{"id":"https://openalex.org/W3207052549","doi":"https://doi.org/10.1038/s41598-021-99705-y","title":"Dynamic alterations in monocyte numbers, subset frequencies and activation markers in acute and convalescent COVID-19 individuals","display_name":"Dynamic alterations in monocyte numbers, subset frequencies and activation markers in acute and convalescent COVID-19 individuals","publication_year":2021,"publication_date":"2021-10-12","ids":{"openalex":"https://openalex.org/W3207052549","doi":"https://doi.org/10.1038/s41598-021-99705-y","mag":"3207052549","pmid":"https://pubmed.ncbi.nlm.nih.gov/34642411","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8511073"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-021-99705-y","doi":"https://doi.org/10.1038/s41598-021-99705-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-99705-y","pdf_url":"https://www.nature.com/articles/s41598-021-99705-y.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3207052549"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-021-99705-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101676321","display_name":"Anuradha Rajamanickam","orcid":"https://orcid.org/0000-0002-8143-5502","observed_orcids":["https://orcid.org/0000-0002-8143-5502"]},"institutions":[{"id":"https://openalex.org/I37048141","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28","country_code":"IN","type":"government","lineage":["https://openalex.org/I37048141"]},{"id":"https://openalex.org/I4210140595","display_name":"National Institute of Research in Tuberculosis","ror":"https://ror.org/03qp1eh12","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210140595"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Anuradha Rajamanickam","raw_affiliation_strings":["International Center for Excellence in Research - ICMR- National Institute for Research in Tuberculosis, Chennai, TamilNadu, India. anuradha@nirt.res.in","International Center for Excellence in Research - ICMR- National Institute for Research in Tuberculosis, Chennai, TamilNadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Center for Excellence in Research - ICMR- National Institute for Research in Tuberculosis, Chennai, TamilNadu, India. anuradha@nirt.res.in","institution_ids":["https://openalex.org/I37048141","https://openalex.org/I4210140595"]},{"raw_affiliation_string":"International Center for Excellence in Research - ICMR- National Institute for Research in Tuberculosis, Chennai, TamilNadu, India","institution_ids":["https://openalex.org/I37048141","https://openalex.org/I4210140595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021222633","display_name":"Nathella Pavan Kumar","orcid":"https://orcid.org/0000-0003-2969-2621","observed_orcids":["https://orcid.org/0000-0003-2969-2621","https://orcid.org/0000-0002-4901-1507"]},"institutions":[{"id":"https://openalex.org/I4210140595","display_name":"National Institute of Research in Tuberculosis","ror":"https://ror.org/03qp1eh12","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210140595"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nathella Pavan Kumar","raw_affiliation_strings":["Immunology-ICMR-National Institute for Research in Tuberculosis, Chennai, TamilNadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology-ICMR-National Institute for Research in Tuberculosis, Chennai, TamilNadu, India","institution_ids":["https://openalex.org/I4210140595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015500974","display_name":"Arul Nancy","orcid":"https://orcid.org/0000-0002-9561-8967","observed_orcids":["https://orcid.org/0000-0002-9561-8967"]},"institutions":[{"id":"https://openalex.org/I37048141","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28","country_code":"IN","type":"government","lineage":["https://openalex.org/I37048141"]},{"id":"https://openalex.org/I4210140595","display_name":"National Institute of Research in Tuberculosis","ror":"https://ror.org/03qp1eh12","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210140595"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arul Nancy Pandiarajan","raw_affiliation_strings":["International Center for Excellence in Research - ICMR- National Institute for Research in Tuberculosis, Chennai, TamilNadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Center for Excellence in Research - ICMR- National Institute for Research in Tuberculosis, Chennai, TamilNadu, India","institution_ids":["https://openalex.org/I37048141","https://openalex.org/I4210140595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070136561","display_name":"Nandhini Selvaraj","orcid":"https://orcid.org/0009-0001-7284-9156","observed_orcids":["https://orcid.org/0009-0001-7284-9156"]},"institutions":[{"id":"https://openalex.org/I37048141","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28","country_code":"IN","type":"government","lineage":["https://openalex.org/I37048141"]},{"id":"https://openalex.org/I4210140595","display_name":"National Institute of Research in Tuberculosis","ror":"https://ror.org/03qp1eh12","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210140595"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nandhini Selvaraj","raw_affiliation_strings":["International Center for Excellence in Research - ICMR- National Institute for Research in Tuberculosis, Chennai, TamilNadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Center for Excellence in Research - ICMR- National Institute for Research in Tuberculosis, Chennai, TamilNadu, India","institution_ids":["https://openalex.org/I37048141","https://openalex.org/I4210140595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090044485","display_name":"Saravanan