{"id":"https://openalex.org/W3206993334","doi":"https://doi.org/10.7774/cevr.2021.10.3.229","title":"Staphylococcus aureus derived hyaluronic acid and bacillus Calmette-Gu\u00e9rin purified proteins as immune enhancers to rabies vaccine and related immuno-histopathological alterations","display_name":"Staphylococcus aureus derived hyaluronic acid and bacillus Calmette-Gu\u00e9rin purified proteins as immune enhancers to rabies vaccine and related immuno-histopathological alterations","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3206993334","doi":"https://doi.org/10.7774/cevr.2021.10.3.229","mag":"3206993334","pmid":"https://pubmed.ncbi.nlm.nih.gov/34703805","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8511591"},"language":"en","primary_location":{"id":"doi:10.7774/cevr.2021.10.3.229","doi":"https://doi.org/10.7774/cevr.2021.10.3.229","is_oa":true,"landing_page_url":"https://doi.org/10.7774/cevr.2021.10.3.229","pdf_url":"http://ecevr.org/Synapse/Data/PDFData/9995CEVR/cevr-10-229.pdf","source":{"id":"https://openalex.org/S2764836785","display_name":"Clinical and Experimental Vaccine Research","issn_l":"2287-3651","issn":["2287-3651","2287-366X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319452","host_organization_name":"Seoul : Korean Vaccine Society","host_organization_lineage":["https://openalex.org/P4310319452"],"host_organization_lineage_names":["Seoul : Korean Vaccine Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Vaccine Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://ecevr.org/Synapse/Data/PDFData/9995CEVR/cevr-10-229.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063025932","display_name":"Rania Ibrahim Shebl","orcid":"https://orcid.org/0000-0003-2877-6196","observed_orcids":["https://orcid.org/0000-0003-2877-6196"]},"institutions":[{"id":"https://openalex.org/I61869032","display_name":"Ahram Canadian University","ror":"https://ror.org/02t055680","country_code":"EG","type":"education","lineage":["https://openalex.org/I61869032"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Rania Ibrahim Shebl","raw_affiliation_strings":["Microbiology and Immunology Department, Faculty of Pharmacy, Ahram Canadian University (ACU), Cairo, Egypt"],"raw_orcid":"https://orcid.org/0000-0003-2877-6196","affiliations":[{"raw_affiliation_string":"Microbiology and Immunology Department, Faculty of Pharmacy, Ahram Canadian University (ACU), Cairo, Egypt","institution_ids":["https://openalex.org/I61869032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088890037","display_name":"Mohamed E. Amer","orcid":"https://orcid.org/0000-0001-5964-5362","observed_orcids":["https://orcid.org/0000-0001-5964-5362"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mohamed E. Amer","raw_affiliation_strings":["Histology Department, Faculty of Medicine, Al-Azhar University, Damietta, Egypt"],"raw_orcid":"https://orcid.org/0000-0001-5964-5362","affiliations":[{"raw_affiliation_string":"Histology Department, Faculty of Medicine, Al-Azhar University, Damietta, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075114265","display_name":"Tamer M. M. Abu-Amara","orcid":"https://orcid.org/0000-0003-4326-3663","observed_orcids":["https://orcid.org/0000-0003-4326-3663"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Tamer M. M. Abuamara","raw_affiliation_strings":["Histology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt"],"raw_orcid":"https://orcid.org/0000-0003-4326-3663","affiliations":[{"raw_affiliation_string":"Histology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077838604","display_name":"Emadeldin R. Matar","orcid":"https://orcid.org/0000-0003-2460-4100","observed_orcids":["https://orcid.org/0000-0003-2460-4100"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Emadeldin R. Matar","raw_affiliation_strings":["Pathology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt"],"raw_orcid":"https://orcid.org/0000-0003-2460-4100","affiliations":[{"raw_affiliation_string":"Pathology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041587518","display_name":"Hassan Fathy Ahmed","orcid":"https://orcid.org/0000-0001-5385-0293","observed_orcids":["https://orcid.org/0000-0001-5385-0293"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Hassan Fathy Ahmed","raw_affiliation_strings":["Histology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt"],"raw_orcid":"https://orcid.org/0000-0001-5385-0293","affiliations":[{"raw_affiliation_string":"Histology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037298626","display_name":"Tamer Albasyoni Gomah","orcid":"https://orcid.org/0009-0009-7734-5385","observed_orcids":["https://orcid.org/0009-0009-7734-5385","https://orcid.org/0000-0003-2370-3801"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Tamer Albasyoni Gomah","raw_affiliation_strings":["Histology Department, Faculty of Medicine, Al-Azhar University, Damietta, Egypt"],"raw_orcid":"https://orcid.org/0000-0003-2370-3801","affiliations":[{"raw_affiliation_string":"Histology Department, Faculty of Medicine, Al-Azhar University, Damietta, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037211812","display_name":"Laila E. EI-Moselhy","orcid":"https://orcid.org/0000-0002-1602-335X","observed_orcids":["https://orcid.org/0000-0002-1602-335X"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Laila E. El Moselhy","raw_affiliation_strings":["Histology Department, Faculty of Medicine, Al-Azhar