{"id":"https://openalex.org/W3206491939","doi":"https://doi.org/10.1016/j.vaccine.2021.09.042","title":"Laser vaccine adjuvants: Light-augmented immune responses","display_name":"Laser vaccine adjuvants: Light-augmented immune responses","publication_year":2021,"publication_date":"2021-10-18","ids":{"openalex":"https://openalex.org/W3206491939","doi":"https://doi.org/10.1016/j.vaccine.2021.09.042","mag":"3206491939","pmid":"https://pubmed.ncbi.nlm.nih.gov/34666921"},"language":"en","primary_location":{"id":"doi:10.1016/j.vaccine.2021.09.042","doi":"https://doi.org/10.1016/j.vaccine.2021.09.042","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.vaccine.2021.09.042","pdf_url":null,"source":{"id":"https://openalex.org/S27359860","display_name":"Vaccine","issn_l":"0264-410X","issn":["0264-410X","1873-2518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048622571","display_name":"Yohei Maki","orcid":"https://orcid.org/0000-0002-8926-7320","observed_orcids":["https://orcid.org/0000-0002-8926-7320"]},"institutions":[{"id":"https://openalex.org/I4210087193","display_name":"National Defense Medical College Hospital","ror":"https://ror.org/004ej3g52","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087193"]},{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yohei Maki","raw_affiliation_strings":["Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan","institution_ids":["https://openalex.org/I4210087193","https://openalex.org/I53888640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039744313","display_name":"Satoshi Kashiwagi","orcid":"https://orcid.org/0000-0001-8910-3257","observed_orcids":["https://orcid.org/0000-0001-8910-3257"]},"institutions":[{"id":"https://openalex.org/I4210087356","display_name":"Gordon Center for Medical Imaging","ror":"https://ror.org/004y4rj95","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087356","https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satoshi Kashiwagi","raw_affiliation_strings":["Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I4210087356","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040256302","display_name":"Yoshifumi Kimizuka","orcid":"https://orcid.org/0000-0002-4026-7506","observed_orcids":["https://orcid.org/0000-0002-4026-7506"]},"institutions":[{"id":"https://openalex.org/I4210087193","display_name":"National Defense Medical College Hospital","ror":"https://ror.org/004ej3g52","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087193"]},{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshifumi Kimizuka","raw_affiliation_strings":["Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. Electronic address: ykimizuka@ndmc.ac.jp","Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. Electronic address: ykimizuka@ndmc.ac.jp","institution_ids":["https://openalex.org/I53888640"]},{"raw_affiliation_string":"Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan","institution_ids":["https://openalex.org/I4210087193","https://openalex.org/I53888640"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5040256302"],"corresponding_institution_ids":["https://openalex.org/I4210087193","https://openalex.org/I53888640"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":null,"fwci":0.2482,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.23756345,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"39","issue":"46","first_page":"6805","last_page":"6812"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11566","display_name":"Laser Applications in Dentistry and Medicine","score":0.5038999915122986,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11566","display_name":"Laser Applications in Dentistry and Medicine","score":0.5038999915122986,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.391400009393692,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.050700001418590546,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/light-tissue-interaction","display_name":"light-tissue interaction","score":0.6949999928474426},{"id":"https://openalex.org/keywords/laser-classification","display_name":"laser classification","score":0.5249999761581421},{"id":"https://openalex.org/keywords/immune-response-mechanisms","display_name":"immune response mechanisms","score":0.640999972820282},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.7919999957084656},{"id":"https://openalex.org/keywords/adjuvant-safety","display_name":"adjuvant safety","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.7635678052902222},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6151065826416016},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.6142920851707458},{"id":"https://openalex.org/C3020289777","wikidata":"https://www.wikidata.org/wiki/Q967453","display_name":"Vaccine