{"id":"https://openalex.org/W3206669669","doi":"https://doi.org/10.1007/s00259-021-05571-1","title":"Pharmacokinetic and pharmacodynamic assessment of histamine H3 receptor occupancy by enerisant: a human PET study with a novel H3 binding ligand, [11C]TASP457","display_name":"Pharmacokinetic and pharmacodynamic assessment of histamine H3 receptor occupancy by enerisant: a human PET study with a novel H3 binding ligand, [11C]TASP457","publication_year":2021,"publication_date":"2021-10-15","ids":{"openalex":"https://openalex.org/W3206669669","doi":"https://doi.org/10.1007/s00259-021-05571-1","mag":"3206669669","pmid":"https://pubmed.ncbi.nlm.nih.gov/34651222"},"language":"en","primary_location":{"id":"doi:10.1007/s00259-021-05571-1","doi":"https://doi.org/10.1007/s00259-021-05571-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00259-021-05571-1","pdf_url":null,"source":{"id":"https://openalex.org/S191349260","display_name":"European Journal of Nuclear Medicine and Molecular Imaging","issn_l":"1619-7070","issn":["1619-7070","1619-7089"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Nuclear Medicine and Molecular Imaging","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repo.qst.go.jp/records/84089","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036744590","display_name":"Yasuyuki Kimura","orcid":"https://orcid.org/0000-0002-7927-9483","observed_orcids":["https://orcid.org/0000-0002-7927-9483"]},"institutions":[{"id":"https://openalex.org/I4210114217","display_name":"National Institutes for Quantum Science and Technology","ror":"https://ror.org/020rbyg91","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217"]},{"id":"https://openalex.org/I4405286445","display_name":"Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology","ror":"https://ror.org/0254bng76","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210160102","https://openalex.org/I4405286445"]},{"id":"https://openalex.org/I4405287698","display_name":"Institute for Quantum Medical Science","ror":"https://ror.org/05xta1k13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217","https://openalex.org/I4405287698"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuyuki Kimura","raw_affiliation_strings":["Department of Clinical and Experimental Neuroimaging, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, 7-430 Morioka, Obu, Aichi, 474-8511, Japan","Department of Functional Brain Imaging, Institute for Quantum Medical Science , National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan"],"raw_orcid":"https://orcid.org/0000-0002-7927-9483","affiliations":[{"raw_affiliation_string":"Department of Clinical and Experimental Neuroimaging, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, 7-430 Morioka, Obu, Aichi, 474-8511, Japan","institution_ids":["https://openalex.org/I4405286445"]},{"raw_affiliation_string":"Department of Functional Brain Imaging, Institute for Quantum Medical Science , National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan","institution_ids":["https://openalex.org/I4210114217","https://openalex.org/I4405287698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009790212","display_name":"Keisuke Takahata","orcid":"https://orcid.org/0000-0002-0884-4924","observed_orcids":["https://orcid.org/0000-0002-0884-4924"]},"institutions":[{"id":"https://openalex.org/I4210114217","display_name":"National Institutes for Quantum Science and Technology","ror":"https://ror.org/020rbyg91","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217"]},{"id":"https://openalex.org/I4405287698","display_name":"Institute for Quantum Medical Science","ror":"https://ror.org/05xta1k13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217","https://openalex.org/I4405287698"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keisuke Takahata","raw_affiliation_strings":["Department of Functional Brain Imaging, Institute for Quantum Medical Science , National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Functional Brain Imaging, Institute for Quantum Medical Science , National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan","institution_ids":["https://openalex.org/I4210114217","https://openalex.org/I4405287698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111583362","display_name":"Toshiharu Shimazaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I144245601","display_name":"Taisho Pharmaceutical (Japan)","ror":"https://ror.org/033nw2736","country_code":"JP","type":"company","lineage":["https://openalex.org/I144245601"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiharu Shimazaki","raw_affiliation_strings":["Taisho Pharmaceutical Co, Ltd. 3-24-1 Takada, Toshima-ku, Tokyo, 170-8633, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taisho Pharmaceutical Co, Ltd. 3-24-1 Takada, Toshima-ku, Tokyo, 170-8633, Japan","institution_ids":["https://openalex.org/I144245601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102943186","display_name":"Soichiro Kitamura","orcid":"https://orcid.org/0000-0002-3190-8068","observed_orcids":["https://orcid.org/0000-0002-3190-8068"]},"institutions":[{"id":"https://openalex.org/I4210114217","display_name":"National Institutes for Quantum Science and Technology","ror":"https://ror.org/020rbyg91","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217"]},{"id":"https://openalex.org/I4405287698","display_name":"Institute for Quantum Medical Science","ror":"https://ror.org/05xta1k13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217","https://openalex.org/I4405287698"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Soichiro Kitamura","raw_affiliation_strings":["Department of Functional Brain Imaging, Institute for Quantum Medical Science , National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Functional Brain Imaging, Institute for Quantum Medical Science , National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan","institution_ids":["https://openalex.org/I4210114217","https://openalex.org/I4405287698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060847562","display_name":"Chie Seki","orcid":"https://orcid.org/0000-0002-3222-7125","observed_orcids":["https://orcid.org/0000-0002-3222-7125"]},"institutions":[{"id":"https://openalex.org/I4210114217","display_name":"National Institutes for Quantum Science and Technology","ror":"https://ror.org/020rbyg91","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217"]},{"id":"https://openalex.org/I4405287698","display_name":"Institute for Quantum Medical Science","ror":"https://ror.org/05xta1k13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217","https://openalex.org/I4405287698"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chie Seki","raw_affiliation_strings":["Department of Functional Brain Imaging, Institute for Quantum Medical Science , National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Functional Brain Imaging, Institute for Quantum Medical Science , National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan","institution_ids":["https://openalex.org/I4210114217","https://openalex.org/I4405287698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100989798","display_name":"Yoko Ikoma","orcid":"https://orcid.org/0000-0001-6312-2353","observed_orcids":["https://orcid.org/0000-0001-6312-2353"]},"institutions":[{"id":"https://openalex.org/I4210114217","display_name":"National Institutes for Quantum Science and Technology","ror":"https://ror.org/020rbyg91","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217"]},{"id":"https://openalex.org/I4405287698","display_name":"Institute for Quantum Medical Science","ror":"https://ror.org/05xta1k13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217","https://openalex.org/I4405287698"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoko Ikoma","raw_affiliation_strings":["Department of Molecular Imaging and Theranostics, Institute for Quantum Medical Science , National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Imaging and Theranostics, Institute for Quantum Medical Science , National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan","institution_ids":["https://openalex.org/I4210114217","https://openalex.org/I4405287698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103095045","display_name":"Masanori Ichise","orcid":"https://orcid.org/0000-0003-4216-6976","observed_orcids":["https://orcid.org/0000-0003-4216-6976"]},"institutions":[{"id":"https://openalex.org/I4210114217","display_name":"National Institutes for Quantum Science and Technology","ror":"https://ror.org/020rbyg91","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217"]},{"id":"https://openalex.org/I4405286445","display_name":"Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology","ror":"https://ror.org/0254bng76","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210160102","https://openalex.org/I4405286445"]},{"id":"https://openalex.org/I4405287698","display_name":"Institute for Quantum Medical Science","ror":"https://ror.org/05xta1k13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217","https://openalex.org/I4405287698"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masanori Ichise","raw_affiliation_strings":["Department of Clinical and Experimental Neuroimaging, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, 7-430 Morioka, Obu, Aichi, 474-8511, Japan","Department of Functional Brain Imaging, Institute for Quantum Medical Science , National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Experimental Neuroimaging, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, 7-430 Morioka, Obu, Aichi, 474-8511, Japan","institution_ids":["https://openalex.org/I4405286445"]},{"raw_affiliation_string":"Department of Functional Brain Imaging, Institute for Quantum Medical Science , National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan","institution_ids":["https://openalex.org/I4210114217","https://openalex.org/I4405287698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064403117","display_name":"Kazunori Kawamura","orcid":"https://orcid.org/0000-0001-6786-678X","observed_orcids":["https://orcid.org/0000-0001-6786-678X"]},"institutions":[{"id":"https://openalex.org/I4210114217","display_name":"National Institutes for Quantum Science and Technology","ror":"https://ror.org/020rbyg91","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217"]},{"id":"https://openalex.org/I4405287698","display_name":"Institute for Quantum Medical Science","ror":"https://ror.org/05xta1k13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217","https://openalex.org/I4405287698"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazunori Kawamura","raw_affiliation_strings":["Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science , National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage, Chiba, Chiba, 263-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science , National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage, Chiba, Chiba, 263-8555, Japan","institution_ids":["https://openalex.org/I4210114217","https://openalex.org/I4405287698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063918859","display_name":"Makiko Yamada","orcid":"https://orcid.org/0000-0002-2897-3045","observed_orcids":["https://orcid.org/0000-0002-2897-3045"]},"institutions":[{"id":"https://openalex.org/I4210114217","display_name":"National Institutes for Quantum Science and Technology","ror":"https://ror.org/020rbyg91","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217"]},{"id":"https://openalex.org/I4405287698","display_name":"Institute for Quantum Medical Science","ror":"https://ror.org/05xta1k13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217","https://openalex.org/I4405287698"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makiko Yamada","raw_affiliation_strings":["Department of Functional Brain Imaging, Institute for Quantum Medical Science , National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Functional Brain Imaging, Institute for Quantum Medical Science , National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan","institution_ids":["https://openalex.org/I4210114217","https://openalex.org/I4405287698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030087345","display_name":"Ming\u2010Rong Zhang","orcid":"https://orcid.org/0000-0002-3001-9605","observed_orcids":["https://orcid.org/0000-0002-3001-9605"]},"institutions":[{"id":"https://openalex.org/I4210114217","display_name":"National Institutes for Quantum Science and Technology","ror":"https://ror.org/020rbyg91","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217"]},{"id":"https://openalex.org/I4405287698","display_name":"Institute for Quantum Medical Science","ror":"https://ror.org/05xta1k13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217","https://openalex.org/I4405287698"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ming-Rong Zhang","raw_affiliation_strings":["Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science , National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage, Chiba, Chiba, 263-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science , National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage, Chiba, Chiba, 263-8555, Japan","institution_ids":["https://openalex.org/I4210114217","https://openalex.org/I4405287698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002819177","display_name":"Makoto Higuchi","orcid":"https://orcid.org/0000-0002-3934-5810","observed_orcids":["https://orcid.org/0000-0002-3934-5810"]},"institutions":[{"id":"https://openalex.org/I4210114217","display_name":"National Institutes for Quantum Science and Technology","ror":"https://ror.org/020rbyg91","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217"]},{"id":"https://openalex.org/I4405287698","display_name":"Institute for Quantum Medical Science","ror":"https://ror.org/05xta1k13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217","https://openalex.org/I4405287698"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Makoto Higuchi","raw_affiliation_strings":["Department of Functional Brain Imaging, Institute for Quantum Medical Science , National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan. higuchi.makoto@qst.go.jp","Department of Functional Brain Imaging, Institute for Quantum Medical Science\n, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Functional Brain Imaging, Institute for Quantum Medical Science , National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan. higuchi.makoto@qst.go.jp","institution_ids":["https://openalex.org/I4210114217","https://openalex.org/I4405287698"]},{"raw_affiliation_string":"Department of Functional Brain Imaging, Institute for Quantum Medical Science\n, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan","institution_ids":["https://openalex.org/I4210114217","https://openalex.org/I4405287698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038520400","display_name":"Izumi Nishino","orcid":"https://orcid.org/0000-0002-7754-1986","observed_orcids":["https://orcid.org/0000-0002-7754-1986"]},"institutions":[{"id":"https://openalex.org/I144245601","display_name":"Taisho Pharmaceutical (Japan)","ror":"https://ror.org/033nw2736","country_code":"JP","type":"company","lineage":["https://openalex.org/I144245601"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Izumi Nishino","raw_affiliation_strings":["Taisho Pharmaceutical Co, Ltd. 3-24-1 Takada, Toshima-ku, Tokyo, 170-8633, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taisho Pharmaceutical Co, Ltd. 3-24-1 Takada, Toshima-ku, Tokyo, 170-8633, Japan","institution_ids":["https://openalex.org/I144245601"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085556975","display_name":"Tetsuya Suhara","orcid":"https://orcid.org/0000-0003-2916-225X","observed_orcids":["https://orcid.org/0000-0003-2916-225X"]},"institutions":[{"id":"https://openalex.org/I4210114217","display_name":"National Institutes for Quantum Science and Technology","ror":"https://ror.org/020rbyg91","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217"]},{"id":"https://openalex.org/I4405287698","display_name":"Institute for Quantum Medical Science","ror":"https://ror.org/05xta1k13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217","https://openalex.org/I4405287698"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuya Suhara","raw_affiliation_strings":["Department of Functional Brain Imaging, Institute for Quantum Medical Science , National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Functional Brain Imaging, Institute for Quantum Medical Science , National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan","institution_ids":["https://openalex.org/I4210114217","https://openalex.org/I4405287698"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5002819177"],"corresponding_institution_ids":["https://openalex.org/I4210114217","https://openalex.org/I4405287698"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":0.4568,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.50785667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"49","issue":"4","first_page":"1127","last_page":"1135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.5576000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.5576000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.07599999755620956,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0714000016450882,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histamine-h3-receptor","display_name":"histamine H3 receptor","score":0.9200000166893005},{"id":"https://openalex.org/keywords/receptor-occupancy","display_name":"receptor occupancy","score":0.9679999947547913},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.6549999713897705},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9599999785423279},{"id":"https://openalex.org/keywords/pet-radiotracer","display_name":"PET