{"id":"https://openalex.org/W3207103934","doi":"https://doi.org/10.1515/epoly-2021-0076","title":"A novel CT contrast agent for intestinal-targeted imaging through rectal administration","display_name":"A novel CT contrast agent for intestinal-targeted imaging through rectal administration","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3207103934","doi":"https://doi.org/10.1515/epoly-2021-0076","mag":"3207103934"},"language":"en","primary_location":{"id":"doi:10.1515/epoly-2021-0076","doi":"https://doi.org/10.1515/epoly-2021-0076","is_oa":true,"landing_page_url":"https://doi.org/10.1515/epoly-2021-0076","pdf_url":"https://www.degruyter.com/document/doi/10.1515/epoly-2021-0076/pdf","source":{"id":"https://openalex.org/S150382113","display_name":"e-Polymers","issn_l":"1618-7229","issn":["1618-7229","2197-4586"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"e-Polymers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.degruyter.com/document/doi/10.1515/epoly-2021-0076/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042467730","display_name":"Jingyao Zhu","orcid":"https://orcid.org/0000-0002-9001-6713","observed_orcids":["https://orcid.org/0000-0002-9001-6713"]},"institutions":[{"id":"https://openalex.org/I4210138803","display_name":"National Engineering Research Center for Nanotechnology","ror":"https://ror.org/048d94c63","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138803"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyao Zhu","raw_affiliation_strings":["Laboratory of Nano-Biomedical Technology, National Engineering Research Center for Nanotechnology , Shanghai 200241 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Nano-Biomedical Technology, National Engineering Research Center for Nanotechnology , Shanghai 200241 , China","institution_ids":["https://openalex.org/I4210138803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110118630","display_name":"Hao Weng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801518579","display_name":"XinHua Hospital","ror":"https://ror.org/04dzvks42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801518579"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Weng","raw_affiliation_strings":["Department of General Surgery and Laboratory of General Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai 200092 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery and Laboratory of General Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai 200092 , China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801518579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108273068","display_name":"Shichen Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138803","display_name":"National Engineering Research Center for Nanotechnology","ror":"https://ror.org/048d94c63","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138803"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shichen Xie","raw_affiliation_strings":["Laboratory of Nano-Biomedical Technology, National Engineering Research Center for Nanotechnology , Shanghai 200241 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Nano-Biomedical Technology, National Engineering Research Center for Nanotechnology , Shanghai 200241 , China","institution_ids":["https://openalex.org/I4210138803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101410504","display_name":"Jiejun Cheng","orcid":"https://orcid.org/0000-0001-6619-335X","observed_orcids":["https://orcid.org/0000-0001-6619-335X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiejun Cheng","raw_affiliation_strings":["Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai 200127 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai 200127 , China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100713400","display_name":"Jun Zhu","orcid":"https://orcid.org/0000-0002-6283-9229","observed_orcids":["https://orcid.org/0000-0002-6283-9229"]},"institutions":[{"id":"https://openalex.org/I4210138803","display_name":"National Engineering Research Center for Nanotechnology","ror":"https://ror.org/048d94c63","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138803"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jun Zhu","raw_affiliation_strings":["Laboratory of Nano-Biomedical Technology, National Engineering Research Center for Nanotechnology , Shanghai 200241 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Nano-Biomedical Technology, National Engineering Research Center for Nanotechnology , Shanghai 200241 , China","institution_ids":["https://openalex.org/I4210138803"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100713400","https://openalex.org/A5101410504"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007","https://openalex.org/I4210138803"],"apc_list":{"value":1000,"currency":"EUR","value_usd":1183},"apc_paid":{"value":1000,"currency":"EUR","value_usd":1183},"fwci":0.2025,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.35189229,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"21","issue":"1","first_page":"754","last_page":"762"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ct-contrast-agents","display_name":"CT contrast agents","score":0.9829999804496765},{"id":"https://openalex.org/keywords/rectal-administration","display_name":"rectal administration","score":0.984000027179718},{"id":"https://openalex.org/keywords/chitosan-nanospheres","display_name":"chitosan nanospheres","score":0.953000009059906},{"id":"https://openalex.org/keywords/iopamidol","display_name":"iopamidol","score":0.9200000166893005},{"id":"https://openalex.org/keywords/5-ht3-receptor","display_name":"5-HT3 receptor","score":0.8679999709129333},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.6700000166893005},{"id":"https://openalex.org/keywords/gastrointestinal-mucosa","display_name":"gastrointestinal mucosa","score":0.8669999837875366},{"id":"https://openalex.org/keywords/contrast-enhancement","display_name":"contrast enhancement","score":0.48500001430511475},{"id":"https://openalex.org/keywords/intestinal-diseases","display_name":"intestinal diseases","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C2776982972","wikidata":"https://www.wikidata.org/wiki/Q424788","display_name":"Iopamidol","level":3,"score":0.8728764057159424},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.531184196472168},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.511039137840271},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5003905296325684},{"id":"https://openalex.org/C44315111","wikidata":"https://www.wikidata.org/wiki/Q1344580","display_name":"Enteral administration","level":3,"score":0.4932026267051697},{"id":"https://openalex.org/C2776873419","wikidata":"https://www.wikidata.org/wiki/Q419892","display_name":"Rectal administration","level":2,"score":0.478950560092926},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.4557184875011444},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.43505120277404785},{"id":"https://openalex.org/C2776093070","wikidata":"https://www.wikidata.org/wiki/Q621636","display_name":"Route of administration","level":2,"score":0.41214632987976074},{"id":"https://openalex.org/C2778172261","wikidata":"https://www.wikidata.org/wiki/Q3796563","display_name":"Imaging agent","level":3,"score":0.41192707419395447},{"id":"https://openalex.org/C2779222893","wikidata":"https://www.wikidata.org/wiki/Q3275337","display_name":"Iodinated contrast","level":3,"score":0.4105271100997925},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3686140775680542},{"id":"https://openalex.org/C2779786684","wikidata":"https://www.wikidata.org/wiki/Q906156","display_name":"Contrast medium","level":2,"score":0.31140828132629395},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23380938172340393},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.19700071215629578},{"id":"https://openalex.org/C544519230","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomography","level":2,"score":0.17480969429016113},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.10208815336227417},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0793573260307312},{"id":"https://openalex.org/C78722104","wikidata":"https://www.wikidata.org/wiki/Q21653202","display_name":"Parenteral nutrition","level":2,"score":0.06364744901657104},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1515/epoly-2021-0076","doi":"https://doi.org/10.1515/epoly-2021-0076","is_oa":true,"landing_page_url":"https://doi.org/10.1515/epoly-2021-0076","pdf_url":"https://www.degruyter.com/document/doi/10.1515/epoly-2021-0076/pdf","source":{"id":"https://openalex.org/S150382113","display_name":"e-Polymers","issn_l":"1618-7229","issn":["1618-7229","2197-4586"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"e-Polymers","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:c11d17888d9c4840bb6adcdfa109bf66","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c11d17888d9c4840bb6adcdfa109bf66","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"e-Polymers, Vol 