{"id":"https://openalex.org/W3207102447","doi":"https://doi.org/10.1212/wnl.88.16_supplement.p5.138","title":"Identification of the CNTN1/CASPR complex as the target of autoantibodies in a patient with chronic inflammatory demyelinating polyneuropathy (P5.138)","display_name":"Identification of the CNTN1/CASPR complex as the target of autoantibodies in a patient with chronic inflammatory demyelinating polyneuropathy (P5.138)","publication_year":2017,"publication_date":"2017-04-18","ids":{"openalex":"https://openalex.org/W3207102447","doi":"https://doi.org/10.1212/wnl.88.16_supplement.p5.138","mag":"3207102447"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.88.16_supplement.p5.138","doi":"https://doi.org/10.1212/wnl.88.16_supplement.p5.138","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.88.16_supplement.p5.138","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009123410","display_name":"Stephanie Kade","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107322","display_name":"Euroimmun Medizinische Labordiagnostika (Germany)","ror":"https://ror.org/01qe7ag50","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107322"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stephanie Kade","raw_affiliation_strings":["Institute of Experimental Immunology, Euroimmun AG Luebeck Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Immunology, Euroimmun AG Luebeck Germany","institution_ids":["https://openalex.org/I4210107322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070236411","display_name":"Christine Strippel","orcid":"https://orcid.org/0000-0002-7080-6769","observed_orcids":["https://orcid.org/0000-0002-7080-6769"]},"institutions":[{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christine Strippel","raw_affiliation_strings":["Department of Neurology, University Hospital M\u00fcnster Muenster Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospital M\u00fcnster Muenster Germany","institution_ids":["https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033583223","display_name":"Bianca Teegen","orcid":"https://orcid.org/0000-0003-1770-2685","observed_orcids":["https://orcid.org/0000-0003-1770-2685"]},"institutions":[{"id":"https://openalex.org/I4210107322","display_name":"Euroimmun Medizinische Labordiagnostika (Germany)","ror":"https://ror.org/01qe7ag50","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107322"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bianca Teegen","raw_affiliation_strings":["Institute of Experimental Immunology, Euroimmun AG Luebeck Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Immunology, Euroimmun AG Luebeck Germany","institution_ids":["https://openalex.org/I4210107322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059486091","display_name":"Ramona Miske","orcid":"https://orcid.org/0000-0002-9424-4676","observed_orcids":["https://orcid.org/0000-0002-9424-4676"]},"institutions":[{"id":"https://openalex.org/I4210107322","display_name":"Euroimmun Medizinische Labordiagnostika (Germany)","ror":"https://ror.org/01qe7ag50","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107322"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ramona Miske","raw_affiliation_strings":["Institute of Experimental Immunology, Euroimmun AG Luebeck Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Immunology, Euroimmun AG Luebeck Germany","institution_ids":["https://openalex.org/I4210107322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113812936","display_name":"Madeleine Scharf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107322","display_name":"Euroimmun Medizinische Labordiagnostika (Germany)","ror":"https://ror.org/01qe7ag50","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107322"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Madeleine Scharf","raw_affiliation_strings":["Institute of Experimental Immunology, Euroimmun AG Luebeck Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Immunology, Euroimmun AG Luebeck Germany","institution_ids":["https://openalex.org/I4210107322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075431118","display_name":"Yvonne Denno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107322","display_name":"Euroimmun Medizinische Labordiagnostika (Germany)","ror":"https://ror.org/01qe7ag50","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107322"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Yvonne Denno","raw_affiliation_strings":["Institute of Experimental Immunology, Euroimmun AG Luebeck Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Immunology, Euroimmun AG Luebeck Germany","institution_ids":["https://openalex.org/I4210107322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101957294","display_name":"Christian Probst","orcid":"https://orcid.org/0000-0002-0286-8482","observed_orcids":["https://orcid.org/0000-0002-0286-8482"]},"institutions":[{"id":"https://openalex.org/I4210107322","display_name":"Euroimmun Medizinische Labordiagnostika (Germany)","ror":"https://ror.org/01qe7ag50","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107322"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Probst","raw_affiliation_strings":["Institute of Experimental Immunology, Euroimmun AG