{"id":"https://openalex.org/W3206683353","doi":"https://doi.org/10.1021/acsabm.1c00879","title":"Liposomal Fe(III) Macrocyclic Complexes with Hydroxypropyl Pendants as MRI Probes","display_name":"Liposomal Fe(III) Macrocyclic Complexes with Hydroxypropyl Pendants as MRI Probes","publication_year":2021,"publication_date":"2021-10-15","ids":{"openalex":"https://openalex.org/W3206683353","doi":"https://doi.org/10.1021/acsabm.1c00879","mag":"3206683353","pmid":"https://pubmed.ncbi.nlm.nih.gov/35006776","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9124523"},"language":"en","primary_location":{"id":"doi:10.1021/acsabm.1c00879","doi":"https://doi.org/10.1021/acsabm.1c00879","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsabm.1c00879","pdf_url":null,"source":{"id":"https://openalex.org/S4210214000","display_name":"ACS Applied Bio Materials","issn_l":"2576-6422","issn":["2576-6422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Bio Materials","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9124523","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041631994","display_name":"Samira M. Abozeid","orcid":"https://orcid.org/0000-0002-2896-8924","observed_orcids":["https://orcid.org/0000-0002-2896-8924","https://orcid.org/0000-0001-6574-7795"]},"institutions":[{"id":"https://openalex.org/I159247623","display_name":"Mansoura University","ror":"https://ror.org/01k8vtd75","country_code":"EG","type":"education","lineage":["https://openalex.org/I159247623"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["EG","US"],"is_corresponding":false,"raw_author_name":"Samira M. Abozeid","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Mansoura University, El-Gomhoria Street, 35516 Mansoura, Egypt","Department of Chemistry, The State University of New York at Buffalo, Buffalo, New York 14260, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Mansoura University, El-Gomhoria Street, 35516 Mansoura, Egypt","institution_ids":["https://openalex.org/I159247623"]},{"raw_affiliation_string":"Department of Chemistry, The State University of New York at Buffalo, Buffalo, New York 14260, United States","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059475116","display_name":"Md Saiful I. Chowdhury","orcid":"https://orcid.org/0000-0002-3945-2421","observed_orcids":["https://orcid.org/0000-0002-3945-2421"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Md Saiful I. Chowdhury","raw_affiliation_strings":["Department of Chemistry, The State University of New York at Buffalo, Buffalo, New York 14260, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The State University of New York at Buffalo, Buffalo, New York 14260, United States","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036803810","display_name":"Didar Asik","orcid":"https://orcid.org/0000-0001-6924-3770","observed_orcids":["https://orcid.org/0000-0001-6924-3770"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Didar Asik","raw_affiliation_strings":["Department of Chemistry, The State University of New York at Buffalo, Buffalo, New York 14260, United States"],"raw_orcid":"https://orcid.org/0000-0001-6924-3770","affiliations":[{"raw_affiliation_string":"Department of Chemistry, The State University of New York at Buffalo, Buffalo, New York 14260, United States","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054903525","display_name":"Joseph A. Spernyak","orcid":"https://orcid.org/0000-0002-5049-4737","observed_orcids":["https://orcid.org/0000-0002-5049-4737"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph A. Spernyak","raw_affiliation_strings":["Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14263, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14263, United States","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050648586","display_name":"Janet R. Morrow","orcid":"https://orcid.org/0000-0003-4160-7688","observed_orcids":["https://orcid.org/0000-0003-4160-7688"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Janet R. Morrow","raw_affiliation_strings":["Department of Chemistry, The State University of New York at Buffalo, Buffalo, New York 14260, United States"],"raw_orcid":"https://orcid.org/0000-0003-4160-7688","affiliations":[{"raw_affiliation_string":"Department of Chemistry, The State University of New York at Buffalo, Buffalo, New York 14260, United States","institution_ids":["https://openalex.org/I63190737"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5050648586"],"corresponding_institution_ids":["https://openalex.org/I63190737"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.9103,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.69197066,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"4","issue":"11","first_page":"7951","last_page":"7960"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12603","display_name":"NMR