{"id":"https://openalex.org/W3206505277","doi":null,"title":"Evaluation of the antitumor efficacy and pharmacodynamics of the histone deacetylase inhibitor depsipeptide on childhood cancer models in vivo","display_name":"Evaluation of the antitumor efficacy and pharmacodynamics of the histone deacetylase inhibitor depsipeptide on childhood cancer models in vivo","publication_year":2005,"publication_date":"2005-05-01","ids":{"openalex":"https://openalex.org/W3206505277","mag":"3206505277"},"language":"en","primary_location":{"id":"mag:3206505277","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/65/9_Supplement/972.1","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089034825","display_name":"Claire L. Graham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire L. Graham","raw_affiliation_strings":["St Jude Children's Research Hospital, Memphis, TN,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Jude Children's Research Hospital, Memphis, TN,","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chandra L. Tucker","orcid":"https://orcid.org/0000-0003-3033-1786","observed_orcids":["https://orcid.org/0000-0003-3033-1786"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chandra L. Tucker","raw_affiliation_strings":["St Jude Children's Research Hospital, Memphis, TN,"],"raw_orcid":"https://orcid.org/0000-0003-3033-1786","affiliations":[{"raw_affiliation_string":"St Jude Children's Research Hospital, Memphis, TN,","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033300554","display_name":"Franklin C. Harwood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Franklin C. Harwood","raw_affiliation_strings":["St Jude Children's Research Hospital, Memphis, TN,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Jude Children's Research Hospital, Memphis, TN,","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008374819","display_name":"Lorina Dudkin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lorina Dudkin","raw_affiliation_strings":["St Jude Children's Research Hospital, Memphis, TN,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Jude Children's Research Hospital, Memphis, TN,","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046939499","display_name":"Jeremy Creech","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy Creech","raw_affiliation_strings":["St Jude Children's Research Hospital, Memphis, TN,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Jude Children's Research Hospital, Memphis, TN,","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141110200","display_name":"Edward Favours","orcid":"https://orcid.org/0009-0001-2023-2912","observed_orcids":["https://orcid.org/0009-0001-2023-2912"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Favours","raw_affiliation_strings":["St Jude Children's Research Hospital, Memphis, TN,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Jude Children's Research Hospital, Memphis, TN,","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109173471","display_name":"Peter J. Houghton","orcid":"https://orcid.org/0000-0002-2400-8184","observed_orcids":["https://orcid.org/0000-0002-2400-8184"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter J. Houghton","raw_affiliation_strings":["St Jude Children's Research Hospital, Memphis, TN,"],"raw_orcid":"https://orcid.org/0000-0002-2400-8184","affiliations":[{"raw_affiliation_string":"St Jude Children's Research Hospital, Memphis, TN,","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1313298211"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33183936,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"65","issue":null,"first_page":"972","last_page":"972"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/depsipeptides","display_name":"depsipeptides","score":0.9990000128746033},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9710000157356262},{"id":"https://openalex.org/keywords/pediatric-cancer","display_name":"childhood cancer","score":0.9269999861717224},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.7649999856948853},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8859999775886536},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9739999771118164},{"id":"https://openalex.org/keywords/parp-cleavage","display_name":"PARP cleavage","score":0.9390000104904175},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.7170000076293945},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5879999995231628},{"id":"https://openalex.org/keywords/rhabdomyosarcoma","display_name":"rhabdomyosarcoma","score":0.8510000109672546},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9100000262260437},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.8230000138282776},{"id":"https://openalex.org/keywords/kidney-cancer","display_name":"kidney cancer","score":0.7170000076293945},{"id":"https://openalex.org/keywords/brain-tumors","display_name":"brain tumors","score":0.8859999775886536},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.6259999871253967},{"id":"https://openalex.org/keywords/histone-acetyltransferase","display_name":"histone acetyltransferase","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C168831097","wikidata":"https://www.wikidata.org/wiki/Q413248","display_name":"Depsipeptide","level":2,"score":0.7969229221343994},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.7648523449897766},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.619522750377655},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6177842617034912},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5902610421180725},{"id":"https://openalex.org/C2779085176","wikidata":"https://www.wikidata.org/wiki/Q24721644","display_name":"Histone H4","level":4,"score":0.5652064085006714},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4940043091773987},{"id":"https://openalex.org/C2776202225","wikidata":"https://www.wikidata.org/wiki/Q3569101","display_name":"Histone