{"id":"https://openalex.org/W3206640698","doi":"https://doi.org/10.12998/wjcc.v9.i30.9077","title":"Neoadjuvant radiotherapy dose escalation for locally advanced rectal cancers in the new era of radiotherapy: A review of literature","display_name":"Neoadjuvant radiotherapy dose escalation for locally advanced rectal cancers in the new era of radiotherapy: A review of literature","publication_year":2021,"publication_date":"2021-10-21","ids":{"openalex":"https://openalex.org/W3206640698","doi":"https://doi.org/10.12998/wjcc.v9.i30.9077","mag":"3206640698","pmid":"https://pubmed.ncbi.nlm.nih.gov/34786390","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8567526"},"language":"en","primary_location":{"id":"doi:10.12998/wjcc.v9.i30.9077","doi":"https://doi.org/10.12998/wjcc.v9.i30.9077","is_oa":true,"landing_page_url":"https://doi.org/10.12998/wjcc.v9.i30.9077","pdf_url":null,"source":{"id":"https://openalex.org/S2738453254","display_name":"World Journal of Clinical Cases","issn_l":"2307-8960","issn":["2307-8960"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Clinical Cases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.12998/wjcc.v9.i30.9077","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087240249","display_name":"D. Delishaj","orcid":"https://orcid.org/0000-0002-1782-0852","observed_orcids":["https://orcid.org/0000-0002-1782-0852"]},"institutions":[{"id":"https://openalex.org/I4210113373","display_name":"Alessandro Manzoni Hospital","ror":"https://ror.org/030kaa114","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210113373"]},{"id":"https://openalex.org/I4396570589","display_name":"Aziende Socio Sanitarie Territoriali di Lecco","ror":"https://ror.org/04bmr7q61","country_code":"IT","type":"government","lineage":["https://openalex.org/I4396570589"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Durim Delishaj","raw_affiliation_strings":["Department of Radiation Oncology, Alessandro Manzoni Hospital, Lecco 23900, Italy. d.delishaj@asst-lecco.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Alessandro Manzoni Hospital, Lecco 23900, Italy. d.delishaj@asst-lecco.it","institution_ids":["https://openalex.org/I4210113373","https://openalex.org/I4396570589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064272088","display_name":"Ilaria Costanza Fumagalli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ilaria Costanza Fumagalli","raw_affiliation_strings":["Department of Radiation Oncology, San Donato Hospital, Milan 20097, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, San Donato Hospital, Milan 20097, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009729174","display_name":"Stefano Ursino","orcid":"https://orcid.org/0000-0003-3018-2338","observed_orcids":["https://orcid.org/0000-0003-3018-2338"]},"institutions":[{"id":"https://openalex.org/I4210165410","display_name":"Azienda Ospedaliera Universitaria Pisana","ror":"https://ror.org/05xrcj819","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165410"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Ursino","raw_affiliation_strings":["Department of Radiation Oncology, Santa Chiara University Hospital, Pisa 56126, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Santa Chiara University Hospital, Pisa 56126, Italy","institution_ids":["https://openalex.org/I4210165410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071547398","display_name":"Agostino Cristaudo","orcid":"https://orcid.org/0000-0002-9387-1109","observed_orcids":["https://orcid.org/0000-0002-9387-1109"]},"institutions":[{"id":"https://openalex.org/I4210154214","display_name":"Royal Preston Hospital","ror":"https://ror.org/05kpx1157","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1293129422","https://openalex.org/I4210154214"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Agostino Cristaudo","raw_affiliation_strings":["Royal Preston Hospital, Lancashire Teaching Hospital- NHS Tust, Preston PR2 9HT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Preston Hospital, Lancashire Teaching Hospital- NHS Tust, Preston PR2 9HT, United Kingdom","institution_ids":["https://openalex.org/I4210154214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083153607","display_name":"Francesco Colangelo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113373","display_name":"Alessandro Manzoni Hospital","ror":"https://ror.org/030kaa114","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210113373"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Colangelo","raw_affiliation_strings":["Department of Radiation Oncology, Alessandro Manzoni Hospital, Lecco 23900, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Alessandro Manzoni