{"id":"https://openalex.org/W3206794485","doi":"https://doi.org/10.1002/jor.25191","title":"High fat diet causes inferior vertebral structure and function without disc degeneration in RAGE\u2010KO mice","display_name":"High fat diet causes inferior vertebral structure and function without disc degeneration in RAGE\u2010KO mice","publication_year":2021,"publication_date":"2021-10-21","ids":{"openalex":"https://openalex.org/W3206794485","doi":"https://doi.org/10.1002/jor.25191","mag":"3206794485","pmid":"https://pubmed.ncbi.nlm.nih.gov/34676612","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9021327"},"language":"en","primary_location":{"id":"doi:10.1002/jor.25191","doi":"https://doi.org/10.1002/jor.25191","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jor.25191","pdf_url":null,"source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9021327","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090560896","display_name":"Danielle N. D'Erminio","orcid":"https://orcid.org/0000-0003-1755-6315","observed_orcids":["https://orcid.org/0000-0003-1755-6315"]},"institutions":[{"id":"https://openalex.org/I125687163","display_name":"City College of New York","ror":"https://ror.org/00wmhkr98","country_code":"US","type":"education","lineage":["https://openalex.org/I125687163"]},{"id":"https://openalex.org/I1320796813","display_name":"Mount Sinai Health System","ror":"https://ror.org/04kfn4587","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813"]},{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danielle N. D'Erminio","raw_affiliation_strings":["Department of Biomedical Engineering, The City College of New York at CUNY, New York, New York, USA","Leni &amp; Peter W. May\u00a0Department\u00a0of Orthopaedics Mount Sinai Health System New York New York USA","Leni & Peter W. May Department of Orthopaedics, Mount Sinai Health System, New York, New York, USA"],"raw_orcid":"https://orcid.org/0000-0003-1755-6315","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The City College of New York at CUNY, New York, New York, USA","institution_ids":["https://openalex.org/I125687163","https://openalex.org/I174216632"]},{"raw_affiliation_string":"Leni &amp; Peter W. May\u00a0Department\u00a0of Orthopaedics Mount Sinai Health System New York New York USA","institution_ids":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]},{"raw_affiliation_string":"Leni & Peter W. May Department of Orthopaedics, Mount Sinai Health System, New York, New York, USA","institution_ids":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025369901","display_name":"Divya Krishnamoorthy","orcid":"https://orcid.org/0000-0003-2578-5935","observed_orcids":["https://orcid.org/0000-0003-2578-5935"]},"institutions":[{"id":"https://openalex.org/I1320796813","display_name":"Mount Sinai Health System","ror":"https://ror.org/04kfn4587","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Divya Krishnamoorthy","raw_affiliation_strings":["Department of Research and Development, 3DBio Therapeutics, New York, New York, USA","Leni &amp; Peter W. May\u00a0Department\u00a0of Orthopaedics Mount Sinai Health System New York New York USA","Leni & Peter W. May Department of Orthopaedics, Mount Sinai Health System, New York, New York, USA"],"raw_orcid":"https://orcid.org/0000-0003-2578-5935","affiliations":[{"raw_affiliation_string":"Department of Research and Development, 3DBio Therapeutics, New York, New York, USA","institution_ids":[]},{"raw_affiliation_string":"Leni &amp; Peter W. May\u00a0Department\u00a0of Orthopaedics Mount Sinai Health System New York New York USA","institution_ids":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]},{"raw_affiliation_string":"Leni & Peter W. May Department of Orthopaedics, Mount Sinai Health System, New York, New York, USA","institution_ids":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056210848","display_name":"Alon Lai","orcid":"https://orcid.org/0000-0002-0163-4588","observed_orcids":["https://orcid.org/0000-0002-0163-4588"]},"institutions":[{"id":"https://openalex.org/I1320796813","display_name":"Mount Sinai Health System","ror":"https://ror.org/04kfn4587","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alon Lai","raw_affiliation_strings":["Leni &amp; Peter W. May\u00a0Department\u00a0of Orthopaedics Mount Sinai Health System New York New York USA","Leni & Peter W. May Department of Orthopaedics, Mount Sinai Health System, New York, New York, USA"],"raw_orcid":"https://orcid.org/0000-0002-0163-4588","affiliations":[{"raw_affiliation_string":"Leni &amp; Peter W. May\u00a0Department\u00a0of Orthopaedics Mount Sinai Health System New York New York