{"id":"https://openalex.org/W3206746498","doi":"https://doi.org/10.1021/acs.jnatprod.1c00625","title":"Contemporary Approaches to the Discovery and Development of Broad-Spectrum Natural Product Prototypes for the Control of Coronaviruses","display_name":"Contemporary Approaches to the Discovery and Development of Broad-Spectrum Natural Product Prototypes for the Control of Coronaviruses","publication_year":2021,"publication_date":"2021-10-22","ids":{"openalex":"https://openalex.org/W3206746498","doi":"https://doi.org/10.1021/acs.jnatprod.1c00625","mag":"3206746498","pmid":"https://pubmed.ncbi.nlm.nih.gov/34677966","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8547502"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jnatprod.1c00625","doi":"https://doi.org/10.1021/acs.jnatprod.1c00625","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jnatprod.1c00625","pdf_url":null,"source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC8547502","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008281718","display_name":"George S. Hanna","orcid":"https://orcid.org/0000-0001-7616-064X","observed_orcids":["https://orcid.org/0000-0001-7616-064X"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George S. Hanna","raw_affiliation_strings":["Departments of Drug Discovery and Biomedical Sciences and Public Health, Colleges of Pharmacy and Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, United States"],"raw_orcid":"https://orcid.org/0000-0001-7616-064X","affiliations":[{"raw_affiliation_string":"Departments of Drug Discovery and Biomedical Sciences and Public Health, Colleges of Pharmacy and Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, United States","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053659921","display_name":"Yeun\u2010Mun Choo","orcid":"https://orcid.org/0000-0001-9891-5898","observed_orcids":["https://orcid.org/0000-0001-9891-5898"]},"institutions":[{"id":"https://openalex.org/I33849332","display_name":"University of Malaya","ror":"https://ror.org/00rzspn62","country_code":"MY","type":"education","lineage":["https://openalex.org/I33849332"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Yeun-Mun Choo","raw_affiliation_strings":["Department of Chemistry, University of Malaya, Kuala Lumpur 50603, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Malaya, Kuala Lumpur 50603, Malaysia","institution_ids":["https://openalex.org/I33849332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057229635","display_name":"Ryan C. Harbit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204593131","display_name":"College of Charleston","ror":"https://ror.org/00390t168","country_code":"US","type":"education","lineage":["https://openalex.org/I204593131"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Harbit","raw_affiliation_strings":["College of Charleston, Charleston, South Carolina 29425, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Charleston, Charleston, South Carolina 29425, United States","institution_ids":["https://openalex.org/I204593131"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016528542","display_name":"Heather Paeth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather Paeth","raw_affiliation_strings":["Departments of Drug Discovery and Biomedical Sciences and Public Health, Colleges of Pharmacy and Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Drug Discovery and Biomedical Sciences and Public Health, Colleges of Pharmacy and Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, United States","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023442533","display_name":"Sarah Wilde","orcid":"https://orcid.org/0000-0002-7122-6280","observed_orcids":["https://orcid.org/0000-0002-7122-6280"]},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Wilde","raw_affiliation_strings":["Department of Biology, Clemson University, Clemson, South Carolina 29631, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Clemson University, Clemson, South Carolina 29631, United States","institution_ids":["https://openalex.org/I8078737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046462717","display_name":"James Mackle","orcid":"https://orcid.org/0000-0002-7300-2096","observed_orcids":["https://orcid.org/0000-0002-7300-2096"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James Mackle","raw_affiliation_strings":["School of Biological Sciences & Institute for Global Food Security, Queens University, Belfast, Northern Ireland BT7 1NN, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences & Institute for Global Food Security, Queens University, Belfast, Northern Ireland BT7 1NN, United Kingdom","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072603426","display_name":"Jacopo Umberto Verga","orcid":"https://orcid.org/0000-0003-3814-5937","observed_orcids":["https://orcid.org/0000-0003-3814-5937"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jacopo-Umberto Verga","raw_affiliation_strings":["School of Biological Sciences & Institute for Global Food Security, Queens University, Belfast, Northern Ireland BT7 1NN, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences & Institute for Global Food Security, Queens University, Belfast, Northern Ireland BT7 1NN, United Kingdom","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086890281","display_name":"Bethany Jacobs