radiotracer","score":0.800000011920929},{"id":"https://openalex.org/keywords/target-engagement","display_name":"target engagement","score":0.859000027179718},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.531000018119812},{"id":"https://openalex.org/keywords/narcolepsy","display_name":"narcolepsy","score":0.7789999842643738},{"id":"https://openalex.org/keywords/insomnia","display_name":"insomnia","score":0.5699999928474426},{"id":"https://openalex.org/keywords/inverse-agonists","display_name":"inverse agonists","score":0.7099999785423279},{"id":"https://openalex.org/keywords/sleep-wake-disorders","display_name":"sleep-wake disorders","score":0.5910000205039978},{"id":"https://openalex.org/keywords/plasma-concentration","display_name":"plasma concentration","score":0.43700000643730164},{"id":"https://openalex.org/keywords/healthy-volunteers","display_name":"healthy volunteers","score":0.9570000171661377}],"concepts":[{"id":"https://openalex.org/C63180777","wikidata":"https://www.wikidata.org/wiki/Q288395","display_name":"Histamine H3 receptor","level":4,"score":0.7626941204071045},{"id":"https://openalex.org/C67847695","wikidata":"https://www.wikidata.org/wiki/Q626478","display_name":"Radioligand","level":3,"score":0.7191486954689026},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.6847410202026367},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6526105403900146},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5783000588417053},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5706091523170471},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.5588377118110657},{"id":"https://openalex.org/C89951826","wikidata":"https://www.wikidata.org/wiki/Q1671731","display_name":"Inverse agonist","level":4,"score":0.5530923008918762},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4852583110332489},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47239062190055847},{"id":"https://openalex.org/C10335311","wikidata":"https://www.wikidata.org/wiki/Q309513","display_name":"Histamine H1 receptor","level":4,"score":0.42837023735046387},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41207098960876465},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33886978030204773},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.330028235912323},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.2823762893676758}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007319","descriptor_name":"Sleep Initiation and Maintenance Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009290","descriptor_name":"Narcolepsy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015363","descriptor_name":"Quinolones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018100","descriptor_name":"Receptors, Histamine H3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00259-021-05571-1","doi":"https://doi.org/10.1007/s00259-021-05571-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00259-021-05571-1","pdf_url":null,"source":{"id":"https://openalex.org/S191349260","display_name":"European Journal of Nuclear Medicine and Molecular Imaging","issn_l":"1619-7070","issn":["1619-7070","1619-7089"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Nuclear Medicine and Molecular Imaging","raw_type":"journal-article"},{"id":"pmid:34651222","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34651222","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of nuclear medicine and molecular imaging","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:01116:0005250333","doi":null,"is_oa":true,"landing_page_url":"https://repo.qst.go.jp/records/84089","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European journal of nuclear medicine and molecular imaging","raw_type":"journal article"},{"id":"pmh:oai:repo.qst.go.jp:00084089","doi":null,"is_oa":true,"landing_page_url":"http://id.nii.ac.jp/1657/00084070/","pdf_url":null,"source":{"id":"https://openalex.org/S4377196694","display_name":"QST-Repository (National Institutes for Quantum and Radiological Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210114217","host_organization_name":"National Institutes for Quantum Science and Technology","host_organization_lineage":["https://openalex.org/I4210114217"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://link.springer.com/article/10.1007/s00259-021-05571-1","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:01116:0005250333","doi":null,"is_oa":true,"landing_page_url":"https://repo.qst.go.jp/records/84089","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European journal of nuclear medicine and molecular imaging","raw_type":"journal article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G116542145","display_name":null,"funder_award_id":"20H05711","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1968695161","https://openalex.org/W2001434260","https://openalex.org/W2039849701","https://openalex.org/W2075879209","https://openalex.org/W2078865702","https://openalex.org/W2112278807","https://openalex.org/W2120765078","https://openalex.org/W2142635246","https://openalex.org/W2167811870","https://openalex.org/W2262971706","https://openalex.org/W2278756750","https://openalex.org/W2508721641","https://openalex.org/W2518279034","https://openalex.org/W2586256972","https://openalex.org/W2942146122","https://openalex.org/W2965235206","https://openalex.org/W3015973304","https://openalex.org/W3082878050","https://openalex.org/W4230920194"],"related_works":["https://openalex.org/W2075879209","https://openalex.org/W3082878050","https://openalex.org/W6990277884","https://openalex.org/W1713261992","https://openalex.org/W2262971706","https://openalex.org/W1976012955","https://openalex.org/W3015973304","https://openalex.org/W1601351893","https://openalex.org/W2167811870","https://openalex.org/W1965165459"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-10-25T00:00:00"}