{"id":"https://openalex.org/W3206567252","doi":null,"title":"Introducing physical exercise as a potential strategy in liver cancer prevention and development.","display_name":"Introducing physical exercise as a potential strategy in liver cancer prevention and development.","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3206567252","mag":"3206567252","pmid":"https://pubmed.ncbi.nlm.nih.gov/34659659","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8514208"},"language":"en","primary_location":{"id":"pmh:oai:journals.sbmu.ac.ir/ghfbb:article/2250","doi":null,"is_oa":true,"landing_page_url":"https://journals.sbmu.ac.ir/ghfbb/index.php/ghfbb/article/view/2250","pdf_url":"https://journals.sbmu.ac.ir/ghfbb/index.php/ghfbb/article/download/2250/1354","source":{"id":"https://openalex.org/S2764627315","display_name":"Gastroenterology and hepatology from bed to bench.","issn_l":"2008-2258","issn":["2008-2258","2008-4234"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319135","host_organization_name":"Shahid Beheshti University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319135"],"host_organization_lineage_names":["Shahid Beheshti University of Medical Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008-2258","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journals.sbmu.ac.ir/ghfbb/index.php/ghfbb/article/download/2250/1354","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002630567","display_name":"Mona Zamanian Azodi","orcid":"https://orcid.org/0000-0003-1894-5021","observed_orcids":["https://orcid.org/0000-0003-1894-5021"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mona Zamanian-Azodi","raw_affiliation_strings":["Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015123355","display_name":"Sakineh Khatoon Hajisayah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Sakineh Khatoon Hajisayah","raw_affiliation_strings":["Department of Basic Sciences, School of Rehabilitation Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Sciences, School of Rehabilitation Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109536689","display_name":"Mohhamadreza Razzaghi","orcid":"https://orcid.org/0000-0002-3022-1547","observed_orcids":["https://orcid.org/0000-0002-3022-1547"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohhamadreza Razzaghi","raw_affiliation_strings":["Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091836453","display_name":"Mostafa Rezaei\u2013Tavirani","orcid":"https://orcid.org/0000-0003-1767-7475","observed_orcids":["https://orcid.org/0000-0003-1767-7475","https://orcid.org/0000-0002-5284-3179"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mostafa Rezaei-Tavirani","raw_affiliation_strings":["Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3504,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.48133202,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"14","issue":"4","first_page":"317","last_page":"322"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.5332000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.5332000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.17399999499320984,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.1340000033378601,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.9810000061988831},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.7940000295639038},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma-prevention","display_name":"hepatocellular carcinoma prevention","score":0.8569999933242798},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.8650000095367432},{"id":"https://openalex.org/keywords/liver-proteome","display_name":"liver proteome","score":0.8320000171661377},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.6959999799728394},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.8980000019073486},{"id":"https://openalex.org/keywords/enolase-1","display_name":"alpha-enolase","score":0.6970000267028809},{"id":"https://openalex.org/keywords/pgm1","display_name":"PGM1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hub-proteins","display_name":"hub proteins","score":0.6119999885559082},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.38199999928474426}],"concepts":[{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.6131691336631775},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5387505292892456},{"id":"https://openalex.org/C2780513914","wikidata":"https://www.wikidata.org/wiki/Q18210350","display_name":"Bottleneck","level":2,"score":0.49895477294921875},{"id":"https://openalex.org/C3020255362","wikidata":"https://www.wikidata.org/wiki/Q747883","display_name":"Physical activity","level":2,"score":0.47000983357429504},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.46251049637794495},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4233204424381256},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.4141121804714203},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3616040349006653},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3365369439125061},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33365312218666077},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.13915523886680603},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.09077408909797668},{"id":"https://openalex.org/C149635348","wikidata":"https://www.wikidata.org/wiki/Q193040","display_name":"Embedded system","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:journals.sbmu.ac.ir/ghfbb:article/2250","doi":null,"is_oa":true,"landing_page_url":"https://journals.sbmu.ac.ir/ghfbb/index.php/ghfbb/article/view/2250","pdf_url":"https://journals.sbmu.ac.ir/ghfbb/index.php/ghfbb/article/download/2250/1354","source":{"id":"https://openalex.org/S2764627315","display_name":"Gastroenterology