21, Iss 1, Pp 754-762 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1515/epoly-2021-0076","doi":"https://doi.org/10.1515/epoly-2021-0076","is_oa":true,"landing_page_url":"https://doi.org/10.1515/epoly-2021-0076","pdf_url":"https://www.degruyter.com/document/doi/10.1515/epoly-2021-0076/pdf","source":{"id":"https://openalex.org/S150382113","display_name":"e-Polymers","issn_l":"1618-7229","issn":["1618-7229","2197-4586"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"e-Polymers","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2229998227","display_name":null,"funder_award_id":"18DZ2260400","funder_id":"https://openalex.org/F4320328940","funder_display_name":"Shanghai Key Laboratory of Molecular Imaging"},{"id":"https://openalex.org/G2803025283","display_name":null,"funder_award_id":"81701749","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8386195870","display_name":null,"funder_award_id":"18DZ2260400","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320328940","display_name":"Shanghai Key Laboratory of Molecular Imaging","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3207103934.pdf","grobid_xml":"https://content.openalex.org/works/W3207103934.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W17430403","https://openalex.org/W1530512370","https://openalex.org/W1819750950","https://openalex.org/W1969734756","https://openalex.org/W1982142182","https://openalex.org/W2001273659","https://openalex.org/W2006178558","https://openalex.org/W2010391271","https://openalex.org/W2012394652","https://openalex.org/W2014011572","https://openalex.org/W2022997320","https://openalex.org/W2023819796","https://openalex.org/W2048359072","https://openalex.org/W2049378139","https://openalex.org/W2071772651","https://openalex.org/W2088592029","https://openalex.org/W2119826342","https://openalex.org/W2120052544","https://openalex.org/W2123169680","https://openalex.org/W2127215370","https://openalex.org/W2160300693","https://openalex.org/W2167516940","https://openalex.org/W2235523093","https://openalex.org/W2323433307","https://openalex.org/W2484161709","https://openalex.org/W2585934850","https://openalex.org/W2602684234","https://openalex.org/W2755787882","https://openalex.org/W2889646458","https://openalex.org/W2944474235","https://openalex.org/W3005807253","https://openalex.org/W3177602305"],"related_works":["https://openalex.org/W2944474235","https://openalex.org/W2333580726","https://openalex.org/W1978590557","https://openalex.org/W2037293356","https://openalex.org/W2511391114","https://openalex.org/W2078984136","https://openalex.org/W2075531994","https://openalex.org/W2084823099","https://openalex.org/W4220926268","https://openalex.org/W2320674004"],"abstract_inverted_index":{"Abstract":[0],"In":[1],"this":[2,131],"study,":[3],"a":[4,90],"novel":[5],"CT":[6,71],"contrast":[7,22,58,87,93],"agent":[8],"used":[9],"by":[10,31,65],"rectal":[11,67],"administration":[12,103],"is":[13,24],"developed":[14],"for":[15,69,79],"targeting":[16],"intestinal":[17,70,140],"imaging.":[18],"Iopamidol,":[19],"an":[20],"iodinated":[21],"agent,":[23],"loaded":[25],"in":[26,82,123,136],"chitosan":[27],"(CS)":[28],"nanospheres":[29,38],"modified":[30],"Anti-5-HT3R":[32],"(AH)":[33],"antibody.":[34],"The":[35,60],"obtained":[36],"AH-CS-I":[37,61,75,111,118],"(AH-CS-I":[39],"Ns)":[40],"would":[41,120],"combine":[42],"to":[43],"5-HT3":[44],"receptors":[45],"highly":[46],"expressed":[47],"on":[48],"the":[49,53,57,66,81,86,106,114,124,137,145],"gastrointestinal":[50],"mucosal,":[51],"enhancing":[52],"intestinal-targeting":[54],"ability":[55],"of":[56,85,105,109,139,148],"agent.":[59,88],"Ns":[62,76,119],"were":[63,77],"administered":[64,116],"route":[68],"imaging,":[72],"and":[73,126,142],"FITC-labeled":[74],"prepared":[78],"investigating":[80],"vivo":[83],"distribution":[84],"As":[89],"result,":[91],"obvious":[92],"enhancement":[94],"could":[95,143],"still":[96],"be":[97],"observed":[98],"at":[99],"6":[100],"h":[101],"post":[102],"because":[104],"poorly":[107],"absorption":[108],"enteral":[110],"Ns.":[112],"Unlike":[113],"intravascularly":[115],"agents,":[117],"not":[121],"accumulate":[122],"kidney":[125],"induce":[127],"adverse":[128],"reactions.":[129],"Therefore,":[130],"technology":[132],"has":[133],"potential":[134],"applications":[135],"examination":[138],"diseases":[141],"reduce":[144],"side":[146],"effect":[147],"commercial":[149],"iopamidol.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-10-25T00:00:00"}