Hospital, Lecco 23900, Italy","institution_ids":["https://openalex.org/I4210113373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040308563","display_name":"Antonio Stefanelli","orcid":"https://orcid.org/0000-0003-4444-0668","observed_orcids":["https://orcid.org/0000-0003-4444-0668"]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Stefanelli","raw_affiliation_strings":["Department of Radiation Oncology, Azienda Ospedaliero-Universitaria di Ferrara, Ferrara 44124, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Azienda Ospedaliero-Universitaria di Ferrara, Ferrara 44124, Italy","institution_ids":["https://openalex.org/I201324441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028038342","display_name":"Alessandro Alghisi","orcid":"https://orcid.org/0000-0003-1244-2570","observed_orcids":["https://orcid.org/0000-0003-1244-2570"]},"institutions":[{"id":"https://openalex.org/I4210113373","display_name":"Alessandro Manzoni Hospital","ror":"https://ror.org/030kaa114","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210113373"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Alghisi","raw_affiliation_strings":["Department of Radiation Oncology, Alessandro Manzoni Hospital, Lecco 23900, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Alessandro Manzoni Hospital, Lecco 23900, Italy","institution_ids":["https://openalex.org/I4210113373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088641838","display_name":"Giuseppe De Nobili","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113373","display_name":"Alessandro Manzoni Hospital","ror":"https://ror.org/030kaa114","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210113373"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe De Nobili","raw_affiliation_strings":["Department of Radiation Oncology, Alessandro Manzoni Hospital, Lecco 23900, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Alessandro Manzoni Hospital, Lecco 23900, Italy","institution_ids":["https://openalex.org/I4210113373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041412420","display_name":"Romerai D\u2019Amico","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113373","display_name":"Alessandro Manzoni Hospital","ror":"https://ror.org/030kaa114","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210113373"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Romerai D\u2019Amico","raw_affiliation_strings":["Department of Radiation Oncology, Alessandro Manzoni Hospital, Lecco 23900, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Alessandro Manzoni Hospital, Lecco 23900, Italy","institution_ids":["https://openalex.org/I4210113373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044974757","display_name":"Alessandra Cocchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113373","display_name":"Alessandro Manzoni Hospital","ror":"https://ror.org/030kaa114","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210113373"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Cocchi","raw_affiliation_strings":["Department of Radiation Oncology, Alessandro Manzoni Hospital, Lecco 23900, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Alessandro Manzoni Hospital, Lecco 23900, Italy","institution_ids":["https://openalex.org/I4210113373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052130645","display_name":"Antonio Ardizzoia","orcid":"https://orcid.org/0000-0003-2232-5677","observed_orcids":["https://orcid.org/0000-0003-2232-5677"]},"institutions":[{"id":"https://openalex.org/I4210113373","display_name":"Alessandro Manzoni Hospital","ror":"https://ror.org/030kaa114","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210113373"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Ardizzoia","raw_affiliation_strings":["Department of Clinical Oncology, Alessandro Manzoni Hospital, Lecco 23900, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology, Alessandro Manzoni Hospital, Lecco 23900, Italy","institution_ids":["https://openalex.org/I4210113373"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083646826","display_name":"Carlo Pietro Soatti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113373","display_name":"Alessandro Manzoni Hospital","ror":"https://ror.org/030kaa114","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210113373"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carlo Pietro Soatti","raw_affiliation_strings":["Department of Radiation Oncology, Alessandro Manzoni Hospital, Lecco 23900, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Alessandro Manzoni Hospital, Lecco 