Wolf","orcid":"https://orcid.org/0000-0002-7124-5158","observed_orcids":["https://orcid.org/0000-0002-7124-5158"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bethany J. Wolf","raw_affiliation_strings":["Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, United States","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103635174","display_name":"OP Thomas","orcid":"https://orcid.org/0000-0002-5708-1409","observed_orcids":["https://orcid.org/0000-0002-5708-1409"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Olivier P. Thomas","raw_affiliation_strings":["Marine Biodiscovery, School of Chemistry and Ryan Institute, National University of Ireland Galway, Galway H91Tk33, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-5708-1409","affiliations":[{"raw_affiliation_string":"Marine Biodiscovery, School of Chemistry and Ryan Institute, National University of Ireland Galway, Galway H91Tk33, Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029712826","display_name":"Peter Leslie Croot","orcid":"https://orcid.org/0000-0003-1396-0601","observed_orcids":["https://orcid.org/0000-0003-1396-0601"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Peter Croot","raw_affiliation_strings":["Irish Centre for Research in Applied Geoscience, Earth and Ocean Sciences and Ryan Institute, School of Natural Sciences, National University of Ireland, Galway, Galway H91Tk33, Ireland"],"raw_orcid":"https://orcid.org/0000-0003-1396-0601","affiliations":[{"raw_affiliation_string":"Irish Centre for Research in Applied Geoscience, Earth and Ocean Sciences and Ryan Institute, School of Natural Sciences, National University of Ireland, Galway, Galway H91Tk33, Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084705544","display_name":"James Cray","orcid":"https://orcid.org/0000-0002-8512-7005","observed_orcids":["https://orcid.org/0000-0002-8512-7005"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Cray","raw_affiliation_strings":["Department of Biomedical Education and Anatomy, College of Medicine and Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, Ohio 43210, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Education and Anatomy, College of Medicine and Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032289366","display_name":"Courtney Thomas","orcid":"https://orcid.org/0000-0002-1753-1938","observed_orcids":["https://orcid.org/0000-0002-1753-1938"]},"institutions":[{"id":"https://openalex.org/I139398662","display_name":"South Carolina State University","ror":"https://ror.org/00520ze08","country_code":"US","type":"education","lineage":["https://openalex.org/I139398662"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Courtney Thomas","raw_affiliation_strings":["Department of Chemistry, South Carolina State University, Orangeburg, South Carolina 29117, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, South Carolina State University, Orangeburg, South Carolina 29117, United States","institution_ids":["https://openalex.org/I139398662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100718437","display_name":"Lingzhi Li","orcid":"https://orcid.org/0000-0001-9119-7133","observed_orcids":["https://orcid.org/0000-0001-9119-7133"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling-Zhi Li","raw_affiliation_strings":["School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University/SPU, Shenyang 110016, China"],"raw_orcid":"https://orcid.org/0000-0001-9119-7133","affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University/SPU, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016505833","display_name":"Gary Hardiman","orcid":"https://orcid.org/0000-0003-4558-0400","observed_orcids":["https://orcid.org/0000-0003-4558-0400"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gary Hardiman","raw_affiliation_strings":["School of Biological Sciences & Institute for Global Food Security, Queens University, Belfast, Northern Ireland BT7 1NN, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-4558-0400","affiliations":[{"raw_affiliation_string":"School of Biological Sciences & Institute for Global Food Security, Queens University, Belfast, Northern Ireland BT7 1NN, United Kingdom","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006614163","display_name":"Jin\u2010Feng Hu","orcid":"https://orcid.org/0000-0002-0367-1454","observed_orcids":["https://orcid.org/0000-0002-0367-1454"]},"institutions":[{"id":"https://openalex.org/I4405281598","display_name":"Taizhou University","ror":"https://ror.org/04m19xd94","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405281598"]},{"id":"https://openalex.org/I82760581","display_name":"Taizhou University","ror":"https://ror.org/04fzhyx73","country_code":"CN","type":"education","lineage":["https://openalex.org/I82760581"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin-Feng Hu","raw_affiliation_strings":["School of Advanced Study, Zhejiang Provincial Key Laboratory of Plant Ecology and Conservation, Taizhou University, Zhejiang 318000, China"],"raw_orcid":"https://orcid.org/0000-0002-0367-1454","affiliations":[{"raw_affiliation_string":"School of Advanced Study, Zhejiang Provincial Key Laboratory of Plant Ecology and Conservation, Taizhou University, Zhejiang 318000, China","institution_ids":["https://openalex.org/I4405281598","https://openalex.org/I82760581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043241624","display_name":"Xiaojuan