{"id":"https://openalex.org/W3206669722","doi":"https://doi.org/10.3389/fphar.2021.737764","title":"Securidaca inappendiculata Polyphenol Rich Extract Counteracts Cognitive Deficits, Neuropathy, Neuroinflammation and Oxidative Stress in Diabetic Encephalopathic Rats via p38 MAPK/Nrf2/HO-1 Pathways","display_name":"Securidaca inappendiculata Polyphenol Rich Extract Counteracts Cognitive Deficits, Neuropathy, Neuroinflammation and Oxidative Stress in Diabetic Encephalopathic Rats via p38 MAPK/Nrf2/HO-1 Pathways","publication_year":2021,"publication_date":"2021-10-18","ids":{"openalex":"https://openalex.org/W3206669722","doi":"https://doi.org/10.3389/fphar.2021.737764","mag":"3206669722","pmid":"https://pubmed.ncbi.nlm.nih.gov/34733158","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8558401"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2021.737764","doi":"https://doi.org/10.3389/fphar.2021.737764","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2021.737764","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2021.737764/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphar.2021.737764/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053861266","display_name":"Xiaojun Pang","orcid":"https://orcid.org/0009-0000-4821-0654","observed_orcids":["https://orcid.org/0009-0000-4821-0654"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojun Pang","raw_affiliation_strings":["Department of Neurosurgery, Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035236552","display_name":"Emmanuel Ayobami Makinde","orcid":"https://orcid.org/0000-0003-3677-6241","observed_orcids":["https://orcid.org/0000-0003-3677-6241"]},"institutions":[{"id":"https://openalex.org/I11701301","display_name":"Griffith University","ror":"https://ror.org/02sc3r913","country_code":"AU","type":"education","lineage":["https://openalex.org/I11701301"]},{"id":"https://openalex.org/I131868736","display_name":"Prince of Songkla University","ror":"https://ror.org/0575ycz84","country_code":"TH","type":"education","lineage":["https://openalex.org/I131868736"]}],"countries":["AU","TH"],"is_corresponding":false,"raw_author_name":"Emmanuel Ayobami Makinde","raw_affiliation_strings":["Faculty of Thai Traditional Medicine, Prince of Songkla University, Hat Yai, Thailand","Griffith Institute for Drug Discovery, Griffith University, Brisbane, QLD, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Thai Traditional Medicine, Prince of Songkla University, Hat Yai, Thailand","institution_ids":["https://openalex.org/I131868736"]},{"raw_affiliation_string":"Griffith Institute for Drug Discovery, Griffith University, Brisbane, QLD, Australia","institution_ids":["https://openalex.org/I11701301"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023491060","display_name":"Fredrick Nwude Eze","orcid":"https://orcid.org/0000-0002-3742-9965","observed_orcids":["https://orcid.org/0000-0002-3742-9965"]},"institutions":[{"id":"https://openalex.org/I131868736","display_name":"Prince of Songkla University","ror":"https://ror.org/0575ycz84","country_code":"TH","type":"education","lineage":["https://openalex.org/I131868736"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Fredrick Nwude Eze","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, Thailand","institution_ids":["https://openalex.org/I131868736"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065164194","display_name":"Opeyemi Joshua Olatunji","orcid":"https://orcid.org/0000-0002-6800-4919","observed_orcids":["https://orcid.org/0000-0002-6800-4919"]},"institutions":[{"id":"https://openalex.org/I131868736","display_name":"Prince of Songkla University","ror":"https://ror.org/0575ycz84","country_code":"TH","type":"education","lineage":["https://openalex.org/I131868736"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Opeyemi Joshua Olatunji","raw_affiliation_strings":["Faculty of Thai Traditional Medicine, Prince of Songkla University, Hat Yai, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Thai Traditional Medicine, Prince of Songkla University, Hat Yai, Thailand","institution_ids":["https://openalex.org/I131868736"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5065164194"],"corresponding_institution_ids":["https://openalex.org/I131868736"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":2.1916,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.88403022,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"12","issue":null,"first_page":"737764","last_page":"737764"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.3783999979496002,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.3783999979496002,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.20319999754428864,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.17489999532699585,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/securidaca-inappendiculata","display_name":"Securidaca inappendiculata","score":0.9890000224113464},{"id":"https://openalex.org/keywords/polyphenol-rich-extract","display_name":"polyphenol-rich extract","score":0.9319999814033508},{"id":"https://openalex.org/keywords/diabetic-encephalopathy","display_name":"diabetic