University, Damietta, Egypt"],"raw_orcid":"https://orcid.org/0000-0002-1602-335X","affiliations":[{"raw_affiliation_string":"Histology Department, Faculty of Medicine, Al-Azhar University, Damietta, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069776092","display_name":"Mohammed Abu\u2010Elghait","orcid":"https://orcid.org/0000-0001-9007-1029","observed_orcids":["https://orcid.org/0000-0001-9007-1029"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mohammed Abu-Elghait","raw_affiliation_strings":["Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt"],"raw_orcid":"https://orcid.org/0000-0001-9007-1029","affiliations":[{"raw_affiliation_string":"Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002458709","display_name":"Aly Fahmy Mohamed","orcid":"https://orcid.org/0000-0003-3629-3514","observed_orcids":["https://orcid.org/0000-0003-3629-3514"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aly Fahmy Mohamed","raw_affiliation_strings":["International Center for Training and Advanced Researches (ICTAR-Egypt), Cairo, Egypt"],"raw_orcid":"https://orcid.org/0000-0003-3629-3514","affiliations":[{"raw_affiliation_string":"International Center for Training and Advanced Researches (ICTAR-Egypt), Cairo, Egypt","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5063025932"],"corresponding_institution_ids":["https://openalex.org/I61869032"],"apc_list":null,"apc_paid":null,"fwci":0.8022,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.63954893,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"10","issue":"3","first_page":"229","last_page":"229"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11780","display_name":"Rabies epidemiology and control","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11780","display_name":"Rabies epidemiology and control","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rabies-vaccine","display_name":"rabies vaccine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/vaccine-adjuvants","display_name":"vaccine adjuvants","score":0.9710000157356262},{"id":"https://openalex.org/keywords/beta-propiolactone","display_name":"beta-propiolactone","score":0.8899999856948853},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.9829999804496765},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.8550000190734863},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.781000018119812},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.890999972820282},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.9980000257492065},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.5770000219345093},{"id":"https://openalex.org/keywords/histopathology","display_name":"histopathology","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.634333610534668},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6004467010498047},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.5727068781852722},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.5393663644790649},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.525068461894989},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4859108030796051},{"id":"https://openalex.org/C2776849203","wikidata":"https://www.wikidata.org/wiki/Q39222","display_name":"Rabies","level":2,"score":0.4609452188014984},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.43968650698661804},{"id":"https://openalex.org/C2780674857","wikidata":"https://www.wikidata.org/wiki/Q4007169","display_name":"Rabies vaccine","level":4,"score":0.41266191005706787},{"id":"https://openalex.org/C2777961786","wikidata":"https://www.wikidata.org/wiki/Q698976","display_name":"Rabies virus","level":3,"score":0.39102301001548767},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3833538293838501},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2542778253555298},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2077317237854004},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.07686910033226013},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.7774/cevr.2021.10.3.229","doi":"https://doi.org/10.7774/cevr.2021.10.3.229","is_oa":true,"landing_page_url":"https://doi.org/10.7774/cevr.2021.10.3.229","pdf_url":"http://ecevr.org/Synapse/Data/PDFData/9995CEVR/cevr-10-229.pdf","source":{"id":"https://openalex.org/S2764836785","display_name":"Clinical and Experimental Vaccine Research","issn_l":"2287-3651","issn":["2287-3651","2287-366X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319452","host_organization_name":"Seoul : Korean Vaccine Society","host_organization_lineage":["https://openalex.org/P4310319452"],"host_organization_lineage_names":["Seoul : Korean Vaccine Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Vaccine Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:7430522","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8511591","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:34703805","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34703805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental vaccine research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8511591","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8511591/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Vaccine Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.7774/cevr.2021.10.3.229","doi":"https://doi.org/10.7774/cevr.2021.10.3.229","is_oa":true,"landing_page_url":"https://doi.org/10.7774/cevr.2021.10.3.229","pdf_url":"http://ecevr.org/Synapse/Data/PDFData/9995CEVR/cevr-10-229.pdf","source":{"id":"https://openalex.org/S2764836785","display_name":"Clinical and Experimental Vaccine Research","issn_l":"2287-3651","issn":["2287-3651","2287-366X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319452","host_organization_name":"Seoul : Korean Vaccine Society","host_organization_lineage":["https://openalex.org/P4310319452"],"host_organization_lineage_names":["Seoul : Korean Vaccine Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Vaccine Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3206993334.pdf","grobid_xml":"https://content.openalex.org/works/W3206993334.