-do, Republic of KoreaInstitute of Health Science, Jeonju University, Jeonju-si, Jeollabuk-do, Republic of KoreaResearch Institute, Ato Q&A Co., LTD, Jeonju-si, Jeollabuk-do, Republic of Korea","institution_ids":["https://openalex.org/I70591777"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017308145"],"corresponding_institution_ids":["https://openalex.org/I70591777"],"apc_list":{"value":750,"currency":"USD","value_usd":750},"apc_paid":{"value":750,"currency":"USD","value_usd":750},"fwci":0.7243,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.63495104,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"42","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.37450000643730164,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.37450000643730164,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.3499000072479248,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.09939999878406525,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/humulus-japonicus","display_name":"Humulus japonicus","score":1.0},{"id":"https://openalex.org/keywords/luteolin","display_name":"luteolin","score":1.0},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.8629999756813049},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9670000076293945},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9769999980926514},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.996999979019165},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9810000061988831},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8669999837875366},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.6809999942779541},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.7689999938011169},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.8320000171661377},{"id":"https://openalex.org/keywords/ethanol-extract","display_name":"ethanol extract","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C2776080593","wikidata":"https://www.wikidata.org/wiki/Q415011","display_name":"Luteolin","level":4,"score":0.8753697872161865},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.8323835730552673},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.7238738536834717},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.7078819274902344},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6404772996902466},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.6392738819122314},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6321752667427063},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5664771795272827},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.4840221107006073},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.45095860958099365},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4145490825176239},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3577612042427063},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.3497537076473236},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3398081660270691},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3338524103164673},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.32895559072494507},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2984732389450073},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.28263145685195923},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1526857316493988},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.06810218095779419}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1590/fst.78621","doi":"https://doi.org/10.1590/fst.78621","is_oa":true,"landing_page_url":"https://doi.org/10.1590/fst.78621","pdf_url":"https://www.scielo.br/j/cta/a/sW9PfJLkHP7mgt6hRyVgrzC/?lang=en&format=pdf","source":{"id":"https://openalex.org/S4210223135","display_name":"Food Science and Technology","issn_l":"0101-2061","issn":["0101-2061","1678-457X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20"],"host_organization":"https://openalex.org/P4310312337","host_organization_name":"Sociedade Brasileira de Ci\u00eancia e Tecnologia de Alimentos","host_organization_lineage":["https://openalex.org/P4310312337"],"host_organization_lineage_names":["Sociedade Brasileira de Ci\u00eancia e Tecnologia de Alimentos"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Science and Technology","raw_type":"journal-article"},{"id":"pmh:oai:scielo:S0101-20612022000100798","doi":null,"is_oa":true,"landing_page_url":"http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100798","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:SBCTA","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1590/fst.78621","doi":"https://doi.org/10.1590/fst.78621","is_oa":true,"landing_page_url":"https://doi.org/10.1590/fst.78621","pdf_url":"https://www.scielo.br/j/cta/a/sW9PfJLkHP7mgt6hRyVgrzC/?lang=en&format=pdf","source":{"id":"https://openalex.org/S4210223135","display_name":"Food