spectroscopy and applications","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/3106","display_name":"Nuclear and High Energy Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paramagnetic-liposomes","display_name":"paramagnetic liposomes","score":0.8920000195503235},{"id":"https://openalex.org/keywords/1-4-7-triazacyclononane","display_name":"1,4,7-triazacyclononane","score":0.9860000014305115},{"id":"https://openalex.org/keywords/mri-contrast-agents","display_name":"MRI contrast agents","score":0.9210000038146973},{"id":"https://openalex.org/keywords/relaxivity","display_name":"relaxivity","score":0.8019999861717224},{"id":"https://openalex.org/keywords/t1-and-t2-relaxation-times","display_name":"T1 and T2 relaxation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/chemical-exchange-saturation-transfer","display_name":"chemical exchange saturation transfer","score":0.925000011920929},{"id":"https://openalex.org/keywords/osmotic-gradient","display_name":"osmotic gradient","score":0.6679999828338623},{"id":"https://openalex.org/keywords/z-spectrum","display_name":"Z-spectrum","score":0.7369999885559082},{"id":"https://openalex.org/keywords/dinuclear-iron-complexes","display_name":"dinuclear iron complexes","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.6635838150978088},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4278546869754791},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4006234109401703},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.33489590883255005},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17787572741508484}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005290","descriptor_name":"Ferric Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056831","descriptor_name":"Coordination Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/acsabm.1c00879","doi":"https://doi.org/10.1021/acsabm.1c00879","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsabm.1c00879","pdf_url":null,"source":{"id":"https://openalex.org/S4210214000","display_name":"ACS Applied Bio Materials","issn_l":"2576-6422","issn":["2576-6422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Bio Materials","raw_type":"journal-article"},{"id":"pmid:35006776","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35006776","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS applied bio materials","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9124523","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9124523","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Appl Bio Mater","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9124523","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9124523","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Appl Bio Mater","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.8500000238418579}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1387155684","display_name":null,"funder_award_id":"CHE 1710224","funder_id":"https://openalex.org/F4320337393","funder_display_name":"Division of Chemistry"},{"id":"https://openalex.org/G4914835","display_name":null,"funder_award_id":"CA016056.","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6810687280","display_name":"High Field Electrospray/MALDI Fourier Transform Mass Spectrometer","funder_award_id":"S10RR029517","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000888465","display_name":"Roswell Park Cancer Center Support Grant","funder_award_id":"P30CA016056","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337393","display_name":"Division of Chemistry","ror":"https://ror.org/01ar8dr59"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W1911725476","https://openalex.org/W1923788030","https://openalex.org/W1968322433","https://openalex.org/W1972899171","https://openalex.org/W1979938096","https://openalex.org/W1990946282","https://openalex.org/W1997403945","https://openalex.org/W2002095877","https://openalex.org/W2010304924","https://openalex.org/W2016151582","https://openalex.org/W2029646788","https://openalex.org/W2031778384","https://openalex.org/W2045440907","https://openalex.org/W2045740138","https://openalex.org/W2052647538","https://openalex.org/W2052874119","https://openalex.org/W2057688618","https://openalex.org/W2058739004","https://openalex.org/W2082181399","https://openalex.org/W2086797085","https://openalex.org/W2092831810","https://openalex.org/W2096172068","https://openalex.org/W2108873388","https://openalex.org/W2119569899","https