USA","institution_ids":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]},{"raw_affiliation_string":"Leni & Peter W. May Department of Orthopaedics, Mount Sinai Health System, New York, New York, USA","institution_ids":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054568681","display_name":"Robert C. Hoy","orcid":"https://orcid.org/0000-0001-9000-5793","observed_orcids":["https://orcid.org/0000-0001-9000-5793"]},"institutions":[{"id":"https://openalex.org/I1320796813","display_name":"Mount Sinai Health System","ror":"https://ror.org/04kfn4587","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert C. Hoy","raw_affiliation_strings":["Leni &amp; Peter W. May\u00a0Department\u00a0of Orthopaedics Mount Sinai Health System New York New York USA","Leni & Peter W. May Department of Orthopaedics, Mount Sinai Health System, New York, New York, USA"],"raw_orcid":"https://orcid.org/0000-0001-9000-5793","affiliations":[{"raw_affiliation_string":"Leni &amp; Peter W. May\u00a0Department\u00a0of Orthopaedics Mount Sinai Health System New York New York USA","institution_ids":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]},{"raw_affiliation_string":"Leni & Peter W. May Department of Orthopaedics, Mount Sinai Health System, New York, New York, USA","institution_ids":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010022407","display_name":"Devorah M. Natelson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320796813","display_name":"Mount Sinai Health System","ror":"https://ror.org/04kfn4587","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Devorah M. Natelson","raw_affiliation_strings":["Leni &amp; Peter W. May\u00a0Department\u00a0of Orthopaedics Mount Sinai Health System New York New York USA","Leni & Peter W. May Department of Orthopaedics, Mount Sinai Health System, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leni &amp; Peter W. May\u00a0Department\u00a0of Orthopaedics Mount Sinai Health System New York New York USA","institution_ids":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]},{"raw_affiliation_string":"Leni & Peter W. May Department of Orthopaedics, Mount Sinai Health System, New York, New York, USA","institution_ids":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002493085","display_name":"Jashvant Poeran","orcid":"https://orcid.org/0000-0001-7058-5102","observed_orcids":["https://orcid.org/0000-0001-7058-5102"]},"institutions":[{"id":"https://openalex.org/I1320796813","display_name":"Mount Sinai Health System","ror":"https://ror.org/04kfn4587","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jashvant Poeran","raw_affiliation_strings":["Department of Population Health Science &amp; Policy, and Medicine Mount Sinai Health System New York New York USA","Leni &amp; Peter W. May\u00a0Department\u00a0of Orthopaedics Mount Sinai Health System New York New York USA","Department of Population Health Science & Policy, and Medicine, Mount Sinai Health System, New York, New York, USA","Leni & Peter W. May Department of Orthopaedics, Mount Sinai Health System, New York, New York, USA"],"raw_orcid":"https://orcid.org/0000-0001-7058-5102","affiliations":[{"raw_affiliation_string":"Department of Population Health Science &amp; Policy, and Medicine Mount Sinai Health System New York New York USA","institution_ids":["https://openalex.org/I1320796813"]},{"raw_affiliation_string":"Leni &amp; Peter W. May\u00a0Department\u00a0of Orthopaedics Mount Sinai Health System New York New York USA","institution_ids":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Population Health Science & Policy, and Medicine, Mount Sinai Health System, New York, New York, USA","institution_ids":["https://openalex.org/I1320796813"]},{"raw_affiliation_string":"Leni & Peter W. May Department of Orthopaedics, Mount Sinai Health System, New York, New York, USA","institution_ids":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andrew Torres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320796813","display_name":"Mount Sinai Health System","ror":"https://ror.org/04kfn4587","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Torres","raw_affiliation_strings":["Leni &amp; Peter W. May\u00a0Department\u00a0of Orthopaedics Mount Sinai Health System New York New York USA","Leni & Peter W. May Department of Orthopaedics, Mount Sinai Health System, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leni &amp; Peter W. May\u00a0Department\u00a0of Orthopaedics Mount Sinai Health System New York New York USA","institution_ids":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]},{"raw_affiliation_string":"Leni & Peter W. May Department of Orthopaedics, Mount Sinai Health System, New York, New