{"id":"https://openalex.org/W3207306334","doi":"https://doi.org/10.22625/2072-6732-2021-13-3-55-61","title":"Diagnostic markers in the aspect of the development of HIV-encephalopathy in children","display_name":"Diagnostic markers in the aspect of the development of HIV-encephalopathy in children","publication_year":2021,"publication_date":"2021-10-09","ids":{"openalex":"https://openalex.org/W3207306334","doi":"https://doi.org/10.22625/2072-6732-2021-13-3-55-61","mag":"3207306334"},"language":"en","primary_location":{"id":"doi:10.22625/2072-6732-2021-13-3-55-61","doi":"https://doi.org/10.22625/2072-6732-2021-13-3-55-61","is_oa":true,"landing_page_url":"https://doi.org/10.22625/2072-6732-2021-13-3-55-61","pdf_url":"https://journal.niidi.ru/jofin/article/download/1240/917","source":{"id":"https://openalex.org/S4210186941","display_name":"Journal Infectology","issn_l":"2072-6732","issn":["2072-6732","2499-9865"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312838","host_organization_name":"Journal Infectology","host_organization_lineage":["https://openalex.org/P4310312838"],"host_organization_lineage_names":["Journal Infectology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal Infectology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journal.niidi.ru/jofin/article/download/1240/917","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039746821","display_name":"Saida Saidkhodjaeva","orcid":"https://orcid.org/0000-0002-6317-4476","observed_orcids":["https://orcid.org/0000-0002-6317-4476"]},"institutions":[{"id":"https://openalex.org/I4210162425","display_name":"Tashkent Pediatric Medical Institute","ror":"https://ror.org/05s259e10","country_code":"UZ","type":"healthcare","lineage":["https://openalex.org/I4210162425","https://openalex.org/I4405267534"]}],"countries":["UZ"],"is_corresponding":false,"raw_author_name":"S. N. Saidkhodjaeva","raw_affiliation_strings":["Tashkent Pediatric Medical Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tashkent Pediatric Medical Institute","institution_ids":["https://openalex.org/I4210162425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081317038","display_name":"E. N. Madjidova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162425","display_name":"Tashkent Pediatric Medical Institute","ror":"https://ror.org/05s259e10","country_code":"UZ","type":"healthcare","lineage":["https://openalex.org/I4210162425","https://openalex.org/I4405267534"]}],"countries":["UZ"],"is_corresponding":false,"raw_author_name":"E. N. Madjidova","raw_affiliation_strings":["Tashkent Pediatric Medical Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tashkent Pediatric Medical Institute","institution_ids":["https://openalex.org/I4210162425"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025418159","display_name":"K. Kh. Yuldashev","orcid":"https://orcid.org/0009-0007-9494-7922","observed_orcids":["https://orcid.org/0009-0007-9494-7922"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Kh. Yuldashev","raw_affiliation_strings":["Republican AIDS Cente"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Republican AIDS Cente","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"3","first_page":"55","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.03240000084042549,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13201","display_name":"Infectious Encephalopathies and Encephalitis","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-encephalopathy","display_name":"HIV encephalopathy","score":0.9179999828338623},{"id":"https://openalex.org/keywords/pediatric-hiv","display_name":"pediatric HIV","score":0.7599999904632568},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.8009999990463257},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.6899999976158142},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9440000057220459},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":1.0},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8370000123977661},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.7770000100135803},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.5699999928474426},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.8600000143051147},{"id":"https://openalex.org/keywords/central-nervous-system-injury","display_name":"central nervous system injury","score":0.7319999933242798},{"id":"https://openalex.org/keywords/risk-prediction","display_name":"risk prediction","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.8245641589164734},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6753693222999573},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5284433364868164},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5216223001480103},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.4904334247112274},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4738750159740448},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4632469415664673},{"id":"https://openalex.org/C65409693","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Statistical significance","level":2,"score":0.4413597881793976},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.4176265597343445},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3734767436981201},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3631138801574707},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.14490950107574463},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.22625/2072-6732-2021-13-3-55-61","doi":"https://doi.org/10.22625/2072-6732-2021-13-3-55-61","is_oa":true,"landing_page_url":"https://doi.org/10.22625/2072-6732-2021-13-3-55-61","pdf_url":"https://journal.niidi.ru/jofin/article/download/1240/917","source":{"id":"https://openalex.org/S4210186941","display_name":"Journal Infectology","issn_l":"2072-6732","issn":["2072-6732","2499-9865"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312838","host_organization_name":"Journal Infectology","host_organization_lineage":["https://openalex.org/P4310312838"],"host_organization_lineage_names":["Journal