Luebeck Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Immunology, Euroimmun AG Luebeck Germany","institution_ids":["https://openalex.org/I4210107322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033992254","display_name":"Christiane Radzimski","orcid":"https://orcid.org/0009-0008-0612-9143","observed_orcids":["https://orcid.org/0009-0008-0612-9143"]},"institutions":[{"id":"https://openalex.org/I4210107322","display_name":"Euroimmun Medizinische Labordiagnostika (Germany)","ror":"https://ror.org/01qe7ag50","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107322"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christiane Radzimski","raw_affiliation_strings":["Institute of Experimental Immunology, Euroimmun AG Luebeck Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Immunology, Euroimmun AG Luebeck Germany","institution_ids":["https://openalex.org/I4210107322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058468384","display_name":"WINFRIED ST\u00d6CKER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107322","display_name":"Euroimmun Medizinische Labordiagnostika (Germany)","ror":"https://ror.org/01qe7ag50","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107322"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Winfried St\u00f6cker","raw_affiliation_strings":["Institute of Experimental Immunology, Euroimmun AG Luebeck Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Immunology, Euroimmun AG Luebeck Germany","institution_ids":["https://openalex.org/I4210107322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068927429","display_name":"Nico Melzer","orcid":"https://orcid.org/0000-0002-2420-701X","observed_orcids":["https://orcid.org/0000-0002-2420-701X"]},"institutions":[{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nico Melzer","raw_affiliation_strings":["Department of Neurology, University Hospital M\u00fcnster Muenster Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospital M\u00fcnster Muenster Germany","institution_ids":["https://openalex.org/I4210103666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055583657","display_name":"Lars Komorowski","orcid":"https://orcid.org/0000-0003-4698-3316","observed_orcids":["https://orcid.org/0000-0003-4698-3316"]},"institutions":[{"id":"https://openalex.org/I4210107322","display_name":"Euroimmun Medizinische Labordiagnostika (Germany)","ror":"https://ror.org/01qe7ag50","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107322"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lars Komorowski","raw_affiliation_strings":["Institute of Experimental Immunology, Euroimmun AG Luebeck Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Immunology, Euroimmun AG Luebeck Germany","institution_ids":["https://openalex.org/I4210107322"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"88","issue":"16_supplement","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11730","display_name":"Autoimmune Bullous Skin Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-inflammatory-demyelinating-polyradiculoneuropathy","display_name":"chronic inflammatory demyelinating polyneuropathy","score":0.9269999861717224},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.7940000295639038},{"id":"https://openalex.org/keywords/contactin-1","display_name":"contactin-1","score":0.9390000104904175},{"id":"https://openalex.org/keywords/caspr","display_name":"Caspr","score":0.8650000095367432},{"id":"https://openalex.org/keywords/nodes-of-ranvier","display_name":"nodes of Ranvier","score":0.8460000157356262},{"id":"https://openalex.org/keywords/autoantigen-identification","display_name":"autoantigen identification","score":0.8190000057220459},{"id":"https://openalex.org/keywords/igg3","display_name":"IgG3","score":0.7049999833106995},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.6480000019073486},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9639999866485596},{"id":"https://openalex.org/keywords/demyelination","display_name":"demyelination","score":0.7570000290870667},{"id":"https://openalex.org/keywords/axonal-injury","display_name":"axonal injury","score":0.5879999995231628},{"id":"https://openalex.org/keywords/albuminocytologic-dissociation","display_name":"albuminocytologic dissociation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/blood-cerebrospinal-fluid-barrier","display_name":"blood-CSF barrier","score":0.8029999732971191},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.4480000138282776}],"concepts":[{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.8085477352142334},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6706196069717407},{"id":"https://openalex.org/C2779867792","wikidata":"https://www.wikidata.org/wiki/Q1088030","display_name":"Chronic inflammatory demyelinating