Wang","orcid":"https://orcid.org/0000-0001-5559-6997","observed_orcids":["https://orcid.org/0000-0001-5559-6997"]},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojuan Wang","raw_affiliation_strings":["School of Pharmacy, Lanzhou University, Lanzhou 730300, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Lanzhou University, Lanzhou 730300, China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038581061","display_name":"Dharmeshkumar J. Patel","orcid":"https://orcid.org/0000-0003-1601-256X","observed_orcids":["https://orcid.org/0000-0003-1601-256X"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210146983","display_name":"Children's Healthcare of Atlanta","ror":"https://ror.org/050fhx250","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210146983"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dharmeshkumar Patel","raw_affiliation_strings":["Department of Pediatrics, Laboratory of Biochemical Pharmacology, Emory University School of Medicine, and Children\u2019s Healthcare of Atlanta, Atlanta, Georgia 30322, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Laboratory of Biochemical Pharmacology, Emory University School of Medicine, and Children\u2019s Healthcare of Atlanta, Atlanta, Georgia 30322, United States","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4210146983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087052821","display_name":"Raymond F. Schinazi","orcid":"https://orcid.org/0000-0002-6688-3614","observed_orcids":["https://orcid.org/0000-0002-6688-3614"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210146983","display_name":"Children's Healthcare of Atlanta","ror":"https://ror.org/050fhx250","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210146983"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond F. Schinazi","raw_affiliation_strings":["Department of Pediatrics, Laboratory of Biochemical Pharmacology, Emory University School of Medicine, and Children\u2019s Healthcare of Atlanta, Atlanta, Georgia 30322, United States"],"raw_orcid":"https://orcid.org/0000-0002-6688-3614","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Laboratory of Biochemical Pharmacology, Emory University School of Medicine, and Children\u2019s Healthcare of Atlanta, Atlanta, Georgia 30322, United States","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4210146983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067064525","display_name":"Barry R. O\u2019Keefe","orcid":"https://orcid.org/0000-0003-0772-4856","observed_orcids":["https://orcid.org/0000-0003-0772-4856"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barry R. O\u2019Keefe","raw_affiliation_strings":["Molecular Targets Program, Center for Cancer Research, Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland 21702, United States"],"raw_orcid":"https://orcid.org/0000-0003-0772-4856","affiliations":[{"raw_affiliation_string":"Molecular Targets Program, Center for Cancer Research, Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland 21702, United States","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038919139","display_name":"Mark T. Hamann","orcid":"https://orcid.org/0000-0002-3798-4002","observed_orcids":["https://orcid.org/0000-0002-3798-4002"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark T. Hamann","raw_affiliation_strings":["Departments of Drug Discovery and Biomedical Sciences and Public Health, Colleges of Pharmacy and Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Drug Discovery and Biomedical Sciences and Public Health, Colleges of Pharmacy and Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, United States","institution_ids":["https://openalex.org/I153297377"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":16,"corresponding_author_ids":["https://openalex.org/A5038919139"],"corresponding_institution_ids":["https://openalex.org/I153297377"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.5368,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.56170318,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"84","issue":"11","first_page":"3001","last_page":"3007"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.6869999766349792,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.6869999766349792,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.15549999475479126,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.0560000017285347,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.902999997138977},{"id":"https://openalex.org/keywords/antiviral-agents","display_name":"antiviral agents","score":0.7450000047683716},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9520000219345093},{"id":"https://openalex.org/keywords/betacoronavirus","display_name":"Betacoronavirus","score":0.847000002861023},{"id":"https://openalex.org/keywords/broad-spectrum-inhibitors","display_name":"broad-spectrum inhibitors","score":0.7889999747276306},{"id":"https://openalex.org/keywords/natural-product-database","display_name":"natural product database","score":0.5770000219345093},{"id":"https://openalex.org/keywords/protein-ligand-interactions","display_name":"protein-ligand interactions","score":0.7360000014305115},{"id":"https://openalex.org/keywords/mass-spectrometry","display_name":"mass spectrometry","score":0.8009999990463257},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"computational