{"id":"https://openalex.org/W3207044397","doi":"https://doi.org/10.1038/s41598-021-99659-1","title":"Long-term maintenance of functional primary human hepatocytes in 3D gelatin matrices produced by solution blow spinning","display_name":"Long-term maintenance of functional primary human hepatocytes in 3D gelatin matrices produced by solution blow spinning","publication_year":2021,"publication_date":"2021-10-11","ids":{"openalex":"https://openalex.org/W3207044397","doi":"https://doi.org/10.1038/s41598-021-99659-1","mag":"3207044397","pmid":"https://pubmed.ncbi.nlm.nih.gov/34635750","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8505433"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-021-99659-1","doi":"https://doi.org/10.1038/s41598-021-99659-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-99659-1","pdf_url":"https://www.nature.com/articles/s41598-021-99659-1.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-021-99659-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016122436","display_name":"Mariliis Klaas","orcid":"https://orcid.org/0000-0003-2457-5928","observed_orcids":["https://orcid.org/0000-0003-2457-5928"]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Mariliis Klaas","raw_affiliation_strings":["Institute of Molecular and Cell Biology, University of Tartu, Riia 23b, 51010, Tartu, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Cell Biology, University of Tartu, Riia 23b, 51010, Tartu, Estonia","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048924264","display_name":"Kaidi M\u00f6ll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Kaidi M\u00f6ll","raw_affiliation_strings":["Institute of Technology, University of Tartu, Nooruse 1, 50411, Tartu, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Technology, University of Tartu, Nooruse 1, 50411, Tartu, Estonia","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075577971","display_name":"Kristina M\u00e4emets\u2010Allas","orcid":"https://orcid.org/0000-0002-8510-9405","observed_orcids":["https://orcid.org/0000-0002-8510-9405"]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Kristina M\u00e4emets-Allas","raw_affiliation_strings":["Institute of Molecular and Cell Biology, University of Tartu, Riia 23b, 51010, Tartu, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Cell Biology, University of Tartu, Riia 23b, 51010, Tartu, Estonia","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090178938","display_name":"Mart Loog","orcid":"https://orcid.org/0000-0003-1330-8453","observed_orcids":["https://orcid.org/0000-0003-1330-8453","https://orcid.org/0000-0002-1298-8461"]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Mart Loog","raw_affiliation_strings":["Institute of Technology, University of Tartu, Nooruse 1, 50411, Tartu, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Technology, University of Tartu, Nooruse 1, 50411, Tartu, Estonia","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061650981","display_name":"Martin J\u00e4rvek\u00fclg","orcid":"https://orcid.org/0000-0002-9181-3124","observed_orcids":["https://orcid.org/0000-0002-9181-3124"]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Martin J\u00e4rvek\u00fclg","raw_affiliation_strings":["Laboratory of Physics of Nanostructures, Institute of Physics, University of Tartu, W. Ostwaldi 1, 50411, Tartu, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Physics of Nanostructures, Institute of Physics, University of Tartu, W. Ostwaldi 1, 50411, Tartu, Estonia","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083779705","display_name":"Viljar Jaks","orcid":"https://orcid.org/0000-0002-2221-6262","observed_orcids":["https://orcid.org/0000-0002-2221-6262"]},"institutions":[{"id":"https://openalex.org/I2802241215","display_name":"Tartu University Hospital","ror":"https://ror.org/01dm91j21","country_code":"EE","type":"healthcare","lineage":["https://openalex.org/I2802241215"]},{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":true,"raw_author_name":"Viljar Jaks","raw_affiliation_strings":["Dermatology Clinic, Tartu University Hospital, Raja 31, 50417, Tartu, Estonia. viljar.jaks@ut.ee","Institute of Molecular and Cell Biology, University of Tartu, Riia 23b, 51010, Tartu, Estonia. viljar.jaks@ut.ee","Dermatology Clinic, Tartu University Hospital, Raja 31, 50417, Tartu, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology Clinic, Tartu University Hospital, Raja 31, 50417, Tartu, Estonia. viljar.jaks@ut.ee","institution_ids":["https://openalex.org/I2802241215"]},{"raw_affiliation_string":"Institute of Molecular and Cell Biology, University of Tartu, Riia 23b, 