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W65372312","https://openalex.org/W1173600150","https://openalex.org/W1966120871","https://openalex.org/W1990954596","https://openalex.org/W1995791232","https://openalex.org/W2021127656","https://openalex.org/W2021199802","https://openalex.org/W2036873761","https://openalex.org/W2045998027","https://openalex.org/W2089717164","https://openalex.org/W2091432666","https://openalex.org/W2156728669","https://openalex.org/W2158822880","https://openalex.org/W2166556848","https://openalex.org/W2213968270","https://openalex.org/W2256756668","https://openalex.org/W2333231591","https://openalex.org/W2336118379","https://openalex.org/W2339442565","https://openalex.org/W2473120803","https://openalex.org/W2807313281","https://openalex.org/W2888087638","https://openalex.org/W2888089762","https://openalex.org/W2913688862","https://openalex.org/W2914269281","https://openalex.org/W2965773057","https://openalex.org/W2972469799","https://openalex.org/W2990092235","https://openalex.org/W3003822528","https://openalex.org/W3005621850","https://openalex.org/W3021925405","https://openalex.org/W3092797747","https://openalex.org/W3161478181","https://openalex.org/W4211133799","https://openalex.org/W4290348133"],"related_works":["https://openalex.org/W2213968270","https://openalex.org/W1562547677","https://openalex.org/W2921207098","https://openalex.org/W1970470225","https://openalex.org/W268944088","https://openalex.org/W2187914877","https://openalex.org/W2904898889","https://openalex.org/W2016062486","https://openalex.org/W2391890575","https://openalex.org/W1956505666"],"abstract_inverted_index":{"Purpose:":[0],"One":[1],"of":[2,10,16,31,47,77,98,147,173,185,199,225,249,262],"the":[3,7,14,28,44,54,87,96,105,145,155,171,186,193,197,200,226,247],"essential":[4],"goals":[5],"regarding":[6],"successful":[8],"control":[9],"rabies":[11,62,127,176,252],"infection":[12],"is":[13],"development":[15,248],"a":[17,164,243],"safe,":[18],"effective,":[19],"and":[20,37,41,50,59,67,80,93,101,107,119,159,205,215,238,259],"inexpensive":[21],"vaccine.the":[22],"current":[23],"study":[24],"aimed":[25],"to":[26,162,179,220],"evaluate":[27],"inactivation":[29,45],"potential":[30],"\u03b2-propiolactone":[32],"(\u03b2PL),":[33],"binary":[34],"ethyleneimine":[35],"(BEI),":[36],"hydrogen":[38],"peroxide":[39],"(H2O2).Materials":[40],"Methods:":[42],"Estimating":[43],"kinetics":[46],"\u03b2PL,":[48,78],"BEI,":[49,79],"H2O2":[51,81],"revealed":[52],"that":[53,139,221,236],"tested":[55,187],"inactivants":[56],"could":[57,142,240],"completely":[58],"irreversibly":[60],"inactivate":[61],"virus":[63],"within":[64],"2,":[65],"12,":[66],"4":[68],"hours,":[69],"respectively":[70],"while":[71],"maintaining":[72],"its":[73],"viral":[74],"immunogenicity.The":[75],"potency":[76],"inactivated":[82],"vaccines":[83,218,253],"was":[84,168],"higher":[85,165],"than":[86],"World":[88],"Health":[89],"Organization":[90],"acceptance":[91],"limit":[92],"were":[94,130,189,210],"in":[95,170,196],"order":[97],"3.75,":[99],"4.21,":[100],"3.64":[102],"IU/mL,":[103],"respectively.Monitoring":[104],"humoral":[106],"cellular":[108],"immunity":[109],"elicited":[110],"post-immunization":[111],"using":[112,133,203],"Staphylococcus":[113],"aureus":[114],"derived":[115],"hyaluronic":[116],"acid":[117],"(HA)":[118],"bacillus":[120],"Calmette-Gu\u00e9rin":[121],"purified":[122],"protein":[123],"derivative":[124],"(PPD)":[125],"adjuvanted":[126,175,181,217,251],"vaccine":[128,177],"candidates":[129],"carried":[131],"out":[132],"enzyme-linked":[134],"immunosorbent":[135],"assay.Results:":[136],"Results":[137],"demonstrated":[138],"both":[140],"adjuvants":[141,188],"progressively":[143],"enhance":[144],"release":[146],"anti-rabies":[148],"total":[149],"immunoglobulin":[150],"G":[151],"as":[152,154,230,242],"well":[153],"pro-inflammatory":[156],"mediators":[157],"(interferongamma":[158],"interleukin-5)":[160],"relative":[161],"time.However,":[163],"immune":[166,256],"response":[167],"developed":[169],"case":[172],"HA":[174,214,237],"compared":[178,219],"PPD":[180,216,239],"one.The":[182],"harmful":[183],"consequences":[184],"considered":[190],"via":[191],"investigating":[192],"histopathological":[194],"changes":[195],"tissues":[198],"immunized":[201],"rats":[202],"hematoxylin":[204],"eosin":[206],"stain.Lower":[207],"adverse":[208],"effects":[209],"observed":[211],"post-vaccination":[212],"with":[213,254],"detected":[222],"following":[223],"administration":[224],"currently":[227],"used":[228],"alum":[229],"standard":[231],"adjuvant.Conclusion:":[232],"Our":[233],"findings":[234],"suggested":[235],"serve":[241],"promising":[244],"platform":[245],"for":[246],"newly":[250],"elevated":[255],"enhancing":[257],"potentials":[258],"lower":[260],"risk":[261],"health":[263],"hazards.":[264]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-10-25T00:00:00"}