://openalex.org/W2123202621","https://openalex.org/W2132600802","https://openalex.org/W2140388375","https://openalex.org/W2144611965","https://openalex.org/W2153548049","https://openalex.org/W2160478157","https://openalex.org/W2196985026","https://openalex.org/W2212223961","https://openalex.org/W2236481087","https://openalex.org/W2267660839","https://openalex.org/W2316142734","https://openalex.org/W2329875254","https://openalex.org/W2444288974","https://openalex.org/W2547229409","https://openalex.org/W2561331732","https://openalex.org/W2743701252","https://openalex.org/W2753466980","https://openalex.org/W2757645865","https://openalex.org/W2788087525","https://openalex.org/W2800237692","https://openalex.org/W2803030336","https://openalex.org/W2896682297","https://openalex.org/W2922117188","https://openalex.org/W2950428398","https://openalex.org/W2952918110","https://openalex.org/W2988592997","https://openalex.org/W2995481085","https://openalex.org/W3011566364","https://openalex.org/W3020348439","https://openalex.org/W3022600674","https://openalex.org/W3025655500","https://openalex.org/W3031031824","https://openalex.org/W3034251015","https://openalex.org/W3084634998","https://openalex.org/W3106122858","https://openalex.org/W3109163802","https://openalex.org/W3127513196","https://openalex.org/W3166981230","https://openalex.org/W3184926791","https://openalex.org/W3196039172","https://openalex.org/W3197850751","https://openalex.org/W4210687305","https://openalex.org/W4235358290","https://openalex.org/W4240330364","https://openalex.org/W4249509226"],"related_works":["https://openalex.org/W4384303726","https://openalex.org/W2045471478","https://openalex.org/W2123202621","https://openalex.org/W3166981230","https://openalex.org/W2025527587","https://openalex.org/W2077586572","https://openalex.org/W2071794337","https://openalex.org/W3025655500","https://openalex.org/W1983392809","https://openalex.org/W4391433180"],"abstract_inverted_index":{"Paramagnetic":[0],"liposomes":[1,33,183],"containing":[2,24],"Fe(III)":[3,175],"complexes":[4,20],"were":[5,34,154],"prepared":[6],"by":[7,115],"incorporation":[8],"of":[9,21,31,93,140,150,161,181,190,199,213],"mononuclear":[10,42],"(Fe(L1)":[11],"or":[12,14,75],"Fe(L3))":[13],"dinuclear":[15],"(Fe":[16],"2":[17,77,87,201],"(L2))":[18],"coordination":[19],"1,4,7-triazacyclononane":[22],"macrocycles":[23],"2-hydroxypropyl":[25],"pendant":[26],"groups.":[27],"Two":[28],"different":[29],"types":[30],"paramagnetic":[32,182],"prepared.":[35],"The":[36,51,146,177],"first":[37],"type,":[38,53],"LipoA,":[39],"has":[40,55],"the":[41,47,56,62,66,131,141,157,173,197,225,240],"Fe(L1)":[43,73],"complex":[44,59,129],"loaded":[45,70],"into":[46,61],"internal":[48,67],"aqueous":[49,68],"core.":[50],"second":[52],"LipoB,":[54],"amphiphilic":[57,128,174],"Fe(L3)":[58],"inserted":[60],"liposomal":[63,132],"bilayer":[64],"and":[65,85,152],"core":[69],"with":[71,95,106,143,196],"either":[72],"(LipoB1)":[74],"Fe":[76,166],"(L2)":[78],"(LipoB2).":[79],"LipoA":[80,94,162],"enhances":[81],"both":[82],"T":[83,86],"1":[84,148,159,179,204],"water":[88],"proton":[89],"relaxation":[90],"rates.":[91],"Treatment":[92],"osmotic":[96,144],"gradients":[97],"to":[98,224],"produce":[99],"a":[100,104,107,135,164,188,233],"nonspherical":[101],"liposome":[102,105,142],"produces":[103],"chemical":[108],"exchange":[109],"saturation":[110],"transfer":[111],"effect":[112],"as":[113],"shown":[114],"an":[116,127,169],"asymmetry":[117],"analysis":[118],"but":[119],"only":[120],"at":[121,207,232],"high":[122,208],"osmolarity.":[123],"LipoB1,":[124],"which":[125,229],"contains":[126],"in":[130,215,221],"bilayer,":[133],"produced":[134],"broadened":[136],"Z-spectrum":[137],"upon":[138],"treatment":[139],"gradients.":[145],"r":[147,158,178,200,203],"relaxivity":[149,160],"LipoB1":[151,214],"LipoB2":[153],"higher":[155,235],"than":[156,239],"on":[163],"per":[165,237],"basis,":[167],"suggesting":[168],"important":[170],"contribution":[171],"from":[172],"center.":[176],"relaxivities":[180],"are":[184],"relatively":[185],"constant":[186],"over":[187],"range":[189],"magnetic":[191],"field":[192,209],"strengths":[193],"(1.4\u20139.4":[194],"T),":[195],"ratio":[198],"/":[202],"substantially":[205],"increasing":[206],"strengths.":[210],"MRI":[211],"studies":[212],"mice":[216],"showed":[217],"prolonged":[218],"contrast":[219],"enhancement":[220],"blood":[222],"compared":[223],"clinically":[226],"employed":[227],"Gd(DOTA),":[228],"was":[230],"injected":[231],"2-fold":[234],"dose":[236],"metal":[238],"Fe(III)-loaded":[241],"liposomes.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-10-25T00:00:00"}