Infectology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal Infectology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:042b7c31971c4c069e502ea0ad342a7b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/042b7c31971c4c069e502ea0ad342a7b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0416\u0443\u0440\u043d\u0430\u043b \u0438\u043d\u0444\u0435\u043a\u0442\u043e\u043b\u043e\u0433\u0438\u0438, Vol 13, Iss 3, Pp 55-61 (2021)","raw_type":"article"},{"id":"pmh:oai:oai.jofin.elpub.ru:article/1240","doi":null,"is_oa":true,"landing_page_url":"https://journal.niidi.ru/jofin/article/view/1240","pdf_url":null,"source":{"id":"https://openalex.org/S4210186941","display_name":"Journal Infectology","issn_l":"2072-6732","issn":["2072-6732","2499-9865"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312838","host_organization_name":"Journal Infectology","host_organization_lineage":["https://openalex.org/P4310312838"],"host_organization_lineage_names":["Journal Infectology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal Infectology; \u0422\u043e\u043c 13, \u2116 3 (2021); 55-61","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.22625/2072-6732-2021-13-3-55-61","doi":"https://doi.org/10.22625/2072-6732-2021-13-3-55-61","is_oa":true,"landing_page_url":"https://doi.org/10.22625/2072-6732-2021-13-3-55-61","pdf_url":"https://journal.niidi.ru/jofin/article/download/1240/917","source":{"id":"https://openalex.org/S4210186941","display_name":"Journal Infectology","issn_l":"2072-6732","issn":["2072-6732","2499-9865"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312838","host_organization_name":"Journal Infectology","host_organization_lineage":["https://openalex.org/P4310312838"],"host_organization_lineage_names":["Journal Infectology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal Infectology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3207306334.pdf","grobid_xml":"https://content.openalex.org/works/W3207306334.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1510691009","https://openalex.org/W1974642156","https://openalex.org/W1989245618","https://openalex.org/W1990377573","https://openalex.org/W2007380557","https://openalex.org/W2015705590","https://openalex.org/W2018499708","https://openalex.org/W2025707054","https://openalex.org/W2031491870","https://openalex.org/W2040059881","https://openalex.org/W2044170979","https://openalex.org/W2060842811","https://openalex.org/W2068703382","https://openalex.org/W2072505863","https://openalex.org/W2093743952","https://openalex.org/W2129488246","https://openalex.org/W2130008789","https://openalex.org/W2139984845","https://openalex.org/W2140528351","https://openalex.org/W2157219171","https://openalex.org/W2473943912","https://openalex.org/W2528862740"],"related_works":["https://openalex.org/W4389460124","https://openalex.org/W2467297237","https://openalex.org/W2091977834","https://openalex.org/W2123786919","https://openalex.org/W2131058450","https://openalex.org/W2095164617","https://openalex.org/W2926460971","https://openalex.org/W4391276951","https://openalex.org/W2172076545","https://openalex.org/W3182970271"],"abstract_inverted_index":{"The":[0,27,69,92,154,224],"aim":[1],"of":[2,20,25,66,77,86,94,107,128,139,149,160,167,170,177,186,197,210,216,231,234,261],"the":[3,8,62,75,87,95,105,116,137,157,165,168,178,184,194,198,207,214,219,229,232,259],"study":[4,28,63,93,155],"was":[5,72,141,181,190,238],"to":[6,48,115,218],"evaluate":[7],"diagnostic":[9,195,199],"markers":[10,180],"in":[11,61,98,164,213,228,240,245,258,272],"children":[12,31,59,99],"with":[13,17,40,100,125,145,255],"HIV":[14,67,101,188,236,264],"\u2014encephalopathy":[15,189],"(HIVE)":[16],"varying":[18],"degrees":[19],"severity.":[21],"Material":[22],"and":[23,36,43,110,121,133,136,183,269],"methods":[24],"research:":[26],"included":[29,60],"260":[30],"(153":[32],"boys":[33],"\u2014":[34],"58.85%":[35],"107":[37],"girls":[38],"\u201441.7%)":[39],"HIV-positive":[41],"status":[42],"receiving":[44],"antiretroviral":[45],"therapy":[46],"according":[47],"an":[49,243,256,270],"individually":[50],"selected":[51],"scheme":[52],"for":[53,283],"at":[54],"least":[55],"6":[56],"months.":[57],"All":[58],"showed":[64],"signs":[65],"encephalopathy.":[68,173],"activity":[70,96],"response":[71,97,163],"assessed":[73],"by":[74,206,266,279],"concentration":[76,106,138,179,196,247,275],"IL-6,":[78],"IL-10,":[79],"TNF-alpha,":[80],"C-reactive":[81],"protein,":[82],"C3,":[83],"C4":[84],"components":[85],"complement":[88],"(immunofelometric":[89],"analysis).":[90],"Results:":[91],"encephalopathy":[102,265],"found":[103,239],"that":[104],"TNF":[108,273],"\u2014alpha":[109],"IL-6":[111,246],"were":[112],"increased,":[113],"compared,":[114],"reference":[117,126,147],"values":[118,127],"(12.67\u00b10.25":[119],"PG/ml":[120,132,144,278],"23.04\u00b10.64":[122],"PG/ml,":[123],"respectively,":[124],"less":[129],"than":[130,151],"8.1":[131],"7pg/ml,":[134],"respectively),":[135],"IL-10":[140],"reduced":[142],"(5.93\u00b10.10":[143],"a":[146],"value":[148],"more":[150],"9.1":[152],"PG/ml).":[153],"analyzed":[156],"predictor":[158,226],"significance":[159,227],"various":[161],"parameters":[162],"aspect":[166,230],"development":[169,215,233],"symptomatic":[171,187,235,263],"HIV-":[172],"A":[174],"comparative":[175],"analysis":[176],"performed,":[182],"incidence":[185],"determined":[191],"depending":[192],"on":[193],"marker.":[200],"This":[201],"finding":[202],"is":[203,253],"probably":[204],"explained":[205],"effector":[208],"role":[209],"systemic":[211],"inflammation":[212],"damage":[217],"Central":[220],"nervous":[221],"system.":[222],"Conclusion.":[223],"maximum":[225],"-encephalopathy":[237],"proinflammatory":[241],"cytokines:":[242],"increase":[244,257,271],"above":[248,276],"19.6":[249],"PG":[250],"/":[251],"ml":[252],"associated":[254],"risk":[260],"developing":[262],"9.14":[267],"times,":[268],"-alpha":[274],"12.5":[277],"4.07":[280],"times":[281],"(p<0.001":[282],"both":[284],"factors).":[285]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2021-10-25T00:00:00"}