23900, Italy","institution_ids":["https://openalex.org/I4210113373"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5991,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.65674128,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"9","issue":"30","first_page":"9077","last_page":"9089"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13110","display_name":"Colorectal and Anal Carcinomas","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/locally-advanced-rectal-cancer","display_name":"locally advanced rectal cancer","score":0.9819999933242798},{"id":"https://openalex.org/keywords/preoperative-radiotherapy","display_name":"preoperative radiotherapy","score":0.9120000004768372},{"id":"https://openalex.org/keywords/radiotherapy-dose-escalation","display_name":"radiation dose escalation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/pathological-complete-response","display_name":"pathological complete response","score":0.6980000138282776},{"id":"https://openalex.org/keywords/tumor-downstaging","display_name":"tumor downstaging","score":0.8889999985694885},{"id":"https://openalex.org/keywords/volumetric-modulated-arc-therapy","display_name":"volumetric modulated arc therapy","score":0.8130000233650208},{"id":"https://openalex.org/keywords/intensity-modulated-radiotherapy","display_name":"intensity-modulated radiotherapy","score":0.996999979019165},{"id":"https://openalex.org/keywords/image-guided-radiotherapy","display_name":"image-guided radiotherapy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/equivalent-dose-in-2-gy","display_name":"equivalent dose in 2 Gy","score":0.6399999856948853},{"id":"https://openalex.org/keywords/surgical-complications","display_name":"surgical complications","score":0.7400000095367432},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"chemoradiotherapy","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9463359117507935},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.7710108757019043},{"id":"https://openalex.org/C2777201421","wikidata":"https://www.wikidata.org/wiki/Q2445481","display_name":"Total mesorectal excision","level":4,"score":0.6508676409721375},{"id":"https://openalex.org/C9267231","wikidata":"https://www.wikidata.org/wiki/Q15841445","display_name":"Image-guided radiation therapy","level":3,"score":0.6342911720275879},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5060591101646423},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.43939682841300964},{"id":"https://openalex.org/C2778424827","wikidata":"https://www.wikidata.org/wiki/Q5090613","display_name":"Chemoradiotherapy","level":3,"score":0.4365350008010864},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.4199650287628174},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.36746934056282043},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2680973708629608},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2349211573600769},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.12998/wjcc.v9.i30.9077","doi":"https://doi.org/10.12998/wjcc.v9.i30.9077","is_oa":true,"landing_page_url":"https://doi.org/10.12998/wjcc.v9.i30.9077","pdf_url":null,"source":{"id":"https://openalex.org/S2738453254","display_name":"World Journal of Clinical Cases","issn_l":"2307-8960","issn":["2307-8960"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Clinical Cases","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8567526","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8567526/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8567526/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World J Clin Cases","raw_type":"Text"},{"id":"pmid:34786390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34786390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World journal of clinical cases","raw_type":"Journal Article"},{"id":"pmh:oai:arpi.unipi.it:11568/1119032","doi":null,"is_oa":true,"landing_page_url":"https://www.wjgnet.com/2307-8960/full/v9/i30/9077.htm","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.12998/wjcc.v9.i30.9077","doi":"https://doi.org/10.12998/wjcc.v9.i30.9077","is_oa":true,"landing_page_url":"https://doi.org/10.12998/wjcc.v9.i30.9077","pdf_url":null,"source":{"id":"https://openalex.org/S2738453254","display_name":"World Journal of Clinical Cases","issn_l":"2307-8960","issn":["2307-8960"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Clinical Cases","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3206640698.pdf","grobid_xml":"https://content.openalex.org/works/W3206640698.