chemistry","score":0.8989999890327454},{"id":"https://openalex.org/keywords/antiviral-drug-screening","display_name":"antiviral drug screening","score":0.6570000052452087},{"id":"https://openalex.org/keywords/zoonotic-viruses","display_name":"zoonotic viruses","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.674228310585022},{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.6723705530166626},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6669824719429016},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5583613514900208},{"id":"https://openalex.org/C3020442560","wikidata":"https://www.wikidata.org/wiki/Q4971815","display_name":"Broad spectrum","level":2,"score":0.5373313426971436},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.5226321220397949},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.45096758008003235},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4385261833667755},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4293651282787323},{"id":"https://openalex.org/C90673727","wikidata":"https://www.wikidata.org/wiki/Q901718","display_name":"Product (mathematics)","level":2,"score":0.4228404462337494},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.39640629291534424},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3738032877445221},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.30802130699157715},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2710097134113312},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2366478443145752},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17944952845573425},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1768048107624054},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.12345868349075317},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09224650263786316},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000073640","descriptor_name":"Betacoronavirus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062126","descriptor_name":"Databases, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1021/acs.jnatprod.1c00625","doi":"https://doi.org/10.1021/acs.jnatprod.1c00625","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jnatprod.1c00625","pdf_url":null,"source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:7437369","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8547502","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:34677966","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34677966","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of natural products","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8547502","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8547502/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Nat Prod","raw_type":"Text"},{"id":"pmh:oai:pure.qub.ac.uk/portal:publications/1b0a2e33-ca4a-4cbb-8791-c9de23cf060e","doi":null,"is_oa":false,"landing_page_url":"https://pure.qub.ac.uk/en/publications/1b0a2e33-ca4a-4cbb-8791-c9de23cf060e","pdf_url":null,"source":{"id":"https://openalex.org/S4306402319","display_name":"Research Portal (Queen's University Belfast)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126231945","host_organization_name":"Queen's University Belfast","host_organization_lineage":["https://openalex.org/I126231945"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hanna, G S, Choo, Y-M, Harbit, R, Paeth, H, Wilde, S, Mackle, J, Verga, J-U, Wolf, B J, Thomas, O P, Croot, P, Cray, J, Thomas, C, Li, L-Z, Hardiman, G, Hu, J-F, Wang, X, Patel, D, Schinazi, R F, O\u2019Keefe, B R & Hamann, M T 2021, 'Contemporary approaches to the discovery and development of broad-spectrum natural product prototypes for the control of coronaviruses', Journal of Natural Products, vol. 84, no. 11, pp. 3001\u20133007. https://doi.org/10.1021/acs.jnatprod.1c00625","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:7437369","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8547502","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2763334823","display_name":"Natural Product HCV Drugs from Rare Plant-Microbe Interactions","funder_award_id":"R01AT007318","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"},{"id":"https://openalex.org/G2997292278","display_name":"Medical University of South Carolina Transdisciplinary Collaborative Center in Precision Medicine and Minority Men's Health","funder_award_id":"U54MD010706","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"},{"id":"https://openalex.org/G3420755868","display_name":"Complimentary NMR and Bio-Assay Guided Screening of Edible Marine Algae for AGE Inhibitors to Control Glycative Stress and Reduce Risk of Neurodegeneration.","funder_award_id":"F31AT011158","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"},{"id":"https://openalex.org/G9000873514","display_name":"The Genetic Basis of Opioid Dependence Vulnerablility in a Rodent Model","funder_award_id":"U01DA045300","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G9000885469","display_name":"Center for AIDS Research at Emory University","funder_award_id":"P30AI050409","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337534","display_name":"National Institute on Minority Health and Health