deacetylase inhibitor","level":5,"score":0.4836803376674652},{"id":"https://openalex.org/C2776262904","wikidata":"https://www.wikidata.org/wiki/Q905901","display_name":"Vorinostat","level":5,"score":0.4728337228298187},{"id":"https://openalex.org/C2778001298","wikidata":"https://www.wikidata.org/wiki/Q1036906","display_name":"Histone acetyltransferase","level":4,"score":0.4272557497024536},{"id":"https://openalex.org/C4951695","wikidata":"https://www.wikidata.org/wiki/Q18046437","display_name":"HDAC11","level":5,"score":0.41360852122306824},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32872241735458374},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17079955339431763},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07280951738357544}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3206505277","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/65/9_Supplement/972.1","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2100874086","https://openalex.org/W2061352751","https://openalex.org/W757195406","https://openalex.org/W2052181006","https://openalex.org/W2601537845","https://openalex.org/W2023501346","https://openalex.org/W2015136452","https://openalex.org/W2539405260","https://openalex.org/W2106357158","https://openalex.org/W2009984954"],"abstract_inverted_index":{"4119":[0],"Histone":[2],"acetyltransferases":[3],"and":[4,14,19,36,81,105,114,142,144,158,168,178,181,199,213,237,244,253,287,294,356,408],"histone":[5,163,189,194,211,344],"deacetylases":[6],"(HDACs)":[7],"control":[8,243],"the":[9,97,160,207,226,261,301,319,321,373,377],"acetylation":[10,98,164,195,212,359],"state":[11,99],"of":[12,24,100,109,119,162,188,210,229,275,318,358,376],"histones":[13,101],"other":[15],"proteins":[16],"regulating":[17],"transcription":[18],"protein":[20,107],"function.":[21],"A":[22],"number":[23],"structurally":[25],"diverse":[26],"HDAC":[27],"inhibitors":[28],"have":[29,37,62,150,309,399],"been":[30,38],"developed":[31],"as":[32,88,370,396],"cancer":[33],"therapeutic":[34],"agents":[35],"shown":[39],"to":[40,95,233,390],"cause":[41],"differentiation,":[42],"cell":[43],"cycle":[44],"arrest":[45,220],"or":[46],"apoptosis.":[47],"Depsipeptide":[48],"is":[49,394],"a":[50,185,367,386,403],"natural":[51],"tetrapeptide":[52],"that":[53,171,306,333],"was":[54,93,123,256,266,282,314],"isolated":[55],"from":[56],"Chromobacterium":[57],"violaceum":[58],"No.":[59],"968.":[60],"We":[61,149],"evaluated":[63],"depsipeptide":[64,334,382,397],"against":[65],"39":[66,131],"independently":[67],"derived":[68],"childhood":[69],"tumors":[70,132,157,175,183,205,289,296,308],"(9":[71],"brain":[72],"tumors,":[73],"11":[74],"kidney":[75],"cancers,":[76],"9":[77],"rhabdomyosarcomas,":[78],"3":[79],"neuroblastomas,":[80],"7":[82],"osteosarcomas)":[83],"growing":[84],"in":[85,154,172,193,218,231,242,260,316,339,365,402],"scid":[86],"mice":[87],"xenografts.":[89],"Western":[90],"Blot":[91],"analysis":[92],"performed":[94],"determine":[96],"(H2A,":[102,165],"H2B,":[103,166],"H3":[104,167],"H4),":[106],"levels":[108,209,323],"p53,":[110,292],"pp53":[111,280],"(ser15),":[112],"p21cip1":[113,276],"cleaved":[115],"PARP":[116,313],"following":[117],"administration":[118],"depsipeptide.":[120],"The":[121,354],"MTD":[122],"4.4":[124],"mg/kg":[125],"administered":[126],"q7dx3iv":[127],"(repeated":[128],"q21dx2).":[129],"Of":[130],"evaluated,":[133],"three":[134,173],"were":[135,200,240,324],"considered":[136],"sensitive":[137,156,249],"(2":[138],"stable":[139,291],"disease,":[140],"IRS56":[141,252],"BT35,":[143,284],"1":[145],"complete":[146],"response,":[147],"BT27).":[148],"compared":[151],"pharmacodynamic":[152],"changes":[153],"these":[155,307],"contrasted":[159],"pattern":[161,187],"H4)":[169],"with":[170,273,351],"resistant":[174,182],"(GBM2,":[176],"SKNEP":[177,286,295],"WT10).":[179],"Sensitive":[180],"followed":[184],"similar":[186],"acetylation;":[190],"maximal":[191,268],"increases":[192],"occurred":[196],"at":[197,269],"8hr":[198],"elevated":[201],"for":[202],"96hr.":[203],"BT35":[204],"showed":[206],"highest":[208,322],"therefore":[214],"more":[215],"genes":[216],"involved":[217],"growth":[219],"may":[221,360,371],"be":[222,361,372,391],"transcribed.":[223],"To":[224],"investigate":[225],"putative":[227],"role":[228],"p53":[230,236,259,374],"sensitivity":[232],"depsipeptide,":[234],"total":[235],"phospho-p53":[238],"(Ser15)":[239,281],"determined":[241],"treated":[245],"tumors.":[246],"In":[247],"two":[248],"tumor":[250,368,388],"lines,":[251],"BT27,":[254],"there":[255],"no":[257,279],"detectable":[258],"controls":[262],"but":[263],"an":[264,362],"increase":[265],"observed":[267],"8":[270],"hr":[271],"associated":[272],"induction":[274],"after":[277,328],"treatment;":[278],"detected.":[283],"GBM2,":[285],"WT10":[288],"had":[290,298],"GBM2":[293],"also":[297],"pp53,":[299],"throughout":[300],"time":[302],"course":[303],"studied":[304],"suggesting":[305],"mutant":[310],"p53.":[311],"Cleaved":[312],"detected":[315,325],"all":[317],"tumors;":[320],"24":[326],"hours":[327],"treatment.":[329],"Our":[330],"results":[331],"demonstrate":[332],"does":[335,348],"inhibit":[336],"its":[337],"target":[338],"vivo":[340],"i.e.":[341],"causes":[342],"increased":[343],"acetylation,":[345],"however":[346],"this":[347],"not":[349],"correlate":[350],"drug":[352],"sensitivity.":[353],"magnitude":[355],"duration":[357],"important":[363],"factor":[364],"whether":[366,381],"responds,":[369],"status":[375],"tumor.":[378],"Altogether,":[379],"determining":[380],"would":[383],"work":[384],"on":[385],"given":[387],"seems":[389],"multifactorial,":[392],"which":[393],"understandable":[395],"can":[398],"multiple":[400],"effects":[401],"cell.":[404],"Supported":[405],"by":[406],"CA23099":[407],"ALSAC.":[409]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2021-10-25T00:00:00"}