adjuvant","level":3,"score":0.5474714040756226},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5015609264373779},{"id":"https://openalex.org/C2987362361","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser light","level":3,"score":0.48972347378730774},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.4782066345214844},{"id":"https://openalex.org/C520434653","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser","level":2,"score":0.429463267326355},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.4180188477039337},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41608238220214844},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.08154210448265076},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000089582","descriptor_name":"Adjuvants, Vaccine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007109","descriptor_name":"Immunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007834","descriptor_name":"Lasers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.vaccine.2021.09.042","doi":"https://doi.org/10.1016/j.vaccine.2021.09.042","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.vaccine.2021.09.042","pdf_url":null,"source":{"id":"https://openalex.org/S27359860","display_name":"Vaccine","issn_l":"0264-410X","issn":["0264-410X","1873-2518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"journal-article"},{"id":"pmid:34666921","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34666921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5206106080","display_name":"Application of Near-Infrared Laser into Mucosal Vaccine Using Photobiomodulation","funder_award_id":"19K16703","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320310760","display_name":"Uehara Memorial Foundation","ror":"https://ror.org/00gc20a07"},{"id":"https://openalex.org/F4320315887","display_name":"GlaxoSmithKline Japan","ror":"https://ror.org/01j6sxy67"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W1897342331","https://openalex.org/W1918817725","https://openalex.org/W1966763936","https://openalex.org/W1968211648","https://openalex.org/W1980062145","https://openalex.org/W1982580075","https://openalex.org/W1987306279","https://openalex.org/W2002419419","https://openalex.org/W2009820177","https://openalex.org/W2012728588","https://openalex.org/W2014081858","https://openalex.org/W2018516011","https://openalex.org/W2021207488","https://openalex.org/W2027347827","https://openalex.org/W2028194551","https://openalex.org/W2029884055","https://openalex.org/W2031631972","https://openalex.org/W2032569684","https://openalex.org/W2033458284","https://openalex.org/W2048265579","https://openalex.org/W2048422869","https://openalex.org/W2057090900","https://openalex.org/W2062274977","https://openalex.org/W2071330198","https://openalex.org/W2090326173","https://openalex.org/W2091143237","https://openalex.org/W2092304479","https://openalex.org/W2092557417","https://openalex.org/W2102200089","https://openalex.org/W2115453935","https://openalex.org/W2121640968","https://openalex.org/W2124540381","https://openalex.org/W2126344303","https://openalex.org/W2135147563","https://openalex.org/W2144801376","https://openalex.org/W2149833300","https://openalex.org/W2153124699","https://openalex.org/W2154575177","https://openalex.org/W2155176367","https://openalex.org/W2161797937","https://openalex.org/W2264916381","https://openalex.org/W2315643928","https://openalex.org/W2324549278","https://openalex.org/W2336000290","https://openalex.org/W2423598418","https://openalex.org/W2565473109","https://openalex.org/W2602852954","https://openalex.org/W2605588408","https://openalex.org/W2614008691","https://openalex.org/W2737300260","https://openalex.org/W2792896584","https://openalex.org/W2803319413","https://openalex.org/W2810461321","https://openalex.org/W2883121408","https://openalex.org/W2884145325","https://openalex.org/W2886103417","https://openalex.org/W2890157392","https://openalex.org/W2900063234","https://openalex.org/W2900637798","https://openalex.org/W2901025172","https://openalex.org/W2907776327","https://openalex.org/W2964086043","https://openalex.org/W2990640985","https://openalex.org/W3003543996","https://openalex.org/W3020206123","https://openalex.org/W3091948925","https://openalex.org/W3094319191","https://openalex.org/W3147310958","https://openalex.org/W3191710337","https://openalex.org/W4211003453","https://openalex.org/W4322574969","https://openalex.org/W6640099018"],"related_works":["https://openalex.org/W3003543996","https://openalex.org/W2315643928","https://openalex.org/W2764195480","https://openalex.org/W2324549278","https://openalex.org/W4313412476","https://openalex.org/W3134503613","https://openalex.org/W2268836794","https://openalex.org/W2171263898","https://openalex.org/W1573116542","https://openalex.org/W2092304479"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-10-25T00:00:00"}