and hepatology from bed to bench.","issn_l":"2008-2258","issn":["2008-2258","2008-4234"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319135","host_organization_name":"Shahid Beheshti University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319135"],"host_organization_lineage_names":["Shahid Beheshti University of Medical Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008-2258","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8514208","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8514208","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterol Hepatol Bed Bench","raw_type":"Text"},{"id":"pmid:34659659","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34659659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology and hepatology from bed to bench","raw_type":"Journal Article"},{"id":"mag:3206567252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34659659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:journals.sbmu.ac.ir/ghfbb:article/2250","doi":null,"is_oa":true,"landing_page_url":"https://journals.sbmu.ac.ir/ghfbb/index.php/ghfbb/article/view/2250","pdf_url":"https://journals.sbmu.ac.ir/ghfbb/index.php/ghfbb/article/download/2250/1354","source":{"id":"https://openalex.org/S2764627315","display_name":"Gastroenterology and hepatology from bed to bench.","issn_l":"2008-2258","issn":["2008-2258","2008-4234"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319135","host_organization_name":"Shahid Beheshti University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319135"],"host_organization_lineage_names":["Shahid Beheshti University of Medical Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2008-2258","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3206567252.pdf","grobid_xml":"https://content.openalex.org/works/W3206567252.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1729222511","https://openalex.org/W1973334073","https://openalex.org/W1993892330","https://openalex.org/W2023876251","https://openalex.org/W2026935738","https://openalex.org/W2028532361","https://openalex.org/W2060353744","https://openalex.org/W2099616702","https://openalex.org/W2125913359","https://openalex.org/W2144656637","https://openalex.org/W2152026276","https://openalex.org/W2155142785","https://openalex.org/W2157808390","https://openalex.org/W2165577181","https://openalex.org/W2169589032","https://openalex.org/W2183515631","https://openalex.org/W2211041313","https://openalex.org/W2212486231","https://openalex.org/W2329675021","https://openalex.org/W2480422257","https://openalex.org/W2528211973","https://openalex.org/W2565997835","https://openalex.org/W2774108532","https://openalex.org/W2852832966","https://openalex.org/W2896798787","https://openalex.org/W2900569176","https://openalex.org/W2913957270","https://openalex.org/W2922562273","https://openalex.org/W3004409334","https://openalex.org/W3010247737"],"related_works":["https://openalex.org/W7018989317","https://openalex.org/W4280650129","https://openalex.org/W4392592709","https://openalex.org/W4387115596","https://openalex.org/W7220671039","https://openalex.org/W2972671641","https://openalex.org/W2895615073","https://openalex.org/W4220722797","https://openalex.org/W2792727755","https://openalex.org/W2947950948"],"abstract_inverted_index":{"AIM:":[0],"This":[1],"study":[2],"aimed":[3],"to":[4,32,59,69,92],"investigate":[5,60],"the":[6,22,61,102,107,132,139,155,166,176],"anticancer":[7,50,163,177],"properties":[8,164,178],"of":[9,24,28,44,64,66,135,157,165,179],"physical":[10,25,45,70,180],"activity":[11,71],"by":[12,82,118,187],"network":[13,55,89,136,173],"analysis":[14,56],"in":[15,154,159],"trained":[16],"rats.":[17],"BACKGROUND:":[18],"Much":[19],"evidence":[20],"supports":[21],"benefits":[23],"activity,":[26,46,181],"most":[27],"which":[29,182],"are":[30,147],"related":[31],"metabolism":[33],"regulation":[34],"and":[35,80,85,111,124,143],"body":[36],"health.":[37],"Deeper":[38],"investigation":[39],"deals":[40],"with":[41],"other":[42],"features":[43],"such":[47],"as":[48,116,128],"its":[49,86],"properties.":[51],"METHODS:":[52],"Protein-protein":[53],"interaction":[54],"was":[57,90,99],"applied":[58],"proteome":[62],"profile":[63],"livers":[65],"rats":[67],"subjected":[68],"through":[72],"bioinformatics.":[73],"Twelve":[74],"differentially":[75],"expressed":[76],"proteins":[77],"were":[78,113,126,169],"searched":[79],"analyzed":[81,91],"Cytoscape":[83],"3.7.2":[84],"plug-ins.":[87],"The":[88,162,172],"identify":[93],"hub-bottleneck":[94],"nodes.":[95],"An":[96],"action":[97],"map":[98],"constructed":[100],"for":[101],"central":[103,129,167],"proteins.":[104],"RESULTS:":[105],"Among":[106],"queried":[108],"proteins,":[109],"Eno1":[110],"Pgm1":[112],"only":[114],"assigned":[115],"hubs":[117],"Network":[119],"Analzyer.":[120],"Gpi,":[121],"Pkm,":[122],"Aldoa,":[123],"Aldoart2":[125],"identified":[127],"nodes":[130,168],"among":[131],"first":[133],"neighbors":[134],"elements.":[137],"Furthermore,":[138],"glycolytic,":[140],"carbohydrate":[141],"catabolic,":[142],"glucose":[144],"metabolic":[145],"processes":[146],"key":[148],"elements":[149],"that":[150],"could":[151],"be":[152],"imperative":[153],"mechanism":[156],"exercise":[158],"liver":[160],"function.":[161],"highlighted.":[170],"CONCLUSION:":[171],"findings":[174],"indicate":[175],"has":[183],"also":[184],"been":[185],"supported":[186],"previous":[188],"investigations.":[189]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2021-10-25T00:00:00"}