York, USA","institution_ids":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011457012","display_name":"Damien M. Laudier","orcid":"https://orcid.org/0000-0003-4674-7460","observed_orcids":["https://orcid.org/0000-0003-4674-7460"]},"institutions":[{"id":"https://openalex.org/I1320796813","display_name":"Mount Sinai Health System","ror":"https://ror.org/04kfn4587","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Damien M. Laudier","raw_affiliation_strings":["Leni &amp; Peter W. May\u00a0Department\u00a0of Orthopaedics Mount Sinai Health System New York New York USA","Leni & Peter W. May Department of Orthopaedics, Mount Sinai Health System, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leni &amp; Peter W. May\u00a0Department\u00a0of Orthopaedics Mount Sinai Health System New York New York USA","institution_ids":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]},{"raw_affiliation_string":"Leni & Peter W. May Department of Orthopaedics, Mount Sinai Health System, New York, New York, USA","institution_ids":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006081657","display_name":"Philip R. Nasser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320796813","display_name":"Mount Sinai Health System","ror":"https://ror.org/04kfn4587","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip Nasser","raw_affiliation_strings":["Leni &amp; Peter W. May\u00a0Department\u00a0of Orthopaedics Mount Sinai Health System New York New York USA","Leni & Peter W. May Department of Orthopaedics, Mount Sinai Health System, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leni &amp; Peter W. May\u00a0Department\u00a0of Orthopaedics Mount Sinai Health System New York New York USA","institution_ids":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]},{"raw_affiliation_string":"Leni & Peter W. May Department of Orthopaedics, Mount Sinai Health System, New York, New York, USA","institution_ids":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091765205","display_name":"Deepak Vashishth","orcid":"https://orcid.org/0000-0001-5712-0167","observed_orcids":["https://orcid.org/0000-0001-5712-0167"]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepak Vashishth","raw_affiliation_strings":["Department of Biomedical Engineering Centre for Biotechnology &amp; Interdisciplinary Studies, Rensselaer Polytechnic Institute Troy New York USA","Department of Biomedical Engineering, Centre for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering Centre for Biotechnology &amp; Interdisciplinary Studies, Rensselaer Polytechnic Institute Troy New York USA","institution_ids":["https://openalex.org/I165799507"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Centre for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, USA","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004375970","display_name":"Svenja Illien\u2010J\u00fcnger","orcid":"https://orcid.org/0000-0001-9895-0693","observed_orcids":["https://orcid.org/0000-0001-9895-0693"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Svenja Illien\u2010J\u00fcnger","raw_affiliation_strings":["Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA"],"raw_orcid":"https://orcid.org/0000-0001-9895-0693","affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003784305","display_name":"James C. Iatridis","orcid":"https://orcid.org/0000-0002-2186-0590","observed_orcids":["https://orcid.org/0000-0002-2186-0590"]},"institutions":[{"id":"https://openalex.org/I1320796813","display_name":"Mount Sinai Health System","ror":"https://ror.org/04kfn4587","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James C. Iatridis","raw_affiliation_strings":["Leni &amp; Peter W. May\u00a0Department\u00a0of Orthopaedics Mount Sinai Health System New York New York USA","Leni & Peter W. May Department of Orthopaedics, Mount Sinai Health System, New York, New York, USA"],"raw_orcid":"https://orcid.org/0000-0002-2186-0590","affiliations":[{"raw_affiliation_string":"Leni &amp; Peter W. May\u00a0Department\u00a0of Orthopaedics Mount Sinai Health System New York New York USA","institution_ids":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]},{"raw_affiliation_string":"Leni & Peter W. May Department of Orthopaedics, Mount Sinai Health System, New York, New York, USA","institution_ids":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5003784305"],"corresponding_institution_ids":["https://openalex.org/I1320796813","https://openalex.org/I98704320"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":1.1659,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.77266805,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"40","issue":"7","first_page":"1672","last_page":"1686"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.996999979019165},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8209999799728394},{"id":"https://openalex.org/keywords/vertebral-trabecular-bone","display_name":"vertebral