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1585172067","https://openalex.org/W1880063947","https://openalex.org/W1971142314","https://openalex.org/W2000393470","https://openalex.org/W2000807684","https://openalex.org/W2012903508","https://openalex.org/W2026735682","https://openalex.org/W2029482643","https://openalex.org/W2031996887","https://openalex.org/W2043945205","https://openalex.org/W2049235944","https://openalex.org/W2051667674","https://openalex.org/W2057901226","https://openalex.org/W2073631512","https://openalex.org/W2077086851","https://openalex.org/W2085188388","https://openalex.org/W2085482416","https://openalex.org/W2102724015","https://openalex.org/W2125452425","https://openalex.org/W2127433346","https://openalex.org/W2155492044","https://openalex.org/W2171221213","https://openalex.org/W2187358799","https://openalex.org/W2274765040","https://openalex.org/W2324957104","https://openalex.org/W2398356964","https://openalex.org/W2413331746","https://openalex.org/W2485009944","https://openalex.org/W2492618519","https://openalex.org/W2588784344","https://openalex.org/W2591910347","https://openalex.org/W2607138199","https://openalex.org/W2749255563","https://openalex.org/W2755512079","https://openalex.org/W2756681395","https://openalex.org/W2757048513","https://openalex.org/W2800160906","https://openalex.org/W2883744841","https://openalex.org/W2906171552","https://openalex.org/W2911862581","https://openalex.org/W2913400159","https://openalex.org/W2914194034","https://openalex.org/W2914830843","https://openalex.org/W2939109472","https://openalex.org/W2942649711","https://openalex.org/W2949968771","https://openalex.org/W2975847422","https://openalex.org/W2981869043","https://openalex.org/W2989688934","https://openalex.org/W3009963727","https://openalex.org/W3012889413","https://openalex.org/W3016146809","https://openalex.org/W3036804620","https://openalex.org/W3041942177","https://openalex.org/W3134887329","https://openalex.org/W4244315786"],"related_works":["https://openalex.org/W4402047365","https://openalex.org/W6892534230","https://openalex.org/W6927226119","https://openalex.org/W3041942177","https://openalex.org/W7128468523","https://openalex.org/W3093860669","https://openalex.org/W3016146809","https://openalex.org/W6908504371","https://openalex.org/W3093880366","https://openalex.org/W4210680856"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,96,147],"standard":[2],"treatment":[3],"of":[4,43,62,83,90,99,153,194,206],"locally":[5],"advanced":[6],"rectal":[7],"cancers":[8],"(LARC)":[9],"consists":[10],"on":[11,26],"neoadjuvant":[12,63,182],"chemoradiotherapy":[13],"followed":[14],"by":[15,111],"total":[16,152],"mesorectal":[17],"excision.":[18],"Different":[19],"data":[20],"in":[21],"literature":[22,81],"showed":[23],"a":[24,79,151],"benefit":[25],"tumor":[27],"downstaging":[28],"and":[29,93,113,134,169],"pathological":[30],"complete":[31],"response":[32],"(pCR)":[33],"rate":[34,205],"using":[35,48,69,122,184],"radiotherapy":[36,64,71,141,144,183],"dose":[37,46,65,126],"escalation,":[38],"however":[39],"there":[40],"is":[41,187,201],"shortage":[42],"studies":[44,121],"regarding":[45],"escalation":[47,66,181],"the":[49,60,84,173],"innovative":[50,70,185],"techniques":[51,186],"for":[52,67,172,189],"LARC":[53,68,190],"(T3-4":[54],"or":[55,142],"N1-2).":[56],"AIM:":[57],"To":[58],"analyze":[59],"role":[61],"techniques.":[72,146],"METHODS:":[73],"In":[74],"December":[75,108],"2020,":[76],"we":[77],"conducted":[78],"comprehensive":[80],"search":[82],"following":[85],"electronic":[86],"databases:":[87],"PubMed,":[88],"Web":[89],"Science,":[91],"Scopus":[92],"Cochrane":[94],"library.":[95],"limit":[97],"period":[98],"research":[100],"included":[101,171],"articles":[102],"published":[103],"from":[104],"January":[105],"2009":[106],"to":[107,118,158],"2020.":[109],"Screening":[110],"title":[112],"abstract":[114],"was":[115],"carried":[116],"out":[117],"identify":[119],"only":[120],"radiation":[123],"doses":[124,197],"equivalent":[125],"2":[127],"Gy":[128,133,200],"fraction":[129],"(EQD2)":[130],"\u2265":[131],"54":[132],"Volumetric":[135],"Modulated":[136],"Arc":[137],"Therapy":[138],"(VMAT),":[139],"intensity-modulated":[140],"image-guided":[143],"(IGRT)":[145],"authors'":[148],"searches":[149],"generated":[150],"2287":[154],"results":[155],"and,":[156],"according":[157],"PRISMA":[159],"Group":[160],"(2009)":[161],"screening":[162],"process,":[163],"21":[164],"publications":[165],"fulfil":[166],"selection":[167],"criteria":[168],"were":[170],"review.":[174],"RESULTS:":[175],"value":[176],"=":[177],"0.047).":[178],"CONCLUSION:":[179],"Dose":[180],"safe":[188],"achieving":[191],"higher":[192,204],"rates":[193],"pCR.":[195],"EQD2":[196],">":[198],"58.9":[199],"associated":[202],"with":[203],"surgical":[207],"complications.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":6}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2021-10-25T00:00:00"}