Science and Technology","issn_l":"0101-2061","issn":["0101-2061","1678-457X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20"],"host_organization":"https://openalex.org/P4310312337","host_organization_name":"Sociedade Brasileira de Ci\u00eancia e Tecnologia de Alimentos","host_organization_lineage":["https://openalex.org/P4310312337"],"host_organization_lineage_names":["Sociedade Brasileira de Ci\u00eancia e Tecnologia de Alimentos"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Science and Technology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322064","display_name":"Korea Institute for Advancement of Technology","ror":"https://ror.org/015w1qa96"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3207338596.pdf","grobid_xml":"https://content.openalex.org/works/W3207338596.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1166587220","https://openalex.org/W1584106444","https://openalex.org/W1902165456","https://openalex.org/W1980739328","https://openalex.org/W1987739764","https://openalex.org/W2005904261","https://openalex.org/W2013357710","https://openalex.org/W2023666964","https://openalex.org/W2045262404","https://openalex.org/W2053483879","https://openalex.org/W2054330377","https://openalex.org/W2066922594","https://openalex.org/W2108359814","https://openalex.org/W2147924866","https://openalex.org/W2151283331","https://openalex.org/W2162853795","https://openalex.org/W2175833749","https://openalex.org/W2178915804","https://openalex.org/W2257748093","https://openalex.org/W2340338776","https://openalex.org/W2515847119","https://openalex.org/W2555922125","https://openalex.org/W2569935680","https://openalex.org/W2583673455","https://openalex.org/W2735527928","https://openalex.org/W2740246561","https://openalex.org/W2741568582","https://openalex.org/W2778926818","https://openalex.org/W2784298198","https://openalex.org/W2792813804","https://openalex.org/W2805274467","https://openalex.org/W2810312233","https://openalex.org/W2896169701","https://openalex.org/W2938593367","https://openalex.org/W2993877328","https://openalex.org/W3035481337"],"related_works":["https://openalex.org/W4416024582","https://openalex.org/W4404523716","https://openalex.org/W1548655794","https://openalex.org/W7222276211","https://openalex.org/W3213757637","https://openalex.org/W2338588307","https://openalex.org/W2078721084","https://openalex.org/W2009609561","https://openalex.org/W2331133042","https://openalex.org/W2896230667"],"abstract_inverted_index":{"Humulus":[0],"japonicus":[1],"(HJ)":[2],"is":[3],"administered":[4],"to":[5,14,25],"patients":[6],"with":[7,82,88],"pulmonary":[8],"disease":[9,12],"and":[10,17,54,93,103,110,117,130],"skin":[11],"owing":[13],"its":[15,34,55],"anti-inflammatory":[16,47],"antioxidant":[18],"effects.":[19],"Lately,":[20],"HJ":[21,50],"has":[22],"been":[23,40],"shown":[24],"exert":[26],"impacts":[27,35,48],"on":[28,36,59],"protection":[29],"against":[30],"neurodegenerative":[31],"sickness.":[32],"Nevertheless,":[33],"microglia":[37],"have":[38],"not":[39],"discovered":[41],"in":[42,114],"depth.":[43],"As":[44],"a":[45,135],"result,":[46],"of":[49,73,97],"ethanol":[51],"extract":[52],"(HJE)":[53],"active":[56],"compound":[57],"luteolin":[58,70,94],"lipopolysaccharide-stimulated":[60],"SIM-A9":[61],"cells":[62],"were":[63],"investigated.":[64],"The":[65],"results":[66,122],"showed":[67],"that":[68,124],"HJE":[69,92,125],"inhibited":[71],"generation":[72],"interleukin-1\u03b2,":[74],"tumor":[75],"necrosis":[76],"factor-\u03b1,":[77],"nitric":[78],"oxide,":[79],"interleukin-6,":[80],"together":[81],"prostaglandin":[83],"E2,":[84],"iNOS,":[85],"COX-2":[86],"along":[87],"HO-1":[89],"induction.":[90],"Furthermore,":[91],"reduced":[95],"degrees":[96],"NF-\u03baB":[98],"pathway":[99],"components":[100],"within":[101],"cytoplasm":[102,116],"nucleus,":[104],"while":[105],"reducing":[106],"cytoplasmic":[107],"MAPK":[108],"levels":[109,113],"increasing":[111],"Nrf2":[112],"the":[115],"nucleus.":[118],"In":[119],"conclusion,":[120],"our":[121],"demonstrate":[123],"might":[126],"exhibit":[127],"neuroprotective":[128],"effects":[129],"could":[131],"be":[132],"used":[133],"as":[134],"novel":[136],"drug":[137],"for":[138],"various":[139],"neurological":[140],"diseases.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2021-10-25T00:00:00"}