{"id":"https://openalex.org/W3206839712","doi":"https://doi.org/10.1093/eurheartj/ehab724.3333","title":"IL-8 promotes the calcification of human aortic valve interstitial cells, which is prevented through antagonizing CXCR1 and CXCR2 receptors","display_name":"IL-8 promotes the calcification of human aortic valve interstitial cells, which is prevented through antagonizing CXCR1 and CXCR2 receptors","publication_year":2021,"publication_date":"2021-10-01","ids":{"openalex":"https://openalex.org/W3206839712","doi":"https://doi.org/10.1093/eurheartj/ehab724.3333","mag":"3206839712"},"language":"en","primary_location":{"id":"doi:10.1093/eurheartj/ehab724.3333","doi":"https://doi.org/10.1093/eurheartj/ehab724.3333","is_oa":false,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehab724.3333","pdf_url":null,"source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066505067","display_name":"Kawthar Dhayni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4401200359","display_name":"M\u00e9canismes physiopathologiques et cons\u00e9quences des calcifications cardiovasculaires","ror":"https://ror.org/00bgnvd66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4401200359","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4647051","display_name":"Universit\u00e9 de Picardie Jules Verne","ror":"https://ror.org/01gyxrk03","country_code":"FR","type":"education","lineage":["https://openalex.org/I4647051"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"K Dhayni","raw_affiliation_strings":["UPJV Amiens, MP3CV Laboratory. UPJV UR 7517, Amiens, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UPJV Amiens, MP3CV Laboratory. UPJV UR 7517, Amiens, France","institution_ids":["https://openalex.org/I4401200359","https://openalex.org/I4647051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011349769","display_name":"Yuthiline Chabry","orcid":"https://orcid.org/0000-0002-9601-951X","observed_orcids":["https://orcid.org/0000-0002-9601-951X"]},"institutions":[{"id":"https://openalex.org/I4210096553","display_name":"Centre Hospitalier Universitaire Amiens-Picardie","ror":"https://ror.org/010567a58","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210096553"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Y Chabry","raw_affiliation_strings":["University Hospital of Amiens, Department of cardiac surgery, Amiens, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital of Amiens, Department of cardiac surgery, Amiens, France","institution_ids":["https://openalex.org/I4210096553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063300681","display_name":"Lucie H\u00e9naut","orcid":"https://orcid.org/0000-0002-4745-3424","observed_orcids":["https://orcid.org/0000-0002-4745-3424"]},"institutions":[{"id":"https://openalex.org/I4401200359","display_name":"M\u00e9canismes physiopathologiques et cons\u00e9quences des calcifications cardiovasculaires","ror":"https://ror.org/00bgnvd66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4401200359","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4647051","display_name":"Universit\u00e9 de Picardie Jules Verne","ror":"https://ror.org/01gyxrk03","country_code":"FR","type":"education","lineage":["https://openalex.org/I4647051"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"L Henaut","raw_affiliation_strings":["UPJV Amiens, MP3CV Laboratory. UPJV UR 7517, Amiens, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UPJV Amiens, MP3CV Laboratory. UPJV UR 7517, Amiens, France","institution_ids":["https://openalex.org/I4401200359","https://openalex.org/I4647051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004132295","display_name":"Hakim Ouled\u2010Haddou","orcid":"https://orcid.org/0000-0002-3342-1288","observed_orcids":["https://orcid.org/0000-0002-3342-1288"]},"institutions":[{"id":"https://openalex.org/I4401200268","display_name":"H\u00e9matopo\u00ef\u00e8se et immunologie","ror":"https://ror.org/03keztm33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4401200268","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4647051","display_name":"Universit\u00e9 de Picardie Jules Verne","ror":"https://ror.org/01gyxrk03","country_code":"FR","type":"education","lineage":["https://openalex.org/I4647051"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"H Ouled-Haddou","raw_affiliation_strings":["UPJV Amiens, HEMATIM Laboratory, UPJV UR 4666, Amiens, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UPJV