51010, Tartu, Estonia. viljar.jaks@ut.ee","institution_ids":["https://openalex.org/I56085075"]},{"raw_affiliation_string":"Dermatology Clinic, Tartu University Hospital, Raja 31, 50417, Tartu, Estonia","institution_ids":["https://openalex.org/I2802241215"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083779705"],"corresponding_institution_ids":["https://openalex.org/I2802241215","https://openalex.org/I56085075"],"apc_list":{"value":1990,"currency":"USD","value_usd":1990},"apc_paid":{"value":1990,"currency":"USD","value_usd":1990},"fwci":1.1472,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.72743976,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"11","issue":"1","first_page":"20165","last_page":"20165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.8295999765396118,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.8295999765396118,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.07699999958276749,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.03999999910593033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/solution-blow-spinning","display_name":"solution blow spinning","score":0.9909999966621399},{"id":"https://openalex.org/keywords/gelatin-scaffolds","display_name":"gelatin scaffolds","score":0.8240000009536743},{"id":"https://openalex.org/keywords/porcine-gelatin","display_name":"porcine gelatin","score":0.8420000076293945},{"id":"https://openalex.org/keywords/human-hepatocytes","display_name":"human hepatocytes","score":0.7820000052452087},{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.6790000200271606},{"id":"https://openalex.org/keywords/drug-screening","display_name":"drug screening","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cyp-gene-expression","display_name":"CYP gene expression","score":0.7350000143051147},{"id":"https://openalex.org/keywords/hepatocyte-polarization","display_name":"hepatocyte polarization","score":0.6340000033378601},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.6579999923706055},{"id":"https://openalex.org/keywords/cytocompatibility","display_name":"cytocompatibility","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C2778823387","wikidata":"https://www.wikidata.org/wiki/Q179254","display_name":"Gelatin","level":2,"score":0.8902319669723511},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7267592549324036},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.6561518907546997},{"id":"https://openalex.org/C154815118","wikidata":"https://www.wikidata.org/wiki/Q453762","display_name":"Spinning","level":2,"score":0.576668381690979},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5086649060249329},{"id":"https://openalex.org/C12820456","wikidata":"https://www.wikidata.org/wiki/Q920873","display_name":"Microfiber","level":2,"score":0.5043238401412964},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.48019397258758545},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.46207597851753235},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.39227843284606934},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32368946075439453},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32225871086120605},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18689116835594177},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16342231631278992},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.1391409933567047},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09577599167823792}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005780","descriptor_name":"Gelatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D054457","descriptor_name":"Tissue Scaffolds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-021-99659-1","doi":"https://doi.org/10.1038/s41598-021-99659-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-99659-1","pdf_url":"https://www.nature.com/articles/s41598-021-99659-1.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8505433","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8505433","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:34635750","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34635750","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:fb3cbe72366b46c580ff8c4f55db7031","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fb3cbe72366b46c580ff8c4f55db7031","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-021-99659-1","doi":"https://doi.org/10.1038/s41598-021-99659-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-99659-1","pdf_url":"https://www.nature.com/articles/s41598-021-99659-1.