Munisankar","orcid":"https://orcid.org/0000-0001-8394-0038","observed_orcids":["https://orcid.org/0000-0001-8394-0038"]},"institutions":[{"id":"https://openalex.org/I37048141","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28","country_code":"IN","type":"government","lineage":["https://openalex.org/I37048141"]},{"id":"https://openalex.org/I4210140595","display_name":"National Institute of Research in Tuberculosis","ror":"https://ror.org/03qp1eh12","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210140595"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Saravanan Munisankar","raw_affiliation_strings":["International Center for Excellence in Research - ICMR- National Institute for Research in Tuberculosis, Chennai, TamilNadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Center for Excellence in Research - ICMR- National Institute for Research in Tuberculosis, Chennai, TamilNadu, India","institution_ids":["https://openalex.org/I37048141","https://openalex.org/I4210140595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109590430","display_name":"Rachel Mariam Renji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37048141","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28","country_code":"IN","type":"government","lineage":["https://openalex.org/I37048141"]},{"id":"https://openalex.org/I4210140595","display_name":"National Institute of Research in Tuberculosis","ror":"https://ror.org/03qp1eh12","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210140595"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rachel Mariam Renji","raw_affiliation_strings":["International Center for Excellence in Research - ICMR- National Institute for Research in Tuberculosis, Chennai, TamilNadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Center for Excellence in Research - ICMR- National Institute for Research in Tuberculosis, Chennai, TamilNadu, India","institution_ids":["https://openalex.org/I37048141","https://openalex.org/I4210140595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020778281","display_name":"Vijayalakshmi Venkatramani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37048141","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28","country_code":"IN","type":"government","lineage":["https://openalex.org/I37048141"]},{"id":"https://openalex.org/I4210140595","display_name":"National Institute of Research in Tuberculosis","ror":"https://ror.org/03qp1eh12","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210140595"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vijayalakshmi Venkatramani","raw_affiliation_strings":["International Center for Excellence in Research - ICMR- National Institute for Research in Tuberculosis, Chennai, TamilNadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Center for Excellence in Research - ICMR- National Institute for Research in Tuberculosis, Chennai, TamilNadu, India","institution_ids":["https://openalex.org/I37048141","https://openalex.org/I4210140595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076582132","display_name":"Manoj Vasanth Murhekar","orcid":"https://orcid.org/0000-0002-1720-7628","observed_orcids":["https://orcid.org/0000-0002-1720-7628"]},"institutions":[{"id":"https://openalex.org/I4210100069","display_name":"National Institute of Epidemiology","ror":"https://ror.org/011471042","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210100069"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manoj Murhekar","raw_affiliation_strings":["ICMR-National Institute of Epidemiology, Chennai, TamilNadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICMR-National Institute of Epidemiology, Chennai, TamilNadu, India","institution_ids":["https://openalex.org/I4210100069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110948266","display_name":"Jeromie Wesley Vivian Thangaraj","orcid":"https://orcid.org/0000-0002-7423-7209","observed_orcids":["https://orcid.org/0000-0002-7423-7209"]},"institutions":[{"id":"https://openalex.org/I4210100069","display_name":"National Institute of Epidemiology","ror":"https://ror.org/011471042","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210100069"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jeromie W. V. Thangaraj","raw_affiliation_strings":["ICMR-National Institute of Epidemiology, Chennai, TamilNadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICMR-National Institute of Epidemiology, Chennai, TamilNadu, India","institution_ids":["https://openalex.org/I4210100069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109508989","display_name":"Muthusamy Santhosh Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100069","display_name":"National Institute of Epidemiology","ror":"https://ror.org/011471042","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210100069"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Muthusamy Santhosh Kumar","raw_affiliation_strings":["ICMR-National Institute of Epidemiology, Chennai, TamilNadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICMR-National Institute of Epidemiology, Chennai, TamilNadu, India","institution_ids":["https://openalex.org/I4210100069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043496374","display_name":"C. P. Girish Kumar","orcid":"https://orcid.org/0000-0002-5464-1028","observed_orcids":["https://orcid.org/0000-0002-5464-1028"]},"institutions":[{"id":"https://openalex.org/I4210100069","display_name":"National Institute of Epidemiology","ror":"https://ror.org/011471042","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210100069"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"C. P. Girish Kumar","raw_affiliation_strings":["ICMR-National Institute of Epidemiology, Chennai, TamilNadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICMR-National Institute of