trabecular bone","score":0.7789999842643738},{"id":"https://openalex.org/keywords/cortical-bone","display_name":"cortical bone","score":0.7409999966621399},{"id":"https://openalex.org/keywords/intervertebral-disc-degeneration","display_name":"intervertebral disc degeneration","score":0.9279999732971191},{"id":"https://openalex.org/keywords/receptor-for-advanced-glycation-end-products","display_name":"receptor for advanced glycation end products","score":0.9279999732971191},{"id":"https://openalex.org/keywords/rage-knockout-mice","display_name":"RAGE knockout mice","score":0.8899999856948853},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9850000143051147},{"id":"https://openalex.org/keywords/back-pain","display_name":"back pain","score":0.8090000152587891},{"id":"https://openalex.org/keywords/tissue-mechanics","display_name":"tissue mechanics","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.8769999742507935},{"id":"https://openalex.org/keywords/impaired-glucose-tolerance","display_name":"impaired glucose tolerance","score":0.6510000228881836},{"id":"https://openalex.org/keywords/youth-obesity","display_name":"youth obesity","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C2778857457","wikidata":"https://www.wikidata.org/wiki/Q153641","display_name":"Rage (emotion)","level":2,"score":0.8188269138336182},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6524159908294678},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6498464345932007},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6371156573295593},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4667019844055176},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.4619908630847931},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3265780210494995},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21052607893943787},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16812917590141296},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.11662018299102783},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067759","descriptor_name":"Receptor for Advanced Glycation End Products","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007403","descriptor_name":"Intervertebral Disc","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055959","descriptor_name":"Intervertebral Disc Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/jor.25191","doi":"https://doi.org/10.1002/jor.25191","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jor.25191","pdf_url":null,"source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},{"id":"pmid:34676612","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34676612","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of orthopaedic research : official publication of the Orthopaedic Research Society","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9021327","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9021327","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Orthop Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9021327","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9021327","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Orthop Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.5899999737739563,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6191993650","display_name":"Model of Human Disc Regeneration in the spectrum of Degenerative Disc Disease","funder_award_id":"R01AR057397","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G8328484183","display_name":"Diabetes Induced Disc Degeneration and Prevention","funder_award_id":"R01AR069315","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G8818165976","display_name":"Skyscan 1172 Ex-vivo MicroComputed Tomography System","funder_award_id":"1s10od010751-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000874624","display_name":"Role of TNFalpha in discogenic pain progression and as a treatment target","funder_award_id":"R01AR078857","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000913238","display_name":"Mechanisms for Regenerative Healing in Intervertebral