Amiens, HEMATIM Laboratory, UPJV UR 4666, Amiens, France","institution_ids":["https://openalex.org/I4401200268","https://openalex.org/I4647051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077063021","display_name":"Carine Avondo","orcid":"https://orcid.org/0000-0001-9310-7840","observed_orcids":["https://orcid.org/0000-0001-9310-7840"]},"institutions":[{"id":"https://openalex.org/I4401200359","display_name":"M\u00e9canismes physiopathologiques et cons\u00e9quences des calcifications cardiovasculaires","ror":"https://ror.org/00bgnvd66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4401200359","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4647051","display_name":"Universit\u00e9 de Picardie Jules Verne","ror":"https://ror.org/01gyxrk03","country_code":"FR","type":"education","lineage":["https://openalex.org/I4647051"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C Avondo","raw_affiliation_strings":["UPJV Amiens, MP3CV Laboratory. UPJV UR 7517, Amiens, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UPJV Amiens, MP3CV Laboratory. UPJV UR 7517, Amiens, France","institution_ids":["https://openalex.org/I4401200359","https://openalex.org/I4647051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016320226","display_name":"Christophe Michel Tribouilloy","orcid":"https://orcid.org/0000-0001-7867-3668","observed_orcids":["https://orcid.org/0000-0001-7867-3668"]},"institutions":[{"id":"https://openalex.org/I4210096553","display_name":"Centre Hospitalier Universitaire Amiens-Picardie","ror":"https://ror.org/010567a58","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210096553"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C Tribouilloy","raw_affiliation_strings":["University Hospital of Amiens, Department of Cardiology, Amiens, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital of Amiens, Department of Cardiology, Amiens, France","institution_ids":["https://openalex.org/I4210096553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024507243","display_name":"Thierry Caus","orcid":"https://orcid.org/0000-0001-9120-9026","observed_orcids":["https://orcid.org/0000-0001-9120-9026"]},"institutions":[{"id":"https://openalex.org/I4210096553","display_name":"Centre Hospitalier Universitaire Amiens-Picardie","ror":"https://ror.org/010567a58","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210096553"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"T Caus","raw_affiliation_strings":["University Hospital of Amiens, Department of cardiac surgery, Amiens, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital of Amiens, Department of cardiac surgery, Amiens, France","institution_ids":["https://openalex.org/I4210096553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026001986","display_name":"Kazem Zibara","orcid":"https://orcid.org/0000-0002-9887-072X","observed_orcids":["https://orcid.org/0000-0002-9887-072X"]},"institutions":[{"id":"https://openalex.org/I160368002","display_name":"Lebanese University","ror":"https://ror.org/05x6qnc69","country_code":"LB","type":"education","lineage":["https://openalex.org/I160368002"]}],"countries":["LB"],"is_corresponding":false,"raw_author_name":"K Zibara","raw_affiliation_strings":["Lebanese University, Department of Biology, Faculty of Sciences, Beirut, Lebanon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lebanese University, Department of Biology, Faculty of Sciences, Beirut, Lebanon","institution_ids":["https://openalex.org/I160368002"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108415860","display_name":"Sa\u00efd Kamel","orcid":"https://orcid.org/0009-0008-4801-4846","observed_orcids":["https://orcid.org/0009-0008-4801-4846"]},"institutions":[{"id":"https://openalex.org/I4401200359","display_name":"M\u00e9canismes physiopathologiques et cons\u00e9quences des calcifications cardiovasculaires","ror":"https://ror.org/00bgnvd66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4401200359","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4647051","display_name":"Universit\u00e9 de Picardie Jules Verne","ror":"https://ror.org/01gyxrk03","country_code":"FR","type":"education","lineage":["https://openalex.org/I4647051"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S Kamel","raw_affiliation_strings":["UPJV Amiens, MP3CV Laboratory. UPJV UR 7517, Amiens, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UPJV Amiens, MP3CV Laboratory. UPJV UR 