Epidemiology, Chennai, TamilNadu, India","institution_ids":["https://openalex.org/I4210100069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084961890","display_name":"Tarun Bhatnagar","orcid":"https://orcid.org/0000-0002-5603-1418","observed_orcids":["https://orcid.org/0000-0002-5603-1418"]},"institutions":[{"id":"https://openalex.org/I4210100069","display_name":"National Institute of Epidemiology","ror":"https://ror.org/011471042","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210100069"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Tarun Bhatnagar","raw_affiliation_strings":["ICMR-National Institute of Epidemiology, Chennai, TamilNadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICMR-National Institute of Epidemiology, Chennai, TamilNadu, India","institution_ids":["https://openalex.org/I4210100069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049001101","display_name":"Manickam Ponnaiah","orcid":"https://orcid.org/0000-0002-0797-0822","observed_orcids":["https://orcid.org/0000-0002-0797-0822"]},"institutions":[{"id":"https://openalex.org/I4210100069","display_name":"National Institute of Epidemiology","ror":"https://ror.org/011471042","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210100069"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manickam Ponnaiah","raw_affiliation_strings":["ICMR-National Institute of Epidemiology, Chennai, TamilNadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICMR-National Institute of Epidemiology, Chennai, TamilNadu, India","institution_ids":["https://openalex.org/I4210100069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079533457","display_name":"Ramasamy Sabarinathan","orcid":"https://orcid.org/0000-0003-1803-9977","observed_orcids":["https://orcid.org/0000-0003-1803-9977"]},"institutions":[{"id":"https://openalex.org/I4210100069","display_name":"National Institute of Epidemiology","ror":"https://ror.org/011471042","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210100069"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"R. Sabarinathan","raw_affiliation_strings":["ICMR-National Institute of Epidemiology, Chennai, TamilNadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICMR-National Institute of Epidemiology, Chennai, TamilNadu, India","institution_ids":["https://openalex.org/I4210100069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109522175","display_name":"V. Saravanakumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100069","display_name":"National Institute of Epidemiology","ror":"https://ror.org/011471042","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210100069"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"V. Saravanakumar","raw_affiliation_strings":["ICMR-National Institute of Epidemiology, Chennai, TamilNadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICMR-National Institute of Epidemiology, Chennai, TamilNadu, India","institution_ids":["https://openalex.org/I4210100069"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077213465","display_name":"Subash Babu","orcid":"https://orcid.org/0000-0001-9783-8042","observed_orcids":["https://orcid.org/0000-0001-9783-8042"]},"institutions":[{"id":"https://openalex.org/I37048141","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28","country_code":"IN","type":"government","lineage":["https://openalex.org/I37048141"]},{"id":"https://openalex.org/I4210140595","display_name":"National Institute of Research in Tuberculosis","ror":"https://ror.org/03qp1eh12","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210140595"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Subash Babu","raw_affiliation_strings":["International Center for Excellence in Research - ICMR- National Institute for Research in Tuberculosis, Chennai, TamilNadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Center for Excellence in Research - ICMR- National Institute for Research in Tuberculosis, Chennai, TamilNadu, India","institution_ids":["https://openalex.org/I37048141","https://openalex.org/I4210140595"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101676321"],"corresponding_institution_ids":["https://openalex.org/I37048141","https://openalex.org/I4210140595"],"apc_list":{"value":1990,"currency":"USD","value_usd":1990},"apc_paid":{"value":1990,"currency":"USD","value_usd":1990},"fwci":5.1034,"has_fulltext":true,"cited_by_count":69,"citation_normalized_percentile":{"value":0.96537018,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"11","issue":"1","first_page":"20254","last_page":"20254"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9819999933242798},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9419999718666077},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.9700000286102295},{"id":"https://openalex.org/keywords/monocyte-subsets","display_name":"monocyte subsets","score":0.9610000252723694},{"id":"https://openalex.org/keywords/classical-monocytes","display_name":"classical monocytes","score":0.9599999785423279},{"id":"https://openalex.org/keywords/intermediate-monocytes","display_name":"intermediate monocytes","score":0.9860000014305115},{"id":"https://openalex.org/keywords/nonclassical-monocytes","display_name":"non-classical monocytes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/soluble-cd14","display_name":"soluble CD14","score":0.972000002861023},{"id":"https://openalex.org/keywords/soluble-cd163","display_name":"soluble CD163","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tissue-factor","display_name":"tissue factor","score":0.7990000247955322},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9950000047683716},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.9100000262260437},{"id":"https://openalex.org/keywords/convalescence","display_name":"convalescence","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.9111288785934448},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5931575894355774},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.572971522808075},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.5385405421257019},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46943095326423645},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.32897433638572693},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26814526319503784},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.059872061014175415}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003289","descriptor_name":"Convalescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-021-99705-y","doi":"https://doi.org/10.1038/s41598-021-99705-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-99705-y","pdf_url":"https://www.nature.com/articles/s41598-021-99705-y.