Discs","funder_award_id":"R01AR080096","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1487314455","https://openalex.org/W1748826709","https://openalex.org/W1968158856","https://openalex.org/W1968200687","https://openalex.org/W1988622196","https://openalex.org/W1994834259","https://openalex.org/W1998290348","https://openalex.org/W1999158053","https://openalex.org/W2004838447","https://openalex.org/W2019354883","https://openalex.org/W2025456497","https://openalex.org/W2025766908","https://openalex.org/W2047877478","https://openalex.org/W2058327392","https://openalex.org/W2058798456","https://openalex.org/W2064157841","https://openalex.org/W2100078508","https://openalex.org/W2105015858","https://openalex.org/W2108344016","https://openalex.org/W2122392577","https://openalex.org/W2125321976","https://openalex.org/W2130310947","https://openalex.org/W2135106986","https://openalex.org/W2143211538","https://openalex.org/W2145590456","https://openalex.org/W2148614594","https://openalex.org/W2154411860","https://openalex.org/W2155953811","https://openalex.org/W2163351331","https://openalex.org/W2167885775","https://openalex.org/W2171361305","https://openalex.org/W2346845070","https://openalex.org/W2413260192","https://openalex.org/W2564689489","https://openalex.org/W2591890510","https://openalex.org/W2725477209","https://openalex.org/W2750311541","https://openalex.org/W2770177629","https://openalex.org/W2773766539","https://openalex.org/W2808080300","https://openalex.org/W2809408585","https://openalex.org/W2909052956","https://openalex.org/W2911223028","https://openalex.org/W2921427704","https://openalex.org/W2928542065","https://openalex.org/W2950828808","https://openalex.org/W2975833369","https://openalex.org/W2991064596","https://openalex.org/W2994372134","https://openalex.org/W3021807401","https://openalex.org/W4386941393"],"related_works":["https://openalex.org/W2770177629","https://openalex.org/W4282966905","https://openalex.org/W2950828808","https://openalex.org/W3021807401","https://openalex.org/W2278920062","https://openalex.org/W3139152594","https://openalex.org/W6920493037","https://openalex.org/W2025766908","https://openalex.org/W7094563050","https://openalex.org/W4285395988"],"abstract_inverted_index":{"Back":[0,238],"pain":[1,239],"and":[2,11,20,35,40,62,70,101,107,126,128,191,200,208,223,231,235,240,249,258],"spinal":[3,221,229,241],"pathologies":[4,242],"are":[5,18,47,66,243,256],"associated":[6,244],"with":[7,51,109,138,178,193,211,233,245],"obesity":[8,246],"in":[9,49,113,143,153,187,247],"juveniles":[10,248],"adults,":[12,250],"yet":[13,251],"studies":[14,252],"identifying":[15,253],"causal":[16,254],"relationships":[17,255],"lacking":[19,257],"none":[21,259],"investigate":[22,260],"sex":[23,195,261],"differences.":[24,262],"This":[25],"study":[26],"determined":[27],"if":[28,44,63],"high":[29],"fat":[30,77,111],"(HF)":[31],"diet":[32,81,94,119,146,158,185,213,218],"causes":[33],"structural":[34,207],"functional":[36,209],"changes":[37,46,65],"to":[38,96],"vertebrae":[39],"intervertebral":[41],"discs":[42],"(IVDs);":[43],"these":[45,64],"modulated":[48],"mice":[50,72],"systematic":[52],"ablation":[53],"for":[54,57,82,228],"the":[55,90,226],"receptor":[56],"advanced":[58],"glycation":[59],"endproducts":[60],"(RAGE-KO);":[61],"sex-dependent.":[67],"Wild-type":[68],"(WT)":[69],"RAGE-KO":[71,114,160,174],"were":[73,171],"fed":[74],"a":[75,132,139],"low":[76],"(LF)":[78],"or":[79],"HF":[80,93,118,145,157,184,212],"12":[83],"weeks":[84],"starting":[85],"at":[86],"6":[87],"weeks,":[88],"representing":[89],"juvenile":[91],"population.":[92],"led":[95],"weight/fat":[97],"gain,":[98],"glucose":[99],"intolerance,":[100],"increased":[102],"cytokine":[103],"levels":[104],"(IL-5,":[105],"MIG,":[106],"RANTES);":[108],"less":[110],"gain":[112],"females.":[115,144],"Most":[116],"importantly,":[117],"reduced":[120,148],"vertebral":[121,189],"trabecular":[122],"bone":[123],"volume":[124],"fraction":[125,151],"compressive":[127],"shear":[129],"moduli,":[130],"without":[131],"modifying":[133,202],"effect":[134,142],"of":[135,167,204],"RAGE-KO,":[136],"but":[137,175],"more":[140],"pronounced":[141],"caused":[147],"cortical":[149],"area":[150],"only":[152],"WT":[154],"males.":[155],"Neither":[156],"nor":[159],"affected":[161,172],"IVD":[162,198],"degeneration":[163,232],"grade.":[164],"Biomechanical":[165],"properties":[166],"coccygeal":[168],"motion":[169],"segments":[170],"by":[173],"not":[176],"diet,":[177],"some":[179,194],"interactions":[180],"identified.":[181],"In":[182],"conclusion,":[183],"resulted":[186],"inferior":[188],"structure":[190],"function":[192],"differences,":[196],"no":[197],"degeneration,":[199],"few":[201],"effects":[203],"RAGE-KO.":[205],"These":[206],"deficiencies":[210],"provide":[214],"further":[215],"evidence":[216],"that":[217],"can":[219],"affect":[220],"structures":[222],"may":[224],"increase":[225],"risk":[227],"injury":[230],"aging":[234],"additional":[236],"stressors.":[237]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-10-25T00:00:00"}