7517, Amiens, France","institution_ids":["https://openalex.org/I4401200359","https://openalex.org/I4647051"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044273026","display_name":"Youssef Bennis","orcid":"https://orcid.org/0000-0002-0186-4797","observed_orcids":["https://orcid.org/0000-0002-0186-4797"]},"institutions":[{"id":"https://openalex.org/I4401200359","display_name":"M\u00e9canismes physiopathologiques et cons\u00e9quences des calcifications cardiovasculaires","ror":"https://ror.org/00bgnvd66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4401200359","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4647051","display_name":"Universit\u00e9 de Picardie Jules Verne","ror":"https://ror.org/01gyxrk03","country_code":"FR","type":"education","lineage":["https://openalex.org/I4647051"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Y Bennis","raw_affiliation_strings":["UPJV Amiens, MP3CV Laboratory. UPJV UR 7517, Amiens, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UPJV Amiens, MP3CV Laboratory. UPJV UR 7517, Amiens, France","institution_ids":["https://openalex.org/I4401200359","https://openalex.org/I4647051"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3918,"currency":"EUR","value_usd":4592},"apc_paid":null,"fwci":0.3494,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.55998478,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"42","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12924","display_name":"Dermatological and Skeletal Disorders","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9769999980926514},{"id":"https://openalex.org/keywords/calcific-aortic-stenosis","display_name":"calcific aortic stenosis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/aortic-valve-interstitial-cells","display_name":"aortic valve interstitial cells","score":0.9340000152587891},{"id":"https://openalex.org/keywords/valvular-calcification","display_name":"valve calcification","score":0.7680000066757202},{"id":"https://openalex.org/keywords/cxcr1","display_name":"CXCR1","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cxcr2","display_name":"CXCR2","score":1.0},{"id":"https://openalex.org/keywords/elastin","display_name":"elastin","score":0.7059999704360962},{"id":"https://openalex.org/keywords/matrix-metalloproteinase-12","display_name":"matrix metalloproteinase-12","score":0.9490000009536743},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":0.531000018119812},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6050000190734863},{"id":"https://openalex.org/keywords/elastin-degradation","display_name":"elastin degradation","score":0.30399999022483826},{"id":"https://openalex.org/keywords/myofibroblast-differentiation","display_name":"myofibroblast differentiation","score":0.49300000071525574}],"concepts":[{"id":"https://openalex.org/C2779869378","wikidata":"https://www.wikidata.org/wiki/Q409747","display_name":"Elastin","level":2,"score":0.7747284173965454},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7627304792404175},{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.7545791864395142},{"id":"https://openalex.org/C2780714102","wikidata":"https://www.wikidata.org/wiki/Q616071","display_name":"Aortic valve","level":2,"score":0.5868111848831177},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5209635496139526},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.45704135298728943},{"id":"https://openalex.org/C2781414266","wikidata":"https://www.wikidata.org/wiki/Q531019","display_name":"Aortic valve stenosis","level":3,"score":0.4269183278083801},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4239826798439026},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3962319791316986},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36039209365844727},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1392921805381775},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09172391891479492},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/eurheartj/ehab724.3333","doi":"https://doi.org/10.1093/eurheartj/ehab724.3333","is_oa":false,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehab724.3333","pdf_url":null,"source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4385402968","https://openalex.org/W4392224555","https://openalex.org/W7151306435","https://openalex.org/W7213384754","https://openalex.org/W7212975416","https://openalex.org/W4376134960","https://openalex.org/W2900458161","https://openalex.org/W3217535837