polyneuropathy","level":3,"score":0.6379599571228027},{"id":"https://openalex.org/C2775892965","wikidata":"https://www.wikidata.org/wiki/Q1502312","display_name":"Polyneuropathy","level":2,"score":0.561587929725647},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3903310298919678},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37773144245147705},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3106098473072052},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.16931653022766113}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1212/wnl.88.16_supplement.p5.138","doi":"https://doi.org/10.1212/wnl.88.16_supplement.p5.138","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.88.16_supplement.p5.138","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1566573763","https://openalex.org/W2591775523","https://openalex.org/W4307562893","https://openalex.org/W3095467523","https://openalex.org/W2961244222","https://openalex.org/W2335477060","https://openalex.org/W4207063073","https://openalex.org/W2494661094","https://openalex.org/W2765414746","https://openalex.org/W4389460585"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"identify":[2],"the":[3,19,47,80,120,133,170,192,218,224,246,250,283],"target":[4,50],"of":[5,10,21,79,109,119,128,163,169,176,191,249,268,274,288],"autoantibodies":[6,275],"in":[7,25,41,97,256,261,286],"a":[8,27,42,107,187,214,240],"case":[9],"chronic":[11],"inflammatory":[12],"demyelinating":[13],"polyradiculoneuropathy":[14],"(CIDP).":[15],"Background:":[16],"Autoantibodies":[17],"against":[18,276],"nodes":[20,287],"Ranvier":[22],"occasionally":[23],"appear":[24],"CIDP,":[26],"frequent":[28],"but":[29,124],"heterogeneous":[30],"neuropathy.":[31],"We":[32],"discovered":[33],"an":[34,161,271,314,340,372],"unspecified":[35],"IgG":[36],"reactivity":[37,248],"on":[38,282],"brain":[39],"tissue":[40,247],"patient\u2019s":[43],"serum":[44,81],"and":[45,60,64,84,99,132,142,160,194,205,211,234],"identified":[46,202],"corresponding":[48,199],"neuronal":[49],"antigens.":[51],"Design/Methods:":[52],"The":[53,93,103,198,266],"Caucasian":[54],"male":[55],"(46y)":[56],"underwent":[57],"neurological,":[58],"neuroimaging":[59],"laboratory":[61],"investigation.":[62],"Serum":[63],"cerebrospinal":[65],"fluid":[66],"(CSF)":[67],"were":[68,87,95,178,201],"analyzed":[69],"by":[70,77],"indirect":[71],"immunofluorescence":[72],"assay":[73],"(IFA).":[74],"Histo-immunoprecipitates":[75],"obtained":[76],"incubation":[78],"with":[82,106,156,167,217,310,336,368],"rat":[83],"porcine":[85],"cerebellum":[86],"subjected":[88],"to":[89,292,320,326,346,352,358,378,384,390],"mass":[90],"spectrometric":[91],"analysis.":[92],"antigens":[94],"expressed":[96,281],"HEK293":[98,207],"used":[100],"for":[101,115,308,334,366],"IFA.":[102],"patient":[104,219],"presented":[105],"history":[108],"progressive":[110],"distal-symmetric":[111],"flaccid":[112],"sensorimotor":[113],"tetraparesis":[114],"12":[116],"months.":[117],"MRI":[118],"head":[121],"was":[122,253],"unremarkable":[123],"revealed":[125,186],"contrast":[126],"enhancement":[127],"spinal":[129],"nerve":[130],"roots":[131],"cauda":[134],"equina.":[135],"Nerve":[136],"conduction":[137],"studies":[138],"showed":[139,153,213],"pronounced":[140],"demyelination":[141],"axonal":[143,284],"damage.":[144],"Electromyography":[145],"demonstrated":[146],"widespread":[147],"pathologic":[148],"spontaneous":[149],"activity.":[150],"CSF":[151,164],"analysis":[152],"albuminocytological":[154],"dissociation":[155],"normal":[157],"cell":[158],"count":[159],"elevation":[162],"total":[165],"protein":[166],"disruption":[168],"blood-CSF":[171],"barrier":[172],"function.":[173],"Known":[174],"causes":[175],"polyneuropathy":[177],"ruled":[179],"out":[180],"using":[181],"standard":[182],"techniques.":[183],"Results:":[184],"IFA":[185],"granular":[188],"IgG3":[189],"staining":[190],"hippocampal":[193],"cerebellar":[195],"molecular":[196],"layers.":[197],"autoantigens":[200],"as":[203,313,339,371],"CNTN1":[204,210],"CASPR.":[206],"co-expressing":[208],"human":[209],"CASPR":[212],"specific":[215],"reaction":[216],"serum.":[220],"However,":[221],"cells":[222],"expressing":[223],"individual":[225],"proteins":[226],"or":[227],"32":[228],"established":[229],"neural":[230],"autoantigens,":[231],"including":[232],"CNTN2":[233],"CASPR2,":[235],"did":[236],"not":[237],"react.":[238],"In":[239],"neutralization":[241],"experiment,":[242],"recombinant":[243],"CNTN1/CASPR":[244],"abolished":[245],"samples.":[251],"Anti-CNTN1/CASPR-IgG":[252],"neither":[254],"detectable":[255],"29":[257],"disease":[258],"controls":[259],"nor":[260],"48":[262],"healthy":[263],"controls.":[264],"Conclusions:":[265],"discovery":[267],"anti-CNTN1/CASPR-IgG":[269],"confirms":[270],"earlier":[272],"report":[273],"this":[277],"complex":[278],"that":[279],"is":[280],"surface":[285],"Ranvier.":[289],"It":[290],"remains":[291],"be":[293],"assessed":[294],"whether":[295],"these":[296],"antibodies":[297],"carry":[298],"pathogenic":[299],"potential.":[300],"Disclosure:":[301],"Dr.":[302,316,322,328,342,348,354,360,374,380,386],"Kade":[303],"has":[304,318,324,330,344,350,356,362,376,382,388],"received":[305,331,363],"personal":[306,332,364],"compensation":[307,333,365],"activities":[309,335,367],"Euroimmun":[311,337,369],"AG":[312,338,370],"employee.":[315,341,373],"Strippel":[317],"nothing":[319,325,345,351,357,377,383,389],"disclose.":[321,327,347,353,359,379,385,391],"Teegen":[323],"Miske":[329],"Scharf":[343],"Denno":[349],"Probst":[355],"Radzimski":[361],"St\u00f6cker":[375],"Melzer":[381],"Komorowski":[387]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2021-10-25T00:00:00"}