Disparities","ror":"https://ror.org/0493hgw16"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W1235673195","https://openalex.org/W1828394588","https://openalex.org/W1964927055","https://openalex.org/W1990226486","https://openalex.org/W1994311174","https://openalex.org/W2025583562","https://openalex.org/W2055367007","https://openalex.org/W2074682587","https://openalex.org/W2102380386","https://openalex.org/W2130479394","https://openalex.org/W2132182129","https://openalex.org/W2157436515","https://openalex.org/W2167678937","https://openalex.org/W2198699001","https://openalex.org/W2283606770","https://openalex.org/W2555163954","https://openalex.org/W2749961947","https://openalex.org/W2786563270","https://openalex.org/W2790225116","https://openalex.org/W2792529702","https://openalex.org/W2803627340","https://openalex.org/W2884406458","https://openalex.org/W2886363386","https://openalex.org/W2898364362","https://openalex.org/W2902511468","https://openalex.org/W2911632687","https://openalex.org/W2914571707","https://openalex.org/W2917946285","https://openalex.org/W2947208986","https://openalex.org/W2981121446","https://openalex.org/W2981992332","https://openalex.org/W2984933828","https://openalex.org/W2999044305","https://openalex.org/W3001442590","https://openalex.org/W3003217347","https://openalex.org/W3003464757","https://openalex.org/W3007643904","https://openalex.org/W3009678818","https://openalex.org/W3011701533","https://openalex.org/W3011834523","https://openalex.org/W3013494536","https://openalex.org/W3015529274","https://openalex.org/W3015608194","https://openalex.org/W3020409391","https://openalex.org/W3022734398","https://openalex.org/W3022916237","https://openalex.org/W3025387116","https://openalex.org/W3025838913","https://openalex.org/W3026051701","https://openalex.org/W3033612639","https://openalex.org/W3038444556","https://openalex.org/W3045600629","https://openalex.org/W3080789666","https://openalex.org/W3087118881","https://openalex.org/W3088276225","https://openalex.org/W3088790168","https://openalex.org/W3092880773","https://openalex.org/W3093626887","https://openalex.org/W3095722964","https://openalex.org/W3104453838","https://openalex.org/W3115760622","https://openalex.org/W3118695441","https://openalex.org/W3122927255","https://openalex.org/W3126546961","https://openalex.org/W3157786842","https://openalex.org/W3174482775","https://openalex.org/W3174731125","https://openalex.org/W4206175653"],"related_works":["https://openalex.org/W7005959304","https://openalex.org/W4391042814","https://openalex.org/W4361274153","https://openalex.org/W4317212848","https://openalex.org/W4293220678","https://openalex.org/W3030667364","https://openalex.org/W3091391658","https://openalex.org/W4289874826","https://openalex.org/W4307506045","https://openalex.org/W3136244716"],"abstract_inverted_index":{"The":[0,78],"pressing":[1],"need":[2,178],"for":[3,90,123,138,166,179,210],"SARS-CoV-2":[4],"controls":[5],"has":[6],"led":[7],"to":[8,13,55,151,186,216],"a":[9,201],"reassessment":[10],"of":[11,20,59,68,84,95,98,126,135,147,171,191,204,213],"strategies":[12],"identify":[14],"and":[15,24,41,44,66,71,82,93,108,140,143,169],"develop":[16],"natural":[17,38],"product":[18,39],"inhibitors":[19,97],"zoonotic,":[21],"highly":[22],"virulent,":[23],"rapidly":[25],"emerging":[26],"viruses.":[27],"This":[28],"review":[29],"article":[30],"addresses":[31],"how":[32],"contemporary":[33],"approaches":[34],"involving":[35],"computational":[36],"chemistry,":[37],"(NP)":[40],"protein":[42],"databases,":[43],"mass":[45],"spectrometry":[46],"(MS)":[47],"derived":[48],"target\u2013ligand":[49],"interaction":[50],"analysis":[51],"can":[52],"be":[53],"utilized":[54],"expedite":[56],"the":[57,64,91,109,124,133,145,167,176,183,188,211],"interrogation":[58],"NP":[60,127,157],"structures":[61],"while":[62,206],"minimizing":[63],"time":[65],"expense":[67],"extraction,":[69],"purification,":[70],"screening":[72,193],"in":[73,221],"BioSafety":[74],"Laboratories":[75],"(BSL)3":[76],"laboratories.":[77],"unparalleled":[79],"structural":[80,136],"diversity":[81],"complexity":[83],"NPs":[85,139],"is":[86,185],"an":[87],"extraordinary":[88],"resource":[89],"discovery":[92,212],"development":[94],"broad-spectrum":[96],"viral":[99,222],"genera,":[100],"including":[101],"Betacoronavirus,":[102],"which":[103],"contains":[104],"MERS,":[105],"SARS,":[106],"SARS-CoV-2,":[107],"common":[110],"cold.":[111],"There":[112],"are":[113],"two":[114],"key":[115],"technological":[116],"advances":[117],"that":[118],"have":[119],"created":[120],"unique":[121,172],"opportunities":[122,209],"identification":[125,168],"prototypes":[128],"with":[129,200],"greater":[130],"efficiency:":[131],"(1)":[132],"application":[134,146],"databases":[137],"target":[141,218],"proteins":[142,219],"(2)":[144],"modern":[148],"MS":[149],"techniques":[150],"assess":[152],"protein\u2013ligand":[153],"interactions":[154],"directly":[155],"from":[156],"extracts.":[158],"These":[159],"approaches,":[160],"developed":[161],"over":[162],"years,":[163],"now":[164],"allow":[165],"isolation":[170],"antiviral":[173],"ligands":[174,215],"without":[175],"immediate":[177],"BSL3":[180],"facilities.":[181],"Overall,":[182],"goal":[184],"improve":[187],"success":[189],"rate":[190],"NP-based":[192],"by":[194],"focusing":[195],"resources":[196],"on":[197],"source":[198],"materials":[199],"higher":[202],"likelihood":[203],"success,":[205],"simultaneously":[207],"providing":[208],"novel":[214],"selectively":[217],"involved":[220],"infection.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-10-25T00:00:00"}