","https://openalex.org/W2274637114","https://openalex.org/W7223556188"],"abstract_inverted_index":{"Abstract":[0],"Background/Introduction":[1],"Inflammation":[2],"is":[3,16],"a":[4,29,69,220,231,279],"key":[5],"feature":[6],"of":[7,40,55,105,115,134,146,163,172,176,183,199,205,213,238,251,257,265,268,277,282,286,295,307,313,322,348,380,397],"calcific":[8],"aortic":[9,42,56,201,324,378],"valve":[10,43,63,202],"stenosis":[11],"(CAVS)":[12],"against":[13],"which":[14,364],"there":[15],"currently":[17],"no":[18],"pharmacological":[19],"treatment.":[20],"Purpose":[21],"To":[22],"verify":[23],"the":[24,38,99,110,161,168,181,194,236,241,246,255,263,266,293,305,311,346,368,390],"hypothesis":[25],"that":[26,133,276],"interleukin-8":[27],"(IL-8),":[28],"pro-inflammatory":[30],"factor":[31],"involved":[32],"in":[33,68,167,193,235,240,319,331,350],"arterial":[34],"calcifications,":[35],"also":[36],"promotes":[37],"calcification":[39,237,290,347],"human":[41,200,323,375],"interstitial":[44],"cells":[45],"(hVICs).":[46],"Methods":[47],"Primary":[48],"hVICs":[49,106,239,289,349],"were":[50,66,165,208,301],"isolated":[51],"from":[52,59,211],"healthy":[53],"pieces":[54],"valves":[57,212,379],"harvested":[58],"patients":[60,381],"undergoing":[61],"surgical":[62],"replacement.":[64],"They":[65],"cultured":[67],"pro-calcifying":[70],"condition":[71],"(Pi-3.8mM)":[72],"with":[73,98,340,382],"or":[74,170],"without":[75,249],"IL-8":[76,147,164,227,259,287,344,362],"(5":[77],"to":[78,83,245,335,371,388],"50":[79],"pg/ml)":[80],"for":[81,367],"up":[82],"21":[84],"days.":[85],"Calcification":[86],"was":[87,96,107,140,152,189,222,317,328,354],"analysed":[88,141,190],"by":[89,109,142,154,191,304,357,374],"alizarin":[90],"red":[91],"staining":[92],"and":[93,120,122,127,138,150,157,160,178,185,187,196,219,270,274,291,298,315,338,360,377],"calcium":[94],"content":[95],"measured":[97],"o-cresolphthalein":[100],"complexone":[101],"method.":[102],"The":[103,113,144,284],"viability":[104],"verified":[108],"MTT":[111],"assay.":[112],"expression":[114,145,182,264,294,312,327],"osteogenic":[116],"(BMP2,":[117],"OPN,":[118,278],"osterix":[119],"ALP)":[121],"myofibrotic":[123],"(alpha-SMA,":[124],"collagen-1,":[125],"collagen-3":[126],"elastin)":[128],"markers":[129],"as":[130,132],"well":[131],"metalloproteases":[135],"(MMP-2,":[136],"-9":[137],"-12)":[139],"RT-qPCR.":[143],"receptors,":[148,363],"CXCR-1":[149,177,184,314,359],"CXCR-2":[151,361],"evaluated":[153],"Western":[155],"blot":[156],"flow":[158],"cytometry,":[159],"effects":[162,285],"tested":[166],"presence":[169,256],"absence":[171],"SCH527123,":[173],"an":[174,272],"antagonist":[175],"CXCR-2.":[179],"Finally,":[180],"-2":[186,316],"elastin":[188,269,297],"immunohistochemistry":[192],"calcified":[195,332],"non-calcified":[197,336],"areas":[198,333,337],"samples.":[203],"All":[204],"these":[206],"experiments":[207],"carried":[209],"out":[210],"at":[214],"least":[215],"5":[216],"different":[217],"donors":[218],"P<0.05":[221],"considered":[223],"statistically":[224],"significant.":[225],"Results":[226],"(15":[228],"pg/mL)":[229],"caused":[230],"significant":[232],"\u223c2-fold":[233],"increase":[234],"Pi":[242],"condition,":[243,248],"compared":[244,334],"Pi-only":[247],"modulation":[250],"cell":[252],"viability.":[253],"In":[254,309],"Pi,":[258],"exposure":[260],"significantly":[261,302,355],"stimulated":[262],"transcripts":[267,300],"MMP-12,":[271,296],"elastase,":[273],"reduced":[275],"well-known":[280],"inhibitor":[281],"calcification.":[283],"on":[288,292],"OPN":[299],"prevented":[303,356],"addition":[306],"SCH527123.":[308],"addition,":[310],"confirmed":[318],"histological":[320],"samples":[321],"valves.":[325],"This":[326,352],"more":[329],"pronounced":[330],"co-localized":[339],"degraded":[341],"elastin.":[342],"Conclusion":[343],"promoted":[345],"culture.":[351],"effect":[353],"antagonizing":[358],"we":[365],"showed":[366],"first":[369],"time":[370],"be":[372],"expressed":[373],"VICs":[376],"CAVS.":[383],"Further":[384],"studies":[385],"are":[386],"underway":[387],"clarify":[389],"cellular":[391],"mechanisms":[392],"involved.":[393],"Funding":[394],"Acknowledgement":[395],"Type":[396],"funding":[398,403],"sources:":[399],"Public":[400],"Institution(s).":[401],"Main":[402],"source(s):":[404],"F\u00e9d\u00e9ration":[405],"Hospitalo-Universitaire":[406],"REMOD-VHF":[407]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-10-25T00:00:00"}