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:34642411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34642411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8511073","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8511073/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:eprints.nirt.res.in:1870","doi":null,"is_oa":false,"landing_page_url":"http://eprints.nirt.res.in/1870/1/202152.pdf","pdf_url":"http://eprints.nirt.res.in/1870/1/202152.pdf","source":{"id":"https://openalex.org/S4377196491","display_name":"NIRT Institutional Scholarship Repository (National Institute of Research in Tuberculosis)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210140595","host_organization_name":"National Institute of Research in Tuberculosis","host_organization_lineage":["https://openalex.org/I4210140595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:33680c86d3764ec7a1763ce879b0908e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/33680c86d3764ec7a1763ce879b0908e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-021-99705-y","doi":"https://doi.org/10.1038/s41598-021-99705-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-99705-y","pdf_url":"https://www.nature.com/articles/s41598-021-99705-y.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320720","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3207052549.pdf","grobid_xml":"https://content.openalex.org/works/W3207052549.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W17446229","https://openalex.org/W1772141148","https://openalex.org/W1981126412","https://openalex.org/W1988070702","https://openalex.org/W1990048254","https://openalex.org/W1999300957","https://openalex.org/W2006734344","https://openalex.org/W2010275186","https://openalex.org/W2030743391","https://openalex.org/W2085099489","https://openalex.org/W2098152094","https://openalex.org/W2791016534","https://openalex.org/W2804158667","https://openalex.org/W2967035454","https://openalex.org/W3019269725","https://openalex.org/W3023982717","https://openalex.org/W3024879069","https://openalex.org/W3033194401","https://openalex.org/W3041842588","https://openalex.org/W3046656138","https://openalex.org/W3047168254","https://openalex.org/W3047549677","https://openalex.org/W3080819661","https://openalex.org/W3082675822","https://openalex.org/W3088419707","https://openalex.org/W3108943464","https://openalex.org/W3109620665","https://openalex.org/W3132445051"],"related_works":["https://openalex.org/W4390584541","https://openalex.org/W4362587443","https://openalex.org/W4286462113","https://openalex.org/W4312301178","https://openalex.org/W4224304409","https://openalex.org/W4313588628","https://openalex.org/W3088419707","https://openalex.org/W7051424213","https://openalex.org/W4309093610"],"abstract_inverted_index":{"Monocytes":[0],"are":[1],"thought":[2],"to":[3,95],"play":[4],"an":[5],"important":[6],"role":[7],"in":[8,29,57,168,181,189],"host":[9],"defence":[10],"and":[11,22,31,55,83,88,98,122,144,150,155,158,166,186,191],"pathogenesis":[12],"of":[13,19,39,43,49,60,70,80,86,105,118,141,147,153,162,178],"COVID-19.":[14,33],"However,":[15],"a":[16],"comprehensive":[17],"examination":[18],"monocyte":[20,44,50,142,182],"numbers":[21],"function":[23],"has":[24],"not":[25],"been":[26],"performed":[27],"longitudinally":[28],"acute":[30,190],"convalescent":[32,192],"We":[34],"examined":[35],"the":[36,41,46,77,84,103],"absolute":[37,78],"counts":[38,79,143],"monocytes,":[40],"frequency":[42,104],"subsets,":[45],"plasma":[47,116,160],"levels":[48,117,140,161],"activation":[51,187],"markers":[52],"using":[53],"flowcytometry":[54],"ELISA":[56],"seven":[58],"groups":[59],"COVID-19":[61,133,193],"individuals,":[62],"classified":[63],"based":[64],"on":[65],"days":[66],"since":[67],"RT-PCR":[68],"confirmation":[69],"SARS-CoV2":[71],"infection.":[72],"Our":[73],"data":[74],"shows":[75],"that":[76],"total":[81],"monocytes":[82,90,107,149,157],"frequencies":[85,146,152,185],"intermediate":[87,154],"non-classical":[89,156],"increases":[91],"from":[92,109,127],"Days":[93,96,110,113,128,131],"15-30":[94,111,129],"61-90":[97],"plateau":[99],"thereafter.":[100],"In":[101],"contrast,":[102],"classical":[106,148],"decreases":[108],"till":[112,130],"121-150.":[114],"The":[115],"sCD14,":[119,163],"CRP,":[120,164],"sCD163":[121,165],"sTissue":[123],"Factor":[124],"(sTF)-all":[125],"decrease":[126],"151-180.":[132],"patients":[134],"with":[135,170],"severe":[136],"disease":[137],"exhibit":[138],"higher":[139,145],"lower":[151],"elevated":[159],"sTF":[167],"comparison":[169],"mild":[171],"disease.":[172],"Thus,":[173],"our":[174],"study":[175],"provides":[176],"evidence":[177],"dynamic":[179],"alterations":[180],"counts,":[183],"subset":[184],"status":[188],"individuals.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":22},{"year":2022,"cited_by_count":15}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2021-10-25T00:00:00"}