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5333992380","display_name":null,"funder_award_id":"PRG057","funder_id":"https://openalex.org/F4320321090","funder_display_name":"Eesti Teadusagentuur"},{"id":"https://openalex.org/G5436951729","display_name":"Interactions between the extracellular matrix and macrophages in the pathology of Dupuytren's disease","funder_award_id":"PSG609","funder_id":"https://openalex.org/F4320321090","funder_display_name":"Eesti Teadusagentuur"}],"funders":[{"id":"https://openalex.org/F4320321090","display_name":"Eesti Teadusagentuur","ror":"https://ror.org/00jjeja18"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3207044397.pdf","grobid_xml":"https://content.openalex.org/works/W3207044397.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1061628335","https://openalex.org/W1829351585","https://openalex.org/W1916777863","https://openalex.org/W1981230656","https://openalex.org/W2018187848","https://openalex.org/W2023296392","https://openalex.org/W2044241207","https://openalex.org/W2046011628","https://openalex.org/W2054635074","https://openalex.org/W2060088854","https://openalex.org/W2061712172","https://openalex.org/W2062652813","https://openalex.org/W2067642526","https://openalex.org/W2079277029","https://openalex.org/W2290311699","https://openalex.org/W2345415005","https://openalex.org/W2474510574","https://openalex.org/W2482599381","https://openalex.org/W2518335133","https://openalex.org/W2549831703","https://openalex.org/W2557305825","https://openalex.org/W2558581266","https://openalex.org/W2610545851","https://openalex.org/W2782718389","https://openalex.org/W2792041093","https://openalex.org/W2792548707","https://openalex.org/W2804922717","https://openalex.org/W2808754728","https://openalex.org/W2905317708","https://openalex.org/W2952244974","https://openalex.org/W2954064367","https://openalex.org/W2977786572","https://openalex.org/W2989265205","https://openalex.org/W3026271055","https://openalex.org/W3026731970","https://openalex.org/W3044144040","https://openalex.org/W3153323717"],"related_works":["https://openalex.org/W4353041323","https://openalex.org/W2936783936","https://openalex.org/W4387692895","https://openalex.org/W7216918439","https://openalex.org/W3015983535","https://openalex.org/W2003990668","https://openalex.org/W3138200822","https://openalex.org/W1994648960","https://openalex.org/W2291966916","https://openalex.org/W7100647013"],"abstract_inverted_index":{"Solution":[0],"blow":[1],"spinning":[2],"(SBS)":[3],"has":[4],"recently":[5],"emerged":[6],"as":[7,29,119],"a":[8,186],"novel":[9],"method":[10],"that":[11,36,77,97,181],"can":[12],"produce":[13],"nano-":[14],"and":[15,108,158,165,188],"microfiber":[16],"structures":[17],"suitable":[18],"for":[19,27,46,91,105,122,172,191,195],"tissue":[20,80,95,133],"engineering.":[21],"Gelatin":[22],"is":[23,31,87],"an":[24,88,127],"excellent":[25],"precursor":[26],"SBS":[28,60,65,117,139],"it":[30],"derived":[32],"mainly":[33],"from":[34,61],"collagens":[35],"are":[37,185],"abundant":[38],"in":[39,101,135,153,168,193],"natural":[40],"extracellular":[41,81],"matrices.":[42],"Here":[43],"we":[44],"report,":[45],"the":[47,50,145,160],"first":[48],"time":[49],"successful":[51],"generation":[52],"of":[53,78,129,147,162],"3D":[54,93,130],"thermally":[55],"crosslinked":[56],"preforms":[57],"by":[58],"using":[59],"porcine":[62],"gelatin.":[63],"These":[64],"mats":[66,118,140],"were":[67,141],"shown":[68],"to":[69,76,109,125,155],"have":[70],"three-dimensional":[71],"fibrous":[72],"porous":[73],"structure":[74],"similar":[75],"mammalian":[79],"matrix.":[82],"In":[83],"pharma":[84],"industry,":[85],"there":[86],"urgent":[89],"need":[90],"adequate":[92],"liver":[94,113,132],"models":[96],"could":[98],"be":[99],"used":[100,116],"high":[102],"throughput":[103],"setting":[104],"drug":[106,111,196],"screening":[107],"assess":[110],"induced":[112],"injury.":[114],"We":[115],"culturing":[120],"substrates":[121],"human":[123,131],"hepatocytes":[124],"create":[126],"array":[128],"equivalents":[134],"96-well":[136],"format.":[137],"The":[138],"highly":[142],"cytocompatible,":[143],"facilitated":[144],"induction":[146],"hepatocyte":[148,163],"specific":[149],"CYP":[150],"gene":[151],"expression":[152],"response":[154],"common":[156],"medications,":[157],"supported":[159],"maintenance":[161],"differentiation":[164],"polarization":[166],"status":[167],"long":[169],"term":[170],"cultures":[171],"more":[173],"than":[174],"3":[175],"weeks.":[176],"Together,":[177],"our":[178],"results":[179],"show":[180],"SBS-generated":[182],"gelatin":[183],"scaffolds":[184],"simple":[187],"efficient":[189],"platform":[190],"use":[192],"vitro":[194],"testing":[197],"applications.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-10-25T00:00:00"}