encephalopathy","score":0.9890000224113464},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.722000002861023},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.824999988079071},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":1.0},{"id":"https://openalex.org/keywords/p38-mapk-pathway","display_name":"p38 MAPK pathway","score":0.8790000081062317},{"id":"https://openalex.org/keywords/nrf2-ho-1-signaling-pathway","display_name":"Nrf2/HO-1 pathway","score":0.9890000224113464},{"id":"https://openalex.org/keywords/acetylcholinesterase","display_name":"acetylcholinesterase","score":0.9850000143051147},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9679999947547913},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9890000224113464},{"id":"https://openalex.org/keywords/depression-like-behavior","display_name":"depression-like behavior","score":0.6669999957084656},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.8085242509841919},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.656768798828125},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6514878273010254},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.6053147315979004},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5617281198501587},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5067160725593567},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48147621750831604},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4736004173755646},{"id":"https://openalex.org/C2779085643","wikidata":"https://www.wikidata.org/wiki/Q7096029","display_name":"Open field","level":2,"score":0.46093741059303284},{"id":"https://openalex.org/C136569192","wikidata":"https://www.wikidata.org/wiki/Q4880745","display_name":"Behavioural despair test","level":4,"score":0.457244873046875},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.4520133435726166},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.44882094860076904},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.44792720675468445},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.44329679012298584},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.4321977198123932},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4281558692455292},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.4179847240447998},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39055144786834717},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.3160117268562317},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18239948153495789},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.15345609188079834},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.1357826292514801},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.12183526158332825},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3389/fphar.2021.737764","doi":"https://doi.org/10.3389/fphar.2021.737764","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2021.737764","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2021.737764/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:7450266","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8558401","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:34733158","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34733158","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8558401","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8558401/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:2ef3dd7b86f649f9bed4409b289538a1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2ef3dd7b86f649f9bed4409b289538a1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 12 (2021)","raw_type":"article"},{"id":"pmh:oai:research-repository.griffith.edu.au:10072/411350","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10072/411350","pdf_url":null,"source":{"id":"https://openalex.org/S7407064376","display_name":"Griffith Research Online","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2021.737764","doi":"https://doi.org/10.3389/fphar.2021.737764","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2021.737764","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2021.737764/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322692","display_name":"Prince of Songkla University","ror":"https://ror.org/0575ycz84"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3206669722.pdf","grobid_xml":"https://content.openalex.org/works/W3206669722.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W131773637","https://openalex.org/W639089527","https://openalex.org/W1912999573","https://openalex.org/W1971048984","https://openalex.org/W1983072558","https://openalex.org/W1987972424","https://openalex.org/W1993271363","https://openalex.org/W2005500310","https://openalex.org/W2020291132","https://openalex.org/W2024318669","https://openalex.org/W2037111632","https://openalex.org/W2049724153","https://openalex.org/W2058550328","https://openalex.org/W2058748943","https://openalex.org/W2070279065","https://openalex.org/W2075215957","https://openalex.org/W2081272995","https://openalex.org/W2085143181","https://openalex.org/W2085805657","https://openalex.org/W2087292928","https://openalex.org/W2093684639","https://openalex.org/W2094015758","https://openalex.org/W2096299938","https://openalex.org/W2105236625","https://openalex.org/W2113635822","https://openalex.org/W2117176621","https://openalex.org/W2133390798","https://openalex.org/W2148570818","https://openalex.org/W2260464481","https://openalex.org/W2296578831","https://openalex.org/W2418221308","https://openalex.org/W2507600934","https://openalex.org/W2512955684","https://openalex.org/W2533161465","https://openalex.org/W2562338046","https://openalex.org/W2585376553","https://openalex.org/W2611373298","https://openalex.org/W2734263382","https://openalex.org/W2767779645","https://openalex.org/W2769458780","https://openalex.org/W2795500191","https://openalex.org/W2883601824","https://openalex.org/W2884234047","https://openalex.org/W2896100155","https://openalex.org/W2901057870","https://openalex.org/W2904217420","https://openalex.org/W2914147912","https://openalex.org/W2924650933","https://openalex.org/W2946706119","https://openalex.org/W2950877036","https://openalex.org/W2981760867","https://openalex.org/W2993773924","https://openalex.org/W2993965395","https://openalex.org/W2999523158","https://openalex.org/W3012149055","https://openalex.org/W3015238180","https://openalex.org/W3015960371","https://openalex.org/W3028677469","https://openalex.org/W3040494789","https://openalex.org/W3041041132","https://openalex.org/W3043897045","https://openalex.org/W3044578806","https://openalex.org/W3044689957","https://openalex.org/W3088304730","https://openalex.org/W3090433308","https://openalex.org/W3092043890","https://openalex.org/W3093087254","https://openalex.org/W3093112387","https://openalex.org/W3094189594","https://openalex.org/W3110258185","https://openalex.org/W3113038478","https://openalex.org/W3118811283","https://openalex.org/W3128224400","https://openalex.org/W3129013365","https://openalex.org/W3135269378","https://openalex.org/W3136090219","https://openalex.org/W3161842012","https://openalex.org/W4212888272"],"related_works":["https://openalex.org/W4404026288","https://openalex.org/W2236618080","https://openalex.org/W1982749330","https://openalex.org/W2166960390","https://openalex.org/W4401869435","https://openalex.org/W2025693083","https://openalex.org/W7133481568","https://openalex.org/W1983591907","https://openalex.org/W2337485834","https://openalex.org/W2031952545"],"abstract_inverted_index":{"polyphenol":[0],"rich":[1],"extract":[2],"(SiPE)":[3],"against":[4],"diabetic":[5,32,188],"encephalopathy":[6,210],"in":[7,156,183],"rats":[8,33],"and":[9,30,40,47,56,67,82,93,97,126,164,177,198,217],"elucidated":[10],"the":[11,31,53,86,112,157,184,200],"potential":[12],"mechanisms":[13],"of":[14,28,101,115,187,214],"action.":[15],"Type":[16],"2":[17,124],"diabetes":[18],"mellitus":[19],"(T2DM)":[20],"was":[21,62,75],"induced":[22],"using":[23,52,64,77],"high":[24],"fructose":[25],"solution/intraperitoneal":[26],"injection":[27],"streptozotocin":[29],"were":[34,50,105,130],"treated":[35],"with":[36],"SiPE":[37,140,169,190,207],"(50,":[38],"100":[39],"200":[41],"mg/kg)":[42],"for":[43],"8":[44],"weeks.":[45],"Learning":[46],"memory":[48],"functions":[49],"assessed":[51,76],"Morris":[54,158],"water":[55,159],"Y":[57,161],"maze":[58,162],"tests,":[59,70],"depressive":[60],"behaviour":[61],"evaluated":[63],"forced":[65],"swimming":[66],"open":[68],"field":[69],"while":[71],"neuropathic":[72],"pain":[73],"assessment":[74],"hot":[78],"plate,":[79],"tail":[80],"immersion":[81],"formalin":[83],"tests.":[84],"After":[85],"experiments,":[87],"acetylcholinesterase":[88],"(AChE),":[89],"oxidative":[90,215],"stress":[91,216],"biomarkers":[92],"proinflammatory":[94],"cytokines,":[95],"caspase-3":[96],"nuclear":[98,119],"factor":[99,120,123],"kappa-light-chain-enhancer":[100],"activated":[102],"B":[103],"(NF-\u03baB)":[104],"determined":[106,131],"by":[107,132],"ELISA":[108],"kits.":[109],"In":[110],"addition,":[111],"expression":[113],"levels":[114,176],"p38,":[116],"phospho-p38":[117],"(p-p38),":[118],"erythroid":[121],"2-related":[122],"(Nrf2)":[125],"heme":[127],"oxygenase-1":[128],"(HO-1)":[129],"western":[133],"blot":[134],"analyses.":[135],"The":[136,203],"results":[137],"indicated":[138],"that":[139,206],"administration":[141,191],"significantly":[142,193],"lowered":[143],"blood":[144],"glucose":[145],"level,":[146],"attenuated":[147],"body":[148],"weight":[149],"loss,":[150],"thermal/chemical":[151],"hyperalgesia,":[152],"improved":[153],"behavioural":[154],"deficit":[155],"maze,":[160],"test":[163],"reduced":[165,170],"depressive-like":[166],"behaviours.":[167],"Furthermore,":[168],"AChE,":[171],"caspase-3,":[172],"NF-\u03baB,":[173],"malonaldehyde":[174],"malondialdehyde":[175],"simultaneously":[178],"increased":[179],"antioxidant":[180],"enzymes":[181],"activity":[182],"brain":[185],"tissues":[186],"rats.":[189],"also":[192],"suppressed":[194],"p38":[195],"MAPK":[196],"pathway":[197],"upregulated":[199],"Nrf2":[201],"pathway.":[202],"findings":[204],"suggested":[205],"exerted":[208],"antidiabetic":[209],"effects":[211],"via":[212],"modulation":[213],"inflammation.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-10-25T00:00:00"}
